Gene Gene information from NCBI Gene database.
Entrez ID 84541
Gene name Kelch repeat and BTB domain containing 8
Gene symbol KBTBD8
Synonyms (NCBI Gene)
TA-KRPTAKRP
Chromosome 3
Chromosome location 3p14.1
miRNA miRNA information provided by mirtarbase database.
353
miRTarBase ID miRNA Experiments Reference
MIRT016028 hsa-miR-374b-5p Sequencing 20371350
MIRT092531 hsa-miR-100-5p PAR-CLIP 21572407
MIRT092530 hsa-miR-99a-5p PAR-CLIP 21572407
MIRT092533 hsa-miR-99b-5p PAR-CLIP 21572407
MIRT308293 hsa-miR-548n PAR-CLIP 21572407
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
18
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 21145461, 26399832, 28514442, 30190310, 33961781
GO:0005737 Component Cytoplasm IBA
GO:0005737 Component Cytoplasm IEA
GO:0005794 Component Golgi apparatus IEA
GO:0005819 Component Spindle IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
616607 30691 ENSG00000163376
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q8NFY9
Protein name Kelch repeat and BTB domain-containing protein 8 (T-cell activation kelch repeat protein) (TA-KRP)
Protein function Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification (PubMed:26399832). The BCR(KBTBD8) complex acts by mediating monoubiquitination of NOLC1 and TCOF1: monoubiqui
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00651 BTB 39 147 BTB/POZ domain Domain
PF07707 BACK 152 254 BTB And C-terminal Kelch Domain
PF01344 Kelch_1 330 377 Kelch motif Repeat
PF01344 Kelch_1 379 428 Kelch motif Repeat
PF01344 Kelch_1 470 516 Kelch motif Repeat
Sequence
MAASADLSKSSPTPNGIPSSDPASDAMDPFHACSILKQLKTMYDEGQLTDIVVEVDHGKT
FSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEAESMDLVLNYAYTSRVILTEANV
QALFTAASIFQIPSIQDQCAKYMISHL
DPQNSIGVFIFADHYGHQELGDRSKEYIRKKFL
CVTKEQEFLQLTKDQLISILDSDDLNVDREEHVYESIIRWFEHEQNEREVHLPEIFAKCI
RFPLMEDTFIEKIP
PQFAQAIAKSCVEKGPSNTNGCTQRLGMTASEMIICFDAAHKHSGK
KQTVPCLDIVTGRVFKLCKPPNDLREVGILVSPDNDIYIAGGYRPSSSEVSIDHKAENDF
WMYDHSTNRWLSKPSLL
RARIGCKLVYCCGKMYAIGGRVYEGDGRNSLKSVECYDSRENC
WTTVCAMP
VAMEFHNAVEYKEKIYVLQGEFFLFYEPQKDYWGFLTPMTVPRIQGLAAVYK
DSIYYIAGTCGNHQRMFTVEAYDIELNKWTRKKDFP
CDQSINPYLKLVLFQNKLHLFVRA
TQVTVEEHVFRTSRKNSLYQYDDIADQWMKVYETPDRLWDLGRHFECAVAKLYPQCLQKV
L
Sequence length 601
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Neddylation
Antigen processing: Ubiquitination & Proteasome degradation