FIBCD1 (fibrinogen C domain containing 1)

Gene

• Entrez ID: 84929
• Gene name: Fibrinogen C domain containing 1
• Gene symbol: FIBCD1
• Synonyms (NCBI Gene): -
• Chromosome: 9
• Chromosome location: 9q34.12
• Summary: FIBCD1 is a conserved type II transmembrane endocytic receptor that binds chitin and is located primarily in the intestinal brush border (Schlosser et al., 2009 [PubMed 19710473]).[supplied by OMIM, Apr 2010]

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT017721	hsa-miR-335-5p	Microarray	18185580
MIRT486519	hsa-miR-4285	PAR-CLIP	23592263
MIRT486517	hsa-miR-6770-5p	PAR-CLIP	23592263
MIRT486516	hsa-miR-6717-5p	PAR-CLIP	23592263
MIRT486515	hsa-miR-92b-5p	PAR-CLIP	23592263
MIRT486514	hsa-miR-3144-5p	PAR-CLIP	23592263
MIRT486513	hsa-miR-3191-3p	PAR-CLIP	23592263
MIRT486512	hsa-miR-4652-5p	PAR-CLIP	23592263
MIRT486511	hsa-miR-92a-2-5p	PAR-CLIP	23592263
MIRT486510	hsa-miR-491-5p	PAR-CLIP	23592263
MIRT486509	hsa-miR-6810-5p	PAR-CLIP	23592263
MIRT486508	hsa-miR-1908-5p	PAR-CLIP	23592263
MIRT486519	hsa-miR-4285	PAR-CLIP	23592263
MIRT486517	hsa-miR-6770-5p	PAR-CLIP	23592263
MIRT486516	hsa-miR-6717-5p	PAR-CLIP	23592263
MIRT486515	hsa-miR-92b-5p	PAR-CLIP	23592263
MIRT486514	hsa-miR-3144-5p	PAR-CLIP	23592263
MIRT486513	hsa-miR-3191-3p	PAR-CLIP	23592263
MIRT486512	hsa-miR-4652-5p	PAR-CLIP	23592263
MIRT486511	hsa-miR-92a-2-5p	PAR-CLIP	23592263
MIRT486510	hsa-miR-491-5p	PAR-CLIP	23592263
MIRT486509	hsa-miR-6810-5p	PAR-CLIP	23592263
MIRT486508	hsa-miR-1908-5p	PAR-CLIP	23592263
MIRT996621	hsa-miR-1275	CLIP-seq
MIRT996622	hsa-miR-1293	CLIP-seq
MIRT996623	hsa-miR-1827	CLIP-seq
MIRT996624	hsa-miR-18a	CLIP-seq
MIRT996625	hsa-miR-18b	CLIP-seq
MIRT996626	hsa-miR-214	CLIP-seq
MIRT996627	hsa-miR-3180-5p	CLIP-seq
MIRT996628	hsa-miR-3619-5p	CLIP-seq
MIRT996629	hsa-miR-3918	CLIP-seq
MIRT996630	hsa-miR-3940-5p	CLIP-seq
MIRT996631	hsa-miR-4447	CLIP-seq
MIRT996632	hsa-miR-4472	CLIP-seq
MIRT996633	hsa-miR-4483	CLIP-seq
MIRT996634	hsa-miR-4487	CLIP-seq
MIRT996635	hsa-miR-4507	CLIP-seq
MIRT996636	hsa-miR-4525	CLIP-seq
MIRT996637	hsa-miR-4665-5p	CLIP-seq
MIRT996638	hsa-miR-4723-5p	CLIP-seq
MIRT996639	hsa-miR-4735-3p	CLIP-seq
MIRT996640	hsa-miR-4761-5p	CLIP-seq
MIRT996641	hsa-miR-4768-3p	CLIP-seq
MIRT996642	hsa-miR-520a-5p	CLIP-seq
MIRT996643	hsa-miR-525-5p	CLIP-seq
MIRT996644	hsa-miR-539	CLIP-seq
MIRT996645	hsa-miR-624	CLIP-seq
MIRT996646	hsa-miR-625	CLIP-seq
MIRT996647	hsa-miR-761	CLIP-seq
MIRT996648	hsa-miR-767-5p	CLIP-seq
MIRT996649	hsa-miR-191	CLIP-seq
MIRT996650	hsa-miR-3202	CLIP-seq
MIRT996651	hsa-miR-323-5p	CLIP-seq
MIRT996652	hsa-miR-3613-5p	CLIP-seq
MIRT996653	hsa-miR-3689a-3p	CLIP-seq
MIRT996654	hsa-miR-3689c	CLIP-seq
MIRT996655	hsa-miR-4271	CLIP-seq
MIRT996656	hsa-miR-4276	CLIP-seq
MIRT996631	hsa-miR-4447	CLIP-seq
MIRT996632	hsa-miR-4472	CLIP-seq
MIRT996657	hsa-miR-4640-3p	CLIP-seq
MIRT996658	hsa-miR-4725-3p	CLIP-seq
MIRT996659	hsa-miR-4728-5p	CLIP-seq
MIRT996660	hsa-miR-4747-5p	CLIP-seq
MIRT996661	hsa-miR-541	CLIP-seq
MIRT996662	hsa-miR-654-5p	CLIP-seq
MIRT996663	hsa-miR-876-3p	CLIP-seq
MIRT1995507	hsa-miR-1243	CLIP-seq
MIRT1995508	hsa-miR-1254	CLIP-seq
MIRT1995509	hsa-miR-1256	CLIP-seq
MIRT1995510	hsa-miR-1266	CLIP-seq
MIRT1995511	hsa-miR-1273	CLIP-seq
MIRT996622	hsa-miR-1293	CLIP-seq
MIRT1995512	hsa-miR-1343	CLIP-seq
MIRT1995513	hsa-miR-1538	CLIP-seq
MIRT1995514	hsa-miR-181a	CLIP-seq
MIRT1995515	hsa-miR-181b	CLIP-seq
MIRT1995516	hsa-miR-181c	CLIP-seq
MIRT1995517	hsa-miR-181d	CLIP-seq
MIRT1995518	hsa-miR-185	CLIP-seq
MIRT1995519	hsa-miR-3116	CLIP-seq
MIRT1995520	hsa-miR-3162-3p	CLIP-seq
MIRT1995521	hsa-miR-3179	CLIP-seq
MIRT1995522	hsa-miR-3180	CLIP-seq
MIRT1995523	hsa-miR-3180-3p	CLIP-seq
MIRT1995524	hsa-miR-3192	CLIP-seq
MIRT1995525	hsa-miR-3196	CLIP-seq
MIRT996650	hsa-miR-3202	CLIP-seq
MIRT1995526	hsa-miR-3654	CLIP-seq
MIRT1995527	hsa-miR-3663-5p	CLIP-seq
MIRT1995528	hsa-miR-3675-5p	CLIP-seq
MIRT996653	hsa-miR-3689a-3p	CLIP-seq
MIRT996654	hsa-miR-3689c	CLIP-seq
MIRT1995529	hsa-miR-3922-5p	CLIP-seq
MIRT1995530	hsa-miR-3936	CLIP-seq
MIRT1995531	hsa-miR-4262	CLIP-seq
MIRT1995532	hsa-miR-4269	CLIP-seq
MIRT1995533	hsa-miR-4290	CLIP-seq
MIRT1995534	hsa-miR-4306	CLIP-seq
MIRT1995535	hsa-miR-4434	CLIP-seq
MIRT996631	hsa-miR-4447	CLIP-seq
MIRT1995536	hsa-miR-4471	CLIP-seq
MIRT996632	hsa-miR-4472	CLIP-seq
MIRT1995537	hsa-miR-4481	CLIP-seq
MIRT996633	hsa-miR-4483	CLIP-seq
MIRT1995538	hsa-miR-4516	CLIP-seq
MIRT1995539	hsa-miR-4518	CLIP-seq
MIRT1995540	hsa-miR-4530	CLIP-seq
MIRT1995541	hsa-miR-4531	CLIP-seq
MIRT1995542	hsa-miR-4642	CLIP-seq
MIRT1995543	hsa-miR-4644	CLIP-seq
MIRT1995544	hsa-miR-4645-5p	CLIP-seq
MIRT1995545	hsa-miR-4651	CLIP-seq
MIRT1995546	hsa-miR-4667-3p	CLIP-seq
MIRT1995547	hsa-miR-4673	CLIP-seq
MIRT1995548	hsa-miR-4685-5p	CLIP-seq
MIRT1995549	hsa-miR-4691-3p	CLIP-seq
MIRT1995550	hsa-miR-4693-3p	CLIP-seq
MIRT996659	hsa-miR-4728-5p	CLIP-seq
MIRT1995551	hsa-miR-4733-3p	CLIP-seq
MIRT1995552	hsa-miR-4745-3p	CLIP-seq
MIRT1995553	hsa-miR-4745-5p	CLIP-seq
MIRT996660	hsa-miR-4747-5p	CLIP-seq
MIRT1995554	hsa-miR-4749-3p	CLIP-seq
MIRT1995555	hsa-miR-4755-3p	CLIP-seq
MIRT1995556	hsa-miR-4757-5p	CLIP-seq
MIRT1995557	hsa-miR-4771	CLIP-seq
MIRT1995558	hsa-miR-486-3p	CLIP-seq
MIRT1995559	hsa-miR-542-5p	CLIP-seq
MIRT1995560	hsa-miR-543	CLIP-seq
MIRT1995561	hsa-miR-550a	CLIP-seq
MIRT1995562	hsa-miR-552	CLIP-seq
MIRT1995563	hsa-miR-582-3p	CLIP-seq
MIRT1995564	hsa-miR-608	CLIP-seq
MIRT1995565	hsa-miR-634	CLIP-seq
MIRT1995566	hsa-miR-661	CLIP-seq
MIRT1995567	hsa-miR-766	CLIP-seq
MIRT996622	hsa-miR-1293	CLIP-seq
MIRT1995513	hsa-miR-1538	CLIP-seq
MIRT996626	hsa-miR-214	CLIP-seq
MIRT2229531	hsa-miR-22	CLIP-seq
MIRT2229532	hsa-miR-3160-3p	CLIP-seq
MIRT1995520	hsa-miR-3162-3p	CLIP-seq
MIRT996628	hsa-miR-3619-5p	CLIP-seq
MIRT1995527	hsa-miR-3663-5p	CLIP-seq
MIRT996656	hsa-miR-4276	CLIP-seq
MIRT1995536	hsa-miR-4471	CLIP-seq
MIRT996633	hsa-miR-4483	CLIP-seq
MIRT996634	hsa-miR-4487	CLIP-seq
MIRT1995545	hsa-miR-4651	CLIP-seq
MIRT1995548	hsa-miR-4685-5p	CLIP-seq
MIRT1995552	hsa-miR-4745-3p	CLIP-seq
MIRT1995554	hsa-miR-4749-3p	CLIP-seq
MIRT1995556	hsa-miR-4757-5p	CLIP-seq
MIRT1995558	hsa-miR-486-3p	CLIP-seq
MIRT996661	hsa-miR-541	CLIP-seq
MIRT2229533	hsa-miR-558	CLIP-seq
MIRT1995563	hsa-miR-582-3p	CLIP-seq
MIRT1995564	hsa-miR-608	CLIP-seq
MIRT996662	hsa-miR-654-5p	CLIP-seq
MIRT996647	hsa-miR-761	CLIP-seq
MIRT1995513	hsa-miR-1538	CLIP-seq
MIRT2388001	hsa-miR-3153	CLIP-seq
MIRT1995520	hsa-miR-3162-3p	CLIP-seq
MIRT1995524	hsa-miR-3192	CLIP-seq
MIRT996651	hsa-miR-323-5p	CLIP-seq
MIRT996652	hsa-miR-3613-5p	CLIP-seq
MIRT996653	hsa-miR-3689a-3p	CLIP-seq
MIRT996654	hsa-miR-3689c	CLIP-seq
MIRT996631	hsa-miR-4447	CLIP-seq
MIRT996632	hsa-miR-4472	CLIP-seq
MIRT2388002	hsa-miR-4668-5p	CLIP-seq
MIRT996659	hsa-miR-4728-5p	CLIP-seq
MIRT1995552	hsa-miR-4745-3p	CLIP-seq
MIRT1995554	hsa-miR-4749-3p	CLIP-seq
MIRT996661	hsa-miR-541	CLIP-seq
MIRT996662	hsa-miR-654-5p	CLIP-seq
MIRT996663	hsa-miR-876-3p	CLIP-seq
MIRT2449694	hsa-miR-4323	CLIP-seq
MIRT2449695	hsa-miR-455-3p	CLIP-seq
MIRT2449696	hsa-miR-4758-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	25416956, 32296183
GO:0005615	Component	Extracellular space	IBA
GO:0008061	Function	Chitin binding	IDA	19710473
GO:0008061	Function	Chitin binding	IEA
GO:0016020	Component	Membrane	IDA	19710473
GO:0016020	Component	Membrane	IEA
GO:0031012	Component	Extracellular matrix	IBA
GO:0046872	Function	Metal ion binding	IEA

Other IDs

• MIM: 613357
• HGNC: 25922
• e!Ensembl: ENSG00000130720

Protein

• UniProt ID: Q8N539
• Protein name: Fibrinogen C domain-containing protein 1
• Protein function: Acetyl group-binding receptor which shows a high-affinity and calcium-dependent binding to acetylated structures such as chitin, some N-acetylated carbohydrates, and amino acids, but not to their non-acetylated counterparts. Can facilitate the e
• PDB: 4M7F, 4M7H, 6ZQR, 6ZQX, 6ZQY, 6ZR0, 6ZR3, 6ZR4
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00147	Fibrinogen_C	240 → 457	Fibrinogen beta and gamma chains, C-terminal globular domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Expressed in the small and large intestinal epithelial cells with a highly polarized localization to the apical surface corresponding to the brush border and in the ducts of the salivary gland. {ECO:0000269|PubMed:19710473}.
• Sequence:

  MVNDRWKTMGGAAQLEDRPRDKPQRPSCGYVLCTVLLALAVLLAVAVTGAVLFLNHAHAP
  GTAPPPVVSTGAASANSALVTVERADSSHLSILIDPRCPDLTDSFARLESAQASVLQALT
  EHQAQPRLVGDQEQELLDTLADQLPRLLARASELQTECMGLRKGHGTLGQGLSALQSEQG
  RLIQLLSESQGHMAHLVNSVSDILDALQRDRGLGRPRNKADLQRAPARGTRPRGCATGSR
  PRDCLDVLLSGQQDDGVYSVFPTHYPAGFQVYCDMRTDGGGWTVFQRREDGSVNFFRGWD
  AYRDGFGRLTGEHWLGLKRIHALTTQAAYELHVDLEDFENGTAYARYGSFGVGLFSVDPE
  EDGYPLTVADYSGTAGDSLLKHSGMRFTTKDRDSDHSENNCAAFYRGAWWYRNCHTSNLN
  GQYLRGAHASYADGVEWSSWTGWQYSLKFSEMKIRPVREDR

• Sequence length: 461