Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	84888
Gene name	Signal peptide peptidase like 2A
Gene symbol	SPPL2A
Synonyms (NCBI Gene)	IMD86IMP3PSL2
Chromosome	15
Chromosome location	15q21.2
Summary	This gene encodes a member of the GXGD family of aspartic proteases, which are transmembrane proteins with two conserved catalytic motifs localized within the membrane-spanning regions, as well as a member of the signal peptide peptidase-like protease (SP

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miRTarBase ID	miRNA	Experiments	Reference
MIRT398430	hsa-miR-5580-3p	HITS-CLIP	21572407
MIRT707563	hsa-miR-5000-5p	HITS-CLIP	21572407
MIRT510709	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT510708	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT707562	hsa-miR-5007-3p	HITS-CLIP	21572407
MIRT510707	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT698913	hsa-miR-551b-5p	HITS-CLIP	23313552
MIRT698912	hsa-miR-425-5p	HITS-CLIP	23313552
MIRT698911	hsa-miR-4528	HITS-CLIP	23313552
MIRT698910	hsa-miR-138-2-3p	HITS-CLIP	23313552
MIRT698909	hsa-miR-642a-3p	HITS-CLIP	23313552
MIRT698908	hsa-miR-642b-3p	HITS-CLIP	23313552
MIRT698907	hsa-miR-3674	HITS-CLIP	23313552
MIRT510707	hsa-miR-1277-5p	HITS-CLIP	23313552
MIRT398430	hsa-miR-5580-3p	HITS-CLIP	23313552
MIRT510709	hsa-miR-5011-5p	HITS-CLIP	23313552
MIRT510708	hsa-miR-190a-3p	HITS-CLIP	23313552
MIRT632036	hsa-miR-6499-5p	HITS-CLIP	23824327
MIRT632035	hsa-miR-4743-5p	HITS-CLIP	23824327
MIRT673833	hsa-miR-4284	HITS-CLIP	23824327
MIRT632034	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT632033	hsa-miR-3178	HITS-CLIP	23824327
MIRT673832	hsa-miR-7977	HITS-CLIP	23824327
MIRT632036	hsa-miR-6499-5p	HITS-CLIP	23824327
MIRT632035	hsa-miR-4743-5p	HITS-CLIP	23824327
MIRT632034	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT632033	hsa-miR-3178	HITS-CLIP	23824327
MIRT673838	hsa-miR-548a-3p	HITS-CLIP	23824327
MIRT673837	hsa-miR-548ar-3p	HITS-CLIP	23824327
MIRT673836	hsa-miR-548az-3p	HITS-CLIP	23824327
MIRT673835	hsa-miR-548e-3p	HITS-CLIP	23824327
MIRT673834	hsa-miR-548f-3p	HITS-CLIP	23824327
MIRT632036	hsa-miR-6499-5p	HITS-CLIP	23824327
MIRT632035	hsa-miR-4743-5p	HITS-CLIP	23824327
MIRT673833	hsa-miR-4284	HITS-CLIP	23824327
MIRT632034	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT632033	hsa-miR-3178	HITS-CLIP	23824327
MIRT673832	hsa-miR-7977	HITS-CLIP	23824327
MIRT632036	hsa-miR-6499-5p	HITS-CLIP	23824327
MIRT632035	hsa-miR-4743-5p	HITS-CLIP	23824327
MIRT632034	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT632033	hsa-miR-3178	HITS-CLIP	23824327
MIRT398430	hsa-miR-5580-3p	PAR-CLIP	20371350
MIRT510709	hsa-miR-5011-5p	PAR-CLIP	20371350
MIRT510708	hsa-miR-190a-3p	PAR-CLIP	20371350
MIRT510707	hsa-miR-1277-5p	PAR-CLIP	20371350
MIRT520975	hsa-miR-302f	PAR-CLIP	21572407
MIRT520974	hsa-miR-4768-3p	PAR-CLIP	21572407
MIRT520973	hsa-miR-4459	PAR-CLIP	21572407
MIRT520972	hsa-miR-4433a-3p	PAR-CLIP	21572407
MIRT520971	hsa-miR-1247-3p	PAR-CLIP	21572407
MIRT520970	hsa-miR-5091	PAR-CLIP	21572407
MIRT520969	hsa-miR-5739	PAR-CLIP	21572407
MIRT520968	hsa-miR-219b-3p	PAR-CLIP	21572407
MIRT554010	hsa-miR-5702	PAR-CLIP	21572407
MIRT520967	hsa-miR-4785	PAR-CLIP	21572407
MIRT554009	hsa-miR-937-5p	PAR-CLIP	21572407
MIRT520966	hsa-miR-1273e	PAR-CLIP	21572407
MIRT501012	hsa-miR-1271-5p	PAR-CLIP	21572407
MIRT501011	hsa-miR-183-5p	PAR-CLIP	21572407
MIRT501010	hsa-miR-96-5p	PAR-CLIP	21572407
MIRT501009	hsa-miR-223-3p	PAR-CLIP	21572407
MIRT501008	hsa-miR-548a-5p	PAR-CLIP	21572407
MIRT501007	hsa-miR-548ab	PAR-CLIP	21572407
MIRT501006	hsa-miR-548ad-5p	PAR-CLIP	21572407
MIRT501005	hsa-miR-548ae-5p	PAR-CLIP	21572407
MIRT501004	hsa-miR-548ak	PAR-CLIP	21572407
MIRT501003	hsa-miR-548am-5p	PAR-CLIP	21572407
MIRT501002	hsa-miR-548ap-5p	PAR-CLIP	21572407
MIRT501001	hsa-miR-548aq-5p	PAR-CLIP	21572407
MIRT501000	hsa-miR-548ar-5p	PAR-CLIP	21572407
MIRT500999	hsa-miR-548as-5p	PAR-CLIP	21572407
MIRT500998	hsa-miR-548au-5p	PAR-CLIP	21572407
MIRT500997	hsa-miR-548ay-5p	PAR-CLIP	21572407
MIRT500996	hsa-miR-548b-5p	PAR-CLIP	21572407
MIRT500995	hsa-miR-548bb-5p	PAR-CLIP	21572407
MIRT500994	hsa-miR-548c-5p	PAR-CLIP	21572407
MIRT500993	hsa-miR-548d-5p	PAR-CLIP	21572407
MIRT500992	hsa-miR-548h-5p	PAR-CLIP	21572407
MIRT500991	hsa-miR-548i	PAR-CLIP	21572407
MIRT500990	hsa-miR-548j-5p	PAR-CLIP	21572407
MIRT500989	hsa-miR-548o-5p	PAR-CLIP	21572407
MIRT500988	hsa-miR-548w	PAR-CLIP	21572407
MIRT500987	hsa-miR-548y	PAR-CLIP	21572407
MIRT500986	hsa-miR-559	PAR-CLIP	21572407
MIRT500985	hsa-miR-548av-5p	PAR-CLIP	21572407
MIRT500984	hsa-miR-548k	PAR-CLIP	21572407
MIRT500982	hsa-miR-8054	PAR-CLIP	21572407
MIRT500983	hsa-miR-548l	PAR-CLIP	21572407
MIRT500981	hsa-miR-580-5p	PAR-CLIP	21572407
MIRT500980	hsa-miR-1278	PAR-CLIP	21572407
MIRT500979	hsa-miR-142-5p	PAR-CLIP	21572407
MIRT500977	hsa-miR-5590-3p	PAR-CLIP	21572407
MIRT500978	hsa-miR-16-1-3p	PAR-CLIP	21572407
MIRT500976	hsa-miR-3655	PAR-CLIP	21572407
MIRT500975	hsa-miR-4697-3p	PAR-CLIP	21572407
MIRT520975	hsa-miR-302f	PAR-CLIP	23446348
MIRT520974	hsa-miR-4768-3p	PAR-CLIP	23446348
MIRT520973	hsa-miR-4459	PAR-CLIP	23446348
MIRT520972	hsa-miR-4433a-3p	PAR-CLIP	23446348
MIRT520971	hsa-miR-1247-3p	PAR-CLIP	23446348
MIRT520970	hsa-miR-5091	PAR-CLIP	23446348
MIRT520969	hsa-miR-5739	PAR-CLIP	23446348
MIRT520968	hsa-miR-219b-3p	PAR-CLIP	23446348
MIRT520967	hsa-miR-4785	PAR-CLIP	23446348
MIRT520966	hsa-miR-1273e	PAR-CLIP	23446348
MIRT398430	hsa-miR-5580-3p	PAR-CLIP	23446348
MIRT510709	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT510708	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT510707	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT501012	hsa-miR-1271-5p	PAR-CLIP	24398324
MIRT501011	hsa-miR-183-5p	PAR-CLIP	24398324
MIRT501010	hsa-miR-96-5p	PAR-CLIP	24398324
MIRT501009	hsa-miR-223-3p	PAR-CLIP	24398324
MIRT501008	hsa-miR-548a-5p	PAR-CLIP	24398324
MIRT501007	hsa-miR-548ab	PAR-CLIP	24398324
MIRT501006	hsa-miR-548ad-5p	PAR-CLIP	24398324
MIRT501005	hsa-miR-548ae-5p	PAR-CLIP	24398324
MIRT501004	hsa-miR-548ak	PAR-CLIP	24398324
MIRT501003	hsa-miR-548am-5p	PAR-CLIP	24398324
MIRT501002	hsa-miR-548ap-5p	PAR-CLIP	24398324
MIRT501001	hsa-miR-548aq-5p	PAR-CLIP	24398324
MIRT501000	hsa-miR-548ar-5p	PAR-CLIP	24398324
MIRT500999	hsa-miR-548as-5p	PAR-CLIP	24398324
MIRT500998	hsa-miR-548au-5p	PAR-CLIP	24398324
MIRT500997	hsa-miR-548ay-5p	PAR-CLIP	24398324
MIRT500996	hsa-miR-548b-5p	PAR-CLIP	24398324
MIRT500995	hsa-miR-548bb-5p	PAR-CLIP	24398324
MIRT500994	hsa-miR-548c-5p	PAR-CLIP	24398324
MIRT500993	hsa-miR-548d-5p	PAR-CLIP	24398324
MIRT500992	hsa-miR-548h-5p	PAR-CLIP	24398324
MIRT500991	hsa-miR-548i	PAR-CLIP	24398324
MIRT500990	hsa-miR-548j-5p	PAR-CLIP	24398324
MIRT500989	hsa-miR-548o-5p	PAR-CLIP	24398324
MIRT500988	hsa-miR-548w	PAR-CLIP	24398324
MIRT500987	hsa-miR-548y	PAR-CLIP	24398324
MIRT500986	hsa-miR-559	PAR-CLIP	24398324
MIRT500985	hsa-miR-548av-5p	PAR-CLIP	24398324
MIRT500984	hsa-miR-548k	PAR-CLIP	24398324
MIRT500982	hsa-miR-8054	PAR-CLIP	24398324
MIRT500983	hsa-miR-548l	PAR-CLIP	24398324
MIRT500981	hsa-miR-580-5p	PAR-CLIP	24398324
MIRT500980	hsa-miR-1278	PAR-CLIP	24398324
MIRT500979	hsa-miR-142-5p	PAR-CLIP	24398324
MIRT500977	hsa-miR-5590-3p	PAR-CLIP	24398324
MIRT500978	hsa-miR-16-1-3p	PAR-CLIP	24398324
MIRT500976	hsa-miR-3655	PAR-CLIP	24398324
MIRT500975	hsa-miR-4697-3p	PAR-CLIP	24398324
MIRT467264	hsa-miR-4695-5p	PAR-CLIP	23592263
MIRT467263	hsa-miR-1910-3p	PAR-CLIP	23592263
MIRT467262	hsa-miR-6511a-5p	PAR-CLIP	23592263
MIRT467261	hsa-miR-6808-5p	PAR-CLIP	23592263
MIRT467260	hsa-miR-6893-5p	PAR-CLIP	23592263
MIRT467259	hsa-miR-940	PAR-CLIP	23592263
MIRT467258	hsa-miR-3174	PAR-CLIP	23592263
MIRT467257	hsa-miR-4257	PAR-CLIP	23592263
MIRT467256	hsa-miR-665	PAR-CLIP	23592263
MIRT467255	hsa-miR-4649-3p	PAR-CLIP	23592263
MIRT467254	hsa-miR-1827	PAR-CLIP	23592263
MIRT467253	hsa-miR-377-5p	PAR-CLIP	23592263
MIRT467252	hsa-miR-6086	PAR-CLIP	23592263
MIRT467251	hsa-miR-2467-3p	PAR-CLIP	23592263
MIRT467250	hsa-miR-873-5p	PAR-CLIP	23592263
MIRT467249	hsa-miR-3612	PAR-CLIP	23592263
MIRT467248	hsa-miR-650	PAR-CLIP	23592263
MIRT467247	hsa-miR-6073	PAR-CLIP	23592263
MIRT467246	hsa-miR-142-3p	PAR-CLIP	23592263
MIRT467245	hsa-miR-921	PAR-CLIP	23592263
MIRT467244	hsa-miR-6807-5p	PAR-CLIP	23592263
MIRT467243	hsa-miR-4724-5p	PAR-CLIP	23592263
MIRT398430	hsa-miR-5580-3p	HITS-CLIP	21572407
MIRT707563	hsa-miR-5000-5p	HITS-CLIP	21572407
MIRT510709	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT510708	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT707562	hsa-miR-5007-3p	HITS-CLIP	21572407
MIRT510707	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT698913	hsa-miR-551b-5p	HITS-CLIP	23313552
MIRT698912	hsa-miR-425-5p	HITS-CLIP	23313552
MIRT698911	hsa-miR-4528	HITS-CLIP	23313552
MIRT698910	hsa-miR-138-2-3p	HITS-CLIP	23313552
MIRT698909	hsa-miR-642a-3p	HITS-CLIP	23313552
MIRT698908	hsa-miR-642b-3p	HITS-CLIP	23313552
MIRT698907	hsa-miR-3674	HITS-CLIP	23313552
MIRT510707	hsa-miR-1277-5p	HITS-CLIP	23313552
MIRT398430	hsa-miR-5580-3p	HITS-CLIP	23313552
MIRT510709	hsa-miR-5011-5p	HITS-CLIP	23313552
MIRT510708	hsa-miR-190a-3p	HITS-CLIP	23313552
MIRT632036	hsa-miR-6499-5p	HITS-CLIP	23824327
MIRT632035	hsa-miR-4743-5p	HITS-CLIP	23824327
MIRT673833	hsa-miR-4284	HITS-CLIP	23824327
MIRT632034	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT632033	hsa-miR-3178	HITS-CLIP	23824327
MIRT673832	hsa-miR-7977	HITS-CLIP	23824327
MIRT632036	hsa-miR-6499-5p	HITS-CLIP	23824327
MIRT632035	hsa-miR-4743-5p	HITS-CLIP	23824327
MIRT632034	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT632033	hsa-miR-3178	HITS-CLIP	23824327
MIRT673838	hsa-miR-548a-3p	HITS-CLIP	23824327
MIRT673837	hsa-miR-548ar-3p	HITS-CLIP	23824327
MIRT673836	hsa-miR-548az-3p	HITS-CLIP	23824327
MIRT673835	hsa-miR-548e-3p	HITS-CLIP	23824327
MIRT673834	hsa-miR-548f-3p	HITS-CLIP	23824327
MIRT632036	hsa-miR-6499-5p	HITS-CLIP	23824327
MIRT632035	hsa-miR-4743-5p	HITS-CLIP	23824327
MIRT673833	hsa-miR-4284	HITS-CLIP	23824327
MIRT632034	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT632033	hsa-miR-3178	HITS-CLIP	23824327
MIRT673832	hsa-miR-7977	HITS-CLIP	23824327
MIRT632036	hsa-miR-6499-5p	HITS-CLIP	23824327
MIRT632035	hsa-miR-4743-5p	HITS-CLIP	23824327
MIRT632034	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT632033	hsa-miR-3178	HITS-CLIP	23824327
MIRT398430	hsa-miR-5580-3p	PAR-CLIP	20371350
MIRT510709	hsa-miR-5011-5p	PAR-CLIP	20371350
MIRT510708	hsa-miR-190a-3p	PAR-CLIP	20371350
MIRT510707	hsa-miR-1277-5p	PAR-CLIP	20371350
MIRT520975	hsa-miR-302f	PAR-CLIP	21572407
MIRT520974	hsa-miR-4768-3p	PAR-CLIP	21572407
MIRT520973	hsa-miR-4459	PAR-CLIP	21572407
MIRT520972	hsa-miR-4433a-3p	PAR-CLIP	21572407
MIRT520971	hsa-miR-1247-3p	PAR-CLIP	21572407
MIRT520970	hsa-miR-5091	PAR-CLIP	21572407
MIRT520969	hsa-miR-5739	PAR-CLIP	21572407
MIRT520968	hsa-miR-219b-3p	PAR-CLIP	21572407
MIRT554010	hsa-miR-5702	PAR-CLIP	21572407
MIRT520967	hsa-miR-4785	PAR-CLIP	21572407
MIRT554009	hsa-miR-937-5p	PAR-CLIP	21572407
MIRT520966	hsa-miR-1273e	PAR-CLIP	21572407
MIRT501012	hsa-miR-1271-5p	PAR-CLIP	21572407
MIRT501011	hsa-miR-183-5p	PAR-CLIP	21572407
MIRT501010	hsa-miR-96-5p	PAR-CLIP	21572407
MIRT501009	hsa-miR-223-3p	PAR-CLIP	21572407
MIRT501008	hsa-miR-548a-5p	PAR-CLIP	21572407
MIRT501007	hsa-miR-548ab	PAR-CLIP	21572407
MIRT501006	hsa-miR-548ad-5p	PAR-CLIP	21572407
MIRT501005	hsa-miR-548ae-5p	PAR-CLIP	21572407
MIRT501004	hsa-miR-548ak	PAR-CLIP	21572407
MIRT501003	hsa-miR-548am-5p	PAR-CLIP	21572407
MIRT501002	hsa-miR-548ap-5p	PAR-CLIP	21572407
MIRT501001	hsa-miR-548aq-5p	PAR-CLIP	21572407
MIRT501000	hsa-miR-548ar-5p	PAR-CLIP	21572407
MIRT500999	hsa-miR-548as-5p	PAR-CLIP	21572407
MIRT500998	hsa-miR-548au-5p	PAR-CLIP	21572407
MIRT500997	hsa-miR-548ay-5p	PAR-CLIP	21572407
MIRT500996	hsa-miR-548b-5p	PAR-CLIP	21572407
MIRT500995	hsa-miR-548bb-5p	PAR-CLIP	21572407
MIRT500994	hsa-miR-548c-5p	PAR-CLIP	21572407
MIRT500993	hsa-miR-548d-5p	PAR-CLIP	21572407
MIRT500992	hsa-miR-548h-5p	PAR-CLIP	21572407
MIRT500991	hsa-miR-548i	PAR-CLIP	21572407
MIRT500990	hsa-miR-548j-5p	PAR-CLIP	21572407
MIRT500989	hsa-miR-548o-5p	PAR-CLIP	21572407
MIRT500988	hsa-miR-548w	PAR-CLIP	21572407
MIRT500987	hsa-miR-548y	PAR-CLIP	21572407
MIRT500986	hsa-miR-559	PAR-CLIP	21572407
MIRT500985	hsa-miR-548av-5p	PAR-CLIP	21572407
MIRT500984	hsa-miR-548k	PAR-CLIP	21572407
MIRT500982	hsa-miR-8054	PAR-CLIP	21572407
MIRT500983	hsa-miR-548l	PAR-CLIP	21572407
MIRT500981	hsa-miR-580-5p	PAR-CLIP	21572407
MIRT500980	hsa-miR-1278	PAR-CLIP	21572407
MIRT500979	hsa-miR-142-5p	PAR-CLIP	21572407
MIRT500977	hsa-miR-5590-3p	PAR-CLIP	21572407
MIRT500978	hsa-miR-16-1-3p	PAR-CLIP	21572407
MIRT500976	hsa-miR-3655	PAR-CLIP	21572407
MIRT500975	hsa-miR-4697-3p	PAR-CLIP	21572407
MIRT520975	hsa-miR-302f	PAR-CLIP	23446348
MIRT520974	hsa-miR-4768-3p	PAR-CLIP	23446348
MIRT520973	hsa-miR-4459	PAR-CLIP	23446348
MIRT520972	hsa-miR-4433a-3p	PAR-CLIP	23446348
MIRT520971	hsa-miR-1247-3p	PAR-CLIP	23446348
MIRT520970	hsa-miR-5091	PAR-CLIP	23446348
MIRT520969	hsa-miR-5739	PAR-CLIP	23446348
MIRT520968	hsa-miR-219b-3p	PAR-CLIP	23446348
MIRT520967	hsa-miR-4785	PAR-CLIP	23446348
MIRT520966	hsa-miR-1273e	PAR-CLIP	23446348
MIRT398430	hsa-miR-5580-3p	PAR-CLIP	23446348
MIRT510709	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT510708	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT510707	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT501012	hsa-miR-1271-5p	PAR-CLIP	24398324
MIRT501011	hsa-miR-183-5p	PAR-CLIP	24398324
MIRT501010	hsa-miR-96-5p	PAR-CLIP	24398324
MIRT501009	hsa-miR-223-3p	PAR-CLIP	24398324
MIRT501008	hsa-miR-548a-5p	PAR-CLIP	24398324
MIRT501007	hsa-miR-548ab	PAR-CLIP	24398324
MIRT501006	hsa-miR-548ad-5p	PAR-CLIP	24398324
MIRT501005	hsa-miR-548ae-5p	PAR-CLIP	24398324
MIRT501004	hsa-miR-548ak	PAR-CLIP	24398324
MIRT501003	hsa-miR-548am-5p	PAR-CLIP	24398324
MIRT501002	hsa-miR-548ap-5p	PAR-CLIP	24398324
MIRT501001	hsa-miR-548aq-5p	PAR-CLIP	24398324
MIRT501000	hsa-miR-548ar-5p	PAR-CLIP	24398324
MIRT500999	hsa-miR-548as-5p	PAR-CLIP	24398324
MIRT500998	hsa-miR-548au-5p	PAR-CLIP	24398324
MIRT500997	hsa-miR-548ay-5p	PAR-CLIP	24398324
MIRT500996	hsa-miR-548b-5p	PAR-CLIP	24398324
MIRT500995	hsa-miR-548bb-5p	PAR-CLIP	24398324
MIRT500994	hsa-miR-548c-5p	PAR-CLIP	24398324
MIRT500993	hsa-miR-548d-5p	PAR-CLIP	24398324
MIRT500992	hsa-miR-548h-5p	PAR-CLIP	24398324
MIRT500991	hsa-miR-548i	PAR-CLIP	24398324
MIRT500990	hsa-miR-548j-5p	PAR-CLIP	24398324
MIRT500989	hsa-miR-548o-5p	PAR-CLIP	24398324
MIRT500988	hsa-miR-548w	PAR-CLIP	24398324
MIRT500987	hsa-miR-548y	PAR-CLIP	24398324
MIRT500986	hsa-miR-559	PAR-CLIP	24398324
MIRT500985	hsa-miR-548av-5p	PAR-CLIP	24398324
MIRT500984	hsa-miR-548k	PAR-CLIP	24398324
MIRT500982	hsa-miR-8054	PAR-CLIP	24398324
MIRT500983	hsa-miR-548l	PAR-CLIP	24398324
MIRT500981	hsa-miR-580-5p	PAR-CLIP	24398324
MIRT500980	hsa-miR-1278	PAR-CLIP	24398324
MIRT500979	hsa-miR-142-5p	PAR-CLIP	24398324
MIRT500977	hsa-miR-5590-3p	PAR-CLIP	24398324
MIRT500978	hsa-miR-16-1-3p	PAR-CLIP	24398324
MIRT500976	hsa-miR-3655	PAR-CLIP	24398324
MIRT500975	hsa-miR-4697-3p	PAR-CLIP	24398324
MIRT467264	hsa-miR-4695-5p	PAR-CLIP	23592263
MIRT467263	hsa-miR-1910-3p	PAR-CLIP	23592263
MIRT467262	hsa-miR-6511a-5p	PAR-CLIP	23592263
MIRT467261	hsa-miR-6808-5p	PAR-CLIP	23592263
MIRT467260	hsa-miR-6893-5p	PAR-CLIP	23592263
MIRT467259	hsa-miR-940	PAR-CLIP	23592263
MIRT467258	hsa-miR-3174	PAR-CLIP	23592263
MIRT467257	hsa-miR-4257	PAR-CLIP	23592263
MIRT467256	hsa-miR-665	PAR-CLIP	23592263
MIRT467255	hsa-miR-4649-3p	PAR-CLIP	23592263
MIRT467254	hsa-miR-1827	PAR-CLIP	23592263
MIRT467253	hsa-miR-377-5p	PAR-CLIP	23592263
MIRT467252	hsa-miR-6086	PAR-CLIP	23592263
MIRT467251	hsa-miR-2467-3p	PAR-CLIP	23592263
MIRT467250	hsa-miR-873-5p	PAR-CLIP	23592263
MIRT467249	hsa-miR-3612	PAR-CLIP	23592263
MIRT467248	hsa-miR-650	PAR-CLIP	23592263
MIRT467247	hsa-miR-6073	PAR-CLIP	23592263
MIRT467246	hsa-miR-142-3p	PAR-CLIP	23592263
MIRT467245	hsa-miR-921	PAR-CLIP	23592263
MIRT467244	hsa-miR-6807-5p	PAR-CLIP	23592263
MIRT467243	hsa-miR-4724-5p	PAR-CLIP	23592263
MIRT1385445	hsa-miR-124	CLIP-seq
MIRT1385446	hsa-miR-1272	CLIP-seq
MIRT1385447	hsa-miR-1322	CLIP-seq
MIRT1385448	hsa-miR-219-5p	CLIP-seq
MIRT1385449	hsa-miR-223	CLIP-seq
MIRT1385450	hsa-miR-3171	CLIP-seq
MIRT1385451	hsa-miR-3611	CLIP-seq
MIRT1385452	hsa-miR-3917	CLIP-seq
MIRT1385453	hsa-miR-3942-3p	CLIP-seq
MIRT1385454	hsa-miR-425	CLIP-seq
MIRT1385455	hsa-miR-4267	CLIP-seq
MIRT1385456	hsa-miR-4274	CLIP-seq
MIRT1385457	hsa-miR-4307	CLIP-seq
MIRT1385458	hsa-miR-4432	CLIP-seq
MIRT1385459	hsa-miR-4493	CLIP-seq
MIRT1385460	hsa-miR-4519	CLIP-seq
MIRT1385461	hsa-miR-4672	CLIP-seq
MIRT1385462	hsa-miR-4709-3p	CLIP-seq
MIRT1385463	hsa-miR-4782-3p	CLIP-seq
MIRT1385464	hsa-miR-506	CLIP-seq
MIRT1385465	hsa-miR-634	CLIP-seq
MIRT1385466	hsa-miR-642b	CLIP-seq
MIRT1554112	hsa-miR-3143	CLIP-seq
MIRT1554113	hsa-miR-543	CLIP-seq
MIRT1385445	hsa-miR-124	CLIP-seq
MIRT2115324	hsa-miR-129-5p	CLIP-seq
MIRT1385448	hsa-miR-219-5p	CLIP-seq
MIRT1554112	hsa-miR-3143	CLIP-seq
MIRT1385451	hsa-miR-3611	CLIP-seq
MIRT2115325	hsa-miR-3692	CLIP-seq
MIRT1385452	hsa-miR-3917	CLIP-seq
MIRT1385453	hsa-miR-3942-3p	CLIP-seq
MIRT1385455	hsa-miR-4267	CLIP-seq
MIRT1385456	hsa-miR-4274	CLIP-seq
MIRT1385457	hsa-miR-4307	CLIP-seq
MIRT1385458	hsa-miR-4432	CLIP-seq
MIRT1385459	hsa-miR-4493	CLIP-seq
MIRT2115326	hsa-miR-450b-5p	CLIP-seq
MIRT1385460	hsa-miR-4519	CLIP-seq
MIRT1385461	hsa-miR-4672	CLIP-seq
MIRT1385462	hsa-miR-4709-3p	CLIP-seq
MIRT1385463	hsa-miR-4782-3p	CLIP-seq
MIRT1385464	hsa-miR-506	CLIP-seq
MIRT2115327	hsa-miR-507	CLIP-seq
MIRT1554113	hsa-miR-543	CLIP-seq
MIRT2115328	hsa-miR-548c-3p	CLIP-seq
MIRT2115329	hsa-miR-557	CLIP-seq
MIRT1385465	hsa-miR-634	CLIP-seq
MIRT1385466	hsa-miR-642b	CLIP-seq
MIRT1385446	hsa-miR-1272	CLIP-seq
MIRT1385447	hsa-miR-1322	CLIP-seq
MIRT1385449	hsa-miR-223	CLIP-seq
MIRT1385450	hsa-miR-3171	CLIP-seq
MIRT2115325	hsa-miR-3692	CLIP-seq
MIRT1385452	hsa-miR-3917	CLIP-seq
MIRT1385456	hsa-miR-4274	CLIP-seq
MIRT1385460	hsa-miR-4519	CLIP-seq
MIRT1385461	hsa-miR-4672	CLIP-seq
MIRT1385466	hsa-miR-642b	CLIP-seq

Show/Hide all (43)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	16189514, 17965014, 25416956, 32296183, 32814053
GO:0005764	Component	Lysosome	IEA
GO:0005765	Component	Lysosomal membrane	HDA	17897319
GO:0005765	Component	Lysosomal membrane	IBA
GO:0005765	Component	Lysosomal membrane	IEA
GO:0005768	Component	Endosome	IEA
GO:0005770	Component	Late endosome	IDA	16829952
GO:0005770	Component	Late endosome	IEA
GO:0005886	Component	Plasma membrane	IDA
GO:0005886	Component	Plasma membrane	TAS
GO:0006508	Process	Proteolysis	IEA
GO:0006509	Process	Membrane protein ectodomain proteolysis	IDA	16829951, 17965014
GO:0008233	Function	Peptidase activity	IEA
GO:0010803	Process	Regulation of tumor necrosis factor-mediated signaling pathway	TAS
GO:0016020	Component	Membrane	IDA	2313285
GO:0016020	Component	Membrane	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0030659	Component	Cytoplasmic vesicle membrane	IEA
GO:0030660	Component	Golgi-associated vesicle membrane	IBA
GO:0030660	Component	Golgi-associated vesicle membrane	IDA	17965014
GO:0031293	Process	Membrane protein intracellular domain proteolysis	IDA	16829951, 17557115
GO:0031293	Process	Membrane protein intracellular domain proteolysis	IMP	16829952
GO:0031902	Component	Late endosome membrane	IEA
GO:0033619	Process	Membrane protein proteolysis	IBA
GO:0033619	Process	Membrane protein proteolysis	IDA	2313285
GO:0033619	Process	Membrane protein proteolysis	IEA
GO:0042500	Function	Aspartic endopeptidase activity, intramembrane cleaving	IBA
GO:0042500	Function	Aspartic endopeptidase activity, intramembrane cleaving	IDA	2313285
GO:0042500	Function	Aspartic endopeptidase activity, intramembrane cleaving	IEA
GO:0042500	Function	Aspartic endopeptidase activity, intramembrane cleaving	TAS
GO:0042803	Function	Protein homodimerization activity	IDA	15385547
GO:0042803	Function	Protein homodimerization activity	IEA
GO:0050776	Process	Regulation of immune response	IEA
GO:0050776	Process	Regulation of immune response	IMP	16829952
GO:0050776	Process	Regulation of immune response	ISS
GO:0070062	Component	Extracellular exosome	HDA	23533145
GO:0098553	Component	Lumenal side of endoplasmic reticulum membrane	IBA
GO:0098553	Component	Lumenal side of endoplasmic reticulum membrane	IDA	15385547
GO:0098553	Component	Lumenal side of endoplasmic reticulum membrane	IEA
GO:0098554	Component	Cytoplasmic side of endoplasmic reticulum membrane	IBA
GO:0098554	Component	Cytoplasmic side of endoplasmic reticulum membrane	IDA	15385547
GO:0098554	Component	Cytoplasmic side of endoplasmic reticulum membrane	IEA
GO:0098588	Component	Bounding membrane of organelle	IEA

MIM	HGNC	e!Ensembl
608238	30227	ENSG00000138600

Q8TCT8

Protein name

Signal peptide peptidase-like 2A (SPP-like 2A) (SPPL2a) (EC 3.4.23.-) (Intramembrane protease 3) (IMP-3) (Presenilin-like protein 2)

Protein function

Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. Functions in FASLG, ITM2B and TNF processing (PubMed:16829951, PubMed:16829952, PubMed:17557115, PubMed:179

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02225	PA	52 → 148	PA domain	Family
PF04258	Peptidase_A22B	210 → 496	Signal peptide peptidase	Family

Tissue specificity

TISSUE SPECIFICITY: Ubiquitous. {ECO:0000269|PubMed:15385547}.

Sequence

MGPQRRLSPAGAALLWGFLLQLTAAQEAILHASGNGTTKDYCMLYNPYWTALPSTLENAT
SISLMNLTSTPLCNLSDIPPVGIKSKAVVVPWGSCHFLEKARIAQKGGAEAMLVVNNSVL
FPPSGNRSEFPDVKILIAFISYKDFRDMNQTLGDNITVKMYSPSWPNFDYTMVVIFVIAV
FTVALGGYWSGLVELENLKAVTTEDREMRKKKEEYLTFSPLTVVIFVVICCVMMVLLYFF
YKWLVYVMIAIFCIASAMSLYNCLAALIHKIPYGQCTIACRGKNMEVRLIFLSGLCIAVA
VVWAVFRNEDRWAWILQDILGIAFCLNLIKTLKLPNFKSCVILLGLLLLYDVFFVFITPF
ITKNGESIMVELAAGPFGNNEKLPVVIRVPKLIYFSVMSVCLMPVSILGFGDIIVPGLLI
AYCRRFDVQTGSSYIYYVSSTVAYAIGMILTFVVLVLMKKGQPALLYLVPCTLITASVVA
WRRKEMKKFWKGNSYQMMDHLDCATNEENPVISGEQIVQQ

Sequence length

520

Interactions

View interactions

	Reactome
			Regulation of TNFR1 signaling

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Causal Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Immunodeficiency 86	Pathogenic	rs1328617979, rs2141024987	RCV001728165 RCV001728166	★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)

Show/Hide Unknown Diseases (9)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ALZHEIMER DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CHRONIC OBSTRUCTIVE PULMONARY DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CORONARY ARTERY DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
EOSINOPHILIC ESOPHAGITIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GOUT	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LATE-ONSET ALZHEIMER'S DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant tumor of urinary bladder	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SPPL2A-related disorder	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
VENOUS THROMBOEMBOLISM	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (12)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Alzheimer Disease	Associate	33152005	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Arthritis Rheumatoid	Associate	18369459	★★★★★ ★☆☆☆☆ Found in Text Mining only
Autoimmune Diseases	Associate	18369459, 25035924, 33152005	★★★★★ ★☆☆☆☆ Found in Text Mining only
Celiac Disease	Associate	18369459	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus Type 1	Associate	18369459	★★★★★ ★☆☆☆☆ Found in Text Mining only
Frontotemporal Dementia	Associate	33152005	★★★★★ ★☆☆☆☆ Found in Text Mining only
Fused Kidney	Associate	18369459	★★★★★ ★☆☆☆☆ Found in Text Mining only
Graves Disease	Associate	18369459	★★★★★ ★☆☆☆☆ Found in Text Mining only
Growth Factors Combined Defect of	Stimulate	39586751	★★★★★ ★☆☆☆☆ Found in Text Mining only
Inflammation	Associate	32198923	★★★★★ ★☆☆☆☆ Found in Text Mining only
Invasive Pneumococcal Disease Recurrent Isolated 2	Associate	39586751	★★★★★ ★☆☆☆☆ Found in Text Mining only
Spondylitis Ankylosing	Associate	32198923	★★★★★ ★☆☆☆☆ Found in Text Mining only

SPPL2A (signal peptide peptidase like 2A)