Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	8538
Gene name Gene Name - the full gene name approved by the HGNC.	BARX homeobox 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	BARX2
Synonyms (NCBI Gene) Gene synonyms aliases	-
Chromosome Chromosome number	11
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	11q24.3
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a member of the homeobox transcription factor family. A highly related protein in mouse has been shown to influence cellular processes that control cell adhesion and remodeling of the actin cytoskeleton in myoblast fusion and chondrogene

Show/Hide all(135)

miRTarBase ID	miRNA	Experiments	Reference
MIRT017365	hsa-miR-335-5p	Microarray	18185580
MIRT039194	hsa-miR-769-5p	CLASH	23622248
MIRT815925	hsa-miR-1225-5p	CLIP-seq
MIRT815926	hsa-miR-124	CLIP-seq
MIRT815927	hsa-miR-1273d	CLIP-seq
MIRT815928	hsa-miR-1285	CLIP-seq
MIRT815929	hsa-miR-183	CLIP-seq
MIRT815930	hsa-miR-185	CLIP-seq
MIRT815931	hsa-miR-187	CLIP-seq
MIRT815932	hsa-miR-193a-5p	CLIP-seq
MIRT815933	hsa-miR-21	CLIP-seq
MIRT815934	hsa-miR-217	CLIP-seq
MIRT815935	hsa-miR-3064-5p	CLIP-seq
MIRT815936	hsa-miR-3127-5p	CLIP-seq
MIRT815937	hsa-miR-3146	CLIP-seq
MIRT815938	hsa-miR-3158-3p	CLIP-seq
MIRT815939	hsa-miR-3187-5p	CLIP-seq
MIRT815940	hsa-miR-33a	CLIP-seq
MIRT815941	hsa-miR-33b	CLIP-seq
MIRT815942	hsa-miR-361-5p	CLIP-seq
MIRT815943	hsa-miR-3692	CLIP-seq
MIRT815944	hsa-miR-374a	CLIP-seq
MIRT815945	hsa-miR-374b	CLIP-seq
MIRT815946	hsa-miR-3914	CLIP-seq
MIRT815947	hsa-miR-3945	CLIP-seq
MIRT815948	hsa-miR-4253	CLIP-seq
MIRT815949	hsa-miR-4257	CLIP-seq
MIRT815950	hsa-miR-4270	CLIP-seq
MIRT815951	hsa-miR-4277	CLIP-seq
MIRT815952	hsa-miR-4306	CLIP-seq
MIRT815953	hsa-miR-4327	CLIP-seq
MIRT815954	hsa-miR-4419a	CLIP-seq
MIRT815955	hsa-miR-4433	CLIP-seq
MIRT815956	hsa-miR-4436b-5p	CLIP-seq
MIRT815957	hsa-miR-4441	CLIP-seq
MIRT815958	hsa-miR-4446-3p	CLIP-seq
MIRT815959	hsa-miR-4459	CLIP-seq
MIRT815960	hsa-miR-4468	CLIP-seq
MIRT815961	hsa-miR-4506	CLIP-seq
MIRT815962	hsa-miR-4510	CLIP-seq
MIRT815963	hsa-miR-4632	CLIP-seq
MIRT815964	hsa-miR-4633-5p	CLIP-seq
MIRT815965	hsa-miR-4644	CLIP-seq
MIRT815966	hsa-miR-4686	CLIP-seq
MIRT815967	hsa-miR-4711-3p	CLIP-seq
MIRT815968	hsa-miR-4729	CLIP-seq
MIRT815969	hsa-miR-4768-3p	CLIP-seq
MIRT815970	hsa-miR-4779	CLIP-seq
MIRT815971	hsa-miR-490-3p	CLIP-seq
MIRT815972	hsa-miR-491-3p	CLIP-seq
MIRT815973	hsa-miR-506	CLIP-seq
MIRT815974	hsa-miR-520d-5p	CLIP-seq
MIRT815975	hsa-miR-524-5p	CLIP-seq
MIRT815976	hsa-miR-545	CLIP-seq
MIRT815977	hsa-miR-548an	CLIP-seq
MIRT815978	hsa-miR-590-5p	CLIP-seq
MIRT815979	hsa-miR-591	CLIP-seq
MIRT815980	hsa-miR-604	CLIP-seq
MIRT815981	hsa-miR-610	CLIP-seq
MIRT815982	hsa-miR-612	CLIP-seq
MIRT815983	hsa-miR-635	CLIP-seq
MIRT815984	hsa-miR-647	CLIP-seq
MIRT815985	hsa-miR-660	CLIP-seq
MIRT815986	hsa-miR-892b	CLIP-seq
MIRT1941347	hsa-miR-1207-3p	CLIP-seq
MIRT815927	hsa-miR-1273d	CLIP-seq
MIRT815929	hsa-miR-183	CLIP-seq
MIRT815930	hsa-miR-185	CLIP-seq
MIRT815935	hsa-miR-3064-5p	CLIP-seq
MIRT815936	hsa-miR-3127-5p	CLIP-seq
MIRT815937	hsa-miR-3146	CLIP-seq
MIRT815938	hsa-miR-3158-3p	CLIP-seq
MIRT815940	hsa-miR-33a	CLIP-seq
MIRT815941	hsa-miR-33b	CLIP-seq
MIRT1941348	hsa-miR-3689d	CLIP-seq
MIRT1941349	hsa-miR-376c	CLIP-seq
MIRT815949	hsa-miR-4257	CLIP-seq
MIRT815950	hsa-miR-4270	CLIP-seq
MIRT1941350	hsa-miR-4287	CLIP-seq
MIRT815952	hsa-miR-4306	CLIP-seq
MIRT1941351	hsa-miR-4307	CLIP-seq
MIRT815953	hsa-miR-4327	CLIP-seq
MIRT815954	hsa-miR-4419a	CLIP-seq
MIRT1941352	hsa-miR-4422	CLIP-seq
MIRT815955	hsa-miR-4433	CLIP-seq
MIRT815957	hsa-miR-4441	CLIP-seq
MIRT815958	hsa-miR-4446-3p	CLIP-seq
MIRT815959	hsa-miR-4459	CLIP-seq
MIRT1941353	hsa-miR-4469	CLIP-seq
MIRT815962	hsa-miR-4510	CLIP-seq
MIRT1941354	hsa-miR-4514	CLIP-seq
MIRT815964	hsa-miR-4633-5p	CLIP-seq
MIRT815965	hsa-miR-4644	CLIP-seq
MIRT1941355	hsa-miR-4685-3p	CLIP-seq
MIRT815966	hsa-miR-4686	CLIP-seq
MIRT1941356	hsa-miR-4692	CLIP-seq
MIRT815968	hsa-miR-4729	CLIP-seq
MIRT1941357	hsa-miR-4731-5p	CLIP-seq
MIRT815969	hsa-miR-4768-3p	CLIP-seq
MIRT815970	hsa-miR-4779	CLIP-seq
MIRT1941358	hsa-miR-486-3p	CLIP-seq
MIRT815972	hsa-miR-491-3p	CLIP-seq
MIRT1941359	hsa-miR-542-3p	CLIP-seq
MIRT1941360	hsa-miR-548c-3p	CLIP-seq
MIRT815980	hsa-miR-604	CLIP-seq
MIRT815981	hsa-miR-610	CLIP-seq
MIRT815984	hsa-miR-647	CLIP-seq
MIRT815985	hsa-miR-660	CLIP-seq
MIRT815986	hsa-miR-892b	CLIP-seq
MIRT815927	hsa-miR-1273d	CLIP-seq
MIRT815930	hsa-miR-185	CLIP-seq
MIRT815934	hsa-miR-217	CLIP-seq
MIRT815937	hsa-miR-3146	CLIP-seq
MIRT815943	hsa-miR-3692	CLIP-seq
MIRT2180121	hsa-miR-3974	CLIP-seq
MIRT815949	hsa-miR-4257	CLIP-seq
MIRT2180122	hsa-miR-4263	CLIP-seq
MIRT815952	hsa-miR-4306	CLIP-seq
MIRT815954	hsa-miR-4419a	CLIP-seq
MIRT815955	hsa-miR-4433	CLIP-seq
MIRT815956	hsa-miR-4436b-5p	CLIP-seq
MIRT815959	hsa-miR-4459	CLIP-seq
MIRT815962	hsa-miR-4510	CLIP-seq
MIRT815964	hsa-miR-4633-5p	CLIP-seq
MIRT815965	hsa-miR-4644	CLIP-seq
MIRT2180123	hsa-miR-4719	CLIP-seq
MIRT815968	hsa-miR-4729	CLIP-seq
MIRT815969	hsa-miR-4768-3p	CLIP-seq
MIRT815970	hsa-miR-4779	CLIP-seq
MIRT815972	hsa-miR-491-3p	CLIP-seq
MIRT2180124	hsa-miR-493	CLIP-seq
MIRT2180125	hsa-miR-494	CLIP-seq
MIRT2180126	hsa-miR-576-5p	CLIP-seq
MIRT815981	hsa-miR-610	CLIP-seq
MIRT815985	hsa-miR-660	CLIP-seq

Show/Hide all(21)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IEA
GO:0000785	Component	Chromatin	ISA
GO:0000977	Function	RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA	21873635
GO:0000977	Function	RNA polymerase II transcription regulatory region sequence-specific DNA binding	IMP	14744868
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	21873635
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	ISA
GO:0001228	Function	DNA-binding transcription activator activity, RNA polymerase II-specific	IMP	14744868
GO:0001502	Process	Cartilage condensation	IEA
GO:0003677	Function	DNA binding	IDA	10854790
GO:0003682	Function	Chromatin binding	IEA
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005634	Component	Nucleus	IBA	21873635
GO:0005654	Component	Nucleoplasm	IDA
GO:0005667	Component	Transcription regulator complex	IEA
GO:0005794	Component	Golgi apparatus	IDA
GO:0005829	Component	Cytosol	IDA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA	21873635
GO:0014902	Process	Myotube differentiation	IEA
GO:0015629	Component	Actin cytoskeleton	IDA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IMP	14744868
GO:1990837	Function	Sequence-specific double-stranded DNA binding	IDA	28473536

MIM	HGNC	e!Ensembl
604823	956	ENSG00000043039

Protein

UniProt ID

Q9UMQ3

Protein name

Homeobox protein BarH-like 2

Protein function

Transcription factor. Binds optimally to the DNA consensus sequence 5'-YYTAATGRTTTTY-3'. May control the expression of neural adhesion molecules such as L1 or Ng-CAM during embryonic development of both the central and peripherical nervous syste

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00046	Homeodomain	134 → 190	Homeodomain	Domain

Tissue specificity

TISSUE SPECIFICITY: Highly expressed in adult salivary gland and at much lower levels in mammary gland, kidney and placenta.

Sequence

MHCHAELRLSSPGQLKAARRRYKTFMIDEILSKETCDYFEKLSLYSVCPSLVVRPKPLHS
CTGSPSLRAYPLLSVITRQPTVISHLVPATPGIAQALSCHQVTEAVSAEAPGGEALASSE
SETEQPTPRQKKPRRSRTIFTELQLMGLEKKFQKQKYLSTPDRLDLAQSLGLTQLQVKTW
YQNRRMKWKKMVLKGGQEAPTKPKGRPKKNSIPTSEEIEAEEKMNSQAQGQEQLEPSQGQ
EELCEAQEPKARDVPLEMAEPPDPPQELPIPSSEPPPLS

Sequence length

279

Interactions

View interactions

Show/Hide Causal Diseases (1)

Disease term	Disease name	dbSNP ID	References
Causal
Narcolepsy	Narcolepsy	rs104894574, rs387906655	19629137

Show/Hide Unknown Diseases (4)

Disease term	Disease name	Evidence	Source
Unknown
Breast Cancer	Breast Cancer	Importantly, breast cancer patients bearing PRC2 LOF mutations displayed significantly worse prognosis compared with PRC2 wild-type patients	GWAS, CBGDA
Dementia	Dementia		GWAS
Metabolic Syndrome	Metabolic Syndrome		GWAS
Prostate cancer	Prostate cancer	Together, these results show that PRRX2 is an oncogene and might play a role in the aggressiveness of PC within the DNPC population.	GWAS, CBGDA

Show/Hide Text Mining Associations (3)

Disease Name	Relationship Type	References
Associations from Text Mining
Adenocarcinoma of Lung	Associate	35095769, 36793937
Lymphatic Metastasis	Associate	36793937
Lymphoma B Cell	Associate	30308041

BARX2 (BARX homeobox 2)