Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	8564
Gene name Gene Name - the full gene name approved by the HGNC.	Kynurenine 3-monooxygenase
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	KMO
Synonyms (NCBI Gene) Gene synonyms aliases	dJ317G22.1
Chromosome Chromosome number	1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	1q43
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a mitochondrion outer membrane protein that catalyzes the hydroxylation of L-tryptophan metabolite, L-kynurenine, to form L-3-hydroxykynurenine. Studies in yeast identified this gene as a therapeutic target for Huntington disease. [provi

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miRTarBase ID	miRNA	Experiments	Reference
MIRT512965	hsa-miR-4803	PAR-CLIP	22012620
MIRT512964	hsa-miR-302f	PAR-CLIP	22012620
MIRT528926	hsa-miR-501-3p	PAR-CLIP	22012620
MIRT528925	hsa-miR-502-3p	PAR-CLIP	22012620
MIRT512962	hsa-miR-3143	PAR-CLIP	22012620
MIRT512961	hsa-miR-106a-3p	PAR-CLIP	22012620
MIRT512960	hsa-miR-302c-5p	PAR-CLIP	22012620
MIRT512965	hsa-miR-4803	PAR-CLIP	23446348
MIRT512964	hsa-miR-302f	PAR-CLIP	23446348
MIRT512963	hsa-miR-6793-3p	PAR-CLIP	23446348
MIRT512962	hsa-miR-3143	PAR-CLIP	23446348
MIRT512961	hsa-miR-106a-3p	PAR-CLIP	23446348
MIRT512960	hsa-miR-302c-5p	PAR-CLIP	23446348
MIRT738677	hsa-miR-3682-3p	HITS-CLIP	33718276
MIRT512965	hsa-miR-4803	PAR-CLIP	22012620
MIRT512964	hsa-miR-302f	PAR-CLIP	22012620
MIRT528926	hsa-miR-501-3p	PAR-CLIP	22012620
MIRT528925	hsa-miR-502-3p	PAR-CLIP	22012620
MIRT512962	hsa-miR-3143	PAR-CLIP	22012620
MIRT512961	hsa-miR-106a-3p	PAR-CLIP	22012620
MIRT512960	hsa-miR-302c-5p	PAR-CLIP	22012620
MIRT512965	hsa-miR-4803	PAR-CLIP	23446348
MIRT512964	hsa-miR-302f	PAR-CLIP	23446348
MIRT512963	hsa-miR-6793-3p	PAR-CLIP	23446348
MIRT512962	hsa-miR-3143	PAR-CLIP	23446348
MIRT512961	hsa-miR-106a-3p	PAR-CLIP	23446348
MIRT512960	hsa-miR-302c-5p	PAR-CLIP	23446348
MIRT1099421	hsa-miR-1183	CLIP-seq
MIRT1099422	hsa-miR-3121-3p	CLIP-seq
MIRT1099423	hsa-miR-3122	CLIP-seq
MIRT1099424	hsa-miR-3200-5p	CLIP-seq
MIRT1099425	hsa-miR-337-3p	CLIP-seq
MIRT1099426	hsa-miR-339-5p	CLIP-seq
MIRT1099427	hsa-miR-3607-3p	CLIP-seq
MIRT1099428	hsa-miR-3675-5p	CLIP-seq
MIRT1099429	hsa-miR-3689a-3p	CLIP-seq
MIRT1099430	hsa-miR-3689c	CLIP-seq
MIRT1099431	hsa-miR-382	CLIP-seq
MIRT1099432	hsa-miR-3913-5p	CLIP-seq
MIRT1099433	hsa-miR-3929	CLIP-seq
MIRT739500	hsa-miR-3976	CLIP-seq
MIRT1099434	hsa-miR-4419b	CLIP-seq
MIRT1099435	hsa-miR-4426	CLIP-seq
MIRT1099436	hsa-miR-4478	CLIP-seq
MIRT1099437	hsa-miR-4540	CLIP-seq
MIRT1099438	hsa-miR-4647	CLIP-seq
MIRT1099439	hsa-miR-4662b	CLIP-seq
MIRT1099440	hsa-miR-4693-5p	CLIP-seq
MIRT1099441	hsa-miR-4728-5p	CLIP-seq
MIRT1099442	hsa-miR-485-5p	CLIP-seq
MIRT1099443	hsa-miR-486-5p	CLIP-seq
MIRT1099444	hsa-miR-548c-3p	CLIP-seq
MIRT1099445	hsa-miR-618	CLIP-seq
MIRT1099446	hsa-miR-676	CLIP-seq
MIRT1099447	hsa-miR-891a	CLIP-seq
MIRT2026968	hsa-miR-1225-3p	CLIP-seq
MIRT2026969	hsa-miR-1233	CLIP-seq
MIRT2026970	hsa-miR-1246	CLIP-seq
MIRT2026971	hsa-miR-1273e	CLIP-seq
MIRT2026972	hsa-miR-137	CLIP-seq
MIRT2026973	hsa-miR-147	CLIP-seq
MIRT2026974	hsa-miR-1827	CLIP-seq
MIRT2026975	hsa-miR-2052	CLIP-seq
MIRT2026976	hsa-miR-2467-3p	CLIP-seq
MIRT1099423	hsa-miR-3122	CLIP-seq
MIRT2026977	hsa-miR-3612	CLIP-seq
MIRT2026978	hsa-miR-3616-5p	CLIP-seq
MIRT2026979	hsa-miR-3647-5p	CLIP-seq
MIRT2026980	hsa-miR-3667-3p	CLIP-seq
MIRT1099429	hsa-miR-3689a-3p	CLIP-seq
MIRT1099430	hsa-miR-3689c	CLIP-seq
MIRT1099432	hsa-miR-3913-5p	CLIP-seq
MIRT2026981	hsa-miR-3919	CLIP-seq
MIRT1099433	hsa-miR-3929	CLIP-seq
MIRT2026982	hsa-miR-4257	CLIP-seq
MIRT2026983	hsa-miR-4282	CLIP-seq
MIRT2026984	hsa-miR-4289	CLIP-seq
MIRT1099434	hsa-miR-4419b	CLIP-seq
MIRT2026985	hsa-miR-4459	CLIP-seq
MIRT1099436	hsa-miR-4478	CLIP-seq
MIRT2026986	hsa-miR-4684-5p	CLIP-seq
MIRT2026987	hsa-miR-4695-5p	CLIP-seq
MIRT1099441	hsa-miR-4728-5p	CLIP-seq
MIRT2026988	hsa-miR-4761-5p	CLIP-seq
MIRT2026989	hsa-miR-4768-5p	CLIP-seq
MIRT2026990	hsa-miR-4795-5p	CLIP-seq
MIRT2026991	hsa-miR-4802-3p	CLIP-seq
MIRT1099442	hsa-miR-485-5p	CLIP-seq
MIRT2026992	hsa-miR-490-5p	CLIP-seq
MIRT1099444	hsa-miR-548c-3p	CLIP-seq
MIRT2026993	hsa-miR-573	CLIP-seq
MIRT2026994	hsa-miR-650	CLIP-seq
MIRT2026995	hsa-miR-665	CLIP-seq
MIRT2258192	hsa-miR-1182	CLIP-seq
MIRT2258193	hsa-miR-1229	CLIP-seq
MIRT2258194	hsa-miR-133a	CLIP-seq
MIRT2258195	hsa-miR-133b	CLIP-seq
MIRT2026973	hsa-miR-147	CLIP-seq
MIRT2258196	hsa-miR-193a-3p	CLIP-seq
MIRT2258197	hsa-miR-193b	CLIP-seq
MIRT2258198	hsa-miR-197	CLIP-seq
MIRT2258199	hsa-miR-3145-3p	CLIP-seq
MIRT2258200	hsa-miR-3176	CLIP-seq
MIRT2026980	hsa-miR-3667-3p	CLIP-seq
MIRT2258201	hsa-miR-3672	CLIP-seq
MIRT2258202	hsa-miR-3689a-5p	CLIP-seq
MIRT2258203	hsa-miR-3689b	CLIP-seq
MIRT2258204	hsa-miR-3689e	CLIP-seq
MIRT2258205	hsa-miR-3689f	CLIP-seq
MIRT2258206	hsa-miR-3922-3p	CLIP-seq
MIRT2258207	hsa-miR-3977	CLIP-seq
MIRT2258208	hsa-miR-421	CLIP-seq
MIRT2026984	hsa-miR-4289	CLIP-seq
MIRT2258209	hsa-miR-4303	CLIP-seq
MIRT2258210	hsa-miR-4433	CLIP-seq
MIRT2258211	hsa-miR-4463	CLIP-seq
MIRT2258212	hsa-miR-4649-3p	CLIP-seq
MIRT2258213	hsa-miR-4709-5p	CLIP-seq
MIRT2258214	hsa-miR-4720-3p	CLIP-seq
MIRT2258215	hsa-miR-4729	CLIP-seq
MIRT2258216	hsa-miR-4766-5p	CLIP-seq
MIRT2258217	hsa-miR-4775	CLIP-seq
MIRT2258218	hsa-miR-4793-3p	CLIP-seq
MIRT2258219	hsa-miR-4797-5p	CLIP-seq
MIRT2258220	hsa-miR-4804-3p	CLIP-seq
MIRT2258221	hsa-miR-505	CLIP-seq
MIRT2258222	hsa-miR-508-5p	CLIP-seq
MIRT2258223	hsa-miR-590-3p	CLIP-seq
MIRT2258224	hsa-miR-651	CLIP-seq
MIRT2258225	hsa-miR-656	CLIP-seq
MIRT2026995	hsa-miR-665	CLIP-seq
MIRT1099446	hsa-miR-676	CLIP-seq
MIRT2258226	hsa-miR-766	CLIP-seq
MIRT2026968	hsa-miR-1225-3p	CLIP-seq
MIRT2258193	hsa-miR-1229	CLIP-seq
MIRT2026969	hsa-miR-1233	CLIP-seq
MIRT2258198	hsa-miR-197	CLIP-seq
MIRT2258199	hsa-miR-3145-3p	CLIP-seq
MIRT1099431	hsa-miR-382	CLIP-seq
MIRT2258208	hsa-miR-421	CLIP-seq
MIRT2258213	hsa-miR-4709-5p	CLIP-seq
MIRT2258218	hsa-miR-4793-3p	CLIP-seq
MIRT2258221	hsa-miR-505	CLIP-seq
MIRT2258222	hsa-miR-508-5p	CLIP-seq
MIRT2026995	hsa-miR-665	CLIP-seq
MIRT2258226	hsa-miR-766	CLIP-seq
MIRT2452714	hsa-miR-200b	CLIP-seq
MIRT2452715	hsa-miR-200c	CLIP-seq
MIRT1099424	hsa-miR-3200-5p	CLIP-seq
MIRT2452716	hsa-miR-369-3p	CLIP-seq
MIRT2452717	hsa-miR-429	CLIP-seq
MIRT2452718	hsa-miR-4428	CLIP-seq
MIRT2452719	hsa-miR-493	CLIP-seq
MIRT2452714	hsa-miR-200b	CLIP-seq
MIRT2452715	hsa-miR-200c	CLIP-seq
MIRT2452716	hsa-miR-369-3p	CLIP-seq
MIRT2452717	hsa-miR-429	CLIP-seq
MIRT2452719	hsa-miR-493	CLIP-seq
MIRT739500	hsa-miR-3976	CLIP-seq
MIRT2559138	hsa-miR-4307	CLIP-seq
MIRT2559139	hsa-miR-4753-3p	CLIP-seq
MIRT2026989	hsa-miR-4768-5p	CLIP-seq
MIRT2559140	hsa-miR-513a-3p	CLIP-seq
MIRT2559138	hsa-miR-4307	CLIP-seq
MIRT2559139	hsa-miR-4753-3p	CLIP-seq
MIRT2026989	hsa-miR-4768-5p	CLIP-seq
MIRT2559140	hsa-miR-513a-3p	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0004497	Function	Monooxygenase activity	IEA
GO:0004502	Function	Kynurenine 3-monooxygenase activity	IBA
GO:0004502	Function	Kynurenine 3-monooxygenase activity	IDA	9237672, 10672018, 23575632, 26752518, 29208702, 29429898
GO:0004502	Function	Kynurenine 3-monooxygenase activity	IEA
GO:0004502	Function	Kynurenine 3-monooxygenase activity	TAS
GO:0005515	Function	Protein binding	IPI	32814053
GO:0005615	Component	Extracellular space	IEA
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IEA
GO:0005741	Component	Mitochondrial outer membrane	IBA
GO:0005741	Component	Mitochondrial outer membrane	IEA
GO:0005741	Component	Mitochondrial outer membrane	ISS	10672018
GO:0005829	Component	Cytosol	TAS
GO:0006569	Process	L-tryptophan catabolic process	IEA
GO:0006569	Process	L-tryptophan catabolic process	TAS
GO:0009435	Process	NAD+ biosynthetic process	IEA
GO:0009651	Process	Response to salt stress	IDA	10672018
GO:0014049	Process	Positive regulation of glutamate secretion	IEA
GO:0016020	Component	Membrane	IEA
GO:0016174	Function	NAD(P)H oxidase H2O2-forming activity	IDA	10672018, 23575632, 29429898
GO:0016491	Function	Oxidoreductase activity	IEA
GO:0019363	Process	Pyridine nucleotide biosynthetic process	IEA
GO:0019674	Process	NAD+ metabolic process	IDA	23575632, 29429898
GO:0019674	Process	NAD+ metabolic process	IEA
GO:0019805	Process	Quinolinate biosynthetic process	IEA
GO:0031966	Component	Mitochondrial membrane	IEA
GO:0032496	Process	Response to lipopolysaccharide	IEA
GO:0034276	Process	Kynurenic acid biosynthetic process	IEA
GO:0034354	Process	'de novo' NAD+ biosynthetic process from L-tryptophan	IEA
GO:0043420	Process	Anthranilate metabolic process	IEA
GO:0050660	Function	Flavin adenine dinucleotide binding	IDA	10672018
GO:0050660	Function	Flavin adenine dinucleotide binding	IEA
GO:0070189	Process	Kynurenine metabolic process	IBA
GO:0070189	Process	Kynurenine metabolic process	IDA	10672018, 26752518, 29208702, 29429898
GO:0070189	Process	Kynurenine metabolic process	IEA
GO:0071222	Process	Cellular response to lipopolysaccharide	IEA
GO:0071347	Process	Cellular response to interleukin-1	IEA
GO:0071949	Function	FAD binding	IDA	29429898
GO:0071949	Function	FAD binding	IEA
GO:0097052	Process	L-kynurenine metabolic process	IEA
GO:1903296	Process	Positive regulation of glutamate secretion, neurotransmission	IEA

MIM	HGNC	e!Ensembl
603538	6381	ENSG00000117009

Protein

UniProt ID

O15229

Protein name

Kynurenine 3-monooxygenase (EC 1.14.13.9) (Kynurenine 3-hydroxylase)

Protein function

Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn) (PubMed:23575632, PubMed:26752518, PubMed:28604669, PubMed:29208702, PubMed:29429898). Required for synthesis of quinolinic acid, a neurotoxic NMDA rec

PDB

5X68

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01494	FAD_binding_3	8 → 331	FAD binding domain	Family

Tissue specificity

TISSUE SPECIFICITY: Highest levels in placenta and liver. Detectable in kidney. {ECO:0000269|PubMed:9237672}.

Sequence

MDSSVIQRKKVAVIGGGLVGSLQACFLAKRNFQIDVYEAREDTRVATFTRGRSINLALSH
RGRQALKAVGLEDQIVSQGIPMRARMIHSLSGKKSAIPYGTKSQYILSVSRENLNKDLLT
AAEKYPNVKMHFNHRLLKCNPEEGMITVLGSDKVPKDVTCDLIVGCDGAYSTVRSHLMKK
PRFDYSQQYIPHGYMELTIPPKNGDYAMEPNYLHIWPRNTFMMIALPNMNKSFTCTLFMP
FEEFEKLLTSNDVVDFFQKYFPDAIPLIGEKLLVQDFFLLPAQPMISVKCSSFHFKSHCV
LLGDAAHAIVPFFGQGMNAGFEDCLVFDELMDKFSNDLSLCLPVFSRLRIPDDHAISDLS
MYNYIEMRAHVNSSWFIFQKNMERFLHAIMPSTFIPLYTMVTFSRIRYHEAVQRWHWQKK
VINKGLFFLGSLIAISSTYLLIHYMSPRSFLRLRRPWNWIAHFRNTTCFPAKAVDSLEQI
SNLISR

Sequence length

486

Interactions

View interactions

	KEGG		Reactome
	Tryptophan metabolism Metabolic pathways Biosynthesis of cofactors		Tryptophan catabolism

KMO (kynurenine 3-monooxygenase)