Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID	85363
Gene name	Tripartite motif containing 5
Gene symbol	TRIM5
Synonyms (NCBI Gene)	RNF88TRIM5alpha
Chromosome	11
Chromosome location	11p15.4
Summary	The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein forms homo-oligomers via the coilel-co

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miRTarBase ID	miRNA	Experiments	Reference
MIRT052397	hsa-let-7a-5p	CLASH	23622248
MIRT449416	hsa-miR-548u	PAR-CLIP	22100165
MIRT449414	hsa-miR-7161-5p	PAR-CLIP	22100165
MIRT449415	hsa-miR-8087	PAR-CLIP	22100165
MIRT449413	hsa-miR-4712-3p	PAR-CLIP	22100165
MIRT449412	hsa-miR-539-5p	PAR-CLIP	22100165
MIRT449411	hsa-miR-190a-5p	PAR-CLIP	22100165
MIRT449410	hsa-miR-190b	PAR-CLIP	22100165
MIRT449409	hsa-miR-3689a-5p	PAR-CLIP	22100165
MIRT449408	hsa-miR-3689b-5p	PAR-CLIP	22100165
MIRT449407	hsa-miR-3689e	PAR-CLIP	22100165
MIRT449406	hsa-miR-3689f	PAR-CLIP	22100165
MIRT449404	hsa-miR-3161	PAR-CLIP	22100165
MIRT449405	hsa-miR-8070	PAR-CLIP	22100165
MIRT449403	hsa-miR-599	PAR-CLIP	22100165
MIRT439390	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT439390	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT449416	hsa-miR-548u	PAR-CLIP	22100165
MIRT449414	hsa-miR-7161-5p	PAR-CLIP	22100165
MIRT449415	hsa-miR-8087	PAR-CLIP	22100165
MIRT449413	hsa-miR-4712-3p	PAR-CLIP	22100165
MIRT449412	hsa-miR-539-5p	PAR-CLIP	22100165
MIRT449411	hsa-miR-190a-5p	PAR-CLIP	22100165
MIRT449410	hsa-miR-190b	PAR-CLIP	22100165
MIRT449409	hsa-miR-3689a-5p	PAR-CLIP	22100165
MIRT449408	hsa-miR-3689b-5p	PAR-CLIP	22100165
MIRT449407	hsa-miR-3689e	PAR-CLIP	22100165
MIRT449406	hsa-miR-3689f	PAR-CLIP	22100165
MIRT449404	hsa-miR-3161	PAR-CLIP	22100165
MIRT449405	hsa-miR-8070	PAR-CLIP	22100165
MIRT449403	hsa-miR-599	PAR-CLIP	22100165
MIRT1455123	hsa-miR-1252	CLIP-seq
MIRT1455124	hsa-miR-1267	CLIP-seq
MIRT1455125	hsa-miR-128	CLIP-seq
MIRT1455126	hsa-miR-27a	CLIP-seq
MIRT1455127	hsa-miR-27b	CLIP-seq
MIRT1455128	hsa-miR-3121-3p	CLIP-seq
MIRT1455129	hsa-miR-3671	CLIP-seq
MIRT1455130	hsa-miR-3682-3p	CLIP-seq
MIRT1455131	hsa-miR-4687-3p	CLIP-seq
MIRT1455132	hsa-miR-513a-5p	CLIP-seq
MIRT1455133	hsa-miR-567	CLIP-seq
MIRT1455134	hsa-miR-607	CLIP-seq
MIRT1455135	hsa-miR-653	CLIP-seq
MIRT1455136	hsa-miR-935	CLIP-seq
MIRT1455137	hsa-miR-1293	CLIP-seq
MIRT1455138	hsa-miR-24	CLIP-seq
MIRT1455139	hsa-miR-3122	CLIP-seq
MIRT1455140	hsa-miR-3178	CLIP-seq
MIRT1455141	hsa-miR-323-5p	CLIP-seq
MIRT1455142	hsa-miR-3647-3p	CLIP-seq
MIRT1455129	hsa-miR-3671	CLIP-seq
MIRT1455143	hsa-miR-3689a-3p	CLIP-seq
MIRT1455144	hsa-miR-3689c	CLIP-seq
MIRT1455145	hsa-miR-3913-5p	CLIP-seq
MIRT1455146	hsa-miR-4284	CLIP-seq
MIRT1455147	hsa-miR-4438	CLIP-seq
MIRT1455148	hsa-miR-4483	CLIP-seq
MIRT1455149	hsa-miR-4486	CLIP-seq
MIRT1455150	hsa-miR-4505	CLIP-seq
MIRT1455151	hsa-miR-4651	CLIP-seq
MIRT1455152	hsa-miR-4662a-5p	CLIP-seq
MIRT1455153	hsa-miR-4676-5p	CLIP-seq
MIRT1455154	hsa-miR-4728-5p	CLIP-seq
MIRT1455155	hsa-miR-541	CLIP-seq
MIRT1455156	hsa-miR-575	CLIP-seq
MIRT1455157	hsa-miR-592	CLIP-seq
MIRT1455158	hsa-miR-597	CLIP-seq
MIRT1455159	hsa-miR-608	CLIP-seq
MIRT1455160	hsa-miR-616	CLIP-seq
MIRT1455161	hsa-miR-654-5p	CLIP-seq
MIRT1455162	hsa-miR-876-3p	CLIP-seq
MIRT1455124	hsa-miR-1267	CLIP-seq
MIRT1455130	hsa-miR-3682-3p	CLIP-seq
MIRT2136390	hsa-miR-374a	CLIP-seq
MIRT2136391	hsa-miR-374b	CLIP-seq
MIRT2136392	hsa-miR-4521	CLIP-seq
MIRT1455131	hsa-miR-4687-3p	CLIP-seq
MIRT2136393	hsa-miR-642b	CLIP-seq
MIRT1455135	hsa-miR-653	CLIP-seq
MIRT2136394	hsa-miR-664	CLIP-seq
MIRT2136395	hsa-miR-944	CLIP-seq
MIRT2357271	hsa-let-7a	CLIP-seq
MIRT2357272	hsa-let-7b	CLIP-seq
MIRT2357273	hsa-let-7c	CLIP-seq
MIRT2357274	hsa-let-7d	CLIP-seq
MIRT2357275	hsa-let-7e	CLIP-seq
MIRT2357276	hsa-let-7f	CLIP-seq
MIRT2357277	hsa-let-7g	CLIP-seq
MIRT2357278	hsa-let-7i	CLIP-seq
MIRT1455124	hsa-miR-1267	CLIP-seq
MIRT2357279	hsa-miR-202	CLIP-seq
MIRT1455128	hsa-miR-3121-3p	CLIP-seq
MIRT2357280	hsa-miR-3165	CLIP-seq
MIRT2357281	hsa-miR-3622a-3p	CLIP-seq
MIRT2357282	hsa-miR-3622b-3p	CLIP-seq
MIRT2357283	hsa-miR-3656	CLIP-seq
MIRT2357284	hsa-miR-4257	CLIP-seq
MIRT2357285	hsa-miR-4305	CLIP-seq
MIRT2357286	hsa-miR-4458	CLIP-seq
MIRT2357287	hsa-miR-4500	CLIP-seq
MIRT2136392	hsa-miR-4521	CLIP-seq
MIRT1455131	hsa-miR-4687-3p	CLIP-seq
MIRT2357288	hsa-miR-4777-5p	CLIP-seq
MIRT2357289	hsa-miR-518d-5p	CLIP-seq
MIRT2357290	hsa-miR-519b-5p	CLIP-seq
MIRT2357291	hsa-miR-519c-5p	CLIP-seq
MIRT2357292	hsa-miR-520c-5p	CLIP-seq
MIRT2357293	hsa-miR-526a	CLIP-seq
MIRT2357294	hsa-miR-544b	CLIP-seq
MIRT2136393	hsa-miR-642b	CLIP-seq
MIRT1455135	hsa-miR-653	CLIP-seq
MIRT2136394	hsa-miR-664	CLIP-seq
MIRT2357295	hsa-miR-98	CLIP-seq
MIRT2357296	hsa-miR-4708-5p	CLIP-seq
MIRT2357297	hsa-miR-501-3p	CLIP-seq
MIRT2357298	hsa-miR-502-3p	CLIP-seq
MIRT2396365	hsa-miR-1273f	CLIP-seq
MIRT2396366	hsa-miR-143	CLIP-seq
MIRT2136392	hsa-miR-4521	CLIP-seq
MIRT2357296	hsa-miR-4708-5p	CLIP-seq
MIRT2396367	hsa-miR-4770	CLIP-seq
MIRT2136393	hsa-miR-642b	CLIP-seq
MIRT2136394	hsa-miR-664	CLIP-seq
MIRT1455139	hsa-miR-3122	CLIP-seq
MIRT2357280	hsa-miR-3165	CLIP-seq
MIRT2357281	hsa-miR-3622a-3p	CLIP-seq
MIRT2357282	hsa-miR-3622b-3p	CLIP-seq
MIRT2357283	hsa-miR-3656	CLIP-seq
MIRT1455143	hsa-miR-3689a-3p	CLIP-seq
MIRT1455144	hsa-miR-3689c	CLIP-seq
MIRT1455145	hsa-miR-3913-5p	CLIP-seq
MIRT1455154	hsa-miR-4728-5p	CLIP-seq
MIRT2357294	hsa-miR-544b	CLIP-seq
MIRT2651024	hsa-miR-1236	CLIP-seq
MIRT2651025	hsa-miR-1262	CLIP-seq
MIRT1455124	hsa-miR-1267	CLIP-seq
MIRT1455137	hsa-miR-1293	CLIP-seq
MIRT2651026	hsa-miR-146a	CLIP-seq
MIRT2651027	hsa-miR-146b-5p	CLIP-seq
MIRT2651028	hsa-miR-154	CLIP-seq
MIRT1455139	hsa-miR-3122	CLIP-seq
MIRT2651029	hsa-miR-3126-3p	CLIP-seq
MIRT2651030	hsa-miR-3128	CLIP-seq
MIRT2357280	hsa-miR-3165	CLIP-seq
MIRT2651031	hsa-miR-3183	CLIP-seq
MIRT1455141	hsa-miR-323-5p	CLIP-seq
MIRT2357281	hsa-miR-3622a-3p	CLIP-seq
MIRT2357282	hsa-miR-3622b-3p	CLIP-seq
MIRT1455142	hsa-miR-3647-3p	CLIP-seq
MIRT2357283	hsa-miR-3656	CLIP-seq
MIRT1455129	hsa-miR-3671	CLIP-seq
MIRT1455130	hsa-miR-3682-3p	CLIP-seq
MIRT1455143	hsa-miR-3689a-3p	CLIP-seq
MIRT1455144	hsa-miR-3689c	CLIP-seq
MIRT1455145	hsa-miR-3913-5p	CLIP-seq
MIRT2357284	hsa-miR-4257	CLIP-seq
MIRT2651032	hsa-miR-4302	CLIP-seq
MIRT2357285	hsa-miR-4305	CLIP-seq
MIRT1455148	hsa-miR-4483	CLIP-seq
MIRT2136392	hsa-miR-4521	CLIP-seq
MIRT1455151	hsa-miR-4651	CLIP-seq
MIRT2651033	hsa-miR-4659a-3p	CLIP-seq
MIRT2651034	hsa-miR-4659b-3p	CLIP-seq
MIRT1455152	hsa-miR-4662a-5p	CLIP-seq
MIRT2651035	hsa-miR-4668-3p	CLIP-seq
MIRT1455153	hsa-miR-4676-5p	CLIP-seq
MIRT1455131	hsa-miR-4687-3p	CLIP-seq
MIRT2651036	hsa-miR-4697-3p	CLIP-seq
MIRT2651037	hsa-miR-4698	CLIP-seq
MIRT2651038	hsa-miR-4701-3p	CLIP-seq
MIRT2651039	hsa-miR-4720-5p	CLIP-seq
MIRT2651040	hsa-miR-4723-3p	CLIP-seq
MIRT2651041	hsa-miR-4724-5p	CLIP-seq
MIRT1455154	hsa-miR-4728-5p	CLIP-seq
MIRT2357288	hsa-miR-4777-5p	CLIP-seq
MIRT2651042	hsa-miR-4778-3p	CLIP-seq
MIRT2651043	hsa-miR-4799-3p	CLIP-seq
MIRT2357289	hsa-miR-518d-5p	CLIP-seq
MIRT2357290	hsa-miR-519b-5p	CLIP-seq
MIRT2357291	hsa-miR-519c-5p	CLIP-seq
MIRT2357292	hsa-miR-520c-5p	CLIP-seq
MIRT2357293	hsa-miR-526a	CLIP-seq
MIRT1455155	hsa-miR-541	CLIP-seq
MIRT2357294	hsa-miR-544b	CLIP-seq
MIRT1455156	hsa-miR-575	CLIP-seq
MIRT2651044	hsa-miR-580	CLIP-seq
MIRT2651045	hsa-miR-589	CLIP-seq
MIRT1455157	hsa-miR-592	CLIP-seq
MIRT1455158	hsa-miR-597	CLIP-seq
MIRT1455134	hsa-miR-607	CLIP-seq
MIRT1455159	hsa-miR-608	CLIP-seq
MIRT1455160	hsa-miR-616	CLIP-seq
MIRT2136393	hsa-miR-642b	CLIP-seq
MIRT1455135	hsa-miR-653	CLIP-seq
MIRT1455161	hsa-miR-654-5p	CLIP-seq
MIRT2136394	hsa-miR-664	CLIP-seq
MIRT1455162	hsa-miR-876-3p	CLIP-seq
MIRT2651024	hsa-miR-1236	CLIP-seq
MIRT2651025	hsa-miR-1262	CLIP-seq
MIRT1455124	hsa-miR-1267	CLIP-seq
MIRT1455137	hsa-miR-1293	CLIP-seq
MIRT2651026	hsa-miR-146a	CLIP-seq
MIRT2651027	hsa-miR-146b-5p	CLIP-seq
MIRT1455139	hsa-miR-3122	CLIP-seq
MIRT2357280	hsa-miR-3165	CLIP-seq
MIRT2651031	hsa-miR-3183	CLIP-seq
MIRT1455141	hsa-miR-323-5p	CLIP-seq
MIRT2357281	hsa-miR-3622a-3p	CLIP-seq
MIRT2357282	hsa-miR-3622b-3p	CLIP-seq
MIRT1455142	hsa-miR-3647-3p	CLIP-seq
MIRT2357283	hsa-miR-3656	CLIP-seq
MIRT1455129	hsa-miR-3671	CLIP-seq
MIRT1455130	hsa-miR-3682-3p	CLIP-seq
MIRT1455143	hsa-miR-3689a-3p	CLIP-seq
MIRT1455144	hsa-miR-3689c	CLIP-seq
MIRT1455145	hsa-miR-3913-5p	CLIP-seq
MIRT2357284	hsa-miR-4257	CLIP-seq
MIRT2651032	hsa-miR-4302	CLIP-seq
MIRT2357285	hsa-miR-4305	CLIP-seq
MIRT1455148	hsa-miR-4483	CLIP-seq
MIRT2136392	hsa-miR-4521	CLIP-seq
MIRT1455151	hsa-miR-4651	CLIP-seq
MIRT2651033	hsa-miR-4659a-3p	CLIP-seq
MIRT2651034	hsa-miR-4659b-3p	CLIP-seq
MIRT1455152	hsa-miR-4662a-5p	CLIP-seq
MIRT2651035	hsa-miR-4668-3p	CLIP-seq
MIRT1455153	hsa-miR-4676-5p	CLIP-seq
MIRT1455131	hsa-miR-4687-3p	CLIP-seq
MIRT2651036	hsa-miR-4697-3p	CLIP-seq
MIRT2651037	hsa-miR-4698	CLIP-seq
MIRT2651038	hsa-miR-4701-3p	CLIP-seq
MIRT2651040	hsa-miR-4723-3p	CLIP-seq
MIRT2651041	hsa-miR-4724-5p	CLIP-seq
MIRT1455154	hsa-miR-4728-5p	CLIP-seq
MIRT2357288	hsa-miR-4777-5p	CLIP-seq
MIRT2651042	hsa-miR-4778-3p	CLIP-seq
MIRT2357289	hsa-miR-518d-5p	CLIP-seq
MIRT2357290	hsa-miR-519b-5p	CLIP-seq
MIRT2357291	hsa-miR-519c-5p	CLIP-seq
MIRT2357292	hsa-miR-520c-5p	CLIP-seq
MIRT2357293	hsa-miR-526a	CLIP-seq
MIRT1455155	hsa-miR-541	CLIP-seq
MIRT2357294	hsa-miR-544b	CLIP-seq
MIRT1455156	hsa-miR-575	CLIP-seq
MIRT2651044	hsa-miR-580	CLIP-seq
MIRT2651045	hsa-miR-589	CLIP-seq
MIRT1455157	hsa-miR-592	CLIP-seq
MIRT1455158	hsa-miR-597	CLIP-seq
MIRT1455134	hsa-miR-607	CLIP-seq
MIRT1455159	hsa-miR-608	CLIP-seq
MIRT1455160	hsa-miR-616	CLIP-seq
MIRT2136393	hsa-miR-642b	CLIP-seq
MIRT1455135	hsa-miR-653	CLIP-seq
MIRT1455161	hsa-miR-654-5p	CLIP-seq
MIRT2136394	hsa-miR-664	CLIP-seq
MIRT1455162	hsa-miR-876-3p	CLIP-seq

Show/Hide all (49)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000932	Component	P-body	IDA	12878161, 20357094
GO:0002218	Process	Activation of innate immune response	IDA	21512573
GO:0002376	Process	Immune system process	IEA
GO:0003713	Function	Transcription coactivator activity	IDA	23077300
GO:0004842	Function	Ubiquitin-protein transferase activity	IDA	21512573
GO:0005515	Function	Protein binding	IPI	12878161, 15919943, 20357094, 21512573, 22078707, 22493164, 25127057, 25203322, 26618866, 32296183, 32814053, 35156780
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IDA	11331580, 18248090, 25127057
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	TAS
GO:0006914	Process	Autophagy	IDA	25127057
GO:0006914	Process	Autophagy	IEA
GO:0008270	Function	Zinc ion binding	IEA
GO:0010468	Process	Regulation of gene expression	IBA
GO:0010468	Process	Regulation of gene expression	IEA
GO:0016567	Process	Protein ubiquitination	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0019901	Function	Protein kinase binding	IBA
GO:0019901	Function	Protein kinase binding	IPI	25127057
GO:0030674	Function	Protein-macromolecule adaptor activity	IPI	25127057
GO:0031664	Process	Regulation of lipopolysaccharide-mediated signaling pathway	IMP	21512573
GO:0032880	Process	Regulation of protein localization	IBA
GO:0032880	Process	Regulation of protein localization	IMP	25127057
GO:0038187	Function	Pattern recognition receptor activity	IDA	21512573
GO:0042802	Function	Identical protein binding	IEA
GO:0042802	Function	Identical protein binding	IPI	17156811, 22493164, 22829933
GO:0042803	Function	Protein homodimerization activity	IBA
GO:0042803	Function	Protein homodimerization activity	IPI	11331580
GO:0043123	Process	Positive regulation of canonical NF-kappaB signal transduction	IBA
GO:0043123	Process	Positive regulation of canonical NF-kappaB signal transduction	IDA	23077300
GO:0043123	Process	Positive regulation of canonical NF-kappaB signal transduction	IMP	21512573
GO:0043410	Process	Positive regulation of MAPK cascade	IMP	21512573
GO:0044790	Process	Suppression of viral release by host	IDA	18248090
GO:0045087	Process	Innate immune response	IBA
GO:0045087	Process	Innate immune response	IDA	18248090
GO:0045087	Process	Innate immune response	IEA
GO:0045893	Process	Positive regulation of DNA-templated transcription	IEA
GO:0046596	Process	Regulation of viral entry into host cell	IBA
GO:0046597	Process	Host-mediated suppression of symbiont invasion	IDA	18248090
GO:0046872	Function	Metal ion binding	IEA
GO:0051092	Process	Positive regulation of NF-kappaB transcription factor activity	IMP	21512573
GO:0051607	Process	Defense response to virus	IEA
GO:0051607	Process	Defense response to virus	TAS	21512573, 22291694
GO:0061630	Function	Ubiquitin protein ligase activity	IBA
GO:0061630	Function	Ubiquitin protein ligase activity	IEA
GO:0070534	Process	Protein K63-linked ubiquitination	IDA	21512573
GO:0080090	Process	Regulation of primary metabolic process	IEA
GO:1990462	Component	Omegasome	IDA	25127057

MIM	HGNC	e!Ensembl
608487	16276	ENSG00000132256

Q9C035

Protein name

Tripartite motif-containing protein 5 (EC 2.3.2.27) (RING finger protein 88) (RING-type E3 ubiquitin transferase TRIM5)

Protein function

Capsid-specific restriction factor that prevents infection from non-host-adapted retroviruses. Blocks viral replication early in the life cycle, after viral entry but before reverse transcription. In addition to acting as a capsid-specific restr

PDB

2ECV , 2YRG

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF13445	zf-RING_UBOX	15 → 56	RING-type zinc-finger	Domain
PF00643	zf-B_box	90 → 131	B-box zinc finger	Domain
PF00622	SPRY	358 → 489	SPRY domain	Family

Sequence

MASGILVNVKEEVTCPICLELLTQPLSLDCGHSFCQACLTANHKKSMLDKGESSCPVCRI
SYQPENIRPNRHVANIVEKLREVKLSPEGQKVDHCARHGEKLLLFCQEDGKVICWLCERS
QEHRGHHTFLTEEVAREYQVKLQAALEMLRQKQQEAEELEADIREEKASWKTQIQYDKTN
VLADFEQLRDILDWEESNELQNLEKEEEDILKSLTNSETEMVQQTQSLRELISDLEHRLQ
GSVMELLQGVDGVIKRTENVTLKKPETFPKNQRRVFRAPDLKGMLEVFRELTDVRRYWVD
VTVAPNNISCAVISEDKRQVSSPKPQIIYGARGTRYQTFVNFNYCTGILGSQSITSGKHY
WEVDVSKKTAWILGVCAGFQPDAMCNIEKNENYQPKYGYWVIGLEEGVKCSAFQDSSFHT
PSVPFIVPLSVIICPDRVGVFLDYEACTVSFFNITNHGFLIYKFSHCSFSQPVFPYLNPR
KCGVPMTLCSPSS

Sequence length

493

Interactions

View interactions

	KEGG		Reactome
	Viral life cycle - HIV-1 Human immunodeficiency virus 1 infection		Interferon gamma signaling

TRIM5 (tripartite motif containing 5)