Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	8623
Gene name Gene Name - the full gene name approved by the HGNC.	Acetylserotonin O-methyltransferase like
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	ASMTL
Synonyms (NCBI Gene) Gene synonyms aliases	ASMTLX, ASMTLY, ASTML
Chromosome Chromosome number	X\|Y
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	X;Y
Summary Summary of gene provided in NCBI Entrez Gene.	The protein encoded by this gene has an N-terminus that is similar to the multicopy associated filamentation (maf) protein of Bacillus subtilis and to orfE of Escherichia coli, while the C-terminus is similar to N-acetylserotonin O-methyltransferase. This

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miRTarBase ID	miRNA	Experiments	Reference
MIRT027443	hsa-miR-98-5p	Microarray	19088304

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GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	16189514, 24722188, 25416956, 28514442, 32296183, 32814053, 33961781
GO:0005829	Component	Cytosol	IDA
GO:0008168	Function	Methyltransferase activity	IEA
GO:0008171	Function	O-methyltransferase activity	IEA
GO:0009117	Process	Nucleotide metabolic process	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0032259	Process	Methylation	IEA
GO:0036218	Function	DTTP diphosphatase activity	IEA
GO:0036221	Function	UTP diphosphatase activity	IEA
GO:0046983	Function	Protein dimerization activity	IEA
GO:0047429	Function	Nucleoside triphosphate diphosphatase activity	IBA
GO:0047429	Function	Nucleoside triphosphate diphosphatase activity	IEA

MIM	HGNC	e!Ensembl
300162	N/A	HGNC

Protein

UniProt ID

O95671

Protein name

Probable bifunctional dTTP/UTP pyrophosphatase/methyltransferase protein [Includes: dTTP/UTP pyrophosphatase (dTTPase/UTPase) (EC 3.6.1.9) (Nucleoside triphosphate pyrophosphatase) (Nucleotide pyrophosphatase) (Nucleotide PPase); N-acetylserotonin O-methy

Protein function

Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. Can also hydrolyze CTP and the modified nucleotides pseudo-UTP, 5-methyl-UTP (m(5)UTP) and 5-methyl-CTP (m(5)CTP). Has weak activity with dCTP, 8-oxo-GTP and N(4)-methyl-dCTP

PDB

2P5X , 6XI4 , 6XI5

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02545	Maf	14 → 211	Maf-like protein	Domain
PF16864	Dimerisation2	287 → 371	Dimerisation domain	Domain
PF00891	Methyltransf_2	388 → 600	O-methyltransferase domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Widely expressed. In adult, highly expressed in pancreas, placenta, fibroblast, thymus, prostate, testis, ovary and colon. Expressed at lower levels in spleen, small intestine and leukocytes. In fetus, expressed at high levels in the l

Sequence

MVLCPVIGKLLHKRVVLASASPRRQEILSNAGLRFEVVPSKFKEKLDKASFATPYGYAME
TAKQKALEVANRLYQKDLRAPDVVIGADTIVTVGGLILEKPVDKQDAYRMLSRLSGREHS
VFTGVAIVHCSSKDHQLDTRVSEFYEETKVKFSELSEELLWEYVHSGEPMDKAGGYGIQA
LGGMLVESVHGDFLNVVGFPLNHFCKQLVKLYYPPRPEDLRRSVKHDSIPAADTFEDLSD
VEGGGSEPTQRDAGSRDEKAEAGEAGQATAEAECHRTRETLPPFPTRLLELIEGFMLSKG
LLTACKLKVFDLLKDEAPQKAADIASKVDASACGMERLLDICAAMGLLEKTEQGYSNTET
ANVYLASDGEYSLHGFIMHNNDLTWNLFTYLEFAIREGTNQHHRALGKKAEDLFQDAYYQ
SPETRLRFMRAMHGMTKLTACQVATAFNLSRFSSACDVGGCTGALARELAREYPRMQVTV
FDLPDIIELAAHFQPPGPQAVQIHFAAGDFFRDPLPSAELYVLCRILHDWPDDKVHKLLS
RVAESCKPGAGLLLVETLLDEEKRVAQRALMQSLNMLVQTEGKERSLGEYQCLLELHGFH
QVQVVHLGGVLDAILATKVAP

Sequence length

621

Interactions

View interactions

	KEGG
	Pyrimidine metabolism Metabolic pathways Nucleotide metabolism

ASMTL (acetylserotonin O-methyltransferase like)