Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	84539
Gene name Gene Name - the full gene name approved by the HGNC.	Melanin concentrating hormone receptor 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	MCHR2
Synonyms (NCBI Gene) Gene synonyms aliases	GPR145, GPRv17, MCH-2R, MCH-R2, MCH2, MCH2R, MCHR-2, SLT
Chromosome Chromosome number	6
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	6q16.2

Show/Hide all(82)

miRTarBase ID	miRNA	Experiments	Reference
MIRT018648	hsa-miR-335-5p	Microarray	18185580
MIRT1137155	hsa-miR-3145-5p	CLIP-seq
MIRT1137156	hsa-miR-3691-3p	CLIP-seq
MIRT1137157	hsa-miR-151-3p	CLIP-seq
MIRT1137158	hsa-miR-4662a-5p	CLIP-seq
MIRT1137159	hsa-miR-590-3p	CLIP-seq
MIRT2039036	hsa-miR-106a	CLIP-seq
MIRT2039037	hsa-miR-106b	CLIP-seq
MIRT2039038	hsa-miR-150	CLIP-seq
MIRT2039039	hsa-miR-17	CLIP-seq
MIRT2039040	hsa-miR-20a	CLIP-seq
MIRT2039041	hsa-miR-20b	CLIP-seq
MIRT2039042	hsa-miR-302a	CLIP-seq
MIRT2039043	hsa-miR-302b	CLIP-seq
MIRT2039044	hsa-miR-302c	CLIP-seq
MIRT2039045	hsa-miR-302d	CLIP-seq
MIRT2039046	hsa-miR-302e	CLIP-seq
MIRT2039047	hsa-miR-3130-3p	CLIP-seq
MIRT2039048	hsa-miR-372	CLIP-seq
MIRT2039049	hsa-miR-373	CLIP-seq
MIRT2039050	hsa-miR-4252	CLIP-seq
MIRT2039051	hsa-miR-4438	CLIP-seq
MIRT2039052	hsa-miR-4731-5p	CLIP-seq
MIRT2039053	hsa-miR-5095	CLIP-seq
MIRT2039054	hsa-miR-512-3p	CLIP-seq
MIRT2039055	hsa-miR-519d	CLIP-seq
MIRT2039056	hsa-miR-520a-3p	CLIP-seq
MIRT2039057	hsa-miR-520b	CLIP-seq
MIRT2039058	hsa-miR-520c-3p	CLIP-seq
MIRT2039059	hsa-miR-520d-3p	CLIP-seq
MIRT2039060	hsa-miR-520e	CLIP-seq
MIRT2039061	hsa-miR-520g	CLIP-seq
MIRT2039062	hsa-miR-520h	CLIP-seq
MIRT2039063	hsa-miR-93	CLIP-seq
MIRT2039064	hsa-miR-941	CLIP-seq
MIRT2039036	hsa-miR-106a	CLIP-seq
MIRT2039037	hsa-miR-106b	CLIP-seq
MIRT2039038	hsa-miR-150	CLIP-seq
MIRT2039039	hsa-miR-17	CLIP-seq
MIRT2039040	hsa-miR-20a	CLIP-seq
MIRT2039041	hsa-miR-20b	CLIP-seq
MIRT2269060	hsa-miR-27a	CLIP-seq
MIRT2269061	hsa-miR-27b	CLIP-seq
MIRT2039042	hsa-miR-302a	CLIP-seq
MIRT2039043	hsa-miR-302b	CLIP-seq
MIRT2039044	hsa-miR-302c	CLIP-seq
MIRT2039045	hsa-miR-302d	CLIP-seq
MIRT2039046	hsa-miR-302e	CLIP-seq
MIRT2039047	hsa-miR-3130-3p	CLIP-seq
MIRT2269062	hsa-miR-3187-3p	CLIP-seq
MIRT2039048	hsa-miR-372	CLIP-seq
MIRT2039049	hsa-miR-373	CLIP-seq
MIRT2269063	hsa-miR-380	CLIP-seq
MIRT2039050	hsa-miR-4252	CLIP-seq
MIRT2269064	hsa-miR-4435	CLIP-seq
MIRT2039051	hsa-miR-4438	CLIP-seq
MIRT2269065	hsa-miR-4463	CLIP-seq
MIRT2269066	hsa-miR-4464	CLIP-seq
MIRT2269067	hsa-miR-4494	CLIP-seq
MIRT2269068	hsa-miR-4666-5p	CLIP-seq
MIRT2269069	hsa-miR-4701-5p	CLIP-seq
MIRT2039052	hsa-miR-4731-5p	CLIP-seq
MIRT2269070	hsa-miR-4748	CLIP-seq
MIRT2269071	hsa-miR-4781-3p	CLIP-seq
MIRT2269072	hsa-miR-490-5p	CLIP-seq
MIRT2039053	hsa-miR-5095	CLIP-seq
MIRT2039054	hsa-miR-512-3p	CLIP-seq
MIRT2269073	hsa-miR-513a-5p	CLIP-seq
MIRT2039055	hsa-miR-519d	CLIP-seq
MIRT2039056	hsa-miR-520a-3p	CLIP-seq
MIRT2039057	hsa-miR-520b	CLIP-seq
MIRT2039058	hsa-miR-520c-3p	CLIP-seq
MIRT2039059	hsa-miR-520d-3p	CLIP-seq
MIRT2039060	hsa-miR-520e	CLIP-seq
MIRT2039061	hsa-miR-520g	CLIP-seq
MIRT2039062	hsa-miR-520h	CLIP-seq
MIRT2269074	hsa-miR-548s	CLIP-seq
MIRT2269075	hsa-miR-588	CLIP-seq
MIRT2039063	hsa-miR-93	CLIP-seq
MIRT2039064	hsa-miR-941	CLIP-seq
MIRT2039038	hsa-miR-150	CLIP-seq
MIRT2684735	hsa-miR-640	CLIP-seq

Show/Hide all(5)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005886	Component	Plasma membrane	TAS
GO:0005887	Component	Integral component of plasma membrane	IBA	21873635
GO:0007186	Process	G protein-coupled receptor signaling pathway	TAS
GO:0007218	Process	Neuropeptide signaling pathway	IBA	21873635
GO:0008528	Function	G protein-coupled peptide receptor activity	IBA	21873635

MIM	HGNC	e!Ensembl
606111	20867	ENSG00000152034

Protein

UniProt ID

Q969V1

Protein name

Melanin-concentrating hormone receptor 2 (MCH receptor 2) (MCH-R2) (MCHR-2) (G-protein coupled receptor 145) (GPRv17) (MCH-2R) (MCH2) (MCH2R)

Protein function

Receptor for melanin-concentrating hormone, coupled to G proteins that activate phosphoinositide hydrolysis.

PDB

8WST

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00001	7tm_1	51 → 306	7 transmembrane receptor (rhodopsin family)	Family

Tissue specificity

TISSUE SPECIFICITY: Specifically expressed in the brain, with highest levels in cerebral cortex, hippocampus and amygdala. No expression detected in the cerebellum, thalamus or hypothalamus.

Sequence

MNPFHASCWNTSAELLNKSWNKEFAYQTASVVDTVILPSMIGIICSTGLVGNILIVFTII
RSRKKTVPDIYICNLAVADLVHIVGMPFLIHQWARGGEWVFGGPLCTIITSLDTCNQFAC
SAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKFKDG
VESCAFDLTSPDDVLWYTLYLTITTFFFPLPLILVCYILILCYTWEMYQQNKDARCCNPS
VPKQRVMKLTKMVLVLVVVFILSAAPYHVIQLVNLQMEQPTLAFYVGYYLSICLSYASSS
INPFLYILLSGNFQKRLPQIQRRATEKEINNMGNTLKSHF

Sequence length

340

Interactions

View interactions

	KEGG		Reactome
	Neuroactive ligand-receptor interaction Hormone signaling		Peptide ligand-binding receptors G alpha (q) signalling events G alpha (i) signalling events

Show/Hide Causal Diseases (1)

Disease term	Disease name	dbSNP ID	References
Causal
Schizophrenia	Schizophrenia	rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346 View all (12 more)	19502010

Show/Hide Unknown Diseases (3)

Disease term	Disease name	Evidence	Source
Unknown
Breast Cancer	Breast Cancer	Importantly, breast cancer patients bearing PRC2 LOF mutations displayed significantly worse prognosis compared with PRC2 wild-type patients	GWAS, CBGDA
Cystitis	Cystitis		GWAS
Glioblastoma	Glioblastoma	CRISPR screening of E3 ubiquitin ligases reveals Ring Finger Protein 185 as a novel tumor suppressor in glioblastoma repressed by promoter hypermethylation and miR-587	GWAS, CBGDA

Show/Hide Text Mining Associations (8)

Disease Name	Relationship Type	References
Associations from Text Mining
Binge Eating Disorder	Associate	37550530
Colorectal Neoplasms	Associate	35545337
Depressive Disorder	Associate	26461262
Erectile Dysfunction	Associate	30583798
Escherichia coli Infections	Associate	1639518
Gastrointestinal Diseases	Associate	1639518
Hemolytic Uremic Syndrome	Associate	1629337
Osteoporosis	Associate	38484114

MCHR2 (melanin concentrating hormone receptor 2)