MAML2 (mastermind like transcriptional coactivator 2)

Gene

• Entrez ID: 84441
• Gene name: Mastermind like transcriptional coactivator 2
• Gene symbol: MAML2
• Synonyms (NCBI Gene): MAM-3, MAM2, MAM3, MLL-MAML2
• Chromosome: 11
• Chromosome location: 11q21
• Summary: The protein encoded by this gene is a member of the Mastermind-like family of proteins. All family members are proline and glutamine-rich, and contain a conserved basic domain that binds the ankyrin repeat domain of the intracellular domain of the Notch r

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT017074	hsa-miR-335-5p	Microarray	18185580
MIRT536197	hsa-miR-205-5p	PAR-CLIP	22012620
MIRT536196	hsa-miR-3605-3p	PAR-CLIP	22012620
MIRT536195	hsa-miR-6715b-3p	PAR-CLIP	22012620
MIRT536194	hsa-miR-6868-3p	PAR-CLIP	22012620
MIRT440293	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT440293	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT536197	hsa-miR-205-5p	PAR-CLIP	22012620
MIRT536196	hsa-miR-3605-3p	PAR-CLIP	22012620
MIRT536195	hsa-miR-6715b-3p	PAR-CLIP	22012620
MIRT536194	hsa-miR-6868-3p	PAR-CLIP	22012620
MIRT1126932	hsa-miR-3168	CLIP-seq
MIRT1126933	hsa-miR-324-5p	CLIP-seq
MIRT1126934	hsa-miR-34b	CLIP-seq
MIRT1126935	hsa-miR-34c-3p	CLIP-seq
MIRT1126936	hsa-miR-4305	CLIP-seq
MIRT1126937	hsa-miR-4724-3p	CLIP-seq
MIRT1126938	hsa-miR-556-3p	CLIP-seq
MIRT2035932	hsa-miR-1261	CLIP-seq
MIRT2266304	hsa-miR-140-3p	CLIP-seq
MIRT2266305	hsa-miR-3941	CLIP-seq
MIRT2266306	hsa-miR-4643	CLIP-seq
MIRT2266307	hsa-miR-466	CLIP-seq
MIRT2266308	hsa-miR-4672	CLIP-seq
MIRT2266309	hsa-miR-4789-3p	CLIP-seq
MIRT2390482	hsa-miR-1183	CLIP-seq
MIRT2035932	hsa-miR-1261	CLIP-seq
MIRT2266304	hsa-miR-140-3p	CLIP-seq
MIRT2390483	hsa-miR-3690	CLIP-seq
MIRT2390484	hsa-miR-3713	CLIP-seq
MIRT2390485	hsa-miR-4254	CLIP-seq
MIRT2390486	hsa-miR-4277	CLIP-seq
MIRT2390487	hsa-miR-4652-3p	CLIP-seq
MIRT2390488	hsa-miR-4653-3p	CLIP-seq
MIRT2035932	hsa-miR-1261	CLIP-seq
MIRT2035932	hsa-miR-1261	CLIP-seq
MIRT2035932	hsa-miR-1261	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003713	Function	Transcription coactivator activity	IBA
GO:0003713	Function	Transcription coactivator activity	IDA	12370315
GO:0003713	Function	Transcription coactivator activity	IEA
GO:0005515	Function	Protein binding	IPI	12370315
GO:0005634	Component	Nucleus	IDA	12370315
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IBA
GO:0005654	Component	Nucleoplasm	TAS
GO:0007219	Process	Notch signaling pathway	IDA	12370315
GO:0007219	Process	Notch signaling pathway	IEA
GO:0007221	Process	Positive regulation of transcription of Notch receptor target	IBA
GO:0007221	Process	Positive regulation of transcription of Notch receptor target	IEA
GO:0016607	Component	Nuclear speck	IEA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IDA	12370315
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IEA

Other IDs

• MIM: 607537
• HGNC: 16259
• e!Ensembl: ENSG00000184384

Protein

• UniProt ID: Q8IZL2
• Protein name: Mastermind-like protein 2 (Mam-2)
• Protein function: Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Potentiates activation by NOTCH3 and NOTCH4 more efficiently than MAML1 or MAML3. {ECO:0000269|PubMed:12370315, ECO:0000269|
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF09596	MamL-1	31 → 88	MamL-1 domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Widely expressed with high levels detected in placenta, salivary gland and skeletal muscle. {ECO:0000269|PubMed:14720503}.
• Sequence:

  MGDTAPPQAPAGGLGGASGAGLLGGGSVTPRVHSAIVERLRARIAVCRQHHLSCEGRYER
  GRAESSDRERESTLQLLSLVQHGQGARKAGKHTKATATAATTTAPPPPPAAPPAASQAAA
  TAAPPPPPDYHHHHQQHLLNSSNNGGSGGINGEQQPPASTPGDQRNSALIALQGSLKRKQ
  VVNLSPANSKRPNGFVDNSFLDIKRIRVGENLSAGQGGLQINNGQSQIMSGTLPMSQAPL
  RKTNTLPSHTHSPGNGLFNMGLKEVKKEPGETLSCSKHMDGQMTQENIFPNRYGDDPGEQ
  LMDPELQELFNELTNISVPPMSDLELENMINATIKQDDPFNIDLGQQSQRSTPRPSLPME
  KIVIKSEYSPGLTQGPSGSPQLRPPSAGPAFSMANSALSTSSPIPSVPQSQAQPQTGSGA
  SRALPSWQEVSHAQQLKQIAANRQQHARMQQHQQQHQPTNWSALPSSAGPSPGPFGQEKI
  PSPSFGQQTFSPQSSPMPGVAGGSGQSKVMANYMYKAGPSAQGGHLDVLMQQKPQDLSRS
  FINNPHPAMEPRQGNTKPLFHFNSDQANQQMPSVLPSQNKPSLLHYTQQQQQQQQQQQQQ
  QQQQQQQQQQQQQQQQQQQQQSSISAQQQQQQQSSISAQQQQQQQQQQQQQQQQQQQQQQ
  QQQQQPSSQPAQSLPSQPLLRSPLPLQQKLLLQQMQNQPIAGMGYQVSQQQRQDQHSVVG
  QNTGPSPSPNPCSNPNTGSGYMNSQQSLLNQQLMGKKQTLQRQIMEQKQQLLLQQQMLAD
  AEKIAPQDQINRHLSRPPPDYKDQRRNVGNMQPTAQYSGGSSTISLNSNQALANPVSTHT
  ILTPNSSLLSTSHGTRMPSLSTAVQNMGMYGNLPCNQPNTYSVTSGMNQLTQQRNPKQLL
  ANQNNPMMPRPPTLGPSNNNNVATFGAGSVGNSQQLRPNLTHSMASMPPQRTSNVMITSN
  TTAPNWASQEGTSKQQEALTSAGVRFPTGTPAAYTPNQSLQQAVGSQQFSQRAVAPPNQL
  TPAVQMRPMNQMSQTLNGQTMGPLRGLNLRPNQLSTQILPNLNQSGTGLNQSRTGINQPP
  SLTPSNFPSPNQSSRAFQGTDHSSDLAFDFLSQQNDNMGPALNSDADFIDSLLKTEPGND
  DWMKDINLDEILGNNS

• Sequence length: 1156

Pathways

KEGG:

Notch signaling pathway
Th1 and Th2 cell differentiation
Human papillomavirus infection

Reactome:

Pre-NOTCH Transcription and Translation
NOTCH1 Intracellular Domain Regulates Transcription
NOTCH2 intracellular domain regulates transcription
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Notch-HLH transcription pathway
RUNX3 regulates NOTCH signaling
NOTCH3 Intracellular Domain Regulates Transcription
NOTCH4 Intracellular Domain Regulates Transcription