SORBS2 (sorbin and SH3 domain containing 2)

Gene
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
8470
Gene name Gene Name - the full gene name approved by the HGNC.
Sorbin and SH3 domain containing 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
SORBS2
Synonyms (NCBI Gene) Gene synonyms aliases
ARGBP2, PRO0618
Chromosome Chromosome number
4
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
4q35.1
Summary Summary of gene provided in NCBI Entrez Gene.
Arg and c-Abl represent the mammalian members of the Abelson family of non-receptor protein-tyrosine kinases. They interact with the Arg/Abl binding proteins via the SH3 domains present in the carboxy end of the latter group of proteins. This gene encodes
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide all(135)
miRTarBase ID miRNA Experiments Reference
MIRT016899 hsa-miR-335-5p Microarray 18185580
MIRT036452 hsa-miR-1226-3p CLASH 23622248
MIRT664560 hsa-miR-660-3p HITS-CLIP 23824327
MIRT626613 hsa-miR-3690 HITS-CLIP 23824327
MIRT622153 hsa-miR-4254 HITS-CLIP 23824327
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide all(17)
GO ID Ontology Definition Evidence Reference
GO:0003723 Function RNA binding HDA 22658674
GO:0005200 Function Structural constituent of cytoskeleton TAS 9211900
GO:0005515 Function Protein binding IPI 15161933, 16125169, 16374509, 18985028, 21988832, 25416956
GO:0005634 Component Nucleus NAS 9211900
GO:0005886 Component Plasma membrane IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
MIM HGNC e!Ensembl
616349 24098 ENSG00000154556
Protein
Gene miRNA Gene ontology Other IDs Protein Associated diseases
UniProt ID O94875
Protein name Sorbin and SH3 domain-containing protein 2 (Arg-binding protein 2) (ArgBP2) (Arg/Abl-interacting protein 2) (Sorbin)
Protein function Adapter protein that plays a role in the assembling of signaling complexes, being a link between ABL kinases and actin cytoskeleton. Can form complex with ABL1 and CBL, thus promoting ubiquitination and degradation of ABL1. May play a role in th
PDB 5VEI
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF02208 Sorb 70 → 114 Sorbin homologous domain Family
PF00018 SH3_1 869 → 914 SH3 domain Domain
PF00018 SH3_1 944 → 991 SH3 domain Domain
PF14604 SH3_9 1048 → 1098 Variant SH3 domain Domain
Tissue specificity TISSUE SPECIFICITY: Abundantly expressed in heart. In cardiac muscle cells, located in the Z-disks of sarcomere. Also found, but to a lower extent, in small and large intestine, pancreas, thymus, colon, spleen, prostate, testis, brain, ovary and epithelia
Sequence 
MSYYQRPFSPSAYSLPASLNSSIVMQHGTSLDSTDTYPQHAQSLDGTTSSSIPLYRSSEE
EKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKPDDDTDMYNT
PYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVPPPHVPPPVPPL
RPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHERPASLYQSSIDRSL
ERPMSSASMASDFRKRRKSEPAVGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSP
SSPSRAKGGDDSKICPSLCSYSGLNGNPSSELDYCSTYRQHLDVPRDSPRAISFKNGWQM
ARQNAEIWSSTEETVSPKIKSRSCDDLLNDDCDSFPDPKVKSESMGSLLCEEDSKESCPM
AWGSPYVPEVRSNGRSRIRHRSARNAPGFLKMYKKMHRINRKDLMNSEVICSVKSRILQY
ESEQQHKDLLRAWSQCSTEEVPRDMVPTRISEFEKLIQKSKSMPNLGDDMLSPVTLEPPQ
NGLCPKRRFSIEYLLEEENQSGPPARGRRGCQSNALVPIHIEVTSDEQPRAHVEFSDSDQ
DGVVSDHSDYIHLEGSSFCSESDFDHFSFTSSESFYGSSHHHHHHHHHHHRHLISSCKGR
CPASYTRFTTMLKHERARHENTEEPRRQEMDPGLSKLAFLVSPVPFRRKKNSAPKKQTEK
AKCKASVFEALDSALKDICDQIKAEKKRGSLPDNSILHRLISELLPDVPERNSSLRALRR
SPLHQPLHPLPPDGAIHCPPYQNDCGRMPRSASFQDVDTANSSCHHQDRGGALQDRESPR
SYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNW
YEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLR
KGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDR
IHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFV
GTSRRTKFFGTFPGNYVKRL
Sequence length 1100
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide Causal Diseases (1)
Causal
Disease term Disease name dbSNP ID References
Arthritis Degenerative polyarthritis rs1594890601, rs1594882933, rs184370809, rs776489319, rs1594883470 22763110
Show/Hide Unknown Diseases (6)
Unknown
Disease term Disease name Evidence References Source
Congenital Heart Disease congenital heart disease GenCC
Coronary artery disease Coronary artery disease GWAS
Diabetes Diabetes GWAS
Ovarian cancer Ovarian cancer Conditional KD of IL6 in the OCCA xenograft model delays tumor growth GWAS, CBGDA
Show/Hide Text Mining Associations (30)
Associations from Text Mining
Disease Name Relationship Type References
Atherosclerosis Associate 35590369
Breast Neoplasms Associate 28798985
Carcinoma Hepatocellular Associate 33934539
Carcinoma Renal Cell Inhibit 33311452
Cardiovascular Diseases Associate 35794104
Coronary Disease Associate 35590369
Diabetes Mellitus Type 2 Associate 35794104
Esophageal Squamous Cell Carcinoma Associate 24551190
Facioscapulohumeral muscular dystrophy 1a Associate 26359233
Glioma Associate 38177123