Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
858
Gene name Gene Name - the full gene name approved by the HGNC.
Caveolin 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
CAV2
Synonyms (NCBI Gene) Gene synonyms aliases
CAV
Chromosome Chromosome number
7
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
7q31.2
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is a major component of the inner surface of caveolae, small invaginations of the plasma membrane, and is involved in essential cellular functions, including signal transduction, lipid metabolism, cellular growth control a
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT006655 hsa-miR-199a-3p Luciferase reporter assay, qRT-PCR, Western blot 21807947
MIRT006655 hsa-miR-199a-3p Luciferase reporter assay, qRT-PCR, Western blot 21807947
MIRT006655 hsa-miR-199a-3p Luciferase reporter assay, qRT-PCR, Western blot 21807947
MIRT006655 hsa-miR-199a-3p Luciferase reporter assay, qRT-PCR, Western blot 21807947
MIRT028136 hsa-miR-93-5p Sequencing 20371350
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000139 Component Golgi membrane IEA
GO:0001937 Process Negative regulation of endothelial cell proliferation IBA 21873635
GO:0001937 Process Negative regulation of endothelial cell proliferation ISS
GO:0001938 Process Positive regulation of endothelial cell proliferation IEA
GO:0002080 Component Acrosomal membrane IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
601048 1528 ENSG00000105971
Protein
UniProt ID P51636
Protein name Caveolin-2
Protein function May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driv
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01146 Caveolin 16 160 Caveolin Family
Tissue specificity TISSUE SPECIFICITY: Expressed in endothelial cells, smooth muscle cells, skeletal myoblasts and fibroblasts. {ECO:0000269|PubMed:9361015}.
Sequence
Sequence length 162
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Endocytosis
Focal adhesion
Prion disease
Bacterial invasion of epithelial cells
Proteoglycans in cancer
Fluid shear stress and atherosclerosis
  Extra-nuclear estrogen signaling
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Atrial fibrillation Atrial Fibrillation rs120074192, rs121908590, rs121908593, rs121434558, rs587776851, rs387906612, rs387906613, rs387906614, rs387906615, rs199472687, rs199472705, rs199473324, rs587777336, rs587777339, rs587777557
View all (6 more)
20062060
Glaucoma Glaucoma, Open-Angle, Glaucoma, Primary Open Angle rs121918355, rs1566660365, rs1566635134, rs121918356, rs1566634475, rs28936700, rs55771538, rs28936701, rs104893622, rs55989760, rs72549387, rs104893628, rs2125316417, rs104893629, rs74315328
View all (29 more)
20835238
Leukemia Leukemia, Myelocytic, Acute rs121909646, rs121913488, rs587776834, rs752746786, rs869312821, rs767454740, rs1554564297 27903959
Prostate cancer Malignant neoplasm of prostate rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582 15583422
Unknown
Disease term Disease name Evidence References Source
Paroxysmal atrial fibrillation Paroxysmal atrial fibrillation 20062060 ClinVar
Amyotrophic Lateral Sclerosis amyotrophic lateral sclerosis GenCC
Atrial Fibrillation Atrial Fibrillation GWAS
Pancreatic adenocarcinoma Pancreatic adenocarcinoma PDAC patients with high expression of PSMA6 having a significantly shorter overall survival rate. GWAS, CBGDA
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma of Lung Associate 37287976
Alzheimer Disease Associate 22142809, 29343717
Atherosclerosis Associate 14522500
Atrial Fibrillation Associate 20062060, 24239840
Brain Neoplasms Associate 29850392
Breast Neoplasms Associate 15305200, 18612310, 21584795, 27993161, 35132081, 37432976
Carcinogenesis Associate 31642198
Carcinoma Basal Cell Associate 18612310
Carcinoma Intraductal Noninfiltrating Stimulate 21584795
Carcinoma Renal Cell Associate 26043775