Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	8648
Gene name	Nuclear receptor coactivator 1
Gene symbol	NCOA1
Synonyms (NCBI Gene)	F-SRC-1KAT13ARIP160SRC1bHLHe42bHLHe74
Chromosome	2
Chromosome location	2p23.3
Summary	The protein encoded by this gene acts as a transcriptional coactivator for steroid and nuclear hormone receptors. It is a member of the p160/steroid receptor coactivator (SRC) family and like other family members has histone acetyltransferase activity and

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Show/Hide all (295)

miRTarBase ID	miRNA	Experiments	Reference
MIRT006106	hsa-miR-22-3p	Luciferase reporter assayWestern blot	21798241
MIRT006106	hsa-miR-22-3p	Luciferase reporter assayWestern blot	21798241
MIRT006106	hsa-miR-22-3p	Luciferase reporter assayWestern blot	21798241
MIRT051725	hsa-let-7d-5p	CLASH	23622248
MIRT302078	hsa-miR-34a-5p	MicroarrayqRT-PCR	22815788
MIRT655971	hsa-miR-548e-5p	HITS-CLIP	23824327
MIRT006106	hsa-miR-22-3p	qRT-PCRWestern blot	26244872
MIRT735019	hsa-miR-34c-5p	Luciferase reporter assayWestern blottingqRT-PCRELISA	33842985
MIRT655971	hsa-miR-548e-5p	HITS-CLIP	23824327
MIRT1176638	hsa-miR-200b	CLIP-seq
MIRT1176639	hsa-miR-200c	CLIP-seq
MIRT1176640	hsa-miR-362-5p	CLIP-seq
MIRT1176641	hsa-miR-369-3p	CLIP-seq
MIRT1176642	hsa-miR-374a	CLIP-seq
MIRT1176643	hsa-miR-374b	CLIP-seq
MIRT1176644	hsa-miR-429	CLIP-seq
MIRT1176645	hsa-miR-4293	CLIP-seq
MIRT1176646	hsa-miR-4636	CLIP-seq
MIRT1176647	hsa-miR-4699-3p	CLIP-seq
MIRT1176648	hsa-miR-4768-5p	CLIP-seq
MIRT1176649	hsa-miR-4795-3p	CLIP-seq
MIRT1176650	hsa-miR-500b	CLIP-seq
MIRT1176651	hsa-miR-501-5p	CLIP-seq
MIRT1176652	hsa-miR-562	CLIP-seq
MIRT1176653	hsa-miR-596	CLIP-seq
MIRT1176654	hsa-miR-105	CLIP-seq
MIRT1176655	hsa-miR-1283	CLIP-seq
MIRT1176656	hsa-miR-1301	CLIP-seq
MIRT1176657	hsa-miR-1343	CLIP-seq
MIRT1176658	hsa-miR-137	CLIP-seq
MIRT1176659	hsa-miR-1914	CLIP-seq
MIRT1176660	hsa-miR-216a	CLIP-seq
MIRT1176661	hsa-miR-219-5p	CLIP-seq
MIRT1176662	hsa-miR-223	CLIP-seq
MIRT1176663	hsa-miR-2277-3p	CLIP-seq
MIRT1176664	hsa-miR-25	CLIP-seq
MIRT1176665	hsa-miR-3074-5p	CLIP-seq
MIRT1176666	hsa-miR-3121-5p	CLIP-seq
MIRT1176667	hsa-miR-3123	CLIP-seq
MIRT1176668	hsa-miR-3124-3p	CLIP-seq
MIRT1176669	hsa-miR-3148	CLIP-seq
MIRT1176670	hsa-miR-3176	CLIP-seq
MIRT1176671	hsa-miR-3182	CLIP-seq
MIRT1176672	hsa-miR-32	CLIP-seq
MIRT1176673	hsa-miR-320e	CLIP-seq
MIRT1176674	hsa-miR-329	CLIP-seq
MIRT1176675	hsa-miR-338-5p	CLIP-seq
MIRT1176676	hsa-miR-33a	CLIP-seq
MIRT1176677	hsa-miR-33b	CLIP-seq
MIRT1176678	hsa-miR-3613-3p	CLIP-seq
MIRT1176679	hsa-miR-362-3p	CLIP-seq
MIRT1176680	hsa-miR-363	CLIP-seq
MIRT1176681	hsa-miR-3646	CLIP-seq
MIRT1176682	hsa-miR-3647-3p	CLIP-seq
MIRT1176683	hsa-miR-3662	CLIP-seq
MIRT1176684	hsa-miR-367	CLIP-seq
MIRT1176641	hsa-miR-369-3p	CLIP-seq
MIRT1176642	hsa-miR-374a	CLIP-seq
MIRT1176643	hsa-miR-374b	CLIP-seq
MIRT1176685	hsa-miR-377	CLIP-seq
MIRT1176686	hsa-miR-3922-3p	CLIP-seq
MIRT1176687	hsa-miR-3925-5p	CLIP-seq
MIRT1176688	hsa-miR-3941	CLIP-seq
MIRT1176689	hsa-miR-410	CLIP-seq
MIRT1176690	hsa-miR-4277	CLIP-seq
MIRT1176645	hsa-miR-4293	CLIP-seq
MIRT1176691	hsa-miR-4325	CLIP-seq
MIRT1176692	hsa-miR-4330	CLIP-seq
MIRT1176693	hsa-miR-4445	CLIP-seq
MIRT1176694	hsa-miR-4643	CLIP-seq
MIRT1176695	hsa-miR-4652-3p	CLIP-seq
MIRT1176696	hsa-miR-4668-5p	CLIP-seq
MIRT1176647	hsa-miR-4699-3p	CLIP-seq
MIRT1176697	hsa-miR-4699-5p	CLIP-seq
MIRT1176698	hsa-miR-4705	CLIP-seq
MIRT1176699	hsa-miR-4719	CLIP-seq
MIRT1176700	hsa-miR-4731-3p	CLIP-seq
MIRT1176648	hsa-miR-4768-5p	CLIP-seq
MIRT1176701	hsa-miR-4775	CLIP-seq
MIRT1176702	hsa-miR-4777-5p	CLIP-seq
MIRT1176703	hsa-miR-4782-3p	CLIP-seq
MIRT1176704	hsa-miR-4797-5p	CLIP-seq
MIRT1176705	hsa-miR-4801	CLIP-seq
MIRT1176706	hsa-miR-496	CLIP-seq
MIRT1176707	hsa-miR-498	CLIP-seq
MIRT1176708	hsa-miR-5047	CLIP-seq
MIRT1176709	hsa-miR-508-3p	CLIP-seq
MIRT1176710	hsa-miR-513a-3p	CLIP-seq
MIRT1176711	hsa-miR-518d-5p	CLIP-seq
MIRT1176712	hsa-miR-519b-5p	CLIP-seq
MIRT1176713	hsa-miR-519c-5p	CLIP-seq
MIRT1176714	hsa-miR-520c-5p	CLIP-seq
MIRT1176715	hsa-miR-526a	CLIP-seq
MIRT1176716	hsa-miR-548c-3p	CLIP-seq
MIRT1176652	hsa-miR-562	CLIP-seq
MIRT1176717	hsa-miR-590-3p	CLIP-seq
MIRT1176653	hsa-miR-596	CLIP-seq
MIRT1176718	hsa-miR-603	CLIP-seq
MIRT1176719	hsa-miR-642b	CLIP-seq
MIRT1176720	hsa-miR-875-3p	CLIP-seq
MIRT1176721	hsa-miR-890	CLIP-seq
MIRT1176722	hsa-miR-9	CLIP-seq
MIRT1176723	hsa-miR-92a	CLIP-seq
MIRT1176724	hsa-miR-92b	CLIP-seq
MIRT1176725	hsa-miR-944	CLIP-seq
MIRT1176654	hsa-miR-105	CLIP-seq
MIRT1176654	hsa-miR-105	CLIP-seq
MIRT1176654	hsa-miR-105	CLIP-seq
MIRT1176654	hsa-miR-105	CLIP-seq
MIRT1176654	hsa-miR-105	CLIP-seq
MIRT2051184	hsa-miR-4659a-3p	CLIP-seq
MIRT2051185	hsa-miR-4659b-3p	CLIP-seq
MIRT2280304	hsa-miR-4708-5p	CLIP-seq
MIRT1176654	hsa-miR-105	CLIP-seq
MIRT2280305	hsa-miR-128	CLIP-seq
MIRT2280306	hsa-miR-27a	CLIP-seq
MIRT2280307	hsa-miR-27b	CLIP-seq
MIRT2280308	hsa-miR-297	CLIP-seq
MIRT2280309	hsa-miR-3612	CLIP-seq
MIRT2280310	hsa-miR-3614-3p	CLIP-seq
MIRT2280311	hsa-miR-3675-3p	CLIP-seq
MIRT2280312	hsa-miR-3913-3p	CLIP-seq
MIRT2280313	hsa-miR-4279	CLIP-seq
MIRT1176691	hsa-miR-4325	CLIP-seq
MIRT2280314	hsa-miR-4443	CLIP-seq
MIRT2280315	hsa-miR-4635	CLIP-seq
MIRT2280316	hsa-miR-4691-5p	CLIP-seq
MIRT2280317	hsa-miR-4742-3p	CLIP-seq
MIRT1176649	hsa-miR-4795-3p	CLIP-seq
MIRT2280318	hsa-miR-4796-5p	CLIP-seq
MIRT2280319	hsa-miR-489	CLIP-seq
MIRT2280320	hsa-miR-499-3p	CLIP-seq
MIRT2280321	hsa-miR-499a-3p	CLIP-seq
MIRT2280322	hsa-miR-567	CLIP-seq
MIRT2280323	hsa-miR-605	CLIP-seq
MIRT2280324	hsa-miR-650	CLIP-seq
MIRT2280325	hsa-miR-654-3p	CLIP-seq
MIRT2280326	hsa-miR-659	CLIP-seq
MIRT2578754	hsa-miR-1207-5p	CLIP-seq
MIRT2578755	hsa-miR-1225-3p	CLIP-seq
MIRT2578756	hsa-miR-1233	CLIP-seq
MIRT2578757	hsa-miR-1257	CLIP-seq
MIRT2578758	hsa-miR-1265	CLIP-seq
MIRT2578759	hsa-miR-1275	CLIP-seq
MIRT2578760	hsa-miR-1285	CLIP-seq
MIRT2578761	hsa-miR-129-3p	CLIP-seq
MIRT2578762	hsa-miR-1302	CLIP-seq
MIRT1176657	hsa-miR-1343	CLIP-seq
MIRT1176658	hsa-miR-137	CLIP-seq
MIRT1176662	hsa-miR-223	CLIP-seq
MIRT1176664	hsa-miR-25	CLIP-seq
MIRT2578763	hsa-miR-296-3p	CLIP-seq
MIRT1176665	hsa-miR-3074-5p	CLIP-seq
MIRT2578764	hsa-miR-3122	CLIP-seq
MIRT1176668	hsa-miR-3124-3p	CLIP-seq
MIRT2578765	hsa-miR-3187-5p	CLIP-seq
MIRT2578766	hsa-miR-3199	CLIP-seq
MIRT1176672	hsa-miR-32	CLIP-seq
MIRT1176676	hsa-miR-33a	CLIP-seq
MIRT1176677	hsa-miR-33b	CLIP-seq
MIRT2578767	hsa-miR-3605-5p	CLIP-seq
MIRT2280309	hsa-miR-3612	CLIP-seq
MIRT1176678	hsa-miR-3613-3p	CLIP-seq
MIRT2578768	hsa-miR-361-3p	CLIP-seq
MIRT1176680	hsa-miR-363	CLIP-seq
MIRT2578769	hsa-miR-3655	CLIP-seq
MIRT2578770	hsa-miR-3659	CLIP-seq
MIRT1176684	hsa-miR-367	CLIP-seq
MIRT2578771	hsa-miR-3679-3p	CLIP-seq
MIRT2578772	hsa-miR-3690	CLIP-seq
MIRT2578773	hsa-miR-376a	CLIP-seq
MIRT2578774	hsa-miR-376b	CLIP-seq
MIRT2578775	hsa-miR-3909	CLIP-seq
MIRT2578776	hsa-miR-3913-5p	CLIP-seq
MIRT2578777	hsa-miR-3960	CLIP-seq
MIRT2578778	hsa-miR-409-3p	CLIP-seq
MIRT2578779	hsa-miR-4254	CLIP-seq
MIRT1176690	hsa-miR-4277	CLIP-seq
MIRT2280313	hsa-miR-4279	CLIP-seq
MIRT2578780	hsa-miR-4298	CLIP-seq
MIRT2578781	hsa-miR-432	CLIP-seq
MIRT2578782	hsa-miR-4320	CLIP-seq
MIRT2578783	hsa-miR-4425	CLIP-seq
MIRT2578784	hsa-miR-4428	CLIP-seq
MIRT2280314	hsa-miR-4443	CLIP-seq
MIRT2578785	hsa-miR-4446-5p	CLIP-seq
MIRT2578786	hsa-miR-4525	CLIP-seq
MIRT2578787	hsa-miR-4639-5p	CLIP-seq
MIRT1176695	hsa-miR-4652-3p	CLIP-seq
MIRT2578788	hsa-miR-4658	CLIP-seq
MIRT2051184	hsa-miR-4659a-3p	CLIP-seq
MIRT2051185	hsa-miR-4659b-3p	CLIP-seq
MIRT2578789	hsa-miR-4665-5p	CLIP-seq
MIRT2578790	hsa-miR-4677-3p	CLIP-seq
MIRT2578791	hsa-miR-4679	CLIP-seq
MIRT2280316	hsa-miR-4691-5p	CLIP-seq
MIRT2578792	hsa-miR-4723-5p	CLIP-seq
MIRT2280317	hsa-miR-4742-3p	CLIP-seq
MIRT2578793	hsa-miR-4763-3p	CLIP-seq
MIRT1176702	hsa-miR-4777-5p	CLIP-seq
MIRT2578794	hsa-miR-4778-3p	CLIP-seq
MIRT2578795	hsa-miR-515-5p	CLIP-seq
MIRT1176711	hsa-miR-518d-5p	CLIP-seq
MIRT1176712	hsa-miR-519b-5p	CLIP-seq
MIRT1176713	hsa-miR-519c-5p	CLIP-seq
MIRT1176714	hsa-miR-520c-5p	CLIP-seq
MIRT1176715	hsa-miR-526a	CLIP-seq
MIRT2578796	hsa-miR-548g	CLIP-seq
MIRT2578797	hsa-miR-574-5p	CLIP-seq
MIRT2578798	hsa-miR-612	CLIP-seq
MIRT2578799	hsa-miR-625	CLIP-seq
MIRT2280324	hsa-miR-650	CLIP-seq
MIRT2578800	hsa-miR-658	CLIP-seq
MIRT2280326	hsa-miR-659	CLIP-seq
MIRT2578801	hsa-miR-676	CLIP-seq
MIRT1176723	hsa-miR-92a	CLIP-seq
MIRT1176724	hsa-miR-92b	CLIP-seq
MIRT1176725	hsa-miR-944	CLIP-seq
MIRT2578801	hsa-miR-676	CLIP-seq
MIRT2578754	hsa-miR-1207-5p	CLIP-seq
MIRT2578755	hsa-miR-1225-3p	CLIP-seq
MIRT2578756	hsa-miR-1233	CLIP-seq
MIRT2578757	hsa-miR-1257	CLIP-seq
MIRT2578758	hsa-miR-1265	CLIP-seq
MIRT2578759	hsa-miR-1275	CLIP-seq
MIRT2578760	hsa-miR-1285	CLIP-seq
MIRT2578761	hsa-miR-129-3p	CLIP-seq
MIRT2578762	hsa-miR-1302	CLIP-seq
MIRT1176657	hsa-miR-1343	CLIP-seq
MIRT1176658	hsa-miR-137	CLIP-seq
MIRT2685919	hsa-miR-205	CLIP-seq
MIRT1176664	hsa-miR-25	CLIP-seq
MIRT2578763	hsa-miR-296-3p	CLIP-seq
MIRT2685920	hsa-miR-299-5p	CLIP-seq
MIRT1176665	hsa-miR-3074-5p	CLIP-seq
MIRT2578764	hsa-miR-3122	CLIP-seq
MIRT1176668	hsa-miR-3124-3p	CLIP-seq
MIRT2578765	hsa-miR-3187-5p	CLIP-seq
MIRT2578766	hsa-miR-3199	CLIP-seq
MIRT1176672	hsa-miR-32	CLIP-seq
MIRT1176676	hsa-miR-33a	CLIP-seq
MIRT1176677	hsa-miR-33b	CLIP-seq
MIRT2578767	hsa-miR-3605-5p	CLIP-seq
MIRT2280309	hsa-miR-3612	CLIP-seq
MIRT1176678	hsa-miR-3613-3p	CLIP-seq
MIRT2578768	hsa-miR-361-3p	CLIP-seq
MIRT2280310	hsa-miR-3614-3p	CLIP-seq
MIRT1176680	hsa-miR-363	CLIP-seq
MIRT2578769	hsa-miR-3655	CLIP-seq
MIRT2578770	hsa-miR-3659	CLIP-seq
MIRT1176684	hsa-miR-367	CLIP-seq
MIRT2578771	hsa-miR-3679-3p	CLIP-seq
MIRT2578772	hsa-miR-3690	CLIP-seq
MIRT2578773	hsa-miR-376a	CLIP-seq
MIRT2578774	hsa-miR-376b	CLIP-seq
MIRT2578775	hsa-miR-3909	CLIP-seq
MIRT2578776	hsa-miR-3913-5p	CLIP-seq
MIRT2578777	hsa-miR-3960	CLIP-seq
MIRT2578778	hsa-miR-409-3p	CLIP-seq
MIRT2578779	hsa-miR-4254	CLIP-seq
MIRT2280313	hsa-miR-4279	CLIP-seq
MIRT2578780	hsa-miR-4298	CLIP-seq
MIRT2578781	hsa-miR-432	CLIP-seq
MIRT2578782	hsa-miR-4320	CLIP-seq
MIRT2578783	hsa-miR-4425	CLIP-seq
MIRT2578784	hsa-miR-4428	CLIP-seq
MIRT2280314	hsa-miR-4443	CLIP-seq
MIRT2578785	hsa-miR-4446-5p	CLIP-seq
MIRT2578786	hsa-miR-4525	CLIP-seq
MIRT2578787	hsa-miR-4639-5p	CLIP-seq
MIRT1176695	hsa-miR-4652-3p	CLIP-seq
MIRT2578788	hsa-miR-4658	CLIP-seq
MIRT2051184	hsa-miR-4659a-3p	CLIP-seq
MIRT2051185	hsa-miR-4659b-3p	CLIP-seq
MIRT2578789	hsa-miR-4665-5p	CLIP-seq
MIRT2578790	hsa-miR-4677-3p	CLIP-seq
MIRT2578791	hsa-miR-4679	CLIP-seq
MIRT2280316	hsa-miR-4691-5p	CLIP-seq
MIRT2578792	hsa-miR-4723-5p	CLIP-seq
MIRT2280317	hsa-miR-4742-3p	CLIP-seq
MIRT2578793	hsa-miR-4763-3p	CLIP-seq
MIRT2578794	hsa-miR-4778-3p	CLIP-seq
MIRT2578795	hsa-miR-515-5p	CLIP-seq
MIRT2578796	hsa-miR-548g	CLIP-seq
MIRT2578797	hsa-miR-574-5p	CLIP-seq
MIRT2280323	hsa-miR-605	CLIP-seq
MIRT2578798	hsa-miR-612	CLIP-seq
MIRT2578799	hsa-miR-625	CLIP-seq
MIRT2280324	hsa-miR-650	CLIP-seq
MIRT2578800	hsa-miR-658	CLIP-seq
MIRT2280326	hsa-miR-659	CLIP-seq
MIRT2578801	hsa-miR-676	CLIP-seq
MIRT1176723	hsa-miR-92a	CLIP-seq
MIRT1176724	hsa-miR-92b	CLIP-seq
MIRT1176725	hsa-miR-944	CLIP-seq

Show/Hide all (72)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000435	Process	Positive regulation of transcription from RNA polymerase II promoter by galactose	IDA	10207113
GO:0000785	Component	Chromatin	IDA	15831516, 17363140
GO:0000785	Component	Chromatin	ISA
GO:0000977	Function	RNA polymerase II transcription regulatory region sequence-specific DNA binding	IEA
GO:0002155	Process	Regulation of thyroid hormone receptor signaling pathway	IEA
GO:0003677	Function	DNA binding	IEA
GO:0003682	Function	Chromatin binding	IEA
GO:0003713	Function	Transcription coactivator activity	IBA
GO:0003713	Function	Transcription coactivator activity	IDA	10207113, 15919756, 17363140
GO:0003713	Function	Transcription coactivator activity	IEA
GO:0003713	Function	Transcription coactivator activity	NAS	15774904
GO:0004402	Function	Histone acetyltransferase activity	IEA
GO:0005515	Function	Protein binding	IPI	9556555, 10207113, 11682626, 12039952, 12403843, 12578355, 12917342, 14684751, 14698205, 15367689, 15641800, 16282588, 16456540, 16606617, 16957778, 17254542, 17363140, 17476305, 17627277, 17641689, 17673910, 18391212, 19039327, 19786558, 20203100, 20543827, 20682316, 21454491, 2147
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	IEA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005667	Component	Transcription regulator complex	IEA
GO:0005667	Component	Transcription regulator complex	IPI	12909012, 20543827, 20682316
GO:0005829	Component	Cytosol	IDA
GO:0005886	Component	Plasma membrane	IDA
GO:0006338	Process	Chromatin remodeling	IEA
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0007595	Process	Lactation	IEA
GO:0008584	Process	Male gonad development	IEA
GO:0009725	Process	Response to hormone	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0016746	Function	Acyltransferase activity	IEA
GO:0016922	Function	Nuclear receptor binding	IBA
GO:0016922	Function	Nuclear receptor binding	IDA	10207113
GO:0016922	Function	Nuclear receptor binding	IEA
GO:0016922	Function	Nuclear receptor binding	IPI	17363140, 18798693
GO:0021549	Process	Cerebellum development	IEA
GO:0021766	Process	Hippocampus development	IEA
GO:0021854	Process	Hypothalamus development	IEA
GO:0021987	Process	Cerebral cortex development	IEA
GO:0030331	Function	Nuclear estrogen receptor binding	IEA
GO:0030331	Function	Nuclear estrogen receptor binding	IPI	18563714
GO:0030520	Process	Estrogen receptor signaling pathway	IDA	7481822
GO:0032355	Process	Response to estradiol	IEA
GO:0032526	Process	Response to retinoic acid	IEA
GO:0032570	Process	Response to progesterone	IEA
GO:0032870	Process	Cellular response to hormone stimulus	IBA
GO:0032870	Process	Cellular response to hormone stimulus	IEA
GO:0032991	Component	Protein-containing complex	IMP	15641800
GO:0035357	Process	Peroxisome proliferator activated receptor signaling pathway	NAS	16373399
GO:0042789	Process	MRNA transcription by RNA polymerase II	IDA	16373399
GO:0042974	Function	Nuclear retinoic acid receptor binding	IEA
GO:0043065	Process	Positive regulation of apoptotic process	IEA
GO:0044849	Process	Estrous cycle	IEA
GO:0044877	Function	Protein-containing complex binding	IEA
GO:0045666	Process	Positive regulation of neuron differentiation	IEA
GO:0045893	Process	Positive regulation of DNA-templated transcription	IDA	11891224
GO:0045893	Process	Positive regulation of DNA-templated transcription	IDA	15367689
GO:0045925	Process	Positive regulation of female receptivity	IEA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IBA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IDA	9223431, 15919756, 16373399
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IEA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IEA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	ISS
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	NAS	12909012, 15774904
GO:0046965	Function	Nuclear retinoid X receptor binding	IEA
GO:0046983	Function	Protein dimerization activity	IEA
GO:0050847	Process	Progesterone receptor signaling pathway	IDA	10757795
GO:0060179	Process	Male mating behavior	IEA
GO:0060713	Process	Labyrinthine layer morphogenesis	IEA
GO:0061733	Function	Protein-lysine-acetyltransferase activity	IEA
GO:0090575	Component	RNA polymerase II transcription regulator complex	IDA	16373399
GO:1900076	Process	Regulation of cellular response to insulin stimulus	NAS	16373399
GO:1904017	Process	Cellular response to Thyroglobulin triiodothyronine	IEA
GO:1904179	Process	Positive regulation of adipose tissue development	NAS	16373399

MIM	HGNC	e!Ensembl
602691	7668	ENSG00000084676

Q15788

Protein name

Nuclear receptor coactivator 1 (NCoA-1) (EC 2.3.1.48) (Class E basic helix-loop-helix protein 74) (bHLHe74) (Protein Hin-2) (RIP160) (Renal carcinoma antigen NY-REN-52) (Steroid receptor coactivator 1) (SRC-1)

Protein function

Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER),

PDB

1FM6 , 1FM9 , 1K4W , 1K74 , 1K7L , 1KV6 , 1N4H , 1NQ7 , 1NRL , 1P8D , 1PZL , 1RDT , 1TFC , 1U3R , 1U3S , 1X76 , 1X78 , 1X7B , 1X7J , 1XIU , 1XV9 , 1XVP , 1YY4 , 1YYE , 1ZAF , 2A3I , 2C52 , 2FVJ , 2GTK , 2HBH , 2HC4 , 2HCD , 2HFP , 2NPA , 2NV7 , 2P54 , 2PRG , 3BEJ , 3BQD , 3CTB , 3CWD , 3DCT , 3DCU , 3DR1 , 3ET1 , 3ET3 , 3FEI , 3FEJ , 3FUR , 3FXV , 3G8I

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00010	HLH	26 → 81	Helix-loop-helix DNA-binding domain	Domain
PF00989	PAS	112 → 185	PAS fold	Domain
PF14598	PAS_11	259 → 370		Domain
PF16665	NCOA_u2	467 → 590		Disordered
PF08832	SRC-1	628 → 708	Steroid receptor coactivator	Domain
PF08815	Nuc_rec_co-act	924 → 971	Nuclear receptor coactivator	Domain
PF07469	DUF1518	1149 → 1205	Domain of unknown function (DUF1518)	Domain
PF07469	DUF1518	1212 → 1268	Domain of unknown function (DUF1518)	Domain

Tissue specificity

TISSUE SPECIFICITY: Widely expressed. {ECO:0000269|PubMed:15313887, ECO:0000269|PubMed:9427757}.

Sequence

MSGLGDSSSDPANPDSHKRKGSPCDTLASSTEKRRREQENKYLEELAELLSANISDIDSL
SVKPDKCKILKKTVDQIQLMKRMEQEKSTTDDDVQKSDISSSSQGVIEKESLGPLLLEAL
DGFFFVVNCEGRIVFVSENVTSYLGYNQEELMNTSVYSILHVGDHAEFVKNLLPKSLVNG
VPWPQEATRRNSHTFNCRMLIHPPDEPGTENQEACQRYEVMQCFTVSQPKSIQEDGEDFQ
SCLICIARRLPRPPAITGVESFMTKQDTTGKIISIDTSSLRAAGRTGWEDLVRKCIYAFF
QPQGREPSYARQLFQEVMTRGTASSPSYRFILNDGTMLSAHTKCKLCYPQSPDMQPFIMG
IHIIDREHSGLSPQDDTNSGMSIPRVNPSVNPSISPAHGVARSSTLPPSNSNMVSTRINR
QQSSDLHSSSHSNSSNSQGSFGCSPGSQIVANVALNQGQASSQSSNPSLNLNNSPMEGTG
ISLAQFMSPRRQVTSGLATRPRMPNNSFPPNISTLSSPVGMTSSACNNNNRSYSNIPVTS
LQGMNEGPNNSVGFSASSPVLRQMSSQNSPSRLNIQPAKAESKDNKEIASILNEMIQSDN
SSSDGKPLDSGLLHNNDRLSDGDSKYSQTSHKLVQLLTTTAEQQLRHADIDTSCKDVLSC
TGTSNSASANSSGGSCPSSHSSLTERHKILHRLLQEGSPSDITTLSVEPDKKDSASTSVS
VTGQVQGNSSIKLELDASKKKESKDHQLLRYLLDKDEKDLRSTPNLSLDDVKVKVEKKEQ
MDPCNTNPTPMTKPTPEEIKLEAQSQFTADLDQFDQLLPTLEKAAQLPGLCETDRMDGAV
TSVTIKSEILPASLQSATARPTSRLNRLPELELEAIDNQFGQPGTGDQIPWTNNTVTAIN
QSKSEDQCISSQLDELLCPPTTVEGRNDEKALLEQLVSFLSGKDETELAELDRALGIDKL
VQGGGLDVLSERFPPQQATPPLIMEERPNLYSQPYSSPSPTANLPSPFQGMVRQKPSLGT
MPVQVTPPRGAFSPGMGMQPRQTLNRPPAAPNQLRLQLQQRLQGQQQLIHQNRQAILNQF
AATAPVGINMRSGMQQQITPQPPLNAQMLAQRQRELYSQQHRQRQLIQQQRAMLMRQQSF
GNNLPPSSGLPVQMGNPRLPQGAPQQFPYPPNYGTNPGTPPASTSPFSQLAANPEASLAN
RNSMVSRGMTGNIGGQFGTGINPQMQQNVFQYPGAGMVPQGEANFAPSLSPGSSMVPMPI
PPPQSSLLQQTPPASGYQSPDMKAWQQGAIGNNNVFSQAVQNQPTPAQPGVYNNMSITVS
MAGGNTNVQNMNPMMAQMQMSSLQMPGMNTVCPEQINDPALRHTGLYCNQLSSTDLLKTE
ADGTQQVQQVQVFADVQCTVNLVGGDPYLNQPGPLGTQKPTSGPQTPQAQQKSLLQQLLT
E

Sequence length

1441

Interactions

View interactions

	KEGG		Reactome
	Estrogen signaling pathway Thyroid hormone signaling pathway Pathways in cancer Breast cancer		RORA activates gene expression Recycling of bile acids and salts Synthesis of bile acids and bile salts Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Synthesis of bile acids and bile salts via 27-hydroxycholesterol PPARA activates gene expression Endogenous sterols Transcriptional activation of mitochondrial biogenesis Activation of gene expression by SREBF (SREBP) HATs acetylate histones Transcriptional regulation of white adipocyte differentiation SUMOylation of transcription cofactors Regulation of lipid metabolism by PPARalpha Circadian Clock Estrogen-dependent gene expression NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis

128

Show/Hide Unknown Diseases (3)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Acute myeloid leukemia	Likely benign	rs377167840	RCV005933147
NCOA1-related disorder	Uncertain significance; Likely benign; Benign	rs755651796, rs372628856, rs149553409, rs373210831, rs369495754, rs371097965, rs780018468, rs200996024, rs755365583, rs555210413, rs150715004, rs760996585, rs770891804, rs139389349, rs753321862 View all (110 more)	RCV003395626 RCV004741427 RCV004741425 RCV003936653 RCV004741430 RCV004741433 RCV003410225 RCV003420516 RCV003963793 RCV003966288 RCV004741467 RCV004741470 RCV003410322 RCV003410315 RCV003946477 RCV004741478 RCV004741479 RCV004741480 RCV003420672 RCV003397024 RCV004741494 RCV003402581 RCV003404322 RCV003408635 RCV003417041 RCV003427836 RCV003427851 RCV003427853 RCV003417098 RCV003408666 RCV003408673 RCV003392743 RCV003402603 RCV003392768 RCV003402611 RCV003402302 RCV003414515 RCV003416647 RCV003410626 RCV003397283 RCV003408504 RCV003410409 RCV003414193 RCV003414218 RCV003427770 RCV003414260 RCV003405846 RCV003414450 RCV003402653 RCV003402655 RCV003980906 RCV003901058 RCV003896679 RCV003896981 RCV003907242 RCV003921638 RCV003921659 RCV003919783 RCV003923810 RCV003923846 RCV003923993 RCV003924164 RCV003931846 RCV003893610 RCV003896291 RCV003896363 RCV003902148 RCV003902259 RCV003892322 RCV003906964 RCV003906973 RCV003904339 RCV003904621 RCV003964524 RCV003979570 RCV003967364 RCV003979859 RCV003979875 RCV003901937 RCV003903819 RCV003912207 RCV003912214 RCV003899525 RCV003899559 RCV003899576 RCV003909574 RCV003909600 RCV003909724 RCV003933887 RCV003934048 RCV003941871 RCV003952129 RCV003929549 RCV003941409 RCV003941433 RCV003951715 RCV003951783 RCV003943829 RCV003914342 RCV003936921 RCV003937154 RCV003951491 RCV003944410 RCV003944731 RCV003944783 RCV003957139 RCV003969286 RCV003961921 RCV003922007 RCV003932066 RCV003927399 RCV003949117 RCV003952245 RCV003964746 RCV003976880 RCV003981919 RCV003957307 RCV003959386 RCV003963817 RCV003969709 RCV003962289 RCV003972286 RCV004738963 RCV004738964 RCV004738965 RCV003983252
Sarcoma	Uncertain significance	rs772131644	RCV005936846

Show/Hide Text Mining Associations (52)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Bipolar Disorder	Associate	27468165
Bone Diseases	Associate	22174377
Breast Neoplasms	Associate	10688660, 15477868, 19755984, 20003447, 24304549, 24719557, 26621841, 27107013, 28973975
Breast Neoplasms	Inhibit	24705462
Carcinoma	Associate	34067464
Carcinoma Hepatocellular	Associate	28060733
Colorectal Neoplasms	Associate	32764874
Coronary Aneurysm	Associate	24652666
Diabetes Mellitus Type 1	Associate	33083497
Diabetic Nephropathies	Associate	32922187
Diarrhea	Associate	35137184
Endocrine System Diseases	Associate	35137184
Endometrial Hyperplasia	Associate	14601091
Endometrial Neoplasms	Associate	14601091
Ependymoma	Associate	33576087, 34389065
Esophageal Neoplasms	Associate	30270520
Esophageal Squamous Cell Carcinoma	Associate	30270520
Fractures Multiple	Associate	35137184
Glioma	Associate	27560795
Hereditary Angioedema Type III	Associate	19423651
Hereditary Breast and Ovarian Cancer Syndrome	Associate	23936147
Hyperphagia	Associate	35137184
Hypoxia	Inhibit	27560795
Hypoxia Brain	Associate	27560795
Inflammation	Associate	24438340
Kidney Neoplasms	Associate	33574497
Liver Cirrhosis	Associate	35137184
Lymphoma Non Hodgkin	Associate	28264017
Malignant Teratocarcinosarcoma	Associate	26371783
Menorrhagia	Associate	35137184
Mental Disorders	Associate	27468165
Mucocutaneous Lymph Node Syndrome	Associate	24652666
Multiple Myeloma	Associate	28264017
Neoplasm Metastasis	Associate	37378426
Neoplasms	Associate	18845648, 23044996, 24438340, 25081647, 28060733, 31008539, 32187044, 33481105, 33576087, 38000680
Neoplasms Adipose Tissue	Associate	35137184
Obesity	Associate	35137184
Ossification of Posterior Longitudinal Ligament	Associate	17702747
Osteopenic Nonfracture Syndrome	Associate	22174377
Osteoporosis	Associate	40603950
Ovarian Neoplasms	Associate	31464709, 38000680
Prostatic Neoplasms	Associate	12163482, 24705462
Pulmonary Disease Chronic Obstructive	Inhibit	40655182
Rhabdomyosarcoma	Associate	19953635, 32187044
Rhabdomyosarcoma Alveolar	Associate	26371783, 36232302
Sarcoma	Associate	33574497
Supratentorial Neoplasms	Associate	34389065
Thyroid Hormone Resistance Syndrome	Associate	35137184
Urethral Neoplasms	Associate	18845648
Urinary Bladder Neoplasms	Associate	18845648
Uterine Neoplasms	Associate	31464709, 38000680
Wounds and Injuries	Associate	35137184

NCOA1 (nuclear receptor coactivator 1)