Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
|
8566
|
Gene name
Gene Name - the full gene name approved by the HGNC.
|
Pyridoxal kinase |
Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
|
PDXK |
Synonyms (NCBI Gene)
Gene synonyms aliases
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C21orf124, C21orf97, HEL-S-1a, HMSN6C, PKH, PNK, PRED79 |
Disease Acronyms (UniProt)
Disease acronyms from UniProt database
|
HMSN6C |
Chromosome
Chromosome number
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21 |
Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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21q22.3 |
Summary
Summary of gene provided in NCBI Entrez Gene.
|
The protein encoded by this gene phosphorylates vitamin B6, a step required for the conversion of vitamin B6 to pyridoxal-5-phosphate, an important cofactor in intermediary metabolism. The encoded protein is cytoplasmic and probably acts as a homodimer. A |
UniProt ID |
O00764
|
Protein name |
Pyridoxal kinase (EC 2.7.1.35) (Pyridoxine kinase) |
Protein function |
Catalyzes the phosphorylation of the dietary vitamin B6 vitamers pyridoxal (PL), pyridoxine (PN) and pyridoxamine (PM) to form pyridoxal 5'-phosphate (PLP), pyridoxine 5'-phosphate (PNP) and pyridoxamine 5'-phosphate (PMP), respectively (Probabl |
PDB |
2AJP
,
2F7K
,
2YXT
,
2YXU
,
3FHX
,
3FHY
,
3KEU
,
4EN4
,
4EOH
,
8WR2
|
Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF08543
|
Phos_pyr_kin |
70 → 284 |
Phosphomethylpyrimidine kinase |
Family |
|
Tissue specificity |
TISSUE SPECIFICITY: Ubiquitous (PubMed:31187503, PubMed:9099727). Highly expressed in testis (PubMed:9099727). {ECO:0000269|PubMed:31187503, ECO:0000269|PubMed:9099727}.; TISSUE SPECIFICITY: [Isoform 3]: In adult testis and spermatozoa. {ECO:0000269|PubMe |
Sequence |
|
Sequence length |
312 |
Interactions |
View interactions
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