Gene Gene information from NCBI Gene database.
Entrez ID 84687
Gene name Protein phosphatase 1 regulatory subunit 9B
Gene symbol PPP1R9B
Synonyms (NCBI Gene)
PPP1R6PPP1R9SPINOSpn
Chromosome 17
Chromosome location 17q21.33
Summary This gene encodes a scaffold protein that functions as a regulatory subunit of protein phosphatase 1a. Expression of this gene is particularly high in dendritic spines, suggesting that the encoded protein may play a role in receiving signals from the cent
miRNA miRNA information provided by mirtarbase database.
524
miRTarBase ID miRNA Experiments Reference
MIRT023305 hsa-miR-122-5p Microarray 17612493
MIRT053395 hsa-miR-96-5p Microarray 23807165
MIRT504519 hsa-miR-3936 PAR-CLIP 23446348
MIRT504518 hsa-miR-4476 PAR-CLIP 23446348
MIRT504517 hsa-miR-6876-5p PAR-CLIP 23446348
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
98
GO ID Ontology Definition Evidence Reference
GO:0000164 Component Protein phosphatase type 1 complex TAS 11278317
GO:0001560 Process Regulation of cell growth by extracellular stimulus TAS 11278317
GO:0001975 Process Response to amphetamine IEA
GO:0003006 Process Developmental process involved in reproduction IEA
GO:0003779 Function Actin binding IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
603325 9298 ENSG00000108819
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q96SB3
Protein name Neurabin-2 (Neurabin-II) (Protein phosphatase 1 regulatory subunit 9B) (Spinophilin)
Protein function Seems to act as a scaffold protein in multiple signaling pathways. Modulates excitatory synaptic transmission and dendritic spine morphology. Binds to actin filaments (F-actin) and shows cross-linking activity. Binds along the sides of the F-act
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF17817 PDZ_5 426 489 PDZ domain Domain
PF00595 PDZ 496 581 PDZ domain Domain
Sequence
MMKTEPRGPGGPLRSASPHRSAYEAGIQALKPPDAPGPDEAPKGAHHKKYGSNVHRIKSM
FLQMGTTAGPSGEAGGGAGLAEAPRASERGVRLSLPRASSLNENVDHSALLKLGTSVSER
VSRFDSKPAPSAQPAPPPHPPSRLQETRKLFERSAPAAAGGDKEAAARRLLRQERAGLQD
RKLDVVVRFNGSTEALDKLDADAVSPTVSQLSAVFEKADSRTGLHRGPGLPRAAGVPQVN
SKLVSKRSRVFQPPPPPPPAPSGDAPAEKERCPAGQQPPQHRVAPARPPPKPREVRKIKP
VEVEESGESEAESAPGEVIQAEVTVHAALENGSTVATAASPAPEEPKAQAAPEKEAAAVA
PPERGVGNGRAPDVAPEEVDESKKEDFSEADLVDVSAYSGLGEDSAGSALEEDDEDDEED
GEPPYEPESGCVEIPGLSEEEDPAPSRKIHFSTAPIQVFSTYSNEDYDRRNEDVDPMAAS
AEYELEKRV
ERLELFPVELEKDSEGLGISIIGMGAGADMGLEKLGIFVKTVTEGGAAHRD
GRIQVNDLLVEVDGTSLVGVTQSFAASVLRNTKGRVRFMIG
RERPGEQSEVAQLIQQTLE
QERWQREMMEQRYAQYGEDDEETGEYATDEDEELSPTFPGGEMAIEVFELAENEDALSPV
DMEPEKLVHKFKELQIKHAVTEAEIQQLKRKLQSLEQEKGRWRVEKAQLEQSVEENKERM
EKLEGYWGEAQSLCQAVDEHLRETQAQYQALERKYSKAKRLIKDYQQKEIEFLKKETAQR
RVLEESELARKEEMDKLLDKISELEGNLQTLRNSNST
Sequence length 817
Interactions View interactions
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
16
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
PPP1R9B-related disorder Likely benign; Benign; Uncertain significance rs367543202, rs1281442642, rs367543189, rs1158817186, rs2509100699, rs779251272, rs2509101071, rs2509101255, rs2509100059, rs10669851, rs1485177207, rs1359760756, rs1480198791, rs766001724, rs1054096617 RCV003964955
RCV003899052
RCV003896788
RCV003897020
RCV003907196
RCV003921757
RCV003924144
RCV003896310
RCV003901476
RCV003912237
RCV003899518
RCV003913981
RCV003951712
RCV003951428
RCV003983705
RCV003964233
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Developmental Disabilities Associate 37501076
Microcephaly Associate 37501076
Triple Negative Breast Neoplasms Associate 34326372