Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	84992
Gene name	Phosphatidylinositol glycan anchor biosynthesis class Y
Gene symbol	PIGY
Synonyms (NCBI Gene)	HPMRS6PIG-Y
Chromosome	4
Chromosome location	4q22.1
Summary	The protein encoded by this gene is part of the GPI-N-acetylglucosaminyltransferase (GIP-GnT) complex which initiates the biosynthesis of glycosylphosphatidylinositol (GPI). GPI is synthesized in the endoplasmic reticulum and serves as an anchor for many

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miRTarBase ID	miRNA	Experiments
MIRT1233734	hsa-miR-105	CLIP-seq
MIRT1233735	hsa-miR-1273g	CLIP-seq
MIRT1233736	hsa-miR-134	CLIP-seq
MIRT1233737	hsa-miR-137	CLIP-seq
MIRT1233738	hsa-miR-188-3p	CLIP-seq
MIRT1233739	hsa-miR-190	CLIP-seq
MIRT1233740	hsa-miR-190b	CLIP-seq
MIRT1233741	hsa-miR-1910	CLIP-seq
MIRT1233742	hsa-miR-23a	CLIP-seq
MIRT1233743	hsa-miR-23b	CLIP-seq
MIRT1233744	hsa-miR-23c	CLIP-seq
MIRT1233745	hsa-miR-299-3p	CLIP-seq
MIRT1233746	hsa-miR-3074-3p	CLIP-seq
MIRT1233747	hsa-miR-3118	CLIP-seq
MIRT1233748	hsa-miR-3121-5p	CLIP-seq
MIRT1233749	hsa-miR-3126-5p	CLIP-seq
MIRT1233750	hsa-miR-3143	CLIP-seq
MIRT1233751	hsa-miR-3164	CLIP-seq
MIRT1233752	hsa-miR-330-3p	CLIP-seq
MIRT1233753	hsa-miR-3607-5p	CLIP-seq
MIRT1233754	hsa-miR-3646	CLIP-seq
MIRT1233755	hsa-miR-3671	CLIP-seq
MIRT1233756	hsa-miR-3673	CLIP-seq
MIRT1233757	hsa-miR-4287	CLIP-seq
MIRT1233758	hsa-miR-4293	CLIP-seq
MIRT1233759	hsa-miR-4328	CLIP-seq
MIRT1233760	hsa-miR-4469	CLIP-seq
MIRT1233761	hsa-miR-4491	CLIP-seq
MIRT1233762	hsa-miR-4496	CLIP-seq
MIRT1233763	hsa-miR-4501	CLIP-seq
MIRT1233764	hsa-miR-4639-5p	CLIP-seq
MIRT1233765	hsa-miR-4657	CLIP-seq
MIRT1233766	hsa-miR-4670-3p	CLIP-seq
MIRT1233767	hsa-miR-4685-3p	CLIP-seq
MIRT1233768	hsa-miR-4704-3p	CLIP-seq
MIRT1233769	hsa-miR-4768-5p	CLIP-seq
MIRT1233770	hsa-miR-4775	CLIP-seq
MIRT1233771	hsa-miR-4787-3p	CLIP-seq
MIRT1233772	hsa-miR-4790-3p	CLIP-seq
MIRT1233773	hsa-miR-4793-5p	CLIP-seq
MIRT1233774	hsa-miR-483-3p	CLIP-seq
MIRT1233775	hsa-miR-493	CLIP-seq
MIRT1233776	hsa-miR-499-3p	CLIP-seq
MIRT1233777	hsa-miR-499a-3p	CLIP-seq
MIRT1233778	hsa-miR-505	CLIP-seq
MIRT1233779	hsa-miR-520d-5p	CLIP-seq
MIRT1233780	hsa-miR-524-5p	CLIP-seq
MIRT1233781	hsa-miR-548ag	CLIP-seq
MIRT1233782	hsa-miR-548ai	CLIP-seq
MIRT1233783	hsa-miR-586	CLIP-seq
MIRT1233784	hsa-miR-590-3p	CLIP-seq
MIRT1233785	hsa-miR-607	CLIP-seq
MIRT1233786	hsa-miR-877	CLIP-seq
MIRT1233787	hsa-miR-944	CLIP-seq
MIRT1233787	hsa-miR-944	CLIP-seq
MIRT2068816	hsa-miR-4252	CLIP-seq
MIRT1233772	hsa-miR-4790-3p	CLIP-seq
MIRT2068817	hsa-miR-892a	CLIP-seq
MIRT2295867	hsa-miR-1279	CLIP-seq
MIRT2295868	hsa-miR-3120-3p	CLIP-seq
MIRT2295869	hsa-miR-3182	CLIP-seq
MIRT1233759	hsa-miR-4328	CLIP-seq
MIRT2295870	hsa-miR-4659a-3p	CLIP-seq
MIRT2295871	hsa-miR-4659b-3p	CLIP-seq
MIRT2295872	hsa-miR-4698	CLIP-seq
MIRT2295873	hsa-miR-4762-3p	CLIP-seq
MIRT2295874	hsa-miR-889	CLIP-seq
MIRT2432127	hsa-miR-335	CLIP-seq
MIRT2432128	hsa-miR-3919	CLIP-seq
MIRT2432129	hsa-miR-3942-3p	CLIP-seq
MIRT2432130	hsa-miR-4756-3p	CLIP-seq
MIRT2295874	hsa-miR-889	CLIP-seq
MIRT2432127	hsa-miR-335	CLIP-seq
MIRT2432127	hsa-miR-335	CLIP-seq
MIRT2593897	hsa-miR-1236	CLIP-seq
MIRT2295867	hsa-miR-1279	CLIP-seq
MIRT1233738	hsa-miR-188-3p	CLIP-seq
MIRT1233739	hsa-miR-190	CLIP-seq
MIRT1233740	hsa-miR-190b	CLIP-seq
MIRT1233741	hsa-miR-1910	CLIP-seq
MIRT2295868	hsa-miR-3120-3p	CLIP-seq
MIRT2593898	hsa-miR-3124-3p	CLIP-seq
MIRT1233752	hsa-miR-330-3p	CLIP-seq
MIRT2432127	hsa-miR-335	CLIP-seq
MIRT2593899	hsa-miR-3653	CLIP-seq
MIRT2593900	hsa-miR-3658	CLIP-seq
MIRT2432128	hsa-miR-3919	CLIP-seq
MIRT2432129	hsa-miR-3942-3p	CLIP-seq
MIRT2068816	hsa-miR-4252	CLIP-seq
MIRT1233758	hsa-miR-4293	CLIP-seq
MIRT2593901	hsa-miR-4436b-5p	CLIP-seq
MIRT2593902	hsa-miR-4477a	CLIP-seq
MIRT2593903	hsa-miR-4522	CLIP-seq
MIRT2593904	hsa-miR-4687-3p	CLIP-seq
MIRT2593905	hsa-miR-4715-5p	CLIP-seq
MIRT2593906	hsa-miR-4722-3p	CLIP-seq
MIRT2593907	hsa-miR-4753-3p	CLIP-seq
MIRT2432130	hsa-miR-4756-3p	CLIP-seq
MIRT1233770	hsa-miR-4775	CLIP-seq
MIRT1233771	hsa-miR-4787-3p	CLIP-seq
MIRT2593908	hsa-miR-532-3p	CLIP-seq
MIRT2593909	hsa-miR-548m	CLIP-seq
MIRT2593910	hsa-miR-556-3p	CLIP-seq
MIRT1233784	hsa-miR-590-3p	CLIP-seq
MIRT2593911	hsa-miR-647	CLIP-seq
MIRT2295874	hsa-miR-889	CLIP-seq
MIRT2068817	hsa-miR-892a	CLIP-seq
MIRT2593912	hsa-miR-942	CLIP-seq
MIRT2593897	hsa-miR-1236	CLIP-seq
MIRT2295867	hsa-miR-1279	CLIP-seq
MIRT1233738	hsa-miR-188-3p	CLIP-seq
MIRT1233739	hsa-miR-190	CLIP-seq
MIRT1233740	hsa-miR-190b	CLIP-seq
MIRT1233741	hsa-miR-1910	CLIP-seq
MIRT2295868	hsa-miR-3120-3p	CLIP-seq
MIRT2593898	hsa-miR-3124-3p	CLIP-seq
MIRT1233752	hsa-miR-330-3p	CLIP-seq
MIRT2432127	hsa-miR-335	CLIP-seq
MIRT2593899	hsa-miR-3653	CLIP-seq
MIRT2593900	hsa-miR-3658	CLIP-seq
MIRT1233756	hsa-miR-3673	CLIP-seq
MIRT2432128	hsa-miR-3919	CLIP-seq
MIRT2432129	hsa-miR-3942-3p	CLIP-seq
MIRT2068816	hsa-miR-4252	CLIP-seq
MIRT1233758	hsa-miR-4293	CLIP-seq
MIRT2593901	hsa-miR-4436b-5p	CLIP-seq
MIRT2593902	hsa-miR-4477a	CLIP-seq
MIRT2593904	hsa-miR-4687-3p	CLIP-seq
MIRT1233768	hsa-miR-4704-3p	CLIP-seq
MIRT2593905	hsa-miR-4715-5p	CLIP-seq
MIRT2593906	hsa-miR-4722-3p	CLIP-seq
MIRT2593907	hsa-miR-4753-3p	CLIP-seq
MIRT2432130	hsa-miR-4756-3p	CLIP-seq
MIRT1233770	hsa-miR-4775	CLIP-seq
MIRT1233771	hsa-miR-4787-3p	CLIP-seq
MIRT1233773	hsa-miR-4793-5p	CLIP-seq
MIRT2593908	hsa-miR-532-3p	CLIP-seq
MIRT2593909	hsa-miR-548m	CLIP-seq
MIRT2593910	hsa-miR-556-3p	CLIP-seq
MIRT1233784	hsa-miR-590-3p	CLIP-seq
MIRT2593911	hsa-miR-647	CLIP-seq
MIRT2295874	hsa-miR-889	CLIP-seq
MIRT2068817	hsa-miR-892a	CLIP-seq
MIRT2593912	hsa-miR-942	CLIP-seq
MIRT1233787	hsa-miR-944	CLIP-seq

Show/Hide all (14)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000506	Component	Glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex	IBA
GO:0000506	Component	Glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex	IDA	16162815
GO:0000506	Component	Glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex	IPI	16162815
GO:0005515	Function	Protein binding	IPI	16162815, 32296183
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IDA	16162815
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	TAS
GO:0005886	Component	Plasma membrane	IDA	16162815
GO:0006506	Process	GPI anchor biosynthetic process	IBA
GO:0006506	Process	GPI anchor biosynthetic process	IDA	16162815
GO:0006506	Process	GPI anchor biosynthetic process	IEA
GO:0016020	Component	Membrane	IEA
GO:0017176	Function	Phosphatidylinositol N-acetylglucosaminyltransferase activity	IDA	16162815

MIM	HGNC	e!Ensembl
610662	28213	ENSG00000255072

Q3MUY2

Protein name

Phosphatidylinositol N-acetylglucosaminyltransferase subunit Y (Phosphatidylinositol-glycan biosynthesis class Y protein) (PIG-Y)

Protein function

Part of the glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex that catalyzes the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol and participates in the first step of GPI biosynth

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF15159	PIG-Y	2 → 70	Phosphatidylinositol N-acetylglucosaminyltransferase subunit Y	Family

Sequence

MFLSLPTLTVLIPLVSLAGLFYSASVEENFPQGCTSTASLCFYSLLLPITIPVYVFFHLW
TWMGIKLFRHN

Sequence length

Interactions

View interactions

	KEGG		Reactome
	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis Metabolic pathways		Synthesis of glycosylphosphatidylinositol (GPI)

Show/Hide Causal Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Hyperphosphatasia with intellectual disability syndrome 6	Pathogenic	rs869025322, rs869025323	RCV000207478 RCV000207473

Show/Hide Text Mining Associations (13)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
adult multisystem inflammatory disease COVID 19 related	Associate	26293662
Body Dysmorphic Disorders	Associate	26293662
Burkitt Lymphoma	Associate	19302917
Cataract	Associate	26293662
Death	Associate	26293662
Developmental Disabilities	Associate	26293662
Glycosylphosphatidylinositol deficiency	Associate	19302917
Hyperostosis corticalis deformans juvenilis	Associate	30813920
Hyperphosphatasia with Mental Retardation	Associate	30813920
Immunologic Deficiency Syndromes	Associate	26293662
Intellectual Disability	Associate	30813920
Neoplasms	Associate	37609818
Seizures	Associate	26293662

PIGY (phosphatidylinositol glycan anchor biosynthesis class Y)