Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	84869
Gene name Gene Name - the full gene name approved by the HGNC.	Carbonyl reductase 4
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	CBR4
Synonyms (NCBI Gene) Gene synonyms aliases	SDR45C1
Chromosome Chromosome number	4
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	4q32.3

Show/Hide all(126)

miRTarBase ID	miRNA	Experiments	Reference
MIRT020570	hsa-miR-155-5p	Proteomics	18668040
MIRT020570	hsa-miR-155-5p	Reporter assay;Other	20584899
MIRT023498	hsa-miR-1-3p	Proteomics	18668040
MIRT032121	hsa-let-7d-5p	Sequencing	20371350
MIRT865736	hsa-let-7a	CLIP-seq
MIRT865737	hsa-let-7b	CLIP-seq
MIRT865738	hsa-let-7c	CLIP-seq
MIRT865739	hsa-let-7d	CLIP-seq
MIRT865740	hsa-let-7e	CLIP-seq
MIRT865741	hsa-let-7f	CLIP-seq
MIRT865742	hsa-let-7g	CLIP-seq
MIRT865743	hsa-let-7i	CLIP-seq
MIRT865744	hsa-miR-122	CLIP-seq
MIRT865745	hsa-miR-137	CLIP-seq
MIRT865746	hsa-miR-139-5p	CLIP-seq
MIRT865747	hsa-miR-153	CLIP-seq
MIRT865748	hsa-miR-197	CLIP-seq
MIRT865749	hsa-miR-202	CLIP-seq
MIRT865750	hsa-miR-2116	CLIP-seq
MIRT865751	hsa-miR-214	CLIP-seq
MIRT865752	hsa-miR-221	CLIP-seq
MIRT865753	hsa-miR-222	CLIP-seq
MIRT865754	hsa-miR-25	CLIP-seq
MIRT865755	hsa-miR-32	CLIP-seq
MIRT865756	hsa-miR-3619-5p	CLIP-seq
MIRT865757	hsa-miR-3622a-3p	CLIP-seq
MIRT865758	hsa-miR-3622b-3p	CLIP-seq
MIRT865759	hsa-miR-363	CLIP-seq
MIRT865760	hsa-miR-367	CLIP-seq
MIRT865761	hsa-miR-409-3p	CLIP-seq
MIRT865762	hsa-miR-4254	CLIP-seq
MIRT865763	hsa-miR-4291	CLIP-seq
MIRT865764	hsa-miR-4458	CLIP-seq
MIRT865765	hsa-miR-4464	CLIP-seq
MIRT865766	hsa-miR-448	CLIP-seq
MIRT865767	hsa-miR-4481	CLIP-seq
MIRT865768	hsa-miR-4500	CLIP-seq
MIRT865769	hsa-miR-4539	CLIP-seq
MIRT865770	hsa-miR-4643	CLIP-seq
MIRT865771	hsa-miR-466	CLIP-seq
MIRT865772	hsa-miR-4698	CLIP-seq
MIRT865773	hsa-miR-4745-5p	CLIP-seq
MIRT865774	hsa-miR-4748	CLIP-seq
MIRT865775	hsa-miR-4789-3p	CLIP-seq
MIRT865776	hsa-miR-4796-5p	CLIP-seq
MIRT865777	hsa-miR-4803	CLIP-seq
MIRT865778	hsa-miR-501-5p	CLIP-seq
MIRT865779	hsa-miR-5096	CLIP-seq
MIRT865780	hsa-miR-518a-5p	CLIP-seq
MIRT865781	hsa-miR-527	CLIP-seq
MIRT865782	hsa-miR-548ag	CLIP-seq
MIRT865783	hsa-miR-548ai	CLIP-seq
MIRT865784	hsa-miR-548m	CLIP-seq
MIRT865785	hsa-miR-548v	CLIP-seq
MIRT865786	hsa-miR-619	CLIP-seq
MIRT865787	hsa-miR-657	CLIP-seq
MIRT865788	hsa-miR-761	CLIP-seq
MIRT865789	hsa-miR-922	CLIP-seq
MIRT865790	hsa-miR-92a	CLIP-seq
MIRT865791	hsa-miR-92b	CLIP-seq
MIRT865792	hsa-miR-98	CLIP-seq
MIRT1546219	hsa-miR-3163	CLIP-seq
MIRT1546220	hsa-miR-4282	CLIP-seq
MIRT1546221	hsa-miR-4325	CLIP-seq
MIRT1546222	hsa-miR-507	CLIP-seq
MIRT1546223	hsa-miR-557	CLIP-seq
MIRT1956750	hsa-miR-1197	CLIP-seq
MIRT1956751	hsa-miR-1258	CLIP-seq
MIRT1956752	hsa-miR-140-5p	CLIP-seq
MIRT1956753	hsa-miR-3117-3p	CLIP-seq
MIRT1956754	hsa-miR-3121-3p	CLIP-seq
MIRT1956755	hsa-miR-3154	CLIP-seq
MIRT1546219	hsa-miR-3163	CLIP-seq
MIRT1956756	hsa-miR-3672	CLIP-seq
MIRT1956757	hsa-miR-3942-3p	CLIP-seq
MIRT1956758	hsa-miR-433	CLIP-seq
MIRT1956759	hsa-miR-450b-5p	CLIP-seq
MIRT1956760	hsa-miR-4799-5p	CLIP-seq
MIRT1546222	hsa-miR-507	CLIP-seq
MIRT1546223	hsa-miR-557	CLIP-seq
MIRT2194025	hsa-miR-1183	CLIP-seq
MIRT2194026	hsa-miR-147b	CLIP-seq
MIRT2194027	hsa-miR-3143	CLIP-seq
MIRT2194028	hsa-miR-3674	CLIP-seq
MIRT865769	hsa-miR-4539	CLIP-seq
MIRT2194029	hsa-miR-4678	CLIP-seq
MIRT2194030	hsa-miR-4705	CLIP-seq
MIRT2194031	hsa-miR-4773	CLIP-seq
MIRT865777	hsa-miR-4803	CLIP-seq
MIRT2194032	hsa-miR-543	CLIP-seq
MIRT2194033	hsa-miR-545	CLIP-seq
MIRT2194034	hsa-miR-548aa	CLIP-seq
MIRT865782	hsa-miR-548ag	CLIP-seq
MIRT865783	hsa-miR-548ai	CLIP-seq
MIRT865785	hsa-miR-548v	CLIP-seq
MIRT2194035	hsa-miR-637	CLIP-seq
MIRT2194036	hsa-miR-767-3p	CLIP-seq
MIRT2497410	hsa-miR-1200	CLIP-seq
MIRT2497411	hsa-miR-3129-3p	CLIP-seq
MIRT2497412	hsa-miR-3135	CLIP-seq
MIRT2497413	hsa-miR-337-3p	CLIP-seq
MIRT2497414	hsa-miR-3685	CLIP-seq
MIRT2497415	hsa-miR-384	CLIP-seq
MIRT2497416	hsa-miR-3909	CLIP-seq
MIRT2497417	hsa-miR-4302	CLIP-seq
MIRT2497418	hsa-miR-4303	CLIP-seq
MIRT2497419	hsa-miR-4324	CLIP-seq
MIRT2497420	hsa-miR-455-5p	CLIP-seq
MIRT2497421	hsa-miR-4682	CLIP-seq
MIRT1956760	hsa-miR-4799-5p	CLIP-seq
MIRT2497422	hsa-miR-512-3p	CLIP-seq
MIRT2497423	hsa-miR-544b	CLIP-seq
MIRT2497424	hsa-miR-549	CLIP-seq
MIRT2497425	hsa-miR-550a	CLIP-seq
MIRT2497426	hsa-miR-577	CLIP-seq
MIRT2497427	hsa-miR-607	CLIP-seq
MIRT2497410	hsa-miR-1200	CLIP-seq
MIRT2497413	hsa-miR-337-3p	CLIP-seq
MIRT2497414	hsa-miR-3685	CLIP-seq
MIRT2497415	hsa-miR-384	CLIP-seq
MIRT2497418	hsa-miR-4303	CLIP-seq
MIRT2497419	hsa-miR-4324	CLIP-seq
MIRT2497420	hsa-miR-455-5p	CLIP-seq
MIRT2497421	hsa-miR-4682	CLIP-seq
MIRT2497422	hsa-miR-512-3p	CLIP-seq
MIRT2497423	hsa-miR-544b	CLIP-seq

Show/Hide all(19)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003955	Function	NAD(P)H dehydrogenase (quinone) activity	IDA	20837989
GO:0005515	Function	Protein binding	IPI	19571038, 25203508, 32296183
GO:0005759	Component	Mitochondrial matrix	IDA	19000905
GO:0005759	Component	Mitochondrial matrix	TAS
GO:0006633	Process	Fatty acid biosynthetic process	IBA	21873635
GO:0006633	Process	Fatty acid biosynthetic process	IEA
GO:0006633	Process	Fatty acid biosynthetic process	IMP	25203508
GO:0008753	Function	NADPH dehydrogenase (quinone) activity	IDA	19000905
GO:0016616	Function	Oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	IBA	21873635
GO:0044597	Process	Daunorubicin metabolic process	IMP	20837989
GO:0044598	Process	Doxorubicin metabolic process	IMP	20837989
GO:0046949	Process	Fatty-acyl-CoA biosynthetic process	TAS
GO:0047025	Function	3-oxoacyl-[acyl-carrier-protein] reductase (NADH) activity	IMP	25203508
GO:0048038	Function	Quinone binding	IBA	21873635
GO:0048038	Function	Quinone binding	IDA	19000905
GO:0051289	Process	Protein homotetramerization	IDA	19000905
GO:0051290	Process	Protein heterotetramerization	IDA	25203508
GO:0070402	Function	NADPH binding	IDA	19000905, 25203508
GO:1990204	Component	Oxidoreductase complex	IMP	25203508

MIM	HGNC	e!Ensembl
619394	25891	ENSG00000145439

Protein

UniProt ID

Q8N4T8

Protein name

3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100) (3-ketoacyl-[acyl-carrier-protein] reductase beta subunit) (KAR beta subunit) (Carbonyl reductase family member 4) (CBR4) (Quinone reductase CBR4) (EC 1.6.5.10) (Short chain dehydrogenase/reductase

Protein function

Component of the heterotetramer complex KAR (3-ketoacyl-[acyl carrier protein] reductase or 3-ketoacyl-[ACP] reductase) that forms part of the mitochondrial fatty acid synthase (mtFAS). Beta-subunit of the KAR heterotetramer complex, responsible

PDB

4CQL , 4CQM

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF13561	adh_short_C2	8 → 234		Domain

Tissue specificity

TISSUE SPECIFICITY: Detected in liver and kidney (at protein level) (PubMed:19000905). Displays the highest expression in neuronal and muscle tissues (PubMed:25203508). {ECO:0000269|PubMed:19000905, ECO:0000303|PubMed:25203508}.

Sequence

MDKVCAVFGGSRGIGRAVAQLMARKGYRLAVIARNLEGAKAAAGDLGGDHLAFSCDVAKE
HDVQNTFEELEKHLGRVNFLVNAAGINRDGLLVRTKTEDMVSQLHTNLLGSMLTCKAAMR
TMIQQQGGSIVNVGSIVGLKGNSGQSVYSASKGGLVGFSRALAKEVARKKIRVNVVAPGF
VHTDMTKDLKEEHLKKNIPLGRFGETIEVAHAVVFLLESPYITGHVLVVDGGLQLIL

Sequence length

237

Interactions

View interactions

	KEGG		Reactome
	Fatty acid biosynthesis Metabolic pathways Fatty acid metabolism		Fatty acyl-CoA biosynthesis

Show/Hide Unknown Diseases (4)

Disease term	Disease name	Evidence	Source
Unknown
Cerebral amyloid angiopathy	Cerebral amyloid angiopathy		GWAS
Alzheimer disease	Alzheimer disease		GWAS
Schizophrenia	Schizophrenia		GWAS
Glioblastoma	Glioblastoma	CRISPR screening of E3 ubiquitin ligases reveals Ring Finger Protein 185 as a novel tumor suppressor in glioblastoma repressed by promoter hypermethylation and miR-587	GWAS, CBGDA

CBR4 (carbonyl reductase 4)