NEURL4 (neuralized E3 ubiquitin protein ligase 4)

Gene

• Entrez ID: 84461
• Gene name: Neuralized E3 ubiquitin protein ligase 4
• Gene symbol: NEURL4
• Synonyms (NCBI Gene): -
• Chromosome: 17
• Chromosome location: 17p13.1
• Summary: The protein encoded by this gene is predicted and it includes two isoforms resulting from two alternatively spliced transcript variants. [provided by RefSeq, Jul 2008]

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT051170	hsa-miR-16-5p	CLASH	23622248
MIRT040850	hsa-miR-18a-3p	CLASH	23622248
MIRT040850	hsa-miR-18a-3p	CLASH	23622248
MIRT1181208	hsa-miR-128	CLIP-seq
MIRT1181209	hsa-miR-185	CLIP-seq
MIRT1181210	hsa-miR-27a	CLIP-seq
MIRT1181211	hsa-miR-27b	CLIP-seq
MIRT1181212	hsa-miR-299-3p	CLIP-seq
MIRT1181213	hsa-miR-3192	CLIP-seq
MIRT1181214	hsa-miR-326	CLIP-seq
MIRT1181215	hsa-miR-330-5p	CLIP-seq
MIRT1181216	hsa-miR-3607-5p	CLIP-seq
MIRT1181217	hsa-miR-4265	CLIP-seq
MIRT1181218	hsa-miR-4270	CLIP-seq
MIRT1181219	hsa-miR-4296	CLIP-seq
MIRT1181220	hsa-miR-4306	CLIP-seq
MIRT1181221	hsa-miR-4314	CLIP-seq
MIRT1181222	hsa-miR-4322	CLIP-seq
MIRT1181223	hsa-miR-4417	CLIP-seq
MIRT1181224	hsa-miR-4441	CLIP-seq
MIRT1181225	hsa-miR-4644	CLIP-seq
MIRT1181226	hsa-miR-4646-5p	CLIP-seq
MIRT1181227	hsa-miR-513a-5p	CLIP-seq
MIRT1181228	hsa-miR-646	CLIP-seq
MIRT2281855	hsa-miR-4258	CLIP-seq
MIRT2281856	hsa-miR-4286	CLIP-seq
MIRT2281857	hsa-miR-4783-3p	CLIP-seq
MIRT2281858	hsa-miR-663b	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	22441691
GO:0005737	Component	Cytoplasm	IEA
GO:0005739	Component	Mitochondrion	IEA
GO:0005814	Component	Centriole	IEA
GO:0005856	Component	Cytoskeleton	IEA
GO:0007283	Process	Spermatogenesis	IEA
GO:0043504	Process	Mitochondrial DNA repair	IEA
GO:0061630	Function	Ubiquitin protein ligase activity	IBA

Other IDs

• MIM: 615865
• HGNC: 34410
• e!Ensembl: ENSG00000215041

Protein

• UniProt ID: Q96JN8
• Protein name: Neuralized-like protein 4
• Protein function: Promotes CCP110 ubiquitination and proteasome-dependent degradation. By counteracting accumulation of CP110, maintains normal centriolar homeostasis and preventing formation of ectopic microtubular organizing centers. {ECO:0000269|PubMed:2226172
• PDB: 2E63
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF07177	Neuralized	44 → 206	Neuralized	Domain
  PF07177	Neuralized	320 → 483	Neuralized	Domain
  PF07177	Neuralized	523 → 685	Neuralized	Domain
  PF07177	Neuralized	719 → 883	Neuralized	Domain
  PF07177	Neuralized	916 → 1085	Neuralized	Domain
  PF07177	Neuralized	1134 → 1293	Neuralized	Domain

• Tissue specificity: TISSUE SPECIFICITY: Widely expressed at high levels (including brain). {ECO:0000269|PubMed:11347906}.
• Sequence:

  MAAGSGGSGGSGGGPGPGPGGGGGPSGSGSGPGSNGGLGSGGELHPRTGRLVSLSACGRT
  ARRQQPGQEFNHGLVLSREPLRDGRVFTVRIDRKVNSWSGSIEIGVTALDPSVLDFPSSA
  TGLKGGSWVVSGCSVLRDGRSVLEEYGQDLDQLGEGDRVGVERTVAGELRLWVNGRDCGV
  AATGLPPRVWAVVDLYGKCTQITVLPPEPGFSPPTPIPTPPLEPLAPTEDSALAEQGTSA
  DEAFMVSPAQARPETFPNSLESHNDFANMELSEVVSNTILSAYNGGLLNVNLSSPPAGEG
  LGSSGAATSPILTSNDALLFHEKCGTLIKLSNNNKTAERRRPLDEFNNGVVMTNRPLRDN
  EMFEIRIDKLVDKWSGSIEIGVTTHNPNSLEYPATMTNLQSGTIMMSGCGILTNGKGTRR
  EYCEFSLDELQEGDHIGLTRKSNSALHFFINGIDQGVATPLTPPVVYGVVDLYGMAVKVT
  IVHNNNHSDRLRRNNAILRALSPEGALRRAAPAAQAEPERLLFHPNCGQKAAITHEGRTA
  LRPHATDDFNHGVVLSSRALRDGEVFQVRIDKMVDKWAGSIEIGVTTHNPAYLQLPSTMT
  NLRSGTWMMTGNGVMHNGTTILDEYGHNLDRLKAGDTVGVVRREDGTLHFFVNGMTQGPA
  AWNVPPGVYAVVDLYGQAAQATIVDDVEVAPVPEPLPEGNNQVSPSSPSSGAGGSDLRFH
  QLHGSNAVITNGGRTALRHNCRSEFNDAIVISNRALRDGELFEIVIQKMVDRWSGSIEAG
  VTAIRPEDLEFPNTMTDIDYDTWMLSGTAIMQDGNTMRNNYGCDLDALGTGARIGMMRTA
  KGDLHYFINGQDQGAACSGLPPGKEVYAVVDLYGQCVQVSITNATGPMDNSLATSNTATE
  KSFPLHSPVAGVAHRFHSTCGKNVTLEEDGTRAVRAAGYAHGLVFSTKELRAEEVFEVKV
  EELDEKWAGSLRLGLTTLAPGEMGPGAGGGGPGLPPSLPELRTKTTWMVSSCEVRRDGQL
  QRMNYGRNLERLGVGSRVGVRRGADDTMHILVDGEDMGPAATGIAKNVWAVLDLYGPVRG
  VSIVSSTRLEESEGTQPPSPSSDTGSEGEEDDEGEEHGLGGQNEVGIIPTTLEFLENHGK
  NILLSNGNRTATRVASYNQGIVVINQPLVPQLLVQVRIDFLNRQWTSSLVLGVITCAPER
  LNFPASACALKRAAWLLRGRGVFHNGLKICEKFGPNLDTCPEGTILGLRLDSSGGLHLHV
  NGVDQGVAVPDVPQPCHALVDLYGQCEQVTIVNPEPGAASGKSAGTQGDMEKADMVDGIK
  ESVCWGPPPAASPLKSCEYHALCSRFQELLLLPEDYFMPPPKRSLCYCESCRKLRGDEAH
  RRRGEPPREYALPFGWCRFNLRVNPRLEAGTLTKKWHMAYHGSNVAAVRRVLDRGELGAG
  TASILSCRPLKGEPGVGFEEPGENCAPPREEQPPPVLLSPSLQYAGAETLASKVQFRDPK
  SQRTHQAQVAFQVCVRPGSYTPGPPSAALGEPPDPHFSPAELEWVTKEKGATLLCALLVR
  VE

• Sequence length: 1562

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
AUTOIMMUNE DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Hepatocellular carcinoma	Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant tumor of esophagus	Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant tumor of urinary bladder	Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NEURL4-related disorder	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Sarcoma	Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SYSTEMIC LUPUS ERYTHEMATOSUS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thyroid cancer, nonmedullary, 1	Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 1 DIABETES MELLITUS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Uveal melanoma	Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Relationship Type	References	Evidence Score
Azoospermia	Associate	32860660	★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Associate	31817155	★☆☆☆☆ Found in Text Mining only
Infertility Male	Associate	32860660	★☆☆☆☆ Found in Text Mining only
Neoplasms	Associate	31817155	★☆☆☆☆ Found in Text Mining only