Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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8645
|
Gene name
Gene Name - the full gene name approved by the HGNC.
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Potassium two pore domain channel subfamily K member 5 |
Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
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KCNK5 |
Synonyms (NCBI Gene)
Gene synonyms aliases
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K2p5.1, KCNK5b, TASK-2, TASK2 |
Chromosome
Chromosome number
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6 |
Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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6p21.2 |
Summary
Summary of gene provided in NCBI Entrez Gene.
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This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The message for this gene is mainly expressed in the cortical distal tubules and collecting ducts of the kidney. The protein is hi |
UniProt ID |
O95279
|
Protein name |
Potassium channel subfamily K member 5 (Acid-sensitive potassium channel protein TASK-2) (TWIK-related acid-sensitive K(+) channel 2) |
Protein function |
K(+) channel that conducts voltage-dependent outward rectifying currents upon membrane depolarization. Voltage sensing is coupled to K(+) electrochemical gradient in an 'ion flux gating' mode where outward but not inward ion flow opens the gate |
Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF07885
|
Ion_trans_2 |
60 → 138 |
Ion channel |
Family |
PF07885
|
Ion_trans_2 |
160 → 251 |
Ion channel |
Family |
|
Tissue specificity |
TISSUE SPECIFICITY: Abundant expression in kidney, also detected in liver, placenta and small intestine. In the kidney, expression is restricted to the distal tubules and collecting ducts (PubMed:9812978). Not expressed in proximal tubules or glomeruli (P |
Sequence |
|
Sequence length |
499 |
Interactions |
View interactions
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Causal |
Disease term |
Disease name |
dbSNP ID |
References |
Coronary artery disease |
CORONARY ARTERY DISEASE, AUTOSOMAL DOMINANT, 1, Coronary Artery Disease |
rs137852988, rs121918313, rs121918529, rs121918531, rs137852340, rs1555800701, rs1215189537 |
23202125, 29212778 |
Migraine |
Migraine Disorders |
rs794727411 |
23793025, 27322543, 27182965 |
|
Unknown |
Disease term |
Disease name |
Evidence |
References |
Source |
Myocardial Infarction |
Myocardial Infarction |
|
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GWAS |
Eating Disorders |
Eating Disorders |
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|
GWAS |
Gout |
Gout |
|
|
GWAS |
Diabetes |
Diabetes |
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|
GWAS |
Urolithiasis |
Urolithiasis |
|
|
GWAS |
Hypertension |
Hypertension |
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|
GWAS |
Dermatitis |
Dermatitis |
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GWAS |
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