Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein
Entrez ID	8624
Gene name	Proteasome assembly chaperone 1
Gene symbol	PSMG1
Synonyms (NCBI Gene)	C21LRPDSCR2LRPC21PAC-1PAC1Pba1
Chromosome	21
Chromosome location	21q22.2

105

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miRTarBase ID	miRNA	Experiments	Reference
MIRT005249	hsa-miR-155-5p	pSILAC	18668040
MIRT005284	hsa-miR-1-3p	pSILAC	18668040
MIRT005249	hsa-miR-155-5p	Proteomics;Other	18668040
MIRT005284	hsa-miR-1-3p	Proteomics;Other	18668040
MIRT041809	hsa-miR-484	CLASH	23622248
MIRT036600	hsa-miR-940	CLASH	23622248
MIRT654666	hsa-miR-2278	HITS-CLIP	23824327
MIRT654665	hsa-miR-646	HITS-CLIP	23824327
MIRT654664	hsa-miR-483-3p	HITS-CLIP	23824327
MIRT654663	hsa-miR-6736-3p	HITS-CLIP	23824327
MIRT654662	hsa-miR-4286	HITS-CLIP	23824327
MIRT654661	hsa-miR-4660	HITS-CLIP	23824327
MIRT654667	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT654666	hsa-miR-2278	HITS-CLIP	23824327
MIRT654665	hsa-miR-646	HITS-CLIP	23824327
MIRT654664	hsa-miR-483-3p	HITS-CLIP	23824327
MIRT654663	hsa-miR-6736-3p	HITS-CLIP	23824327
MIRT654662	hsa-miR-4286	HITS-CLIP	23824327
MIRT654661	hsa-miR-4660	HITS-CLIP	23824327
MIRT551269	hsa-miR-890	PAR-CLIP	21572407
MIRT551268	hsa-miR-501-3p	PAR-CLIP	21572407
MIRT551267	hsa-miR-502-3p	PAR-CLIP	21572407
MIRT551265	hsa-miR-5690	PAR-CLIP	21572407
MIRT551266	hsa-miR-6804-3p	PAR-CLIP	21572407
MIRT551264	hsa-miR-3622b-5p	PAR-CLIP	21572407
MIRT551263	hsa-miR-4281	PAR-CLIP	21572407
MIRT551262	hsa-miR-7977	PAR-CLIP	21572407
MIRT551261	hsa-miR-500a-3p	PAR-CLIP	21572407
MIRT551260	hsa-miR-133a-3p	PAR-CLIP	21572407
MIRT529873	hsa-miR-5692a	PAR-CLIP	21572407
MIRT529872	hsa-miR-4662a-3p	PAR-CLIP	21572407
MIRT544719	hsa-miR-577	PAR-CLIP	21572407
MIRT529871	hsa-miR-3613-3p	PAR-CLIP	21572407
MIRT529870	hsa-miR-371b-5p	PAR-CLIP	21572407
MIRT529869	hsa-miR-373-5p	PAR-CLIP	21572407
MIRT529868	hsa-miR-616-5p	PAR-CLIP	21572407
MIRT529873	hsa-miR-5692a	PAR-CLIP	22012620
MIRT529872	hsa-miR-4662a-3p	PAR-CLIP	22012620
MIRT529871	hsa-miR-3613-3p	PAR-CLIP	22012620
MIRT529870	hsa-miR-371b-5p	PAR-CLIP	22012620
MIRT529869	hsa-miR-373-5p	PAR-CLIP	22012620
MIRT529868	hsa-miR-616-5p	PAR-CLIP	22012620
MIRT449997	hsa-miR-1225-3p	PAR-CLIP	22100165
MIRT449996	hsa-miR-1233-3p	PAR-CLIP	22100165
MIRT449995	hsa-miR-6087	PAR-CLIP	22100165
MIRT449993	hsa-miR-5093	PAR-CLIP	22100165
MIRT449994	hsa-miR-1908-5p	PAR-CLIP	22100165
MIRT449992	hsa-miR-663a	PAR-CLIP	22100165
MIRT449991	hsa-miR-6787-5p	PAR-CLIP	22100165
MIRT449990	hsa-miR-625-5p	PAR-CLIP	22100165
MIRT449989	hsa-miR-6807-5p	PAR-CLIP	22100165
MIRT449988	hsa-miR-1273e	PAR-CLIP	22100165
MIRT654666	hsa-miR-2278	HITS-CLIP	23824327
MIRT654665	hsa-miR-646	HITS-CLIP	23824327
MIRT654664	hsa-miR-483-3p	HITS-CLIP	23824327
MIRT654663	hsa-miR-6736-3p	HITS-CLIP	23824327
MIRT654662	hsa-miR-4286	HITS-CLIP	23824327
MIRT654661	hsa-miR-4660	HITS-CLIP	23824327
MIRT654667	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT654666	hsa-miR-2278	HITS-CLIP	23824327
MIRT654665	hsa-miR-646	HITS-CLIP	23824327
MIRT654664	hsa-miR-483-3p	HITS-CLIP	23824327
MIRT654663	hsa-miR-6736-3p	HITS-CLIP	23824327
MIRT654662	hsa-miR-4286	HITS-CLIP	23824327
MIRT654661	hsa-miR-4660	HITS-CLIP	23824327
MIRT551269	hsa-miR-890	PAR-CLIP	21572407
MIRT551268	hsa-miR-501-3p	PAR-CLIP	21572407
MIRT551267	hsa-miR-502-3p	PAR-CLIP	21572407
MIRT551265	hsa-miR-5690	PAR-CLIP	21572407
MIRT551266	hsa-miR-6804-3p	PAR-CLIP	21572407
MIRT551264	hsa-miR-3622b-5p	PAR-CLIP	21572407
MIRT551263	hsa-miR-4281	PAR-CLIP	21572407
MIRT551262	hsa-miR-7977	PAR-CLIP	21572407
MIRT551261	hsa-miR-500a-3p	PAR-CLIP	21572407
MIRT551260	hsa-miR-133a-3p	PAR-CLIP	21572407
MIRT529873	hsa-miR-5692a	PAR-CLIP	21572407
MIRT529872	hsa-miR-4662a-3p	PAR-CLIP	21572407
MIRT544719	hsa-miR-577	PAR-CLIP	21572407
MIRT529871	hsa-miR-3613-3p	PAR-CLIP	21572407
MIRT529870	hsa-miR-371b-5p	PAR-CLIP	21572407
MIRT529869	hsa-miR-373-5p	PAR-CLIP	21572407
MIRT529868	hsa-miR-616-5p	PAR-CLIP	21572407
MIRT529873	hsa-miR-5692a	PAR-CLIP	22012620
MIRT529872	hsa-miR-4662a-3p	PAR-CLIP	22012620
MIRT529871	hsa-miR-3613-3p	PAR-CLIP	22012620
MIRT529870	hsa-miR-371b-5p	PAR-CLIP	22012620
MIRT529869	hsa-miR-373-5p	PAR-CLIP	22012620
MIRT529868	hsa-miR-616-5p	PAR-CLIP	22012620
MIRT449997	hsa-miR-1225-3p	PAR-CLIP	22100165
MIRT449996	hsa-miR-1233-3p	PAR-CLIP	22100165
MIRT449995	hsa-miR-6087	PAR-CLIP	22100165
MIRT449993	hsa-miR-5093	PAR-CLIP	22100165
MIRT449994	hsa-miR-1908-5p	PAR-CLIP	22100165
MIRT449992	hsa-miR-663a	PAR-CLIP	22100165
MIRT449991	hsa-miR-6787-5p	PAR-CLIP	22100165
MIRT449990	hsa-miR-625-5p	PAR-CLIP	22100165
MIRT449989	hsa-miR-6807-5p	PAR-CLIP	22100165
MIRT449988	hsa-miR-1273e	PAR-CLIP	22100165
MIRT1271026	hsa-miR-361-3p	CLIP-seq
MIRT1271027	hsa-miR-371-5p	CLIP-seq
MIRT1271028	hsa-miR-4698	CLIP-seq
MIRT1271029	hsa-miR-513c	CLIP-seq
MIRT1271030	hsa-miR-514b-5p	CLIP-seq
MIRT2306045	hsa-miR-1283	CLIP-seq
MIRT2306046	hsa-miR-3127-3p	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	16251969, 32296183, 33961781, 35271311, 35914814
GO:0005634	Component	Nucleus	HDA	21630459
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IDA	15670775
GO:0005737	Component	Cytoplasm	IEA
GO:0005783	Component	Endoplasmic reticulum	IBA
GO:0005783	Component	Endoplasmic reticulum	IDA	15590417
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005794	Component	Golgi apparatus	IDA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0021930	Process	Cerebellar granule cell precursor proliferation	IEA
GO:0043248	Process	Proteasome assembly	IEA
GO:0051131	Process	Chaperone-mediated protein complex assembly	IDA	16251969
GO:0051131	Process	Chaperone-mediated protein complex assembly	IGI	17189198
GO:0060090	Function	Molecular adaptor activity	IDA	16251969
GO:0060090	Function	Molecular adaptor activity	IGI	17189198
GO:0070628	Function	Proteasome binding	IBA
GO:0070628	Function	Proteasome binding	IEA
GO:0080129	Process	Proteasome core complex assembly	IBA
GO:0080129	Process	Proteasome core complex assembly	IEA
GO:0101031	Component	Protein folding chaperone complex	IDA	16251969

MIM	HGNC	e!Ensembl
605296	3043	ENSG00000183527

O95456

Protein name

Proteasome assembly chaperone 1 (PAC-1) (Chromosome 21 leucine-rich protein) (C21-LRP) (Down syndrome critical region protein 2) (Proteasome chaperone homolog 1) (Pba1)

Protein function

Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG2. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the hetero

PDB

8QYJ , 8QYL , 8QYM , 8QYN , 8QYS , 8QZ9 , 8TM3 , 8TM4 , 8TM5 , 8TM6 , 8YIX , 8YIY , 8YIZ

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF16094	PAC1	2 → 287	Proteasome assembly chaperone 4	Family

Tissue specificity

TISSUE SPECIFICITY: In the adult, detected in brain, colon, leukocytes, breast and testis. Widely expressed in the fetus. Also expressed in a variety of proliferating cell lines. {ECO:0000269|PubMed:10872820, ECO:0000269|PubMed:9784380}.

Sequence

MAATFFGEVVKAPCRAGTEDEEEEEEGRRETPEDREVRLQLARKREVRLLRRQTKTSLEV
SLLEKYPCSKFIIAIGNNAVAFLSSFVMNSGVWEEVGCAKLWNEWCRTTDTTHLSSTEAF
CVFYHLKSNPSVFLCQCSCYVAEDQQYQWLEKVFGSCPRKNMQITILTCRHVTDYKTSES
TGSLPSPFLRALKTQNFKDSACCPLLEQPNIVHDLPAAVLSYCQVWKIPAILYLCYTDVM
KLDLITVEAFKPILSTRSLKGLVKNIPQSTEILKKLMTTNEIQSNIYT

Sequence length

288

Interactions

View interactions

PSMG1 (proteasome assembly chaperone 1)