ASMTL (acetylserotonin O-methyltransferase like)

Gene
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
8623
Gene name Gene Name - the full gene name approved by the HGNC.
Acetylserotonin O-methyltransferase like
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
ASMTL
Synonyms (NCBI Gene) Gene synonyms aliases
ASMTLX, ASMTLY, ASTML
Chromosome Chromosome number
X|Y
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
X;Y
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene has an N-terminus that is similar to the multicopy associated filamentation (maf) protein of Bacillus subtilis and to orfE of Escherichia coli, while the C-terminus is similar to N-acetylserotonin O-methyltransferase. This
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(1)
miRTarBase ID miRNA Experiments Reference
MIRT027443 hsa-miR-98-5p Microarray 19088304
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(10)
GO ID Ontology Definition Evidence Reference
GO:0003674 Function Molecular_function ND
GO:0005515 Function Protein binding IPI 16189514, 24722188, 25416956, 28514442, 32296183, 32814053
GO:0005829 Component Cytosol IDA
GO:0008150 Process Biological_process ND
GO:0008171 Function O-methyltransferase activity IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
300162 N/A HGNC
Protein
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID O95671
Protein name Probable bifunctional dTTP/UTP pyrophosphatase/methyltransferase protein [Includes: dTTP/UTP pyrophosphatase (dTTPase/UTPase) (EC 3.6.1.9) (Nucleoside triphosphate pyrophosphatase) (Nucleotide pyrophosphatase) (Nucleotide PPase); N-acetylserotonin O-methy
Protein function Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. Can also hydrolyze CTP and the modified nucleotides pseudo-UTP, 5-methyl-UTP (m(5)UTP) and 5-methyl-CTP (m(5)CTP). Has weak activity with dCTP, 8-oxo-GTP and N(4)-methyl-dCTP
PDB 2P5X , 6XI4 , 6XI5
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF02545 Maf 14 → 211 Maf-like protein Domain
PF16864 Dimerisation2 287 → 371 Dimerisation domain Domain
PF00891 Methyltransf_2 388 → 600 O-methyltransferase domain Domain
Tissue specificity TISSUE SPECIFICITY: Widely expressed. In adult, highly expressed in pancreas, placenta, fibroblast, thymus, prostate, testis, ovary and colon. Expressed at lower levels in spleen, small intestine and leukocytes. In fetus, expressed at high levels in the l
Sequence
Sequence length 621
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG  
  Pyrimidine metabolism
Metabolic pathways
Nucleotide metabolism 		 
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Causal Diseases (1)
Causal
Disease term Disease name dbSNP ID References
Leukemia Leukemia, Myelocytic, Acute, Acute Myeloid Leukemia (AML-M2) rs121909646, rs121913488, rs587776834, rs752746786, rs869312821, rs767454740, rs1554564297 17330099
Show/Hide Text Mining Associations (2)
Associations from Text Mining
Disease Name Relationship Type References
Klinefelter Syndrome Associate 32959501
Tuberculosis Pulmonary Associate 36787336