RIOX2 (ribosomal oxygenase 2)

Gene
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
84864
Gene name Gene Name - the full gene name approved by the HGNC.
Ribosomal oxygenase 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
RIOX2
Synonyms (NCBI Gene) Gene synonyms aliases
JMJD10, MDIG, MINA, MINA53, NO52, ROX
Chromosome Chromosome number
3
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
3q11.2
Summary Summary of gene provided in NCBI Entrez Gene.
MINA is a c-Myc (MYC; MIM 190080) target gene that may play a role in cell proliferation or regulation of cell growth. (Tsuneoka et al., 2002 [PubMed 12091391]; Zhang et al., 2005 [PubMed 15897898]).[supplied by OMIM, May 2008]
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(10)
miRTarBase ID miRNA Experiments Reference
MIRT718291 hsa-miR-8485 HITS-CLIP 19536157
MIRT718290 hsa-miR-603 HITS-CLIP 19536157
MIRT718289 hsa-miR-216b-3p HITS-CLIP 19536157
MIRT718288 hsa-miR-4796-5p HITS-CLIP 19536157
MIRT718287 hsa-miR-6516-3p HITS-CLIP 19536157
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(17)
GO ID Ontology Definition Evidence Reference
GO:0003714 Function Transcription corepressor activity IEA
GO:0005515 Function Protein binding IPI 32296183
GO:0005654 Component Nucleoplasm IDA
GO:0005654 Component Nucleoplasm TAS
GO:0005667 Component Transcription regulator complex IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
612049 19441 ENSG00000170854
Protein
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Q8IUF8
Protein name Ribosomal oxygenase 2 (60S ribosomal protein L27a histidine hydroxylase) (Bifunctional lysine-specific demethylase and histidyl-hydroxylase MINA) (EC 1.14.11.79) (Histone lysine demethylase MINA) (MYC-induced nuclear antigen) (Mineral dust-induced gene pr
Protein function Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Is involved in the demethylation of trimethylated 'Lys-9' on histone H3 (H3K9me3), leading to an increase in ribosomal RNA expression. Also cataly
PDB 2XDV , 4BU2 , 4BXF
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF08007 Cupin_4 51 → 364 Cupin superfamily protein Family
Tissue specificity TISSUE SPECIFICITY: Expressed in liver, skeletal muscle, heart, pancreas, and placenta. Not detected in brain, lung or kidney. Expressed in several lung cancer tissues, but is barely detected in the adjacent non-cancerous tissues. Also highly expressed in
Sequence
Sequence length 465
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
  Reactome
    HDMs demethylate histones
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Causal Diseases (1)
Causal
Disease term Disease name dbSNP ID References
Lung cancer Malignant neoplasm of lung rs121913530, rs121913529, rs878855122, rs1057519784, rs770315135 15897898
Show/Hide Text Mining Associations (21)
Associations from Text Mining
Disease Name Relationship Type References
Breast Neoplasms Stimulate 24309373
Carcinogenesis Associate 24505346, 26293673, 33423409
Carcinoma Non Small Cell Lung Associate 24434654
Carcinoma Squamous Cell Associate 17317935
Carcinoma Squamous Cell Stimulate 33423409
DiGeorge Syndrome Associate 26608785
Emanuel syndrome Associate 35166240
Esophageal Neoplasms Associate 17317935
Esophageal Squamous Cell Carcinoma Associate 17317935
Fibrosis Associate 31903140