Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
Entrez ID	8578
Gene name	Scavenger receptor class F member 1
Gene symbol	SCARF1
Synonyms (NCBI Gene)	SRECSREC-ISREC1
Chromosome	17
Chromosome location	17p13.3
Summary	The protein encoded by this gene is a scavenger receptor that is expressed in endothelial cells. It regulates the uptake of chemically modified low density lipoproteins, including acetylated low density lipoprotein (Ac-LDL), and it may be involved in athe

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miRTarBase ID	miRNA	Experiments	Reference
MIRT052655	hsa-miR-548q	CLASH	23622248
MIRT689504	hsa-miR-508-5p	HITS-CLIP	23313552
MIRT683364	hsa-miR-3154	HITS-CLIP	23313552
MIRT689503	hsa-miR-1910-3p	HITS-CLIP	23313552
MIRT689502	hsa-miR-6511a-5p	HITS-CLIP	23313552
MIRT683363	hsa-miR-6808-5p	HITS-CLIP	23313552
MIRT683362	hsa-miR-6893-5p	HITS-CLIP	23313552
MIRT683361	hsa-miR-940	HITS-CLIP	23313552
MIRT683360	hsa-miR-3929	HITS-CLIP	23313552
MIRT683359	hsa-miR-4419b	HITS-CLIP	23313552
MIRT683358	hsa-miR-4478	HITS-CLIP	23313552
MIRT683357	hsa-miR-4768-3p	HITS-CLIP	23313552
MIRT689501	hsa-miR-1273g-3p	HITS-CLIP	23313552
MIRT689500	hsa-miR-6849-3p	HITS-CLIP	23313552
MIRT683356	hsa-miR-1247-3p	HITS-CLIP	23313552
MIRT689499	hsa-miR-766-3p	HITS-CLIP	23313552
MIRT683354	hsa-miR-4649-3p	HITS-CLIP	23313552
MIRT689498	hsa-miR-4793-3p	HITS-CLIP	23313552
MIRT683353	hsa-miR-6770-5p	HITS-CLIP	23313552
MIRT689497	hsa-miR-4537	HITS-CLIP	23313552
MIRT683352	hsa-miR-1827	HITS-CLIP	23313552
MIRT683351	hsa-miR-485-5p	HITS-CLIP	23313552
MIRT683350	hsa-miR-6884-5p	HITS-CLIP	23313552
MIRT683349	hsa-miR-4722-5p	HITS-CLIP	23313552
MIRT689496	hsa-miR-6499-3p	HITS-CLIP	23313552
MIRT683348	hsa-miR-7160-5p	HITS-CLIP	23313552
MIRT689495	hsa-miR-4327	HITS-CLIP	23313552
MIRT683347	hsa-miR-4434	HITS-CLIP	23313552
MIRT683346	hsa-miR-4516	HITS-CLIP	23313552
MIRT683345	hsa-miR-5703	HITS-CLIP	23313552
MIRT689494	hsa-miR-3612	HITS-CLIP	23313552
MIRT689493	hsa-miR-650	HITS-CLIP	23313552
MIRT683344	hsa-miR-1268a	HITS-CLIP	23313552
MIRT683343	hsa-miR-1268b	HITS-CLIP	23313552
MIRT689492	hsa-miR-6512-3p	HITS-CLIP	23313552
MIRT689491	hsa-miR-6720-5p	HITS-CLIP	23313552
MIRT689490	hsa-miR-7703	HITS-CLIP	23313552
MIRT689489	hsa-miR-455-3p	HITS-CLIP	23313552
MIRT689488	hsa-miR-6516-5p	HITS-CLIP	23313552
MIRT683341	hsa-miR-665	HITS-CLIP	23313552
MIRT683364	hsa-miR-3154	HITS-CLIP	23313552
MIRT683363	hsa-miR-6808-5p	HITS-CLIP	23313552
MIRT683362	hsa-miR-6893-5p	HITS-CLIP	23313552
MIRT683361	hsa-miR-940	HITS-CLIP	23313552
MIRT683360	hsa-miR-3929	HITS-CLIP	23313552
MIRT683359	hsa-miR-4419b	HITS-CLIP	23313552
MIRT683358	hsa-miR-4478	HITS-CLIP	23313552
MIRT683357	hsa-miR-4768-3p	HITS-CLIP	23313552
MIRT683356	hsa-miR-1247-3p	HITS-CLIP	23313552
MIRT683355	hsa-miR-6746-5p	HITS-CLIP	23313552
MIRT683354	hsa-miR-4649-3p	HITS-CLIP	23313552
MIRT683353	hsa-miR-6770-5p	HITS-CLIP	23313552
MIRT683352	hsa-miR-1827	HITS-CLIP	23313552
MIRT683351	hsa-miR-485-5p	HITS-CLIP	23313552
MIRT683350	hsa-miR-6884-5p	HITS-CLIP	23313552
MIRT683349	hsa-miR-4722-5p	HITS-CLIP	23313552
MIRT683348	hsa-miR-7160-5p	HITS-CLIP	23313552
MIRT683347	hsa-miR-4434	HITS-CLIP	23313552
MIRT683346	hsa-miR-4516	HITS-CLIP	23313552
MIRT683345	hsa-miR-5703	HITS-CLIP	23313552
MIRT683344	hsa-miR-1268a	HITS-CLIP	23313552
MIRT683343	hsa-miR-1268b	HITS-CLIP	23313552
MIRT683342	hsa-miR-6771-5p	HITS-CLIP	23313552
MIRT683341	hsa-miR-665	HITS-CLIP	23313552
MIRT442862	hsa-miR-4282	PAR-CLIP	23708386
MIRT442861	hsa-miR-4662a-5p	PAR-CLIP	23708386
MIRT442862	hsa-miR-4282	PAR-CLIP	22100165
MIRT442861	hsa-miR-4662a-5p	PAR-CLIP	22100165
MIRT442861	hsa-miR-4662a-5p	PAR-CLIP	27292025
MIRT689504	hsa-miR-508-5p	HITS-CLIP	23313552
MIRT683364	hsa-miR-3154	HITS-CLIP	23313552
MIRT689503	hsa-miR-1910-3p	HITS-CLIP	23313552
MIRT689502	hsa-miR-6511a-5p	HITS-CLIP	23313552
MIRT683363	hsa-miR-6808-5p	HITS-CLIP	23313552
MIRT683362	hsa-miR-6893-5p	HITS-CLIP	23313552
MIRT683361	hsa-miR-940	HITS-CLIP	23313552
MIRT683360	hsa-miR-3929	HITS-CLIP	23313552
MIRT683359	hsa-miR-4419b	HITS-CLIP	23313552
MIRT683358	hsa-miR-4478	HITS-CLIP	23313552
MIRT683357	hsa-miR-4768-3p	HITS-CLIP	23313552
MIRT689501	hsa-miR-1273g-3p	HITS-CLIP	23313552
MIRT689500	hsa-miR-6849-3p	HITS-CLIP	23313552
MIRT683356	hsa-miR-1247-3p	HITS-CLIP	23313552
MIRT689499	hsa-miR-766-3p	HITS-CLIP	23313552
MIRT683354	hsa-miR-4649-3p	HITS-CLIP	23313552
MIRT689498	hsa-miR-4793-3p	HITS-CLIP	23313552
MIRT683353	hsa-miR-6770-5p	HITS-CLIP	23313552
MIRT689497	hsa-miR-4537	HITS-CLIP	23313552
MIRT683352	hsa-miR-1827	HITS-CLIP	23313552
MIRT683351	hsa-miR-485-5p	HITS-CLIP	23313552
MIRT683350	hsa-miR-6884-5p	HITS-CLIP	23313552
MIRT683349	hsa-miR-4722-5p	HITS-CLIP	23313552
MIRT689496	hsa-miR-6499-3p	HITS-CLIP	23313552
MIRT683348	hsa-miR-7160-5p	HITS-CLIP	23313552
MIRT689495	hsa-miR-4327	HITS-CLIP	23313552
MIRT683347	hsa-miR-4434	HITS-CLIP	23313552
MIRT683346	hsa-miR-4516	HITS-CLIP	23313552
MIRT683345	hsa-miR-5703	HITS-CLIP	23313552
MIRT689494	hsa-miR-3612	HITS-CLIP	23313552
MIRT689493	hsa-miR-650	HITS-CLIP	23313552
MIRT683344	hsa-miR-1268a	HITS-CLIP	23313552
MIRT683343	hsa-miR-1268b	HITS-CLIP	23313552
MIRT689492	hsa-miR-6512-3p	HITS-CLIP	23313552
MIRT689491	hsa-miR-6720-5p	HITS-CLIP	23313552
MIRT689490	hsa-miR-7703	HITS-CLIP	23313552
MIRT689489	hsa-miR-455-3p	HITS-CLIP	23313552
MIRT689488	hsa-miR-6516-5p	HITS-CLIP	23313552
MIRT683341	hsa-miR-665	HITS-CLIP	23313552
MIRT683364	hsa-miR-3154	HITS-CLIP	23313552
MIRT683363	hsa-miR-6808-5p	HITS-CLIP	23313552
MIRT683362	hsa-miR-6893-5p	HITS-CLIP	23313552
MIRT683361	hsa-miR-940	HITS-CLIP	23313552
MIRT683360	hsa-miR-3929	HITS-CLIP	23313552
MIRT683359	hsa-miR-4419b	HITS-CLIP	23313552
MIRT683358	hsa-miR-4478	HITS-CLIP	23313552
MIRT683357	hsa-miR-4768-3p	HITS-CLIP	23313552
MIRT683356	hsa-miR-1247-3p	HITS-CLIP	23313552
MIRT683355	hsa-miR-6746-5p	HITS-CLIP	23313552
MIRT683354	hsa-miR-4649-3p	HITS-CLIP	23313552
MIRT683353	hsa-miR-6770-5p	HITS-CLIP	23313552
MIRT683352	hsa-miR-1827	HITS-CLIP	23313552
MIRT683351	hsa-miR-485-5p	HITS-CLIP	23313552
MIRT683350	hsa-miR-6884-5p	HITS-CLIP	23313552
MIRT683349	hsa-miR-4722-5p	HITS-CLIP	23313552
MIRT683348	hsa-miR-7160-5p	HITS-CLIP	23313552
MIRT683347	hsa-miR-4434	HITS-CLIP	23313552
MIRT683346	hsa-miR-4516	HITS-CLIP	23313552
MIRT683345	hsa-miR-5703	HITS-CLIP	23313552
MIRT683344	hsa-miR-1268a	HITS-CLIP	23313552
MIRT683343	hsa-miR-1268b	HITS-CLIP	23313552
MIRT683342	hsa-miR-6771-5p	HITS-CLIP	23313552
MIRT683341	hsa-miR-665	HITS-CLIP	23313552
MIRT442862	hsa-miR-4282	PAR-CLIP	23708386
MIRT442861	hsa-miR-4662a-5p	PAR-CLIP	23708386
MIRT442862	hsa-miR-4282	PAR-CLIP	22100165
MIRT442861	hsa-miR-4662a-5p	PAR-CLIP	22100165
MIRT1328680	hsa-miR-1268	CLIP-seq
MIRT1328681	hsa-miR-3122	CLIP-seq
MIRT1328682	hsa-miR-3165	CLIP-seq
MIRT1328683	hsa-miR-3665	CLIP-seq
MIRT1328684	hsa-miR-3689a-3p	CLIP-seq
MIRT1328685	hsa-miR-3689c	CLIP-seq
MIRT1328686	hsa-miR-3913-5p	CLIP-seq
MIRT1328687	hsa-miR-4433	CLIP-seq
MIRT1328688	hsa-miR-4459	CLIP-seq
MIRT1328689	hsa-miR-4683	CLIP-seq
MIRT1328690	hsa-miR-4728-5p	CLIP-seq
MIRT1328691	hsa-miR-4736	CLIP-seq
MIRT1328692	hsa-miR-4786-5p	CLIP-seq
MIRT1328693	hsa-miR-4793-5p	CLIP-seq
MIRT1328694	hsa-miR-4794	CLIP-seq
MIRT1328695	hsa-miR-2052	CLIP-seq
MIRT1328696	hsa-miR-376a	CLIP-seq
MIRT1328697	hsa-miR-376b	CLIP-seq
MIRT1328698	hsa-miR-3942-3p	CLIP-seq
MIRT1328699	hsa-miR-4307	CLIP-seq
MIRT1328700	hsa-miR-450b-5p	CLIP-seq
MIRT1328701	hsa-miR-507	CLIP-seq
MIRT1328702	hsa-miR-545	CLIP-seq
MIRT1328703	hsa-miR-557	CLIP-seq
MIRT1328680	hsa-miR-1268	CLIP-seq
MIRT1328681	hsa-miR-3122	CLIP-seq
MIRT1328682	hsa-miR-3165	CLIP-seq
MIRT1328683	hsa-miR-3665	CLIP-seq
MIRT1328684	hsa-miR-3689a-3p	CLIP-seq
MIRT1328685	hsa-miR-3689c	CLIP-seq
MIRT1328686	hsa-miR-3913-5p	CLIP-seq
MIRT1328687	hsa-miR-4433	CLIP-seq
MIRT1328688	hsa-miR-4459	CLIP-seq
MIRT1328689	hsa-miR-4683	CLIP-seq
MIRT1328690	hsa-miR-4728-5p	CLIP-seq
MIRT1328691	hsa-miR-4736	CLIP-seq
MIRT1328680	hsa-miR-1268	CLIP-seq
MIRT1328695	hsa-miR-2052	CLIP-seq
MIRT2097578	hsa-miR-2114	CLIP-seq
MIRT1328682	hsa-miR-3165	CLIP-seq
MIRT2097579	hsa-miR-3613-3p	CLIP-seq
MIRT2097580	hsa-miR-3616-3p	CLIP-seq
MIRT1328698	hsa-miR-3942-3p	CLIP-seq
MIRT1328699	hsa-miR-4307	CLIP-seq
MIRT1328700	hsa-miR-450b-5p	CLIP-seq
MIRT1328701	hsa-miR-507	CLIP-seq
MIRT1328702	hsa-miR-545	CLIP-seq
MIRT1328703	hsa-miR-557	CLIP-seq
MIRT2097578	hsa-miR-2114	CLIP-seq
MIRT1328680	hsa-miR-1268	CLIP-seq
MIRT2618235	hsa-miR-10a	CLIP-seq
MIRT2618236	hsa-miR-10b	CLIP-seq
MIRT1328681	hsa-miR-3122	CLIP-seq
MIRT1328682	hsa-miR-3165	CLIP-seq
MIRT2618237	hsa-miR-339-5p	CLIP-seq
MIRT1328683	hsa-miR-3665	CLIP-seq
MIRT1328684	hsa-miR-3689a-3p	CLIP-seq
MIRT1328685	hsa-miR-3689c	CLIP-seq
MIRT1328686	hsa-miR-3913-5p	CLIP-seq
MIRT2618238	hsa-miR-4421	CLIP-seq
MIRT1328687	hsa-miR-4433	CLIP-seq
MIRT1328688	hsa-miR-4459	CLIP-seq
MIRT1328689	hsa-miR-4683	CLIP-seq
MIRT1328690	hsa-miR-4728-5p	CLIP-seq
MIRT1328691	hsa-miR-4736	CLIP-seq
MIRT1328692	hsa-miR-4786-5p	CLIP-seq
MIRT1328693	hsa-miR-4793-5p	CLIP-seq
MIRT1328694	hsa-miR-4794	CLIP-seq
MIRT2618239	hsa-miR-593	CLIP-seq
MIRT1328692	hsa-miR-4786-5p	CLIP-seq
MIRT2618235	hsa-miR-10a	CLIP-seq
MIRT2618236	hsa-miR-10b	CLIP-seq
MIRT1328681	hsa-miR-3122	CLIP-seq
MIRT1328682	hsa-miR-3165	CLIP-seq
MIRT2618237	hsa-miR-339-5p	CLIP-seq
MIRT1328683	hsa-miR-3665	CLIP-seq
MIRT1328684	hsa-miR-3689a-3p	CLIP-seq
MIRT1328685	hsa-miR-3689c	CLIP-seq
MIRT1328686	hsa-miR-3913-5p	CLIP-seq
MIRT2618238	hsa-miR-4421	CLIP-seq
MIRT1328687	hsa-miR-4433	CLIP-seq
MIRT1328688	hsa-miR-4459	CLIP-seq
MIRT1328689	hsa-miR-4683	CLIP-seq
MIRT1328690	hsa-miR-4728-5p	CLIP-seq
MIRT1328691	hsa-miR-4736	CLIP-seq
MIRT1328692	hsa-miR-4786-5p	CLIP-seq
MIRT1328693	hsa-miR-4793-5p	CLIP-seq
MIRT1328694	hsa-miR-4794	CLIP-seq
MIRT2618239	hsa-miR-593	CLIP-seq

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Transcription factor	Regulation	Reference
ZNF444	Activation	11978792

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GO ID	Ontology	Definition	Evidence	Reference
GO:0004888	Function	Transmembrane signaling receptor activity	TAS	9395444
GO:0005044	Function	Scavenger receptor activity	IBA
GO:0005044	Function	Scavenger receptor activity	IDA	9395444
GO:0005044	Function	Scavenger receptor activity	IEA
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0006707	Process	Cholesterol catabolic process	IC	9395444
GO:0006898	Process	Receptor-mediated endocytosis	TAS	9395444
GO:0007155	Process	Cell adhesion	IEA
GO:0007157	Process	Heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	IBA
GO:0010976	Process	Positive regulation of neuron projection development	IBA
GO:0010976	Process	Positive regulation of neuron projection development	IEA
GO:0010976	Process	Positive regulation of neuron projection development	ISS
GO:0016020	Component	Membrane	IBA
GO:0016020	Component	Membrane	IDA	9395444
GO:0016020	Component	Membrane	IEA
GO:0016322	Process	Neuron remodeling	IBA
GO:0016322	Process	Neuron remodeling	IEA
GO:0016322	Process	Neuron remodeling	ISS
GO:0016358	Process	Dendrite development	IBA
GO:0016358	Process	Dendrite development	IEA
GO:0030169	Function	Low-density lipoprotein particle binding	IBA
GO:0030169	Function	Low-density lipoprotein particle binding	IDA	9395444
GO:0030666	Component	Endocytic vesicle membrane	TAS
GO:0048680	Process	Positive regulation of axon regeneration	IEA
GO:0048680	Process	Positive regulation of axon regeneration	ISS

MIM	HGNC	e!Ensembl
607873	16820	ENSG00000074660

Q14162

Protein name

Scavenger receptor class F member 1 (Acetyl LDL receptor) (Scavenger receptor expressed by endothelial cells 1) (SREC-I)

Protein function

Mediates the binding and degradation of acetylated low density lipoprotein (Ac-LDL). Mediates heterophilic interactions, suggesting a function as adhesion protein. Plays a role in the regulation of neurite-like outgrowth (By similarity). {ECO:00

PDB

8HN0 , 8HNA

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00053	Laminin_EGF	103 → 131	Laminin EGF domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Endothelial cells.

Sequence

MGLGLLLPLLLLWTRGTQGSELDPKGQHVCVASSPSAELQCCAGWRQKDQECTIPICEGP
DACQKDEVCVKPGLCRCKPGFFGAHCSSRCPGQYWGPDCRESCPCHPHGQCEPATGACQC
QADRWGARCEFPCACGPHGRCDPATGVCHCEPGWWSSTCRRPCQCNTAAARCEQATGACV
CKPGWWGRRCSFRCNCHGSPCEQDSGRCACRPGWWGPECQQQCECVRGRCSAASGECTCP
PGFRGARCELPCPAGSHGVQCAHSCGRCKHNEPCSPDTGSCESCEPGWNGTQCQQPCLPG
TFGESCEQQCPHCRHGEACEPDTGHCQRCDPGWLGPRCEDPCPTGTFGEDCGSTCPTCVQ
GSCDTVTGDCVCSAGYWGPSCNASCPAGFHGNNCSVPCECPEGLCHPVSGSCQPGSGSRD
TALIAGSLVPLLLLFLGLACCACCCWAPRSDLKDRPARDGATVSRMKLQVWGTLTSLGST
LPCRSLSSHKLPWVTVSHHDPEVPFNHSFIEPPSAGWATDDSFSSDPESGEADEVPAYCV
PPQEGMVPVAQAGSSEASLAAGAFPPPEDASTPFAIPRTSSLARAKRPSVSFAEGTKFAP
QSRRSSGELSSPLRKPKRLSRGAQSGPEGREAEESTGPEEAEAPESFPAAASPGDSATGH
RRPPLGGRTVAEHVEAIEGSVQESSGPVTTIYMLAGKPRGSEGPVRSVFRHFGSFQKGQA
EAKVKRAIPKPPRQALNRKKGSPGLASGSVGQSPNSAPKAGLPGATGPMAVRPEEAVRGL
GAGTESSRRAQEPVSGCGSPEQDPQKQAEEERQEEPEYENVVPISRPPEP

Sequence length

830

Interactions

View interactions

	KEGG		Reactome
	Efferocytosis		Scavenging by Class F Receptors

SCARF1 (scavenger receptor class F member 1)