Gene Gene information from NCBI Gene database.
Entrez ID 84440
Gene name RAB11 family interacting protein 4
Gene symbol RAB11FIP4
Synonyms (NCBI Gene)
FIP4-Rab11RAB11-FIP4
Chromosome 17
Chromosome location 17q11.2
Summary The protein encoded by this gene interacts with RAB11 and is thought to be involved in bringing recycling endosome membranes to the cleavage furrow in late cytokinesis. Hypoxic conditions can lead to an upregulation of the encoded protein and enhance the
miRNA miRNA information provided by mirtarbase database.
809
miRTarBase ID miRNA Experiments Reference
MIRT710816 hsa-miR-3120-5p HITS-CLIP 19536157
MIRT710815 hsa-miR-431-5p HITS-CLIP 19536157
MIRT710814 hsa-miR-4326 HITS-CLIP 19536157
MIRT710813 hsa-miR-3157-5p HITS-CLIP 19536157
MIRT710812 hsa-miR-6888-3p HITS-CLIP 19536157
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
33
GO ID Ontology Definition Evidence Reference
GO:0003407 Process Neural retina development IEA
GO:0005509 Function Calcium ion binding IEA
GO:0005515 Function Protein binding IPI 12470645, 16148947, 17030804, 22522702, 32296183
GO:0005615 Component Extracellular space HDA 22664934
GO:0005737 Component Cytoplasm IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
611999 30267 ENSG00000131242
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q86YS3
Protein name Rab11 family-interacting protein 4 (FIP4-Rab11) (Rab11-FIP4) (Arfophilin-2)
Protein function Acts as a regulator of endocytic traffic by participating in membrane delivery. Required for the abscission step in cytokinesis, possibly by acting as an 'address tag' delivering recycling endosome membranes to the cleavage furrow during late cy
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF09457 RBD-FIP 596 636 FIP domain Motif
Tissue specificity TISSUE SPECIFICITY: Present at high level in testis (at protein level). Weakly expressed in other tissues. {ECO:0000269|PubMed:12857874}.
Sequence
MAGGAGWSGAPAALLRSVRRLREVFEVCGRDPDGFLRVERVAALGLRFGQGEEVEKLVKY
LDPNDLGRINFKDFCRGVFAMKGCEELLKDVLSVESAGTLPCAPEIPDCVEQGSEVTGPT
FADGELIPREPGFFPEDEEEAMTLAPPEGPQELYTDSPMESTQSLEGSVGSPAEKDGGLG
GLFLPEDKSLVHTPSMTTSDLSTHSTTSLISNEEQFEDYGEGDDVDCAPSSPCPDDETRT
NVYSDLGSSVSSSAGQTPRKMRHVYNSELLDVYCSQCCKKINLLNDLEARLKNLKANSPN
RKISSTAFGRQLMHSSNFSSSNGSTEDLFRDSIDSCDNDITEKVSFLEKKVTELENDSLT
NGDLKSKLKQENTQLVHRVHELEEMVKDQETTAEQALEEEARRHREAYGKLEREKATEVE
LLNARVQQLEEENTELRTTVTRLKSQTEKLDEERQRMSDRLEDTSLRLKDEMDLYKRMMD
KLRQNRLEFQKEREATQELIEDLRKELEHLQMYKLDCERPGRGRSASSGLGEFNARAREV
ELEHEVKRLKQENYKLRDQNDDLNGQILSLSLYEAKNLFAAQTKAQSLAAEIDTASRDEL
MEALKEQEEINFRLRQYMDKIILAILDHNPSILEIK
H
Sequence length 637
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG 
  Endocytosis  
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
1
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Prostate cancer Uncertain significance rs193921026 RCV000149321
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Alzheimer Disease Associate 28800327
Neoplasm Metastasis Associate 28035375
Neoplasms Associate 26015570
Neoplasms Stimulate 28035375
Pancreatic Neoplasms Associate 28035375