Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	8578
Gene name Gene Name - the full gene name approved by the HGNC.	Scavenger receptor class F member 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	SCARF1
Synonyms (NCBI Gene) Gene synonyms aliases	SREC, SREC-I, SREC1
Chromosome Chromosome number	17
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	17p13.3
Summary Summary of gene provided in NCBI Entrez Gene.	The protein encoded by this gene is a scavenger receptor that is expressed in endothelial cells. It regulates the uptake of chemically modified low density lipoproteins, including acetylated low density lipoprotein (Ac-LDL), and it may be involved in athe

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miRTarBase ID	miRNA	Experiments	Reference
MIRT052655	hsa-miR-548q	CLASH	23622248
MIRT689504	hsa-miR-508-5p	HITS-CLIP	23313552
MIRT683364	hsa-miR-3154	HITS-CLIP	23313552
MIRT689503	hsa-miR-1910-3p	HITS-CLIP	23313552
MIRT689502	hsa-miR-6511a-5p	HITS-CLIP	23313552
MIRT683363	hsa-miR-6808-5p	HITS-CLIP	23313552
MIRT683362	hsa-miR-6893-5p	HITS-CLIP	23313552
MIRT683361	hsa-miR-940	HITS-CLIP	23313552
MIRT683360	hsa-miR-3929	HITS-CLIP	23313552
MIRT683359	hsa-miR-4419b	HITS-CLIP	23313552
MIRT683358	hsa-miR-4478	HITS-CLIP	23313552
MIRT683357	hsa-miR-4768-3p	HITS-CLIP	23313552
MIRT689501	hsa-miR-1273g-3p	HITS-CLIP	23313552
MIRT689500	hsa-miR-6849-3p	HITS-CLIP	23313552
MIRT683356	hsa-miR-1247-3p	HITS-CLIP	23313552
MIRT689499	hsa-miR-766-3p	HITS-CLIP	23313552
MIRT683354	hsa-miR-4649-3p	HITS-CLIP	23313552
MIRT689498	hsa-miR-4793-3p	HITS-CLIP	23313552
MIRT683353	hsa-miR-6770-5p	HITS-CLIP	23313552
MIRT689497	hsa-miR-4537	HITS-CLIP	23313552
MIRT683352	hsa-miR-1827	HITS-CLIP	23313552
MIRT683351	hsa-miR-485-5p	HITS-CLIP	23313552
MIRT683350	hsa-miR-6884-5p	HITS-CLIP	23313552
MIRT683349	hsa-miR-4722-5p	HITS-CLIP	23313552
MIRT689496	hsa-miR-6499-3p	HITS-CLIP	23313552
MIRT683348	hsa-miR-7160-5p	HITS-CLIP	23313552
MIRT689495	hsa-miR-4327	HITS-CLIP	23313552
MIRT683347	hsa-miR-4434	HITS-CLIP	23313552
MIRT683346	hsa-miR-4516	HITS-CLIP	23313552
MIRT683345	hsa-miR-5703	HITS-CLIP	23313552
MIRT689494	hsa-miR-3612	HITS-CLIP	23313552
MIRT689493	hsa-miR-650	HITS-CLIP	23313552
MIRT683344	hsa-miR-1268a	HITS-CLIP	23313552
MIRT683343	hsa-miR-1268b	HITS-CLIP	23313552
MIRT689492	hsa-miR-6512-3p	HITS-CLIP	23313552
MIRT689491	hsa-miR-6720-5p	HITS-CLIP	23313552
MIRT689490	hsa-miR-7703	HITS-CLIP	23313552
MIRT689489	hsa-miR-455-3p	HITS-CLIP	23313552
MIRT689488	hsa-miR-6516-5p	HITS-CLIP	23313552
MIRT683341	hsa-miR-665	HITS-CLIP	23313552
MIRT683364	hsa-miR-3154	HITS-CLIP	23313552
MIRT683363	hsa-miR-6808-5p	HITS-CLIP	23313552
MIRT683362	hsa-miR-6893-5p	HITS-CLIP	23313552
MIRT683361	hsa-miR-940	HITS-CLIP	23313552
MIRT683360	hsa-miR-3929	HITS-CLIP	23313552
MIRT683359	hsa-miR-4419b	HITS-CLIP	23313552
MIRT683358	hsa-miR-4478	HITS-CLIP	23313552
MIRT683357	hsa-miR-4768-3p	HITS-CLIP	23313552
MIRT683356	hsa-miR-1247-3p	HITS-CLIP	23313552
MIRT683355	hsa-miR-6746-5p	HITS-CLIP	23313552
MIRT683354	hsa-miR-4649-3p	HITS-CLIP	23313552
MIRT683353	hsa-miR-6770-5p	HITS-CLIP	23313552
MIRT683352	hsa-miR-1827	HITS-CLIP	23313552
MIRT683351	hsa-miR-485-5p	HITS-CLIP	23313552
MIRT683350	hsa-miR-6884-5p	HITS-CLIP	23313552
MIRT683349	hsa-miR-4722-5p	HITS-CLIP	23313552
MIRT683348	hsa-miR-7160-5p	HITS-CLIP	23313552
MIRT683347	hsa-miR-4434	HITS-CLIP	23313552
MIRT683346	hsa-miR-4516	HITS-CLIP	23313552
MIRT683345	hsa-miR-5703	HITS-CLIP	23313552
MIRT683344	hsa-miR-1268a	HITS-CLIP	23313552
MIRT683343	hsa-miR-1268b	HITS-CLIP	23313552
MIRT683342	hsa-miR-6771-5p	HITS-CLIP	23313552
MIRT683341	hsa-miR-665	HITS-CLIP	23313552
MIRT442862	hsa-miR-4282	PAR-CLIP	23708386
MIRT442861	hsa-miR-4662a-5p	PAR-CLIP	23708386
MIRT442862	hsa-miR-4282	PAR-CLIP	22100165
MIRT442861	hsa-miR-4662a-5p	PAR-CLIP	22100165
MIRT442861	hsa-miR-4662a-5p	PAR-CLIP	27292025
MIRT689504	hsa-miR-508-5p	HITS-CLIP	23313552
MIRT683364	hsa-miR-3154	HITS-CLIP	23313552
MIRT689503	hsa-miR-1910-3p	HITS-CLIP	23313552
MIRT689502	hsa-miR-6511a-5p	HITS-CLIP	23313552
MIRT683363	hsa-miR-6808-5p	HITS-CLIP	23313552
MIRT683362	hsa-miR-6893-5p	HITS-CLIP	23313552
MIRT683361	hsa-miR-940	HITS-CLIP	23313552
MIRT683360	hsa-miR-3929	HITS-CLIP	23313552
MIRT683359	hsa-miR-4419b	HITS-CLIP	23313552
MIRT683358	hsa-miR-4478	HITS-CLIP	23313552
MIRT683357	hsa-miR-4768-3p	HITS-CLIP	23313552
MIRT689501	hsa-miR-1273g-3p	HITS-CLIP	23313552
MIRT689500	hsa-miR-6849-3p	HITS-CLIP	23313552
MIRT683356	hsa-miR-1247-3p	HITS-CLIP	23313552
MIRT689499	hsa-miR-766-3p	HITS-CLIP	23313552
MIRT683354	hsa-miR-4649-3p	HITS-CLIP	23313552
MIRT689498	hsa-miR-4793-3p	HITS-CLIP	23313552
MIRT683353	hsa-miR-6770-5p	HITS-CLIP	23313552
MIRT689497	hsa-miR-4537	HITS-CLIP	23313552
MIRT683352	hsa-miR-1827	HITS-CLIP	23313552
MIRT683351	hsa-miR-485-5p	HITS-CLIP	23313552
MIRT683350	hsa-miR-6884-5p	HITS-CLIP	23313552
MIRT683349	hsa-miR-4722-5p	HITS-CLIP	23313552
MIRT689496	hsa-miR-6499-3p	HITS-CLIP	23313552
MIRT683348	hsa-miR-7160-5p	HITS-CLIP	23313552
MIRT689495	hsa-miR-4327	HITS-CLIP	23313552
MIRT683347	hsa-miR-4434	HITS-CLIP	23313552
MIRT683346	hsa-miR-4516	HITS-CLIP	23313552
MIRT683345	hsa-miR-5703	HITS-CLIP	23313552
MIRT689494	hsa-miR-3612	HITS-CLIP	23313552
MIRT689493	hsa-miR-650	HITS-CLIP	23313552
MIRT683344	hsa-miR-1268a	HITS-CLIP	23313552
MIRT683343	hsa-miR-1268b	HITS-CLIP	23313552
MIRT689492	hsa-miR-6512-3p	HITS-CLIP	23313552
MIRT689491	hsa-miR-6720-5p	HITS-CLIP	23313552
MIRT689490	hsa-miR-7703	HITS-CLIP	23313552
MIRT689489	hsa-miR-455-3p	HITS-CLIP	23313552
MIRT689488	hsa-miR-6516-5p	HITS-CLIP	23313552
MIRT683341	hsa-miR-665	HITS-CLIP	23313552
MIRT683364	hsa-miR-3154	HITS-CLIP	23313552
MIRT683363	hsa-miR-6808-5p	HITS-CLIP	23313552
MIRT683362	hsa-miR-6893-5p	HITS-CLIP	23313552
MIRT683361	hsa-miR-940	HITS-CLIP	23313552
MIRT683360	hsa-miR-3929	HITS-CLIP	23313552
MIRT683359	hsa-miR-4419b	HITS-CLIP	23313552
MIRT683358	hsa-miR-4478	HITS-CLIP	23313552
MIRT683357	hsa-miR-4768-3p	HITS-CLIP	23313552
MIRT683356	hsa-miR-1247-3p	HITS-CLIP	23313552
MIRT683355	hsa-miR-6746-5p	HITS-CLIP	23313552
MIRT683354	hsa-miR-4649-3p	HITS-CLIP	23313552
MIRT683353	hsa-miR-6770-5p	HITS-CLIP	23313552
MIRT683352	hsa-miR-1827	HITS-CLIP	23313552
MIRT683351	hsa-miR-485-5p	HITS-CLIP	23313552
MIRT683350	hsa-miR-6884-5p	HITS-CLIP	23313552
MIRT683349	hsa-miR-4722-5p	HITS-CLIP	23313552
MIRT683348	hsa-miR-7160-5p	HITS-CLIP	23313552
MIRT683347	hsa-miR-4434	HITS-CLIP	23313552
MIRT683346	hsa-miR-4516	HITS-CLIP	23313552
MIRT683345	hsa-miR-5703	HITS-CLIP	23313552
MIRT683344	hsa-miR-1268a	HITS-CLIP	23313552
MIRT683343	hsa-miR-1268b	HITS-CLIP	23313552
MIRT683342	hsa-miR-6771-5p	HITS-CLIP	23313552
MIRT683341	hsa-miR-665	HITS-CLIP	23313552
MIRT442862	hsa-miR-4282	PAR-CLIP	23708386
MIRT442861	hsa-miR-4662a-5p	PAR-CLIP	23708386
MIRT442862	hsa-miR-4282	PAR-CLIP	22100165
MIRT442861	hsa-miR-4662a-5p	PAR-CLIP	22100165
MIRT1328680	hsa-miR-1268	CLIP-seq
MIRT1328681	hsa-miR-3122	CLIP-seq
MIRT1328682	hsa-miR-3165	CLIP-seq
MIRT1328683	hsa-miR-3665	CLIP-seq
MIRT1328684	hsa-miR-3689a-3p	CLIP-seq
MIRT1328685	hsa-miR-3689c	CLIP-seq
MIRT1328686	hsa-miR-3913-5p	CLIP-seq
MIRT1328687	hsa-miR-4433	CLIP-seq
MIRT1328688	hsa-miR-4459	CLIP-seq
MIRT1328689	hsa-miR-4683	CLIP-seq
MIRT1328690	hsa-miR-4728-5p	CLIP-seq
MIRT1328691	hsa-miR-4736	CLIP-seq
MIRT1328692	hsa-miR-4786-5p	CLIP-seq
MIRT1328693	hsa-miR-4793-5p	CLIP-seq
MIRT1328694	hsa-miR-4794	CLIP-seq
MIRT1328695	hsa-miR-2052	CLIP-seq
MIRT1328696	hsa-miR-376a	CLIP-seq
MIRT1328697	hsa-miR-376b	CLIP-seq
MIRT1328698	hsa-miR-3942-3p	CLIP-seq
MIRT1328699	hsa-miR-4307	CLIP-seq
MIRT1328700	hsa-miR-450b-5p	CLIP-seq
MIRT1328701	hsa-miR-507	CLIP-seq
MIRT1328702	hsa-miR-545	CLIP-seq
MIRT1328703	hsa-miR-557	CLIP-seq
MIRT1328680	hsa-miR-1268	CLIP-seq
MIRT1328681	hsa-miR-3122	CLIP-seq
MIRT1328682	hsa-miR-3165	CLIP-seq
MIRT1328683	hsa-miR-3665	CLIP-seq
MIRT1328684	hsa-miR-3689a-3p	CLIP-seq
MIRT1328685	hsa-miR-3689c	CLIP-seq
MIRT1328686	hsa-miR-3913-5p	CLIP-seq
MIRT1328687	hsa-miR-4433	CLIP-seq
MIRT1328688	hsa-miR-4459	CLIP-seq
MIRT1328689	hsa-miR-4683	CLIP-seq
MIRT1328690	hsa-miR-4728-5p	CLIP-seq
MIRT1328691	hsa-miR-4736	CLIP-seq
MIRT1328680	hsa-miR-1268	CLIP-seq
MIRT1328695	hsa-miR-2052	CLIP-seq
MIRT2097578	hsa-miR-2114	CLIP-seq
MIRT1328682	hsa-miR-3165	CLIP-seq
MIRT2097579	hsa-miR-3613-3p	CLIP-seq
MIRT2097580	hsa-miR-3616-3p	CLIP-seq
MIRT1328698	hsa-miR-3942-3p	CLIP-seq
MIRT1328699	hsa-miR-4307	CLIP-seq
MIRT1328700	hsa-miR-450b-5p	CLIP-seq
MIRT1328701	hsa-miR-507	CLIP-seq
MIRT1328702	hsa-miR-545	CLIP-seq
MIRT1328703	hsa-miR-557	CLIP-seq
MIRT2097578	hsa-miR-2114	CLIP-seq
MIRT1328680	hsa-miR-1268	CLIP-seq
MIRT2618235	hsa-miR-10a	CLIP-seq
MIRT2618236	hsa-miR-10b	CLIP-seq
MIRT1328681	hsa-miR-3122	CLIP-seq
MIRT1328682	hsa-miR-3165	CLIP-seq
MIRT2618237	hsa-miR-339-5p	CLIP-seq
MIRT1328683	hsa-miR-3665	CLIP-seq
MIRT1328684	hsa-miR-3689a-3p	CLIP-seq
MIRT1328685	hsa-miR-3689c	CLIP-seq
MIRT1328686	hsa-miR-3913-5p	CLIP-seq
MIRT2618238	hsa-miR-4421	CLIP-seq
MIRT1328687	hsa-miR-4433	CLIP-seq
MIRT1328688	hsa-miR-4459	CLIP-seq
MIRT1328689	hsa-miR-4683	CLIP-seq
MIRT1328690	hsa-miR-4728-5p	CLIP-seq
MIRT1328691	hsa-miR-4736	CLIP-seq
MIRT1328692	hsa-miR-4786-5p	CLIP-seq
MIRT1328693	hsa-miR-4793-5p	CLIP-seq
MIRT1328694	hsa-miR-4794	CLIP-seq
MIRT2618239	hsa-miR-593	CLIP-seq
MIRT1328692	hsa-miR-4786-5p	CLIP-seq
MIRT2618235	hsa-miR-10a	CLIP-seq
MIRT2618236	hsa-miR-10b	CLIP-seq
MIRT1328681	hsa-miR-3122	CLIP-seq
MIRT1328682	hsa-miR-3165	CLIP-seq
MIRT2618237	hsa-miR-339-5p	CLIP-seq
MIRT1328683	hsa-miR-3665	CLIP-seq
MIRT1328684	hsa-miR-3689a-3p	CLIP-seq
MIRT1328685	hsa-miR-3689c	CLIP-seq
MIRT1328686	hsa-miR-3913-5p	CLIP-seq
MIRT2618238	hsa-miR-4421	CLIP-seq
MIRT1328687	hsa-miR-4433	CLIP-seq
MIRT1328688	hsa-miR-4459	CLIP-seq
MIRT1328689	hsa-miR-4683	CLIP-seq
MIRT1328690	hsa-miR-4728-5p	CLIP-seq
MIRT1328691	hsa-miR-4736	CLIP-seq
MIRT1328692	hsa-miR-4786-5p	CLIP-seq
MIRT1328693	hsa-miR-4793-5p	CLIP-seq
MIRT1328694	hsa-miR-4794	CLIP-seq
MIRT2618239	hsa-miR-593	CLIP-seq

Transcription factors

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Transcription factor	Regulation	Reference
ZNF444	Activation	11978792

Show/Hide all(27)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004888	Function	Transmembrane signaling receptor activity	TAS	9395444
GO:0005044	Function	Scavenger receptor activity	IBA
GO:0005044	Function	Scavenger receptor activity	IDA	9395444
GO:0005044	Function	Scavenger receptor activity	IEA
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0006707	Process	Cholesterol catabolic process	IC	9395444
GO:0006898	Process	Receptor-mediated endocytosis	TAS	9395444
GO:0007155	Process	Cell adhesion	IEA
GO:0007157	Process	Heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	IBA
GO:0010976	Process	Positive regulation of neuron projection development	IBA
GO:0010976	Process	Positive regulation of neuron projection development	IEA
GO:0010976	Process	Positive regulation of neuron projection development	ISS
GO:0016020	Component	Membrane	IBA
GO:0016020	Component	Membrane	IDA	9395444
GO:0016020	Component	Membrane	IEA
GO:0016322	Process	Neuron remodeling	IBA
GO:0016322	Process	Neuron remodeling	IEA
GO:0016322	Process	Neuron remodeling	ISS
GO:0016358	Process	Dendrite development	IBA
GO:0016358	Process	Dendrite development	IEA
GO:0030169	Function	Low-density lipoprotein particle binding	IBA
GO:0030169	Function	Low-density lipoprotein particle binding	IDA	9395444
GO:0030666	Component	Endocytic vesicle membrane	TAS
GO:0048680	Process	Positive regulation of axon regeneration	IEA
GO:0048680	Process	Positive regulation of axon regeneration	ISS

MIM	HGNC	e!Ensembl
607873	16820	ENSG00000074660

Protein

UniProt ID

Q14162

Protein name

Scavenger receptor class F member 1 (Acetyl LDL receptor) (Scavenger receptor expressed by endothelial cells 1) (SREC-I)

Protein function

Mediates the binding and degradation of acetylated low density lipoprotein (Ac-LDL). Mediates heterophilic interactions, suggesting a function as adhesion protein. Plays a role in the regulation of neurite-like outgrowth (By similarity). {ECO:00

PDB

8HN0 , 8HNA

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00053	Laminin_EGF	103 → 131	Laminin EGF domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Endothelial cells.

Sequence

MGLGLLLPLLLLWTRGTQGSELDPKGQHVCVASSPSAELQCCAGWRQKDQECTIPICEGP
DACQKDEVCVKPGLCRCKPGFFGAHCSSRCPGQYWGPDCRESCPCHPHGQCEPATGACQC
QADRWGARCEFPCACGPHGRCDPATGVCHCEPGWWSSTCRRPCQCNTAAARCEQATGACV
CKPGWWGRRCSFRCNCHGSPCEQDSGRCACRPGWWGPECQQQCECVRGRCSAASGECTCP
PGFRGARCELPCPAGSHGVQCAHSCGRCKHNEPCSPDTGSCESCEPGWNGTQCQQPCLPG
TFGESCEQQCPHCRHGEACEPDTGHCQRCDPGWLGPRCEDPCPTGTFGEDCGSTCPTCVQ
GSCDTVTGDCVCSAGYWGPSCNASCPAGFHGNNCSVPCECPEGLCHPVSGSCQPGSGSRD
TALIAGSLVPLLLLFLGLACCACCCWAPRSDLKDRPARDGATVSRMKLQVWGTLTSLGST
LPCRSLSSHKLPWVTVSHHDPEVPFNHSFIEPPSAGWATDDSFSSDPESGEADEVPAYCV
PPQEGMVPVAQAGSSEASLAAGAFPPPEDASTPFAIPRTSSLARAKRPSVSFAEGTKFAP
QSRRSSGELSSPLRKPKRLSRGAQSGPEGREAEESTGPEEAEAPESFPAAASPGDSATGH
RRPPLGGRTVAEHVEAIEGSVQESSGPVTTIYMLAGKPRGSEGPVRSVFRHFGSFQKGQA
EAKVKRAIPKPPRQALNRKKGSPGLASGSVGQSPNSAPKAGLPGATGPMAVRPEEAVRGL
GAGTESSRRAQEPVSGCGSPEQDPQKQAEEERQEEPEYENVVPISRPPEP

Sequence length

830

Interactions

View interactions

	KEGG		Reactome
	Efferocytosis		Scavenging by Class F Receptors

Show/Hide Unknown Diseases (1)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Intracranial Aneurysm	Intracranial aneurysm	N/A	N/A	GWAS

Show/Hide Text Mining Associations (7)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Adenocarcinoma of Lung	Associate	38204755
Atherosclerosis	Associate	2010531
Inflammation	Associate	29242513, 34236384
Liver Diseases	Associate	29242513
Mycoses	Associate	34236384
Neoplasms	Associate	38204755
Stroke	Associate	35449099

SCARF1 (scavenger receptor class F member 1)