TNS4 (tensin 4)
| Gene | |
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Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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84951 |
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Gene name
Gene Name - the full gene name approved by the HGNC.
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Tensin 4 |
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Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
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TNS4 |
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Synonyms (NCBI Gene)
Gene synonyms aliases
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CTEN, PP14434 |
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Chromosome
Chromosome number
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17 |
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Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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17q21.2 |
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miRNA
miRNA information provided by mirtarbase database.
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Gene ontology (GO)
Gene ontology information of associated ontologies with gene provided by GO database.
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Other IDs
Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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| Protein | ||||||||||||||||
| UniProt ID | Q8IZW8 | |||||||||||||||
| Protein name | Tensin-4 (C-terminal tensin-like protein) | |||||||||||||||
| Protein function | Promotes EGF-induced cell migration by displacing tensin TNS3 from the cytoplasmic tail of integrin ITGB1 which results in dissociation of TNS3 from focal adhesions, disassembly of actin stress fibers and initiation of cell migration (PubMed:176 | |||||||||||||||
| Family and domains |
Pfam
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| Tissue specificity | TISSUE SPECIFICITY: Expressed at low levels in colon (at protein level) (PubMed:19214987, PubMed:19487278). Expressed in prostate and placenta (PubMed:12154022). {ECO:0000269|PubMed:12154022, ECO:0000269|PubMed:19214987, ECO:0000269|PubMed:19487278}. | |||||||||||||||
| Sequence |
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| Sequence length | 715 | |||||||||||||||
| Interactions | View interactions | |||||||||||||||
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Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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Associated diseases
Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
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