Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID	84532
Gene name	Acyl-CoA synthetase short chain family member 1
Gene symbol	ACSS1
Synonyms (NCBI Gene)	ACAS2LACECS1AceCS2L
Chromosome	20
Chromosome location	20p11.21
Summary	This gene encodes a mitochondrial acetyl-CoA synthetase enzyme. A similar protein in mice plays an important role in the tricarboxylic acid cycle by catalyzing the conversion of acetate to acetyl CoA. Alternatively spliced transcript variants encoding mul

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miRTarBase ID	miRNA	Experiments	Reference
MIRT025533	hsa-miR-34a-5p	Proteomics	21566225
MIRT025533	hsa-miR-34a-5p	Proteomics	21566225
MIRT050224	hsa-miR-25-3p	CLASH	23622248
MIRT046084	hsa-miR-125b-5p	CLASH	23622248
MIRT045786	hsa-miR-191-5p	CLASH	23622248
MIRT763705	hsa-miR-1915	CLIP-seq
MIRT763706	hsa-miR-224	CLIP-seq
MIRT763707	hsa-miR-23a	CLIP-seq
MIRT763708	hsa-miR-23b	CLIP-seq
MIRT763709	hsa-miR-23c	CLIP-seq
MIRT763710	hsa-miR-3667-3p	CLIP-seq
MIRT763711	hsa-miR-3918	CLIP-seq
MIRT763712	hsa-miR-4311	CLIP-seq
MIRT763713	hsa-miR-4494	CLIP-seq
MIRT763714	hsa-miR-4512	CLIP-seq
MIRT763715	hsa-miR-4685-5p	CLIP-seq
MIRT763716	hsa-miR-4704-5p	CLIP-seq
MIRT763717	hsa-miR-4726-3p	CLIP-seq
MIRT763718	hsa-miR-4733-5p	CLIP-seq
MIRT763719	hsa-miR-499a-5p	CLIP-seq
MIRT763720	hsa-miR-617	CLIP-seq
MIRT1925081	hsa-miR-147	CLIP-seq
MIRT763705	hsa-miR-1915	CLIP-seq
MIRT1925082	hsa-miR-3151	CLIP-seq
MIRT1925083	hsa-miR-3192	CLIP-seq
MIRT1925084	hsa-miR-3194-5p	CLIP-seq
MIRT1925085	hsa-miR-342-5p	CLIP-seq
MIRT763710	hsa-miR-3667-3p	CLIP-seq
MIRT1925086	hsa-miR-3691-3p	CLIP-seq
MIRT1925087	hsa-miR-3911	CLIP-seq
MIRT763711	hsa-miR-3918	CLIP-seq
MIRT1925088	hsa-miR-4314	CLIP-seq
MIRT1925089	hsa-miR-4447	CLIP-seq
MIRT1925090	hsa-miR-4472	CLIP-seq
MIRT1925091	hsa-miR-4488	CLIP-seq
MIRT763714	hsa-miR-4512	CLIP-seq
MIRT1925092	hsa-miR-4535	CLIP-seq
MIRT1925093	hsa-miR-4639-5p	CLIP-seq
MIRT1925094	hsa-miR-4646-5p	CLIP-seq
MIRT1925095	hsa-miR-4651	CLIP-seq
MIRT1925096	hsa-miR-4664-5p	CLIP-seq
MIRT763715	hsa-miR-4685-5p	CLIP-seq
MIRT1925097	hsa-miR-4697-5p	CLIP-seq
MIRT763717	hsa-miR-4726-3p	CLIP-seq
MIRT763718	hsa-miR-4733-5p	CLIP-seq
MIRT1925098	hsa-miR-4776-5p	CLIP-seq
MIRT1925099	hsa-miR-491-5p	CLIP-seq
MIRT1925100	hsa-miR-492	CLIP-seq
MIRT1925101	hsa-miR-516b	CLIP-seq
MIRT1925102	hsa-miR-608	CLIP-seq
MIRT1925103	hsa-miR-644	CLIP-seq
MIRT2166534	hsa-miR-1193	CLIP-seq
MIRT2166535	hsa-miR-1225-5p	CLIP-seq
MIRT2166536	hsa-miR-1226	CLIP-seq
MIRT2166537	hsa-miR-1243	CLIP-seq
MIRT2166538	hsa-miR-125a-5p	CLIP-seq
MIRT2166539	hsa-miR-125b	CLIP-seq
MIRT2166540	hsa-miR-1266	CLIP-seq
MIRT2166541	hsa-miR-1291	CLIP-seq
MIRT2166542	hsa-miR-1299	CLIP-seq
MIRT2166543	hsa-miR-1343	CLIP-seq
MIRT2166544	hsa-miR-136	CLIP-seq
MIRT1925081	hsa-miR-147	CLIP-seq
MIRT2166545	hsa-miR-1470	CLIP-seq
MIRT2166546	hsa-miR-151-3p	CLIP-seq
MIRT763706	hsa-miR-224	CLIP-seq
MIRT2166547	hsa-miR-2277-3p	CLIP-seq
MIRT2166548	hsa-miR-27a	CLIP-seq
MIRT2166549	hsa-miR-27b	CLIP-seq
MIRT2166550	hsa-miR-3064-3p	CLIP-seq
MIRT2166551	hsa-miR-3065-3p	CLIP-seq
MIRT2166552	hsa-miR-3117-5p	CLIP-seq
MIRT2166553	hsa-miR-3132	CLIP-seq
MIRT2166554	hsa-miR-3141	CLIP-seq
MIRT1925082	hsa-miR-3151	CLIP-seq
MIRT2166555	hsa-miR-3179	CLIP-seq
MIRT2166556	hsa-miR-3185	CLIP-seq
MIRT1925083	hsa-miR-3192	CLIP-seq
MIRT2166557	hsa-miR-335	CLIP-seq
MIRT1925085	hsa-miR-342-5p	CLIP-seq
MIRT2166558	hsa-miR-3529	CLIP-seq
MIRT2166559	hsa-miR-3607-5p	CLIP-seq
MIRT2166560	hsa-miR-3613-3p	CLIP-seq
MIRT2166561	hsa-miR-3616-3p	CLIP-seq
MIRT2166562	hsa-miR-3622a-3p	CLIP-seq
MIRT2166563	hsa-miR-3622b-3p	CLIP-seq
MIRT2166564	hsa-miR-3649	CLIP-seq
MIRT763710	hsa-miR-3667-3p	CLIP-seq
MIRT2166565	hsa-miR-3677-5p	CLIP-seq
MIRT1925086	hsa-miR-3691-3p	CLIP-seq
MIRT2166566	hsa-miR-379	CLIP-seq
MIRT1925087	hsa-miR-3911	CLIP-seq
MIRT2166567	hsa-miR-3922-5p	CLIP-seq
MIRT2166568	hsa-miR-409-3p	CLIP-seq
MIRT2166569	hsa-miR-4263	CLIP-seq
MIRT2166570	hsa-miR-4284	CLIP-seq
MIRT763712	hsa-miR-4311	CLIP-seq
MIRT1925088	hsa-miR-4314	CLIP-seq
MIRT2166571	hsa-miR-4318	CLIP-seq
MIRT2166572	hsa-miR-4319	CLIP-seq
MIRT2166573	hsa-miR-4428	CLIP-seq
MIRT1925089	hsa-miR-4447	CLIP-seq
MIRT2166574	hsa-miR-4457	CLIP-seq
MIRT2166575	hsa-miR-4463	CLIP-seq
MIRT2166576	hsa-miR-4469	CLIP-seq
MIRT1925090	hsa-miR-4472	CLIP-seq
MIRT2166577	hsa-miR-4476	CLIP-seq
MIRT2166578	hsa-miR-4481	CLIP-seq
MIRT1925091	hsa-miR-4488	CLIP-seq
MIRT2166579	hsa-miR-4499	CLIP-seq
MIRT2166580	hsa-miR-4518	CLIP-seq
MIRT2166581	hsa-miR-4528	CLIP-seq
MIRT1925092	hsa-miR-4535	CLIP-seq
MIRT2166582	hsa-miR-4635	CLIP-seq
MIRT1925094	hsa-miR-4646-5p	CLIP-seq
MIRT1925095	hsa-miR-4651	CLIP-seq
MIRT1925096	hsa-miR-4664-5p	CLIP-seq
MIRT2166583	hsa-miR-4666-5p	CLIP-seq
MIRT2166584	hsa-miR-4667-3p	CLIP-seq
MIRT2166585	hsa-miR-4667-5p	CLIP-seq
MIRT2166586	hsa-miR-4682	CLIP-seq
MIRT1925097	hsa-miR-4697-5p	CLIP-seq
MIRT2166587	hsa-miR-4700-5p	CLIP-seq
MIRT2166588	hsa-miR-4709-3p	CLIP-seq
MIRT2166589	hsa-miR-4721	CLIP-seq
MIRT2166590	hsa-miR-4724-3p	CLIP-seq
MIRT2166591	hsa-miR-4731-3p	CLIP-seq
MIRT2166592	hsa-miR-4732-3p	CLIP-seq
MIRT2166593	hsa-miR-4733-3p	CLIP-seq
MIRT2166594	hsa-miR-4745-5p	CLIP-seq
MIRT2166595	hsa-miR-4757-5p	CLIP-seq
MIRT2166596	hsa-miR-4768-3p	CLIP-seq
MIRT1925098	hsa-miR-4776-5p	CLIP-seq
MIRT2166597	hsa-miR-4782-5p	CLIP-seq
MIRT2166598	hsa-miR-4789-5p	CLIP-seq
MIRT2166599	hsa-miR-4797-5p	CLIP-seq
MIRT2166600	hsa-miR-4801	CLIP-seq
MIRT2166601	hsa-miR-4803	CLIP-seq
MIRT2166602	hsa-miR-483-3p	CLIP-seq
MIRT2166603	hsa-miR-486-3p	CLIP-seq
MIRT1925099	hsa-miR-491-5p	CLIP-seq
MIRT1925100	hsa-miR-492	CLIP-seq
MIRT2166604	hsa-miR-510	CLIP-seq
MIRT2166605	hsa-miR-512-5p	CLIP-seq
MIRT2166606	hsa-miR-513a-5p	CLIP-seq
MIRT1925101	hsa-miR-516b	CLIP-seq
MIRT2166607	hsa-miR-548b-3p	CLIP-seq
MIRT2166608	hsa-miR-548c-3p	CLIP-seq
MIRT2166609	hsa-miR-576-5p	CLIP-seq
MIRT2166610	hsa-miR-582-3p	CLIP-seq
MIRT2166611	hsa-miR-583	CLIP-seq
MIRT2166612	hsa-miR-606	CLIP-seq
MIRT1925102	hsa-miR-608	CLIP-seq
MIRT2166613	hsa-miR-637	CLIP-seq
MIRT1925103	hsa-miR-644	CLIP-seq
MIRT2166614	hsa-miR-663b	CLIP-seq
MIRT2166615	hsa-miR-670	CLIP-seq
MIRT2166616	hsa-miR-7	CLIP-seq
MIRT2166617	hsa-miR-759	CLIP-seq
MIRT2166618	hsa-miR-885-5p	CLIP-seq
MIRT2166619	hsa-miR-936	CLIP-seq
MIRT2166556	hsa-miR-3185	CLIP-seq
MIRT2166582	hsa-miR-4635	CLIP-seq
MIRT2166588	hsa-miR-4709-3p	CLIP-seq
MIRT2166597	hsa-miR-4782-5p	CLIP-seq

Show/Hide all (27)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0003987	Function	Acetate-CoA ligase activity	EXP	16788062
GO:0003987	Function	Acetate-CoA ligase activity	IBA
GO:0003987	Function	Acetate-CoA ligase activity	IDA	16788062
GO:0003987	Function	Acetate-CoA ligase activity	IEA
GO:0005515	Function	Protein binding	IPI	16788062, 19535340, 25416956, 32296183
GO:0005524	Function	ATP binding	IEA
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IBA
GO:0005739	Component	Mitochondrion	IEA
GO:0005759	Component	Mitochondrial matrix	IDA	16788062
GO:0005759	Component	Mitochondrial matrix	IEA
GO:0005759	Component	Mitochondrial matrix	TAS
GO:0006068	Process	Ethanol catabolic process	TAS
GO:0006085	Process	Acetyl-CoA biosynthetic process	IBA
GO:0006085	Process	Acetyl-CoA biosynthetic process	IDA	16788062
GO:0006085	Process	Acetyl-CoA biosynthetic process	IEA
GO:0006629	Process	Lipid metabolic process	IEA
GO:0016208	Function	AMP binding	IEA
GO:0016405	Function	CoA-ligase activity	IEA
GO:0016874	Function	Ligase activity	IEA
GO:0016878	Function	Acid-thiol ligase activity	IEA
GO:0019413	Process	Acetate biosynthetic process	IEA
GO:0019427	Process	Acetyl-CoA biosynthetic process from acetate	IEA
GO:0019542	Process	Propionate biosynthetic process	IEA
GO:0050218	Function	Propionate-CoA ligase activity	IEA
GO:0050218	Function	Propionate-CoA ligase activity	ISS

MIM	HGNC	e!Ensembl
614355	16091	ENSG00000154930

Q9NUB1

Protein name

Acetyl-coenzyme A synthetase 2-like, mitochondrial (EC 6.2.1.1) (Acetate--CoA ligase 2) (Acetyl-CoA synthetase 2) (AceCS2) (Acyl-CoA synthetase short-chain family member 1) (Propionate--CoA ligase) (EC 6.2.1.17)

Protein function

Catalyzes the synthesis of acetyl-CoA from short-chain fatty acids (PubMed:16788062). Acetate is the preferred substrate (PubMed:16788062). Can also utilize propionate with a much lower affinity (By similarity). Provides acetyl-CoA that is utili

PDB

3GLR , 3GLT , 3GLU , 4BVE , 4BVF , 4BVG , 4C78 , 5Y4H , 5YTK

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF16177	ACAS_N	58 → 114	Acetyl-coenzyme A synthetase N-terminus	Family
PF00501	AMP-binding	115 → 556	AMP-binding enzyme	Family
PF13193	AMP-binding_C	564 → 642	AMP-binding enzyme C-terminal domain	Domain

Sequence

MAARTLGRGVGRLLGSLRGLSGQPARPPCGVSAPRRAASGPSGSAPAVAAAAAQPGSYPA
LSAQAAREPAAFWGPLARDTLVWDTPYHTVWDCDFSTGKIGWFLGGQLNVSVNCLDQHVR
KSPESVALIWERDEPGTEVRITYRELLETTCRLANTLKRHGVHRGDRVAIYMPVSPLAVA
AMLACARIGAVHTVIFAGFSAESLAGRINDAKCKVVITFNQGLRGGRVVELKKIVDEAVK
HCPTVQHVLVAHRTDNKVHMGDLDVPLEQEMAKEDPVCAPESMGSEDMLFMLYTSGSTGM
PKGIVHTQAGYLLYAALTHKLVFDHQPGDIFGCVADIGWITGHSYVVYGPLCNGATSVLF
ESTPVYPNAGRYWETVERLKINQFYGAPTAVRLLLKYGDAWVKKYDRSSLRTLGSVGEPI
NCEAWEWLHRVVGDSRCTLVDTWWQTETGGICIAPRPSEEGAEILPAMAMRPFFGIVPVL
MDEKGSVVEGSNVSGALCISQAWPGMARTIYGDHQRFVDAYFKAYPGYYFTGDGAYRTEG
GYYQITGRMDDVINISGHRLGTAEIEDAIADHPAVPESAVIGYPHDIKGEAAFAFIVVKD
SAGDSDVVVQELKSMVATKIAKYAVPDEILVVKRLPKTRSGKVMRRLLRKIITSEAQELG
DTTTLEDPSIIAEILSVYQKCKDKQAAAK

Sequence length

689

Interactions

View interactions

	KEGG		Reactome
	Glycolysis / Gluconeogenesis Pyruvate metabolism Glyoxylate and dicarboxylate metabolism Propanoate metabolism Metabolic pathways Carbon metabolism		Ethanol oxidation

ACSS1 (acyl-CoA synthetase short chain family member 1)