Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
84951
Gene name Gene Name - the full gene name approved by the HGNC.
Tensin 4
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
TNS4
Synonyms (NCBI Gene) Gene synonyms aliases
CTEN, PP14434
Chromosome Chromosome number
17
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
17q21.2
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT003769 hsa-miR-1-3p Microarray 15685193
MIRT018760 hsa-miR-335-5p Microarray 18185580
MIRT023010 hsa-miR-124-3p Microarray 18668037
MIRT003769 hsa-miR-1-3p Microarray 15685193
MIRT030073 hsa-miR-26b-5p Microarray 19088304
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0003779 Function Actin binding IEA
GO:0005515 Function Protein binding IPI 17190795, 32296183
GO:0005829 Component Cytosol TAS
GO:0005856 Component Cytoskeleton IEA
GO:0005925 Component Focal adhesion IDA 17190795
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
608385 24352 ENSG00000131746
Protein
UniProt ID Q8IZW8
Protein name Tensin-4 (C-terminal tensin-like protein)
Protein function Promotes EGF-induced cell migration by displacing tensin TNS3 from the cytoplasmic tail of integrin ITGB1 which results in dissociation of TNS3 from focal adhesions, disassembly of actin stress fibers and initiation of cell migration (PubMed:176
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00017 SH2 449 541 SH2 domain Domain
PF08416 PTB 581 714 Phosphotyrosine-binding domain Domain
Tissue specificity TISSUE SPECIFICITY: Expressed at low levels in colon (at protein level) (PubMed:19214987, PubMed:19487278). Expressed in prostate and placenta (PubMed:12154022). {ECO:0000269|PubMed:12154022, ECO:0000269|PubMed:19214987, ECO:0000269|PubMed:19487278}.
Sequence
MSQVMSSPLLAGGHAVSLAPCDEPRRTLHPAPSPSLPPQCSYYTTEGWGAQALMAPVPCM
GPPGRLQQAPQVEAKATCFLPSPGEKALGTPEDLDSYIDFSLESLNQMILELDPTFQLLP
PGTGGSQAELAQSTMSMRKKEESEALDIKYIEVTSARSRCHDGPQHCSSPSVTPPFGSLR
SGGLLLSRDVPRETRSSSESLIFSGNQGRGHQRPLPPSEGLSPRPPNSPSISIPCMGSKA
SSPHGLGSPLVASPRLEKRLGGLAPQRGSRISVLSASPVSDVSYMFGSSQSLLHSSNSSH
QSSSRSLESPANSSSSLHSLGSVSLCTRPSDFQAPRNPTLTMGQPRTPHSPPLAKEHASS
CPPSITNSMVDIPIVLINGCPEPGSSPPQRTPGHQNSVQPGAASPSNPCPATRSNSQTLS
DAPFTTCPEGPARDMQPTMKFVMDTSKYWFKPNITREQAIELLRKEEPGAFVIRDSSSYR
GSFGLALKVQEVPASAQSRPGEDSNDLIRHFLIESSAKGVHLKGADEEPYFGSLSAFVCQ
H
SIMALALPCKLTIPQRELGGADGASDSTDSPASCQKKSAGCHTLYLSSVSVETLTGALA
VQKAISTTFERDILPTPTVVHFKVTEQGITLTDVQRKVFFRRHYPLTTLRFCGMDPEQRK
WQKYCKPSWIFGFVAKSQTEPQENVCHLFAEYDMVQPASQVIGLVTALLQDAER
M
Sequence length 715
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    MET interacts with TNS proteins
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Colorectal cancer Colorectal Carcinoma rs137854568, rs137854573, rs137854575, rs387906234, rs121908380, rs121908702, rs267606674, rs794729661, rs121909055, rs281865417, rs267606884, rs28934575, rs587776769, rs104893815, rs587776800
View all (467 more)
Unknown
Disease term Disease name Evidence References Source
Pancreatic adenocarcinoma Pancreatic adenocarcinoma PDAC patients with high expression of PSMA6 having a significantly shorter overall survival rate. GWAS, CBGDA
Alzheimer disease Alzheimer disease GWAS
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma of Lung Associate 30353687, 33029490, 33195688, 36793937, 39766765
Breast Neoplasms Stimulate 23774213
Carcinogenesis Associate 23625726
Carcinoma Hepatocellular Associate 26035355
Carcinoma Non Small Cell Lung Associate 29985912, 35807355
Colorectal Neoplasms Stimulate 19487278
Colorectal Neoplasms Associate 21698197, 26852686, 30648319, 37328854
Dysplastic Nevus Syndrome Stimulate 24244691
Hereditary pancreatitis Stimulate 23625726
Lung Neoplasms Associate 23774213, 25439778, 29985912