Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	84515
Gene name	Minichromosome maintenance 8 homologous recombination repair factor
Gene symbol	MCM8
Synonyms (NCBI Gene)	C20orf154POF10dJ967N21.5
Chromosome	20
Chromosome location	20p12.3
Summary	The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the mini-chromosome maintenance prot

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SNP ID	Visualize variation	Clinical significance	Consequence
rs138761187	G>A	Pathogenic	Genic downstream transcript variant, splice acceptor variant
rs201115244	C>T	Pathogenic	Coding sequence variant, non coding transcript variant, stop gained
rs606231343	C>G	Pathogenic, not-provided	Coding sequence variant, genic upstream transcript variant, non coding transcript variant, missense variant
rs777947820	TTGA>-	Pathogenic	Non coding transcript variant, coding sequence variant, genic upstream transcript variant, frameshift variant
rs869320753	->TA	Pathogenic	Non coding transcript variant, coding sequence variant, frameshift variant

404

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miRTarBase ID	miRNA	Experiments	Reference
MIRT016553	hsa-miR-193b-3p	Microarray	20304954
MIRT020992	hsa-miR-155-5p	Reporter assay;Other	20584899
MIRT048686	hsa-miR-99a-5p	CLASH	23622248
MIRT721969	hsa-miR-216a-5p	HITS-CLIP	19536157
MIRT721968	hsa-miR-148b-5p	HITS-CLIP	19536157
MIRT721967	hsa-miR-6874-3p	HITS-CLIP	19536157
MIRT721966	hsa-miR-1285-5p	HITS-CLIP	19536157
MIRT721965	hsa-miR-4762-5p	HITS-CLIP	19536157
MIRT721964	hsa-miR-584-3p	HITS-CLIP	19536157
MIRT721962	hsa-miR-4277	HITS-CLIP	19536157
MIRT721963	hsa-miR-20a-3p	HITS-CLIP	19536157
MIRT721961	hsa-miR-544a	HITS-CLIP	19536157
MIRT625688	hsa-miR-3120-5p	HITS-CLIP	23313552
MIRT625687	hsa-miR-4711-3p	HITS-CLIP	23313552
MIRT608304	hsa-miR-6867-5p	HITS-CLIP	23313552
MIRT625686	hsa-miR-6888-3p	HITS-CLIP	23313552
MIRT608300	hsa-miR-574-5p	HITS-CLIP	23313552
MIRT631414	hsa-miR-8062	HITS-CLIP	23824327
MIRT618679	hsa-miR-3677-5p	HITS-CLIP	23824327
MIRT662630	hsa-miR-6513-3p	HITS-CLIP	23824327
MIRT678313	hsa-miR-1247-3p	HITS-CLIP	23824327
MIRT678312	hsa-miR-4532	HITS-CLIP	23824327
MIRT631413	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT631412	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT631411	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT618678	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT631410	hsa-miR-1976	HITS-CLIP	23824327
MIRT618676	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT618677	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT618675	hsa-miR-4727-3p	HITS-CLIP	23824327
MIRT618674	hsa-miR-4460	HITS-CLIP	23824327
MIRT662629	hsa-miR-1297	HITS-CLIP	23824327
MIRT662628	hsa-miR-26a-5p	HITS-CLIP	23824327
MIRT662627	hsa-miR-26b-5p	HITS-CLIP	23824327
MIRT662626	hsa-miR-4465	HITS-CLIP	23824327
MIRT631409	hsa-miR-4279	HITS-CLIP	23824327
MIRT625688	hsa-miR-3120-5p	HITS-CLIP	23824327
MIRT625687	hsa-miR-4711-3p	HITS-CLIP	23824327
MIRT608304	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT625686	hsa-miR-6888-3p	HITS-CLIP	23824327
MIRT608300	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT631414	hsa-miR-8062	HITS-CLIP	23824327
MIRT618679	hsa-miR-3677-5p	HITS-CLIP	23824327
MIRT662630	hsa-miR-6513-3p	HITS-CLIP	23824327
MIRT631413	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT631412	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT631411	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT631410	hsa-miR-1976	HITS-CLIP	23824327
MIRT618675	hsa-miR-4727-3p	HITS-CLIP	23824327
MIRT618674	hsa-miR-4460	HITS-CLIP	23824327
MIRT662629	hsa-miR-1297	HITS-CLIP	23824327
MIRT662628	hsa-miR-26a-5p	HITS-CLIP	23824327
MIRT662627	hsa-miR-26b-5p	HITS-CLIP	23824327
MIRT662626	hsa-miR-4465	HITS-CLIP	23824327
MIRT662625	hsa-miR-1267	HITS-CLIP	23824327
MIRT662624	hsa-miR-367-5p	HITS-CLIP	23824327
MIRT662623	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT662622	hsa-miR-3135b	HITS-CLIP	23824327
MIRT662621	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT662620	hsa-miR-3652	HITS-CLIP	23824327
MIRT662619	hsa-miR-4430	HITS-CLIP	23824327
MIRT662618	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT662617	hsa-miR-6501-5p	HITS-CLIP	23824327
MIRT662616	hsa-miR-4423-5p	HITS-CLIP	23824327
MIRT662615	hsa-miR-744-3p	HITS-CLIP	23824327
MIRT662614	hsa-miR-5698	HITS-CLIP	23824327
MIRT631414	hsa-miR-8062	HITS-CLIP	23824327
MIRT618679	hsa-miR-3677-5p	HITS-CLIP	23824327
MIRT631413	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT631412	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT631411	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT618678	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT631410	hsa-miR-1976	HITS-CLIP	23824327
MIRT618676	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT618677	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT618675	hsa-miR-4727-3p	HITS-CLIP	23824327
MIRT618674	hsa-miR-4460	HITS-CLIP	23824327
MIRT631409	hsa-miR-4279	HITS-CLIP	23824327
MIRT625688	hsa-miR-3120-5p	HITS-CLIP	23824327
MIRT625687	hsa-miR-4711-3p	HITS-CLIP	23824327
MIRT608304	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT625686	hsa-miR-6888-3p	HITS-CLIP	23824327
MIRT608300	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT618679	hsa-miR-3677-5p	HITS-CLIP	23824327
MIRT618678	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT618676	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT618677	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT618675	hsa-miR-4727-3p	HITS-CLIP	23824327
MIRT618674	hsa-miR-4460	HITS-CLIP	23824327
MIRT608305	hsa-miR-892a	HITS-CLIP	24906430
MIRT608304	hsa-miR-6867-5p	HITS-CLIP	24906430
MIRT608302	hsa-miR-3136-5p	HITS-CLIP	24906430
MIRT608303	hsa-miR-4439	HITS-CLIP	24906430
MIRT608301	hsa-miR-943	HITS-CLIP	24906430
MIRT608300	hsa-miR-574-5p	HITS-CLIP	24906430
MIRT515837	hsa-miR-6888-5p	PAR-CLIP	21572407
MIRT515838	hsa-miR-4695-5p	PAR-CLIP	21572407
MIRT515836	hsa-miR-4779	PAR-CLIP	21572407
MIRT515835	hsa-miR-4768-3p	PAR-CLIP	21572407
MIRT515834	hsa-miR-665	PAR-CLIP	21572407
MIRT515833	hsa-miR-6840-3p	PAR-CLIP	21572407
MIRT515832	hsa-miR-1225-3p	PAR-CLIP	21572407
MIRT515831	hsa-miR-1233-3p	PAR-CLIP	21572407
MIRT515830	hsa-miR-4683	PAR-CLIP	21572407
MIRT515829	hsa-miR-6894-5p	PAR-CLIP	21572407
MIRT515828	hsa-miR-4266	PAR-CLIP	21572407
MIRT515827	hsa-miR-6807-5p	PAR-CLIP	21572407
MIRT515826	hsa-miR-1273e	PAR-CLIP	21572407
MIRT515837	hsa-miR-6888-5p	PAR-CLIP	23446348
MIRT515838	hsa-miR-4695-5p	PAR-CLIP	23446348
MIRT515836	hsa-miR-4779	PAR-CLIP	23446348
MIRT515835	hsa-miR-4768-3p	PAR-CLIP	23446348
MIRT515834	hsa-miR-665	PAR-CLIP	23446348
MIRT515833	hsa-miR-6840-3p	PAR-CLIP	23446348
MIRT515832	hsa-miR-1225-3p	PAR-CLIP	23446348
MIRT515831	hsa-miR-1233-3p	PAR-CLIP	23446348
MIRT515830	hsa-miR-4683	PAR-CLIP	23446348
MIRT515829	hsa-miR-6894-5p	PAR-CLIP	23446348
MIRT515828	hsa-miR-4266	PAR-CLIP	23446348
MIRT515827	hsa-miR-6807-5p	PAR-CLIP	23446348
MIRT515826	hsa-miR-1273e	PAR-CLIP	23446348
MIRT020992	hsa-miR-155-5p	HITS-CLIP	22473208
MIRT440265	hsa-miR-374a-5p	HITS-CLIP	22473208
MIRT020992	hsa-miR-155-5p	HITS-CLIP	22473208
MIRT440265	hsa-miR-374a-5p	HITS-CLIP	22473208
MIRT662625	hsa-miR-1267	PAR-CLIP	27292025
MIRT662625	hsa-miR-1267	PAR-CLIP	27292025
MIRT662618	hsa-miR-143-5p	PAR-CLIP	27292025
MIRT662618	hsa-miR-143-5p	PAR-CLIP	27292025
MIRT662622	hsa-miR-3135b	PAR-CLIP	27292025
MIRT662622	hsa-miR-3135b	PAR-CLIP	27292025
MIRT662620	hsa-miR-3652	PAR-CLIP	27292025
MIRT662620	hsa-miR-3652	PAR-CLIP	27292025
MIRT662624	hsa-miR-367-5p	PAR-CLIP	27292025
MIRT662624	hsa-miR-367-5p	PAR-CLIP	27292025
MIRT662616	hsa-miR-4423-5p	PAR-CLIP	27292025
MIRT662616	hsa-miR-4423-5p	PAR-CLIP	27292025
MIRT662619	hsa-miR-4430	PAR-CLIP	27292025
MIRT662619	hsa-miR-4430	PAR-CLIP	27292025
MIRT662621	hsa-miR-504-3p	PAR-CLIP	27292025
MIRT662621	hsa-miR-504-3p	PAR-CLIP	27292025
MIRT662614	hsa-miR-5698	PAR-CLIP	27292025
MIRT662614	hsa-miR-5698	PAR-CLIP	27292025
MIRT662623	hsa-miR-6499-3p	PAR-CLIP	27292025
MIRT662623	hsa-miR-6499-3p	PAR-CLIP	27292025
MIRT662617	hsa-miR-6501-5p	PAR-CLIP	27292025
MIRT662617	hsa-miR-6501-5p	PAR-CLIP	27292025
MIRT662615	hsa-miR-744-3p	PAR-CLIP	27292025
MIRT662615	hsa-miR-744-3p	PAR-CLIP	27292025
MIRT575583	hsa-miR-3120-5p	HITS-CLIP	27418678
MIRT575583	hsa-miR-3120-5p	HITS-CLIP	27418678
MIRT575583	hsa-miR-3120-5p	HITS-CLIP	27418678
MIRT608302	hsa-miR-3136-5p	HITS-CLIP	27418678
MIRT608302	hsa-miR-3136-5p	HITS-CLIP	27418678
MIRT608302	hsa-miR-3136-5p	HITS-CLIP	27418678
MIRT608302	hsa-miR-3136-5p	HITS-CLIP	27418678
MIRT608302	hsa-miR-3136-5p	HITS-CLIP	27418678
MIRT608303	hsa-miR-4439	HITS-CLIP	27418678
MIRT608303	hsa-miR-4439	HITS-CLIP	27418678
MIRT608303	hsa-miR-4439	HITS-CLIP	27418678
MIRT608303	hsa-miR-4439	HITS-CLIP	27418678
MIRT608303	hsa-miR-4439	HITS-CLIP	27418678
MIRT575582	hsa-miR-4711-3p	HITS-CLIP	27418678
MIRT575582	hsa-miR-4711-3p	HITS-CLIP	27418678
MIRT575582	hsa-miR-4711-3p	HITS-CLIP	27418678
MIRT575579	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT575579	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT575579	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT575579	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT575579	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT575579	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT575581	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT575581	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT575581	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT575581	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT575581	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT575581	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT575580	hsa-miR-6888-3p	HITS-CLIP	27418678
MIRT575580	hsa-miR-6888-3p	HITS-CLIP	27418678
MIRT575580	hsa-miR-6888-3p	HITS-CLIP	27418678
MIRT608305	hsa-miR-892a	HITS-CLIP	27418678
MIRT608305	hsa-miR-892a	HITS-CLIP	27418678
MIRT608305	hsa-miR-892a	HITS-CLIP	27418678
MIRT608305	hsa-miR-892a	HITS-CLIP	27418678
MIRT608305	hsa-miR-892a	HITS-CLIP	27418678
MIRT608301	hsa-miR-943	HITS-CLIP	27418678
MIRT608301	hsa-miR-943	HITS-CLIP	27418678
MIRT608301	hsa-miR-943	HITS-CLIP	27418678
MIRT608301	hsa-miR-943	HITS-CLIP	27418678
MIRT608301	hsa-miR-943	HITS-CLIP	27418678
MIRT721969	hsa-miR-216a-5p	HITS-CLIP	19536157
MIRT721968	hsa-miR-148b-5p	HITS-CLIP	19536157
MIRT721967	hsa-miR-6874-3p	HITS-CLIP	19536157
MIRT721966	hsa-miR-1285-5p	HITS-CLIP	19536157
MIRT721965	hsa-miR-4762-5p	HITS-CLIP	19536157
MIRT721964	hsa-miR-584-3p	HITS-CLIP	19536157
MIRT721962	hsa-miR-4277	HITS-CLIP	19536157
MIRT721963	hsa-miR-20a-3p	HITS-CLIP	19536157
MIRT721961	hsa-miR-544a	HITS-CLIP	19536157
MIRT575583	hsa-miR-3120-5p	HITS-CLIP	23313552
MIRT575582	hsa-miR-4711-3p	HITS-CLIP	23313552
MIRT575581	hsa-miR-6867-5p	HITS-CLIP	23313552
MIRT575580	hsa-miR-6888-3p	HITS-CLIP	23313552
MIRT575579	hsa-miR-574-5p	HITS-CLIP	23313552
MIRT631414	hsa-miR-8062	HITS-CLIP	23824327
MIRT618679	hsa-miR-3677-5p	HITS-CLIP	23824327
MIRT662630	hsa-miR-6513-3p	HITS-CLIP	23824327
MIRT678313	hsa-miR-1247-3p	HITS-CLIP	23824327
MIRT678312	hsa-miR-4532	HITS-CLIP	23824327
MIRT631413	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT631412	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT631411	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT618678	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT631410	hsa-miR-1976	HITS-CLIP	23824327
MIRT618676	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT618677	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT618675	hsa-miR-4727-3p	HITS-CLIP	23824327
MIRT618674	hsa-miR-4460	HITS-CLIP	23824327
MIRT662629	hsa-miR-1297	HITS-CLIP	23824327
MIRT662628	hsa-miR-26a-5p	HITS-CLIP	23824327
MIRT662627	hsa-miR-26b-5p	HITS-CLIP	23824327
MIRT662626	hsa-miR-4465	HITS-CLIP	23824327
MIRT631409	hsa-miR-4279	HITS-CLIP	23824327
MIRT575583	hsa-miR-3120-5p	HITS-CLIP	23824327
MIRT575582	hsa-miR-4711-3p	HITS-CLIP	23824327
MIRT575581	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT575580	hsa-miR-6888-3p	HITS-CLIP	23824327
MIRT575579	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT631414	hsa-miR-8062	HITS-CLIP	23824327
MIRT618679	hsa-miR-3677-5p	HITS-CLIP	23824327
MIRT662630	hsa-miR-6513-3p	HITS-CLIP	23824327
MIRT631413	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT631412	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT631411	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT631410	hsa-miR-1976	HITS-CLIP	23824327
MIRT618675	hsa-miR-4727-3p	HITS-CLIP	23824327
MIRT618674	hsa-miR-4460	HITS-CLIP	23824327
MIRT662629	hsa-miR-1297	HITS-CLIP	23824327
MIRT662628	hsa-miR-26a-5p	HITS-CLIP	23824327
MIRT662627	hsa-miR-26b-5p	HITS-CLIP	23824327
MIRT662626	hsa-miR-4465	HITS-CLIP	23824327
MIRT662625	hsa-miR-1267	HITS-CLIP	23824327
MIRT662624	hsa-miR-367-5p	HITS-CLIP	23824327
MIRT662623	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT662622	hsa-miR-3135b	HITS-CLIP	23824327
MIRT662621	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT662620	hsa-miR-3652	HITS-CLIP	23824327
MIRT662619	hsa-miR-4430	HITS-CLIP	23824327
MIRT662618	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT662617	hsa-miR-6501-5p	HITS-CLIP	23824327
MIRT662616	hsa-miR-4423-5p	HITS-CLIP	23824327
MIRT662615	hsa-miR-744-3p	HITS-CLIP	23824327
MIRT662614	hsa-miR-5698	HITS-CLIP	23824327
MIRT631414	hsa-miR-8062	HITS-CLIP	23824327
MIRT618679	hsa-miR-3677-5p	HITS-CLIP	23824327
MIRT631413	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT631412	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT631411	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT618678	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT631410	hsa-miR-1976	HITS-CLIP	23824327
MIRT618676	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT618677	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT618675	hsa-miR-4727-3p	HITS-CLIP	23824327
MIRT618674	hsa-miR-4460	HITS-CLIP	23824327
MIRT631409	hsa-miR-4279	HITS-CLIP	23824327
MIRT575583	hsa-miR-3120-5p	HITS-CLIP	23824327
MIRT575582	hsa-miR-4711-3p	HITS-CLIP	23824327
MIRT575581	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT575580	hsa-miR-6888-3p	HITS-CLIP	23824327
MIRT575579	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT618679	hsa-miR-3677-5p	HITS-CLIP	23824327
MIRT618678	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT618676	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT618677	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT618675	hsa-miR-4727-3p	HITS-CLIP	23824327
MIRT618674	hsa-miR-4460	HITS-CLIP	23824327
MIRT515837	hsa-miR-6888-5p	PAR-CLIP	21572407
MIRT515838	hsa-miR-4695-5p	PAR-CLIP	21572407
MIRT515836	hsa-miR-4779	PAR-CLIP	21572407
MIRT515835	hsa-miR-4768-3p	PAR-CLIP	21572407
MIRT515834	hsa-miR-665	PAR-CLIP	21572407
MIRT515833	hsa-miR-6840-3p	PAR-CLIP	21572407
MIRT515832	hsa-miR-1225-3p	PAR-CLIP	21572407
MIRT515831	hsa-miR-1233-3p	PAR-CLIP	21572407
MIRT515830	hsa-miR-4683	PAR-CLIP	21572407
MIRT515829	hsa-miR-6894-5p	PAR-CLIP	21572407
MIRT515828	hsa-miR-4266	PAR-CLIP	21572407
MIRT515827	hsa-miR-6807-5p	PAR-CLIP	21572407
MIRT515826	hsa-miR-1273e	PAR-CLIP	21572407
MIRT515837	hsa-miR-6888-5p	PAR-CLIP	23446348
MIRT515838	hsa-miR-4695-5p	PAR-CLIP	23446348
MIRT515836	hsa-miR-4779	PAR-CLIP	23446348
MIRT515835	hsa-miR-4768-3p	PAR-CLIP	23446348
MIRT515834	hsa-miR-665	PAR-CLIP	23446348
MIRT515833	hsa-miR-6840-3p	PAR-CLIP	23446348
MIRT515832	hsa-miR-1225-3p	PAR-CLIP	23446348
MIRT515831	hsa-miR-1233-3p	PAR-CLIP	23446348
MIRT515830	hsa-miR-4683	PAR-CLIP	23446348
MIRT515829	hsa-miR-6894-5p	PAR-CLIP	23446348
MIRT515828	hsa-miR-4266	PAR-CLIP	23446348
MIRT515827	hsa-miR-6807-5p	PAR-CLIP	23446348
MIRT515826	hsa-miR-1273e	PAR-CLIP	23446348
MIRT1137808	hsa-miR-1208	CLIP-seq
MIRT1137809	hsa-miR-122	CLIP-seq
MIRT1137810	hsa-miR-129-5p	CLIP-seq
MIRT1137811	hsa-miR-1302	CLIP-seq
MIRT1137812	hsa-miR-200b	CLIP-seq
MIRT1137813	hsa-miR-200c	CLIP-seq
MIRT1137814	hsa-miR-219-5p	CLIP-seq
MIRT1137815	hsa-miR-24	CLIP-seq
MIRT1137816	hsa-miR-3122	CLIP-seq
MIRT1137817	hsa-miR-3150a-5p	CLIP-seq
MIRT1137818	hsa-miR-3150b-5p	CLIP-seq
MIRT1137819	hsa-miR-3163	CLIP-seq
MIRT1137820	hsa-miR-337-3p	CLIP-seq
MIRT1137821	hsa-miR-3613-3p	CLIP-seq
MIRT1137822	hsa-miR-3650	CLIP-seq
MIRT1137823	hsa-miR-3685	CLIP-seq
MIRT1137824	hsa-miR-369-3p	CLIP-seq
MIRT1137825	hsa-miR-3714	CLIP-seq
MIRT1137826	hsa-miR-374a	CLIP-seq
MIRT1137827	hsa-miR-374b	CLIP-seq
MIRT1137828	hsa-miR-384	CLIP-seq
MIRT1137829	hsa-miR-3913-3p	CLIP-seq
MIRT1137830	hsa-miR-3913-5p	CLIP-seq
MIRT1137831	hsa-miR-4284	CLIP-seq
MIRT1137832	hsa-miR-429	CLIP-seq
MIRT1137833	hsa-miR-4298	CLIP-seq
MIRT1137834	hsa-miR-4445	CLIP-seq
MIRT1137835	hsa-miR-4457	CLIP-seq
MIRT1137836	hsa-miR-4474-3p	CLIP-seq
MIRT1137837	hsa-miR-4736	CLIP-seq
MIRT1137838	hsa-miR-4782-3p	CLIP-seq
MIRT1137839	hsa-miR-508-3p	CLIP-seq
MIRT1137840	hsa-miR-509-3p	CLIP-seq
MIRT1137841	hsa-miR-513b	CLIP-seq
MIRT1137842	hsa-miR-548an	CLIP-seq
MIRT1137843	hsa-miR-562	CLIP-seq
MIRT1137844	hsa-miR-940	CLIP-seq
MIRT1137808	hsa-miR-1208	CLIP-seq
MIRT1137810	hsa-miR-129-5p	CLIP-seq
MIRT1137811	hsa-miR-1302	CLIP-seq
MIRT1137812	hsa-miR-200b	CLIP-seq
MIRT1137813	hsa-miR-200c	CLIP-seq
MIRT1137816	hsa-miR-3122	CLIP-seq
MIRT1137819	hsa-miR-3163	CLIP-seq
MIRT2039122	hsa-miR-335	CLIP-seq
MIRT1137821	hsa-miR-3613-3p	CLIP-seq
MIRT1137824	hsa-miR-369-3p	CLIP-seq
MIRT1137825	hsa-miR-3714	CLIP-seq
MIRT1137826	hsa-miR-374a	CLIP-seq
MIRT1137827	hsa-miR-374b	CLIP-seq
MIRT1137829	hsa-miR-3913-3p	CLIP-seq
MIRT1137830	hsa-miR-3913-5p	CLIP-seq
MIRT1137832	hsa-miR-429	CLIP-seq
MIRT1137833	hsa-miR-4298	CLIP-seq
MIRT1137837	hsa-miR-4736	CLIP-seq
MIRT1137842	hsa-miR-548an	CLIP-seq
MIRT2039123	hsa-miR-627	CLIP-seq
MIRT1137844	hsa-miR-940	CLIP-seq
MIRT2269172	hsa-miR-1200	CLIP-seq
MIRT1137808	hsa-miR-1208	CLIP-seq
MIRT1137809	hsa-miR-122	CLIP-seq
MIRT2269173	hsa-miR-1229	CLIP-seq
MIRT2269174	hsa-miR-155	CLIP-seq
MIRT2269175	hsa-miR-186	CLIP-seq
MIRT1137814	hsa-miR-219-5p	CLIP-seq
MIRT1137819	hsa-miR-3163	CLIP-seq
MIRT2269176	hsa-miR-3183	CLIP-seq
MIRT1137821	hsa-miR-3613-3p	CLIP-seq
MIRT1137822	hsa-miR-3650	CLIP-seq
MIRT2269177	hsa-miR-3672	CLIP-seq
MIRT1137825	hsa-miR-3714	CLIP-seq
MIRT2269178	hsa-miR-4324	CLIP-seq
MIRT2269179	hsa-miR-4329	CLIP-seq
MIRT1137834	hsa-miR-4445	CLIP-seq
MIRT1137835	hsa-miR-4457	CLIP-seq
MIRT2269180	hsa-miR-4723-3p	CLIP-seq
MIRT1137837	hsa-miR-4736	CLIP-seq
MIRT1137838	hsa-miR-4782-3p	CLIP-seq
MIRT1137839	hsa-miR-508-3p	CLIP-seq
MIRT1137840	hsa-miR-509-3p	CLIP-seq
MIRT1137841	hsa-miR-513b	CLIP-seq
MIRT2269181	hsa-miR-544b	CLIP-seq
MIRT1137842	hsa-miR-548an	CLIP-seq
MIRT1137843	hsa-miR-562	CLIP-seq
MIRT2269182	hsa-miR-590-3p	CLIP-seq
MIRT1137844	hsa-miR-940	CLIP-seq
MIRT1137809	hsa-miR-122	CLIP-seq
MIRT2390736	hsa-miR-137	CLIP-seq
MIRT2568419	hsa-miR-1227	CLIP-seq
MIRT2568420	hsa-miR-1912	CLIP-seq
MIRT2568421	hsa-miR-3130-5p	CLIP-seq
MIRT2269177	hsa-miR-3672	CLIP-seq
MIRT2568422	hsa-miR-4482	CLIP-seq
MIRT2568423	hsa-miR-455-5p	CLIP-seq
MIRT2568424	hsa-miR-4715-3p	CLIP-seq
MIRT2568419	hsa-miR-1227	CLIP-seq
MIRT2568420	hsa-miR-1912	CLIP-seq
MIRT2568421	hsa-miR-3130-5p	CLIP-seq
MIRT2269177	hsa-miR-3672	CLIP-seq
MIRT2568422	hsa-miR-4482	CLIP-seq
MIRT2568423	hsa-miR-455-5p	CLIP-seq
MIRT2568424	hsa-miR-4715-3p	CLIP-seq

Show/Hide all (2)

Transcription factor	Regulation	Reference
E2F1	Unknown	16325355
MYCN	Activation	17826980

Show/Hide all (39)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0000724	Process	Double-strand break repair via homologous recombination	IBA
GO:0000724	Process	Double-strand break repair via homologous recombination	IEA
GO:0000724	Process	Double-strand break repair via homologous recombination	IMP	23401855
GO:0000724	Process	Double-strand break repair via homologous recombination	NAS	22771115
GO:0003677	Function	DNA binding	IEA
GO:0003682	Function	Chromatin binding	IDA	23401855
GO:0003697	Function	Single-stranded DNA binding	IBA
GO:0004386	Function	Helicase activity	IEA
GO:0005515	Function	Protein binding	IPI	22540012, 23401855, 24299456, 25036637, 26300262, 31467087, 32296183, 33961781
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	23401855, 26300262
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005694	Component	Chromosome	IEA
GO:0006260	Process	DNA replication	IGI	23401855
GO:0006281	Process	DNA repair	IEA
GO:0006974	Process	DNA damage response	IDA	22771115
GO:0006974	Process	DNA damage response	IEA
GO:0007292	Process	Female gamete generation	IEA
GO:0007292	Process	Female gamete generation	ISS
GO:0016787	Function	Hydrolase activity	IEA
GO:0016887	Function	ATP hydrolysis activity	IEA
GO:0017116	Function	Single-stranded DNA helicase activity	IBA
GO:0019899	Function	Enzyme binding	IPI	23401855, 26215093, 26300262
GO:0032406	Function	MutLbeta complex binding	IDA	26300262
GO:0032407	Function	MutSalpha complex binding	IDA	26300262
GO:0032408	Function	MutSbeta complex binding	IDA	26300262
GO:0036298	Process	Recombinational interstrand cross-link repair	IMP	23401855
GO:0042555	Component	MCM complex	IBA
GO:0048232	Process	Male gamete generation	IEA
GO:0048232	Process	Male gamete generation	ISS
GO:0050821	Process	Protein stabilization	IMP	23401855, 26215093
GO:0070716	Process	Mismatch repair involved in maintenance of fidelity involved in DNA-dependent DNA replication	NAS	26300262
GO:0071168	Process	Protein localization to chromatin	IMP	23401855
GO:0097362	Component	MCM8-MCM9 complex	IDA	22771115, 23401855, 26215093, 26300262
GO:0097362	Component	MCM8-MCM9 complex	IEA
GO:0097362	Component	MCM8-MCM9 complex	IPI	26300262

MIM	HGNC	e!Ensembl
608187	16147	ENSG00000125885

Q9UJA3

Protein name

DNA helicase MCM8 (EC 3.6.4.12) (Minichromosome maintenance 8)

Protein function

Component of the MCM8-MCM9 complex, a complex involved in the repair of double-stranded DNA breaks (DBSs) and DNA interstrand cross-links (ICLs) by homologous recombination (HR) (PubMed:23401855). Required for DNA resection by the MRE11-RAD50-NB

PDB

6L0O , 7DP3 , 7WI7 , 7YOX , 8S91 , 8S92 , 8S94

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF17207	MCM_OB	206 → 339	MCM OB domain	Domain
PF00493	MCM	389 → 613	MCM P-loop domain	Domain
PF17855	MCM_lid	664 → 748	MCM AAA-lid domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Highest levels in placenta, lung and pancreas. Low levels in skeletal muscle and kidney. Expressed in various tumors with highest levels in colon and lung cancers. {ECO:0000269|PubMed:12771218}.

Sequence

MNGEYRGRGFGRGRFQSWKRGRGGGNFSGKWREREHRPDLSKTTGKRTSEQTPQFLLSTK
TPQSMQSTLDRFIPYKGWKLYFSEVYSDSSPLIEKIQAFEKFFTRHIDLYDKDEIERKGS
ILVDFKELTEGGEVTNLIPDIATELRDAPEKTLACMGLAIHQVLTKDLERHAAELQAQEG
LSNDGETMVNVPHIHARVYNYEPLTQLKNVRANYYGKYIALRGTVVRVSNIKPLCTKMAF
LCAACGEIQSFPLPDGKYSLPTKCPVPVCRGRSFTALRSSPLTVTMDWQSIKIQELMSDD
QREAGRIPRTIECELVHDLVDSCVPGDTVTITGIVKVSNAEEGSRNKNDKCMFLLYIEAN
SISNSKGQKTKSSEDGCKHGMLMEFSLKDLYAIQEIQAEENLFKLIVNSLCPVIFGHELV
KAGLALALFGGSQKYADDKNRIPIRGDPHILVVGDPGLGKSQMLQAACNVAPRGVYVCGN
TTTTSGLTVTLSKDSSSGDFALEAGALVLGDQGICGIDEFDKMGNQHQALLEAMEQQSIS
LAKAGVVCSLPARTSIIAAANPVGGHYNKAKTVSENLKMGSALLSRFDLVFILLDTPNEH
HDHLLSEHVIAIRAGKQRTISSATVARMNSQDSNTSVLEVVSEKPLSERLKVVPGETIDP
IPHQLLRKYIGYARQYVYPRLSTEAARVLQDFYLELRKQSQRLNSSPITTRQLESLIRLT
EARARLELREEATKEDAEDIVEIMKYSMLGTYSDEFGNLDFERSQHGSGMSNRSTAKRFI
SALNNVAERTYNNIFQFHQLRQIAKELNIQVADFENFIGSLNDQGYLLKKGPKVYQLQTM

Sequence length

840

Interactions

View interactions

	Reactome
			Activation of ATR in response to replication stress CDC6 association with the ORC:origin complex CDT1 association with the CDC6:ORC:origin complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex

Show/Hide Causal Diseases (2)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Azoospermia	Likely pathogenic	rs140044814	RCV001797582
Premature ovarian failure 10	Likely pathogenic; Pathogenic	rs775156125, rs140773345, rs140044814, rs606231343, rs762416121, rs138761187, rs869320753, rs531099221, rs201115244	RCV001839421 RCV001356475 RCV005052841 RCV000162356 RCV005636732 RCV000190838 RCV000190839 RCV003389312 RCV001002743

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
MCM8-related disorder	Benign; Likely benign	rs149433613, rs146490315, rs149767423, rs149662059, rs145133959	RCV003897362 RCV003931725 RCV003914487 RCV003922004 RCV003903282

Show/Hide Text Mining Associations (32)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Adenocarcinoma of Lung	Associate	31323040, 31545501
Adenocarcinoma of Lung	Stimulate	40033404
Azoospermia	Associate	35172124
Breast Neoplasms	Associate	19448619
Carcinoma Hepatocellular	Associate	36575045
Carcinoma Squamous Cell	Stimulate	36445337
Cardiovascular Diseases	Associate	19448619
Choriocarcinoma	Associate	12771218
Chromosomal Instability	Associate	28863940
Chromosome Breakage	Associate	25437880
Chromosome Disorders	Associate	25437880
Colonic Neoplasms	Associate	12771218
Colorectal Neoplasms	Associate	32841224
Colorectal Neoplasms Hereditary Nonpolyposis	Associate	32841224
DNA Virus Infections	Associate	27802094
Endocrine System Diseases	Associate	25437880
Genetic Diseases Inborn	Associate	25437880
Glioma	Associate	37349788
Growth Disorders	Associate	32652893
Hepatoblastoma	Associate	37850543
Infertility	Associate	32841224
Leukemia Myelogenous Chronic BCR ABL Positive	Associate	26823731
Leukemia Myeloid Acute	Associate	30480765
Lung Neoplasms	Associate	35360518
Lymphatic Metastasis	Associate	27695057
Neoplasms	Associate	12771218, 26823731, 32652893, 36575045, 40033404
Osteoporosis	Associate	19448619
Ovarian Dysgenesis 2	Associate	25437880
Ovarian Neoplasms	Associate	28863940
Pancreatic Neoplasms	Associate	27695057
Primary Ovarian Insufficiency	Associate	25437880, 27573988, 27802094, 28863940, 30276597, 32048466, 32652893, 33109206
Uterine Cervical Neoplasms	Associate	34404366

MCM8 (minichromosome maintenance 8 homologous recombination repair factor)