Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID	84844
Gene name	PHD finger protein 5A
Gene symbol	PHF5A
Synonyms (NCBI Gene)	INIRds3SAP14bSF3B7SF3b14bbK223H9.2
Chromosome	22
Chromosome location	22q13.2
Summary	This gene encodes a subunit of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-m

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miRTarBase ID	miRNA	Experiments	Reference
MIRT052678	hsa-miR-1260b	CLASH	23622248
MIRT532634	hsa-miR-6838-3p	PAR-CLIP	22012620
MIRT532633	hsa-miR-6734-3p	PAR-CLIP	22012620
MIRT532632	hsa-miR-20b-3p	PAR-CLIP	22012620
MIRT532631	hsa-miR-4297	PAR-CLIP	22012620
MIRT532630	hsa-miR-5581-5p	PAR-CLIP	22012620
MIRT532629	hsa-miR-1537-5p	PAR-CLIP	22012620
MIRT532627	hsa-miR-4718	PAR-CLIP	22012620
MIRT532628	hsa-miR-4999-5p	PAR-CLIP	22012620
MIRT532626	hsa-miR-4529-5p	PAR-CLIP	22012620
MIRT532624	hsa-miR-4540	PAR-CLIP	22012620
MIRT532625	hsa-miR-202-5p	PAR-CLIP	22012620
MIRT532623	hsa-miR-3187-3p	PAR-CLIP	22012620
MIRT462643	hsa-miR-204-3p	PAR-CLIP	23592263
MIRT462642	hsa-miR-4646-5p	PAR-CLIP	23592263
MIRT462641	hsa-miR-3192-5p	PAR-CLIP	23592263
MIRT462640	hsa-miR-619-5p	PAR-CLIP	23592263
MIRT462639	hsa-miR-6506-5p	PAR-CLIP	23592263
MIRT462638	hsa-miR-3160-3p	PAR-CLIP	23592263
MIRT462637	hsa-miR-558	PAR-CLIP	23592263
MIRT462636	hsa-miR-4487	PAR-CLIP	23592263
MIRT462635	hsa-miR-377-5p	PAR-CLIP	23592263
MIRT462634	hsa-miR-6086	PAR-CLIP	23592263
MIRT462633	hsa-miR-924	PAR-CLIP	23592263
MIRT462632	hsa-miR-6499-3p	PAR-CLIP	23592263
MIRT462631	hsa-miR-4747-5p	PAR-CLIP	23592263
MIRT462630	hsa-miR-5196-5p	PAR-CLIP	23592263
MIRT462629	hsa-miR-4314	PAR-CLIP	23592263
MIRT462628	hsa-miR-627-5p	PAR-CLIP	23592263
MIRT462627	hsa-miR-455-3p	PAR-CLIP	23592263
MIRT462626	hsa-miR-6516-5p	PAR-CLIP	23592263
MIRT532634	hsa-miR-6838-3p	PAR-CLIP	22012620
MIRT532633	hsa-miR-6734-3p	PAR-CLIP	22012620
MIRT532632	hsa-miR-20b-3p	PAR-CLIP	22012620
MIRT532631	hsa-miR-4297	PAR-CLIP	22012620
MIRT532630	hsa-miR-5581-5p	PAR-CLIP	22012620
MIRT532629	hsa-miR-1537-5p	PAR-CLIP	22012620
MIRT532627	hsa-miR-4718	PAR-CLIP	22012620
MIRT532628	hsa-miR-4999-5p	PAR-CLIP	22012620
MIRT532626	hsa-miR-4529-5p	PAR-CLIP	22012620
MIRT532624	hsa-miR-4540	PAR-CLIP	22012620
MIRT532625	hsa-miR-202-5p	PAR-CLIP	22012620
MIRT532623	hsa-miR-3187-3p	PAR-CLIP	22012620
MIRT462643	hsa-miR-204-3p	PAR-CLIP	23592263
MIRT462642	hsa-miR-4646-5p	PAR-CLIP	23592263
MIRT462641	hsa-miR-3192-5p	PAR-CLIP	23592263
MIRT462640	hsa-miR-619-5p	PAR-CLIP	23592263
MIRT462639	hsa-miR-6506-5p	PAR-CLIP	23592263
MIRT462638	hsa-miR-3160-3p	PAR-CLIP	23592263
MIRT462637	hsa-miR-558	PAR-CLIP	23592263
MIRT462636	hsa-miR-4487	PAR-CLIP	23592263
MIRT462635	hsa-miR-377-5p	PAR-CLIP	23592263
MIRT462634	hsa-miR-6086	PAR-CLIP	23592263
MIRT462633	hsa-miR-924	PAR-CLIP	23592263
MIRT462632	hsa-miR-6499-3p	PAR-CLIP	23592263
MIRT462631	hsa-miR-4747-5p	PAR-CLIP	23592263
MIRT462630	hsa-miR-5196-5p	PAR-CLIP	23592263
MIRT462629	hsa-miR-4314	PAR-CLIP	23592263
MIRT462628	hsa-miR-627-5p	PAR-CLIP	23592263
MIRT462627	hsa-miR-455-3p	PAR-CLIP	23592263
MIRT462626	hsa-miR-6516-5p	PAR-CLIP	23592263
MIRT1231128	hsa-miR-1183	CLIP-seq
MIRT1231129	hsa-miR-1231	CLIP-seq
MIRT1231130	hsa-miR-1262	CLIP-seq
MIRT1231131	hsa-miR-1268	CLIP-seq
MIRT1231132	hsa-miR-1268b	CLIP-seq
MIRT1231133	hsa-miR-1275	CLIP-seq
MIRT1231134	hsa-miR-128	CLIP-seq
MIRT1231135	hsa-miR-187	CLIP-seq
MIRT1231136	hsa-miR-223	CLIP-seq
MIRT1231137	hsa-miR-2276	CLIP-seq
MIRT1231138	hsa-miR-27a	CLIP-seq
MIRT1231139	hsa-miR-27b	CLIP-seq
MIRT1231140	hsa-miR-298	CLIP-seq
MIRT1231141	hsa-miR-3137	CLIP-seq
MIRT1231142	hsa-miR-3147	CLIP-seq
MIRT1231143	hsa-miR-3162-3p	CLIP-seq
MIRT1231144	hsa-miR-3179	CLIP-seq
MIRT1231145	hsa-miR-3202	CLIP-seq
MIRT1231146	hsa-miR-4277	CLIP-seq
MIRT1231147	hsa-miR-4307	CLIP-seq
MIRT1231148	hsa-miR-4326	CLIP-seq
MIRT1231149	hsa-miR-4420	CLIP-seq
MIRT1231150	hsa-miR-4425	CLIP-seq
MIRT1231151	hsa-miR-4476	CLIP-seq
MIRT1231152	hsa-miR-4486	CLIP-seq
MIRT1231153	hsa-miR-4638-3p	CLIP-seq
MIRT1231154	hsa-miR-4665-5p	CLIP-seq
MIRT1231155	hsa-miR-4696	CLIP-seq
MIRT1231156	hsa-miR-4701-3p	CLIP-seq
MIRT1231157	hsa-miR-4723-5p	CLIP-seq
MIRT1231158	hsa-miR-4781-3p	CLIP-seq
MIRT1231159	hsa-miR-500a	CLIP-seq
MIRT1231160	hsa-miR-501-5p	CLIP-seq
MIRT1231161	hsa-miR-5096	CLIP-seq
MIRT1231162	hsa-miR-513a-5p	CLIP-seq
MIRT1231163	hsa-miR-585	CLIP-seq
MIRT1231164	hsa-miR-587	CLIP-seq
MIRT2067824	hsa-miR-103a	CLIP-seq
MIRT2067825	hsa-miR-107	CLIP-seq
MIRT2067826	hsa-miR-1184	CLIP-seq
MIRT2067827	hsa-miR-22	CLIP-seq
MIRT2067828	hsa-miR-31	CLIP-seq
MIRT2067829	hsa-miR-3128	CLIP-seq
MIRT1231144	hsa-miR-3179	CLIP-seq
MIRT1231145	hsa-miR-3202	CLIP-seq
MIRT2067830	hsa-miR-3688-5p	CLIP-seq
MIRT2067831	hsa-miR-3977	CLIP-seq
MIRT1231147	hsa-miR-4307	CLIP-seq
MIRT2067832	hsa-miR-4434	CLIP-seq
MIRT1231151	hsa-miR-4476	CLIP-seq
MIRT2067833	hsa-miR-4494	CLIP-seq
MIRT2067834	hsa-miR-4499	CLIP-seq
MIRT2067835	hsa-miR-4516	CLIP-seq
MIRT2067836	hsa-miR-4531	CLIP-seq
MIRT2067837	hsa-miR-4704-5p	CLIP-seq
MIRT2067838	hsa-miR-4712-5p	CLIP-seq
MIRT2067839	hsa-miR-4720-5p	CLIP-seq
MIRT1231157	hsa-miR-4723-5p	CLIP-seq
MIRT2067840	hsa-miR-4771	CLIP-seq
MIRT2067841	hsa-miR-4773	CLIP-seq
MIRT2067842	hsa-miR-4799-3p	CLIP-seq
MIRT2067843	hsa-miR-4802-5p	CLIP-seq
MIRT2067844	hsa-miR-770-5p	CLIP-seq
MIRT2067845	hsa-miR-885-3p	CLIP-seq
MIRT2067846	hsa-miR-922	CLIP-seq
MIRT2067824	hsa-miR-103a	CLIP-seq
MIRT2067825	hsa-miR-107	CLIP-seq
MIRT2067826	hsa-miR-1184	CLIP-seq
MIRT2295286	hsa-miR-1244	CLIP-seq
MIRT2295287	hsa-miR-138	CLIP-seq
MIRT2067827	hsa-miR-22	CLIP-seq
MIRT2067829	hsa-miR-3128	CLIP-seq
MIRT1231147	hsa-miR-4307	CLIP-seq
MIRT1231148	hsa-miR-4326	CLIP-seq
MIRT2067833	hsa-miR-4494	CLIP-seq
MIRT2067834	hsa-miR-4499	CLIP-seq
MIRT2295288	hsa-miR-4690-5p	CLIP-seq
MIRT2067837	hsa-miR-4704-5p	CLIP-seq
MIRT2067838	hsa-miR-4712-5p	CLIP-seq
MIRT2067839	hsa-miR-4720-5p	CLIP-seq
MIRT2067840	hsa-miR-4771	CLIP-seq
MIRT2067842	hsa-miR-4799-3p	CLIP-seq
MIRT2295289	hsa-miR-544	CLIP-seq
MIRT2067844	hsa-miR-770-5p	CLIP-seq
MIRT2067845	hsa-miR-885-3p	CLIP-seq
MIRT2067846	hsa-miR-922	CLIP-seq
MIRT1231131	hsa-miR-1268	CLIP-seq
MIRT1231132	hsa-miR-1268b	CLIP-seq
MIRT1231134	hsa-miR-128	CLIP-seq
MIRT1231136	hsa-miR-223	CLIP-seq
MIRT1231138	hsa-miR-27a	CLIP-seq
MIRT1231139	hsa-miR-27b	CLIP-seq
MIRT1231140	hsa-miR-298	CLIP-seq
MIRT1231146	hsa-miR-4277	CLIP-seq
MIRT1231148	hsa-miR-4326	CLIP-seq
MIRT1231149	hsa-miR-4420	CLIP-seq
MIRT1231152	hsa-miR-4486	CLIP-seq
MIRT1231162	hsa-miR-513a-5p	CLIP-seq
MIRT1231163	hsa-miR-585	CLIP-seq
MIRT1231131	hsa-miR-1268	CLIP-seq
MIRT1231132	hsa-miR-1268b	CLIP-seq
MIRT1231134	hsa-miR-128	CLIP-seq
MIRT1231137	hsa-miR-2276	CLIP-seq
MIRT1231138	hsa-miR-27a	CLIP-seq
MIRT1231139	hsa-miR-27b	CLIP-seq
MIRT1231147	hsa-miR-4307	CLIP-seq
MIRT1231149	hsa-miR-4420	CLIP-seq
MIRT1231152	hsa-miR-4486	CLIP-seq
MIRT1231155	hsa-miR-4696	CLIP-seq
MIRT2592893	hsa-miR-4715-3p	CLIP-seq
MIRT1231161	hsa-miR-5096	CLIP-seq
MIRT1231162	hsa-miR-513a-5p	CLIP-seq
MIRT1231163	hsa-miR-585	CLIP-seq
MIRT1231131	hsa-miR-1268	CLIP-seq
MIRT1231132	hsa-miR-1268b	CLIP-seq
MIRT1231134	hsa-miR-128	CLIP-seq
MIRT1231136	hsa-miR-223	CLIP-seq
MIRT1231137	hsa-miR-2276	CLIP-seq
MIRT1231138	hsa-miR-27a	CLIP-seq
MIRT1231139	hsa-miR-27b	CLIP-seq
MIRT1231146	hsa-miR-4277	CLIP-seq
MIRT1231147	hsa-miR-4307	CLIP-seq
MIRT1231149	hsa-miR-4420	CLIP-seq
MIRT1231152	hsa-miR-4486	CLIP-seq
MIRT1231155	hsa-miR-4696	CLIP-seq
MIRT2592893	hsa-miR-4715-3p	CLIP-seq
MIRT1231161	hsa-miR-5096	CLIP-seq
MIRT1231162	hsa-miR-513a-5p	CLIP-seq
MIRT1231163	hsa-miR-585	CLIP-seq

Show/Hide all (34)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000398	Process	MRNA splicing, via spliceosome	IBA
GO:0000398	Process	MRNA splicing, via spliceosome	IDA	12234937, 27720643, 29360106, 32494006, 34822310, 36797247
GO:0000398	Process	MRNA splicing, via spliceosome	IEA
GO:0000398	Process	MRNA splicing, via spliceosome	NAS	31744343
GO:0003677	Function	DNA binding	IEA
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0003723	Function	RNA binding	IDA	27720643
GO:0003723	Function	RNA binding	IEA
GO:0005515	Function	Protein binding	IPI	17332742, 24981860, 27720643, 32814053, 33961781
GO:0005634	Component	Nucleus	IDA	27720643, 28541300, 29360106
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	NAS	31744343
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005681	Component	Spliceosomal complex	IEA
GO:0005681	Component	Spliceosomal complex	NAS	31744343
GO:0005684	Component	U2-type spliceosomal complex	IDA	32494006, 34822310, 36797247
GO:0005684	Component	U2-type spliceosomal complex	IPI	27720643
GO:0005686	Component	U2 snRNP	IBA
GO:0005686	Component	U2 snRNP	IDA	12234937
GO:0005686	Component	U2 snRNP	NAS	31744343
GO:0005689	Component	U12-type spliceosomal complex	IDA	15146077
GO:0006397	Process	MRNA processing	IEA
GO:0008270	Function	Zinc ion binding	IDA	28541300
GO:0008380	Process	RNA splicing	IEA
GO:0016363	Component	Nuclear matrix	IEA
GO:0016607	Component	Nuclear speck	IEA
GO:0016607	Component	Nuclear speck	ISS
GO:0045893	Process	Positive regulation of DNA-templated transcription	ISS
GO:0046872	Function	Metal ion binding	IEA
GO:0048863	Process	Stem cell differentiation	IEA
GO:0071005	Component	U2-type precatalytic spliceosome	IDA	29360106
GO:0071011	Component	Precatalytic spliceosome	IBA
GO:1903241	Process	U2-type prespliceosome assembly	NAS	31744343

MIM	HGNC	e!Ensembl
617846	18000	ENSG00000100410

Q7RTV0

Protein name

PHD finger-like domain-containing protein 5A (PHD finger-like domain protein 5A) (Splicing factor 3B-associated 14 kDa protein) (SF3b14b)

Protein function

Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:12234937, PubMed:27720643, PubMed:28541300, PubMed:32494006, PubMed:34822310). The 17S U2 SnRNP c

PDB

5IFE , 5O9Z , 5SYB , 5Z56 , 5Z57 , 5Z58 , 5ZYA , 6AH0 , 6AHD , 6EN4 , 6FF4 , 6FF7 , 6QX9 , 6Y50 , 6Y5Q , 7ABG , 7ABH , 7ABI , 7B0I , 7B91 , 7B92 , 7B9C , 7DVQ , 7EVN , 7EVO , 7OMF , 7ONB , 7OPI , 7Q3L , 7Q4O , 7Q4P , 7QTT , 7VPX , 8CH6 , 8H6E , 8H6J , 8H6K , 8H6L , 8HK1 , 8I0P , 8I0R , 8I0S , 8I0T , 8I0U , 8I0V , 8QO9 , 8QXD , 8QZS , 8R08 , 8R09 , 8R0A

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF03660	PHF5	1 → 104	PHF5-like protein	Family

Sequence

MAKHHPDLIFCRKQAGVAIGRLCEKCDGKCVICDSYVRPCTLVRICDECNYGSYQGRCVI
CGGPGVSDAYYCKECTIQEKDRDGCPKIVNLGSSKTDLFYERKKYGFKKR

Sequence length

110

Interactions

View interactions

	KEGG		Reactome
	Spliceosome		mRNA Splicing - Major Pathway

PHF5A (PHD finger protein 5A)