Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	843
Gene name	Caspase 10
Gene symbol	CASP10
Synonyms (NCBI Gene)	ALPS2FLICE-2FLICE2MCH4
Chromosome	2
Chromosome location	2q33.1
Summary	This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo pro

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SNP ID	Visualize variation	Clinical significance	Consequence
rs17860403	C>T	Pathogenic	Coding sequence variant, genic downstream transcript variant, missense variant, intron variant, non coding transcript variant
rs28936699	C>T	Pathogenic	Coding sequence variant, genic downstream transcript variant, missense variant, downstream transcript variant, 3 prime UTR variant
rs80358239	A>C,T	Conflicting-interpretations-of-pathogenicity, likely-benign	3 prime UTR variant, genic downstream transcript variant, missense variant, coding sequence variant, downstream transcript variant
rs121909775	C>A,T	Pathogenic	Non coding transcript variant, missense variant, coding sequence variant, intron variant, stop gained, genic downstream transcript variant
rs121909776	T>C	Uncertain-significance, pathogenic	Non coding transcript variant, 5 prime UTR variant, coding sequence variant, missense variant
rs398122800	->A	Pathogenic	Downstream transcript variant, coding sequence variant, genic downstream transcript variant, 3 prime UTR variant, frameshift variant

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miRTarBase ID	miRNA	Experiments	Reference
MIRT053415	hsa-miR-624-3p	Microarray	23807165
MIRT719199	hsa-miR-140-3p	HITS-CLIP	19536157
MIRT719198	hsa-miR-6511a-3p	HITS-CLIP	19536157
MIRT719197	hsa-miR-6511b-3p	HITS-CLIP	19536157
MIRT719196	hsa-miR-4284	HITS-CLIP	19536157
MIRT719195	hsa-miR-24-3p	HITS-CLIP	19536157
MIRT719194	hsa-miR-597-5p	HITS-CLIP	19536157
MIRT719193	hsa-miR-197-3p	HITS-CLIP	19536157
MIRT719192	hsa-miR-8057	HITS-CLIP	19536157
MIRT719191	hsa-miR-592	HITS-CLIP	19536157
MIRT518524	hsa-miR-580-5p	PAR-CLIP	23446348
MIRT518523	hsa-miR-590-3p	PAR-CLIP	23446348
MIRT518522	hsa-miR-329-5p	PAR-CLIP	23446348
MIRT518521	hsa-miR-1272	PAR-CLIP	23446348
MIRT518520	hsa-miR-1228-3p	PAR-CLIP	23446348
MIRT518519	hsa-miR-6765-3p	PAR-CLIP	23446348
MIRT518518	hsa-miR-4735-5p	PAR-CLIP	23446348
MIRT518517	hsa-miR-4794	PAR-CLIP	23446348
MIRT518516	hsa-miR-664a-5p	PAR-CLIP	23446348
MIRT518515	hsa-miR-655-5p	PAR-CLIP	23446348
MIRT518514	hsa-miR-377-5p	PAR-CLIP	23446348
MIRT518513	hsa-miR-6086	PAR-CLIP	23446348
MIRT518512	hsa-miR-19a-5p	PAR-CLIP	23446348
MIRT518511	hsa-miR-19b-1-5p	PAR-CLIP	23446348
MIRT518510	hsa-miR-19b-2-5p	PAR-CLIP	23446348
MIRT518509	hsa-miR-4775	PAR-CLIP	23446348
MIRT518508	hsa-miR-2113	PAR-CLIP	23446348
MIRT518507	hsa-miR-5010-3p	PAR-CLIP	23446348
MIRT719199	hsa-miR-140-3p	HITS-CLIP	19536157
MIRT719198	hsa-miR-6511a-3p	HITS-CLIP	19536157
MIRT719197	hsa-miR-6511b-3p	HITS-CLIP	19536157
MIRT719196	hsa-miR-4284	HITS-CLIP	19536157
MIRT719195	hsa-miR-24-3p	HITS-CLIP	19536157
MIRT719194	hsa-miR-597-5p	HITS-CLIP	19536157
MIRT719193	hsa-miR-197-3p	HITS-CLIP	19536157
MIRT719192	hsa-miR-8057	HITS-CLIP	19536157
MIRT719191	hsa-miR-592	HITS-CLIP	19536157
MIRT518524	hsa-miR-580-5p	PAR-CLIP	23446348
MIRT518523	hsa-miR-590-3p	PAR-CLIP	23446348
MIRT518522	hsa-miR-329-5p	PAR-CLIP	23446348
MIRT518521	hsa-miR-1272	PAR-CLIP	23446348
MIRT518520	hsa-miR-1228-3p	PAR-CLIP	23446348
MIRT518519	hsa-miR-6765-3p	PAR-CLIP	23446348
MIRT518518	hsa-miR-4735-5p	PAR-CLIP	23446348
MIRT518517	hsa-miR-4794	PAR-CLIP	23446348
MIRT518516	hsa-miR-664a-5p	PAR-CLIP	23446348
MIRT518515	hsa-miR-655-5p	PAR-CLIP	23446348
MIRT518514	hsa-miR-377-5p	PAR-CLIP	23446348
MIRT518513	hsa-miR-6086	PAR-CLIP	23446348
MIRT518512	hsa-miR-19a-5p	PAR-CLIP	23446348
MIRT518511	hsa-miR-19b-1-5p	PAR-CLIP	23446348
MIRT518510	hsa-miR-19b-2-5p	PAR-CLIP	23446348
MIRT518509	hsa-miR-4775	PAR-CLIP	23446348
MIRT518508	hsa-miR-2113	PAR-CLIP	23446348
MIRT518507	hsa-miR-5010-3p	PAR-CLIP	23446348
MIRT863628	hsa-miR-1224-3p	CLIP-seq
MIRT863629	hsa-miR-1225-3p	CLIP-seq
MIRT863630	hsa-miR-1233	CLIP-seq
MIRT863631	hsa-miR-1252	CLIP-seq
MIRT863632	hsa-miR-125a-3p	CLIP-seq
MIRT863633	hsa-miR-1260	CLIP-seq
MIRT863634	hsa-miR-1260b	CLIP-seq
MIRT863635	hsa-miR-1278	CLIP-seq
MIRT863636	hsa-miR-1280	CLIP-seq
MIRT863637	hsa-miR-1293	CLIP-seq
MIRT863638	hsa-miR-1470	CLIP-seq
MIRT863639	hsa-miR-1914	CLIP-seq
MIRT863640	hsa-miR-1972	CLIP-seq
MIRT863641	hsa-miR-19a	CLIP-seq
MIRT863642	hsa-miR-19b	CLIP-seq
MIRT863643	hsa-miR-23a	CLIP-seq
MIRT863644	hsa-miR-23b	CLIP-seq
MIRT863645	hsa-miR-23c	CLIP-seq
MIRT863646	hsa-miR-3065-5p	CLIP-seq
MIRT863647	hsa-miR-3120-5p	CLIP-seq
MIRT863648	hsa-miR-3126-5p	CLIP-seq
MIRT863649	hsa-miR-3151	CLIP-seq
MIRT863650	hsa-miR-3159	CLIP-seq
MIRT863651	hsa-miR-3192	CLIP-seq
MIRT863652	hsa-miR-3201	CLIP-seq
MIRT863653	hsa-miR-340	CLIP-seq
MIRT863654	hsa-miR-3609	CLIP-seq
MIRT863655	hsa-miR-3664-5p	CLIP-seq
MIRT863656	hsa-miR-3672	CLIP-seq
MIRT863657	hsa-miR-3682-5p	CLIP-seq
MIRT863658	hsa-miR-3689a-3p	CLIP-seq
MIRT863659	hsa-miR-3689c	CLIP-seq
MIRT863660	hsa-miR-371-5p	CLIP-seq
MIRT863661	hsa-miR-371b-5p	CLIP-seq
MIRT863662	hsa-miR-383	CLIP-seq
MIRT863663	hsa-miR-3919	CLIP-seq
MIRT863664	hsa-miR-4312	CLIP-seq
MIRT863665	hsa-miR-4419a	CLIP-seq
MIRT863666	hsa-miR-4421	CLIP-seq
MIRT863667	hsa-miR-4433	CLIP-seq
MIRT863668	hsa-miR-4434	CLIP-seq
MIRT863669	hsa-miR-4457	CLIP-seq
MIRT863670	hsa-miR-4483	CLIP-seq
MIRT863671	hsa-miR-4510	CLIP-seq
MIRT863672	hsa-miR-4516	CLIP-seq
MIRT863673	hsa-miR-4522	CLIP-seq
MIRT863674	hsa-miR-4529-5p	CLIP-seq
MIRT863675	hsa-miR-4650-5p	CLIP-seq
MIRT863676	hsa-miR-4651	CLIP-seq
MIRT863677	hsa-miR-4667-3p	CLIP-seq
MIRT863678	hsa-miR-4683	CLIP-seq
MIRT863679	hsa-miR-4690-3p	CLIP-seq
MIRT863680	hsa-miR-4726-3p	CLIP-seq
MIRT863681	hsa-miR-4728-5p	CLIP-seq
MIRT863682	hsa-miR-4740-3p	CLIP-seq
MIRT863683	hsa-miR-4756-3p	CLIP-seq
MIRT863684	hsa-miR-4763-5p	CLIP-seq
MIRT863685	hsa-miR-4768-3p	CLIP-seq
MIRT863686	hsa-miR-4782-5p	CLIP-seq
MIRT863687	hsa-miR-4791	CLIP-seq
MIRT863688	hsa-miR-4793-3p	CLIP-seq
MIRT863689	hsa-miR-490-3p	CLIP-seq
MIRT863690	hsa-miR-508-5p	CLIP-seq
MIRT863691	hsa-miR-5095	CLIP-seq
MIRT863692	hsa-miR-5096	CLIP-seq
MIRT863693	hsa-miR-513b	CLIP-seq
MIRT863694	hsa-miR-520g	CLIP-seq
MIRT863695	hsa-miR-520h	CLIP-seq
MIRT863696	hsa-miR-548ah	CLIP-seq
MIRT863697	hsa-miR-548k	CLIP-seq
MIRT863698	hsa-miR-548n	CLIP-seq
MIRT863699	hsa-miR-608	CLIP-seq
MIRT863700	hsa-miR-624	CLIP-seq
MIRT863701	hsa-miR-665	CLIP-seq
MIRT863702	hsa-miR-720	CLIP-seq
MIRT863703	hsa-miR-758	CLIP-seq
MIRT863704	hsa-miR-766	CLIP-seq
MIRT863705	hsa-miR-873	CLIP-seq
MIRT863706	hsa-miR-935	CLIP-seq
MIRT863707	hsa-miR-944	CLIP-seq
MIRT863708	hsa-miR-1207-3p	CLIP-seq
MIRT863632	hsa-miR-125a-3p	CLIP-seq
MIRT863709	hsa-miR-1271	CLIP-seq
MIRT863710	hsa-miR-142-5p	CLIP-seq
MIRT863711	hsa-miR-182	CLIP-seq
MIRT863712	hsa-miR-34a	CLIP-seq
MIRT863713	hsa-miR-34c-5p	CLIP-seq
MIRT863714	hsa-miR-4493	CLIP-seq
MIRT863715	hsa-miR-449a	CLIP-seq
MIRT863716	hsa-miR-449b	CLIP-seq
MIRT863679	hsa-miR-4690-3p	CLIP-seq
MIRT863680	hsa-miR-4726-3p	CLIP-seq
MIRT863688	hsa-miR-4793-3p	CLIP-seq
MIRT863690	hsa-miR-508-5p	CLIP-seq
MIRT863717	hsa-miR-521	CLIP-seq
MIRT863718	hsa-miR-561	CLIP-seq
MIRT863704	hsa-miR-766	CLIP-seq
MIRT863706	hsa-miR-935	CLIP-seq
MIRT863719	hsa-miR-96	CLIP-seq
MIRT863720	hsa-miR-1228	CLIP-seq
MIRT863721	hsa-miR-124	CLIP-seq
MIRT863631	hsa-miR-1252	CLIP-seq
MIRT863722	hsa-miR-147	CLIP-seq
MIRT863640	hsa-miR-1972	CLIP-seq
MIRT863723	hsa-miR-3126-3p	CLIP-seq
MIRT863649	hsa-miR-3151	CLIP-seq
MIRT863650	hsa-miR-3159	CLIP-seq
MIRT863724	hsa-miR-3179	CLIP-seq
MIRT863651	hsa-miR-3192	CLIP-seq
MIRT863725	hsa-miR-329	CLIP-seq
MIRT863726	hsa-miR-362-3p	CLIP-seq
MIRT863658	hsa-miR-3689a-3p	CLIP-seq
MIRT863659	hsa-miR-3689c	CLIP-seq
MIRT863727	hsa-miR-3714	CLIP-seq
MIRT863728	hsa-miR-3910	CLIP-seq
MIRT863729	hsa-miR-3929	CLIP-seq
MIRT863730	hsa-miR-3941	CLIP-seq
MIRT863731	hsa-miR-4276	CLIP-seq
MIRT863732	hsa-miR-4281	CLIP-seq
MIRT863733	hsa-miR-4314	CLIP-seq
MIRT863665	hsa-miR-4419a	CLIP-seq
MIRT863734	hsa-miR-4419b	CLIP-seq
MIRT863668	hsa-miR-4434	CLIP-seq
MIRT863735	hsa-miR-4438	CLIP-seq
MIRT863669	hsa-miR-4457	CLIP-seq
MIRT863736	hsa-miR-4478	CLIP-seq
MIRT863671	hsa-miR-4510	CLIP-seq
MIRT863672	hsa-miR-4516	CLIP-seq
MIRT863737	hsa-miR-4646-5p	CLIP-seq
MIRT863676	hsa-miR-4651	CLIP-seq
MIRT863681	hsa-miR-4728-5p	CLIP-seq
MIRT863685	hsa-miR-4768-3p	CLIP-seq
MIRT863738	hsa-miR-485-5p	CLIP-seq
MIRT863739	hsa-miR-506	CLIP-seq
MIRT863691	hsa-miR-5095	CLIP-seq
MIRT863692	hsa-miR-5096	CLIP-seq
MIRT863693	hsa-miR-513b	CLIP-seq
MIRT863740	hsa-miR-548ag	CLIP-seq
MIRT863741	hsa-miR-548ai	CLIP-seq
MIRT863742	hsa-miR-603	CLIP-seq
MIRT863699	hsa-miR-608	CLIP-seq
MIRT863700	hsa-miR-624	CLIP-seq
MIRT863701	hsa-miR-665	CLIP-seq
MIRT863703	hsa-miR-758	CLIP-seq
MIRT863705	hsa-miR-873	CLIP-seq
MIRT863743	hsa-miR-940	CLIP-seq
MIRT863651	hsa-miR-3192	CLIP-seq
MIRT863658	hsa-miR-3689a-3p	CLIP-seq
MIRT863659	hsa-miR-3689c	CLIP-seq
MIRT1546167	hsa-miR-3922-5p	CLIP-seq
MIRT863681	hsa-miR-4728-5p	CLIP-seq
MIRT863689	hsa-miR-490-3p	CLIP-seq
MIRT863721	hsa-miR-124	CLIP-seq
MIRT1956059	hsa-miR-1245	CLIP-seq
MIRT1956060	hsa-miR-24	CLIP-seq
MIRT863727	hsa-miR-3714	CLIP-seq
MIRT863728	hsa-miR-3910	CLIP-seq
MIRT863667	hsa-miR-4433	CLIP-seq
MIRT863669	hsa-miR-4457	CLIP-seq
MIRT863739	hsa-miR-506	CLIP-seq
MIRT863691	hsa-miR-5095	CLIP-seq
MIRT863693	hsa-miR-513b	CLIP-seq
MIRT1956061	hsa-miR-552	CLIP-seq
MIRT863700	hsa-miR-624	CLIP-seq
MIRT863705	hsa-miR-873	CLIP-seq
MIRT863706	hsa-miR-935	CLIP-seq
MIRT863743	hsa-miR-940	CLIP-seq
MIRT863628	hsa-miR-1224-3p	CLIP-seq
MIRT1956059	hsa-miR-1245	CLIP-seq
MIRT863633	hsa-miR-1260	CLIP-seq
MIRT863634	hsa-miR-1260b	CLIP-seq
MIRT2193671	hsa-miR-1264	CLIP-seq
MIRT863635	hsa-miR-1278	CLIP-seq
MIRT863636	hsa-miR-1280	CLIP-seq
MIRT2193672	hsa-miR-1283	CLIP-seq
MIRT2193673	hsa-miR-1322	CLIP-seq
MIRT2193674	hsa-miR-135a	CLIP-seq
MIRT2193675	hsa-miR-135b	CLIP-seq
MIRT2193676	hsa-miR-1587	CLIP-seq
MIRT2193677	hsa-miR-186	CLIP-seq
MIRT863639	hsa-miR-1914	CLIP-seq
MIRT2193678	hsa-miR-2861	CLIP-seq
MIRT2193679	hsa-miR-3122	CLIP-seq
MIRT2193680	hsa-miR-3130-5p	CLIP-seq
MIRT2193681	hsa-miR-3133	CLIP-seq
MIRT2193682	hsa-miR-3176	CLIP-seq
MIRT863652	hsa-miR-3201	CLIP-seq
MIRT2193683	hsa-miR-337-3p	CLIP-seq
MIRT2193684	hsa-miR-3613-3p	CLIP-seq
MIRT2193685	hsa-miR-3685	CLIP-seq
MIRT863658	hsa-miR-3689a-3p	CLIP-seq
MIRT863659	hsa-miR-3689c	CLIP-seq
MIRT2193686	hsa-miR-3691-3p	CLIP-seq
MIRT2193687	hsa-miR-3913-5p	CLIP-seq
MIRT863663	hsa-miR-3919	CLIP-seq
MIRT2193688	hsa-miR-3922-3p	CLIP-seq
MIRT1546167	hsa-miR-3922-5p	CLIP-seq
MIRT863729	hsa-miR-3929	CLIP-seq
MIRT2193689	hsa-miR-3934	CLIP-seq
MIRT863730	hsa-miR-3941	CLIP-seq
MIRT2193690	hsa-miR-4310	CLIP-seq
MIRT863664	hsa-miR-4312	CLIP-seq
MIRT863665	hsa-miR-4419a	CLIP-seq
MIRT863734	hsa-miR-4419b	CLIP-seq
MIRT863666	hsa-miR-4421	CLIP-seq
MIRT2193691	hsa-miR-4435	CLIP-seq
MIRT2193692	hsa-miR-4437	CLIP-seq
MIRT863735	hsa-miR-4438	CLIP-seq
MIRT2193693	hsa-miR-4453	CLIP-seq
MIRT863736	hsa-miR-4478	CLIP-seq
MIRT2193694	hsa-miR-4482	CLIP-seq
MIRT2193695	hsa-miR-4501	CLIP-seq
MIRT863671	hsa-miR-4510	CLIP-seq
MIRT2193696	hsa-miR-4517	CLIP-seq
MIRT2193697	hsa-miR-4538	CLIP-seq
MIRT2193698	hsa-miR-455-3p	CLIP-seq
MIRT2193699	hsa-miR-466	CLIP-seq
MIRT2193700	hsa-miR-4672	CLIP-seq
MIRT2193701	hsa-miR-4674	CLIP-seq
MIRT863678	hsa-miR-4683	CLIP-seq
MIRT2193702	hsa-miR-4684-5p	CLIP-seq
MIRT2193703	hsa-miR-4694-3p	CLIP-seq
MIRT2193704	hsa-miR-4698	CLIP-seq
MIRT863681	hsa-miR-4728-5p	CLIP-seq
MIRT2193705	hsa-miR-4731-3p	CLIP-seq
MIRT863684	hsa-miR-4763-5p	CLIP-seq
MIRT863687	hsa-miR-4791	CLIP-seq
MIRT2193706	hsa-miR-4793-5p	CLIP-seq
MIRT2193707	hsa-miR-4801	CLIP-seq
MIRT863738	hsa-miR-485-5p	CLIP-seq
MIRT863691	hsa-miR-5095	CLIP-seq
MIRT2193708	hsa-miR-518a-5p	CLIP-seq
MIRT2193709	hsa-miR-527	CLIP-seq
MIRT2193710	hsa-miR-548aa	CLIP-seq
MIRT2193711	hsa-miR-548ac	CLIP-seq
MIRT2193712	hsa-miR-548ae	CLIP-seq
MIRT2193713	hsa-miR-548aj	CLIP-seq
MIRT2193714	hsa-miR-548am	CLIP-seq
MIRT2193715	hsa-miR-548d-3p	CLIP-seq
MIRT2193716	hsa-miR-548x	CLIP-seq
MIRT2193717	hsa-miR-548z	CLIP-seq
MIRT863718	hsa-miR-561	CLIP-seq
MIRT2193718	hsa-miR-593	CLIP-seq
MIRT2193719	hsa-miR-635	CLIP-seq
MIRT2193720	hsa-miR-642b	CLIP-seq
MIRT2193721	hsa-miR-649	CLIP-seq
MIRT863632	hsa-miR-125a-3p	CLIP-seq
MIRT863679	hsa-miR-4690-3p	CLIP-seq
MIRT863680	hsa-miR-4726-3p	CLIP-seq
MIRT863688	hsa-miR-4793-3p	CLIP-seq
MIRT863690	hsa-miR-508-5p	CLIP-seq
MIRT863704	hsa-miR-766	CLIP-seq
MIRT863708	hsa-miR-1207-3p	CLIP-seq
MIRT2496871	hsa-miR-1248	CLIP-seq
MIRT863635	hsa-miR-1278	CLIP-seq
MIRT2496872	hsa-miR-1343	CLIP-seq
MIRT2496873	hsa-miR-199a-5p	CLIP-seq
MIRT2496874	hsa-miR-199b-5p	CLIP-seq
MIRT2496875	hsa-miR-204	CLIP-seq
MIRT2496876	hsa-miR-211	CLIP-seq
MIRT2496877	hsa-miR-22	CLIP-seq
MIRT2496878	hsa-miR-2278	CLIP-seq
MIRT2496879	hsa-miR-2355-5p	CLIP-seq
MIRT863643	hsa-miR-23a	CLIP-seq
MIRT863644	hsa-miR-23b	CLIP-seq
MIRT863645	hsa-miR-23c	CLIP-seq
MIRT2496880	hsa-miR-2467-3p	CLIP-seq
MIRT2193678	hsa-miR-2861	CLIP-seq
MIRT863647	hsa-miR-3120-5p	CLIP-seq
MIRT2496881	hsa-miR-3135	CLIP-seq
MIRT863651	hsa-miR-3192	CLIP-seq
MIRT2193684	hsa-miR-3613-3p	CLIP-seq
MIRT2496882	hsa-miR-3614-5p	CLIP-seq
MIRT2496883	hsa-miR-3616-3p	CLIP-seq
MIRT2496884	hsa-miR-3646	CLIP-seq
MIRT863655	hsa-miR-3664-5p	CLIP-seq
MIRT863656	hsa-miR-3672	CLIP-seq
MIRT2496885	hsa-miR-3678-3p	CLIP-seq
MIRT863658	hsa-miR-3689a-3p	CLIP-seq
MIRT863659	hsa-miR-3689c	CLIP-seq
MIRT2496886	hsa-miR-3913-3p	CLIP-seq
MIRT2496887	hsa-miR-3936	CLIP-seq
MIRT2496888	hsa-miR-3938	CLIP-seq
MIRT2496889	hsa-miR-3977	CLIP-seq
MIRT2496890	hsa-miR-4287	CLIP-seq
MIRT863664	hsa-miR-4312	CLIP-seq
MIRT2496891	hsa-miR-4327	CLIP-seq
MIRT2193692	hsa-miR-4437	CLIP-seq
MIRT2496892	hsa-miR-4468	CLIP-seq
MIRT2496893	hsa-miR-4469	CLIP-seq
MIRT863714	hsa-miR-4493	CLIP-seq
MIRT863675	hsa-miR-4650-5p	CLIP-seq
MIRT2496894	hsa-miR-4676-5p	CLIP-seq
MIRT2496895	hsa-miR-4677-3p	CLIP-seq
MIRT2496896	hsa-miR-4685-3p	CLIP-seq
MIRT2496897	hsa-miR-4700-3p	CLIP-seq
MIRT2496898	hsa-miR-4703-3p	CLIP-seq
MIRT2496899	hsa-miR-4704-3p	CLIP-seq
MIRT2496900	hsa-miR-4721	CLIP-seq
MIRT863681	hsa-miR-4728-5p	CLIP-seq
MIRT2496901	hsa-miR-4755-5p	CLIP-seq
MIRT863684	hsa-miR-4763-5p	CLIP-seq
MIRT2496902	hsa-miR-4786-3p	CLIP-seq
MIRT2496903	hsa-miR-483-3p	CLIP-seq
MIRT2496904	hsa-miR-489	CLIP-seq
MIRT2496905	hsa-miR-515-5p	CLIP-seq
MIRT2496906	hsa-miR-518d-5p	CLIP-seq
MIRT2496907	hsa-miR-519b-5p	CLIP-seq
MIRT2496908	hsa-miR-519c-5p	CLIP-seq
MIRT2496909	hsa-miR-520c-5p	CLIP-seq
MIRT2496910	hsa-miR-526a	CLIP-seq
MIRT2496911	hsa-miR-544	CLIP-seq
MIRT863718	hsa-miR-561	CLIP-seq
MIRT2496912	hsa-miR-575	CLIP-seq
MIRT2496913	hsa-miR-583	CLIP-seq
MIRT2496914	hsa-miR-623	CLIP-seq
MIRT2496915	hsa-miR-629	CLIP-seq
MIRT2193719	hsa-miR-635	CLIP-seq
MIRT2496916	hsa-miR-645	CLIP-seq
MIRT2496917	hsa-miR-657	CLIP-seq
MIRT863708	hsa-miR-1207-3p	CLIP-seq
MIRT2496871	hsa-miR-1248	CLIP-seq
MIRT2677409	hsa-miR-1262	CLIP-seq
MIRT2193671	hsa-miR-1264	CLIP-seq
MIRT2496872	hsa-miR-1343	CLIP-seq
MIRT2496873	hsa-miR-199a-5p	CLIP-seq
MIRT2496874	hsa-miR-199b-5p	CLIP-seq
MIRT2496875	hsa-miR-204	CLIP-seq
MIRT2496876	hsa-miR-211	CLIP-seq
MIRT2677410	hsa-miR-2110	CLIP-seq
MIRT2677411	hsa-miR-219-2-3p	CLIP-seq
MIRT2496877	hsa-miR-22	CLIP-seq
MIRT2496879	hsa-miR-2355-5p	CLIP-seq
MIRT863643	hsa-miR-23a	CLIP-seq
MIRT863644	hsa-miR-23b	CLIP-seq
MIRT863645	hsa-miR-23c	CLIP-seq
MIRT2496880	hsa-miR-2467-3p	CLIP-seq
MIRT2193678	hsa-miR-2861	CLIP-seq
MIRT2677412	hsa-miR-2964a-3p	CLIP-seq
MIRT2496881	hsa-miR-3135	CLIP-seq
MIRT2677413	hsa-miR-3144-5p	CLIP-seq
MIRT2677414	hsa-miR-3150a-3p	CLIP-seq
MIRT2677415	hsa-miR-3191	CLIP-seq
MIRT2193684	hsa-miR-3613-3p	CLIP-seq
MIRT2496882	hsa-miR-3614-5p	CLIP-seq
MIRT863656	hsa-miR-3672	CLIP-seq
MIRT2496885	hsa-miR-3678-3p	CLIP-seq
MIRT863658	hsa-miR-3689a-3p	CLIP-seq
MIRT863659	hsa-miR-3689c	CLIP-seq
MIRT2193686	hsa-miR-3691-3p	CLIP-seq
MIRT2496886	hsa-miR-3913-3p	CLIP-seq
MIRT2496888	hsa-miR-3938	CLIP-seq
MIRT2496889	hsa-miR-3977	CLIP-seq
MIRT2677416	hsa-miR-4260	CLIP-seq
MIRT863664	hsa-miR-4312	CLIP-seq
MIRT2496891	hsa-miR-4327	CLIP-seq
MIRT2677417	hsa-miR-4452	CLIP-seq
MIRT2677418	hsa-miR-4455	CLIP-seq
MIRT2496892	hsa-miR-4468	CLIP-seq
MIRT863675	hsa-miR-4650-5p	CLIP-seq
MIRT2677419	hsa-miR-4652-5p	CLIP-seq
MIRT2496894	hsa-miR-4676-5p	CLIP-seq
MIRT2496895	hsa-miR-4677-3p	CLIP-seq
MIRT2677420	hsa-miR-4701-3p	CLIP-seq
MIRT2496899	hsa-miR-4704-3p	CLIP-seq
MIRT863681	hsa-miR-4728-5p	CLIP-seq
MIRT2496901	hsa-miR-4755-5p	CLIP-seq
MIRT863684	hsa-miR-4763-5p	CLIP-seq
MIRT2496902	hsa-miR-4786-3p	CLIP-seq
MIRT2496903	hsa-miR-483-3p	CLIP-seq
MIRT2496904	hsa-miR-489	CLIP-seq
MIRT2496905	hsa-miR-515-5p	CLIP-seq
MIRT2496911	hsa-miR-544	CLIP-seq
MIRT863718	hsa-miR-561	CLIP-seq
MIRT2496912	hsa-miR-575	CLIP-seq
MIRT2496913	hsa-miR-583	CLIP-seq
MIRT2677421	hsa-miR-609	CLIP-seq
MIRT2496914	hsa-miR-623	CLIP-seq
MIRT2496915	hsa-miR-629	CLIP-seq
MIRT2193719	hsa-miR-635	CLIP-seq
MIRT2496917	hsa-miR-657	CLIP-seq

Show/Hide all (27)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004197	Function	Cysteine-type endopeptidase activity	IBA
GO:0004197	Function	Cysteine-type endopeptidase activity	IDA	16916640, 16920334
GO:0004197	Function	Cysteine-type endopeptidase activity	IEA
GO:0004197	Function	Cysteine-type endopeptidase activity	IMP	11717445, 21980415
GO:0004197	Function	Cysteine-type endopeptidase activity	TAS	8755496, 10412980
GO:0005515	Function	Protein binding	IPI	12884866, 12887920, 17159907, 17479112, 19557502, 21988832, 23541952, 25241761, 25416956, 25910212
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	TAS
GO:0006508	Process	Proteolysis	IEA
GO:0006915	Process	Apoptotic process	IBA
GO:0006915	Process	Apoptotic process	IEA
GO:0006915	Process	Apoptotic process	TAS	10412980
GO:0008233	Function	Peptidase activity	IEA
GO:0008234	Function	Cysteine-type peptidase activity	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0031265	Component	CD95 death-inducing signaling complex	IBA
GO:0031265	Component	CD95 death-inducing signaling complex	IDA	11717445
GO:0031625	Function	Ubiquitin protein ligase binding	IPI	15069192
GO:0035877	Function	Death effector domain binding	IPI	11717445
GO:0042981	Process	Regulation of apoptotic process	IEA
GO:0043123	Process	Positive regulation of canonical NF-kappaB signal transduction	IMP	12884866
GO:0043525	Process	Positive regulation of neuron apoptotic process	IBA
GO:0051604	Process	Protein maturation	IDA	16916640
GO:0097194	Process	Execution phase of apoptosis	IDA	16916640
GO:0097342	Component	Ripoptosome	IDA	21737330
GO:1900119	Process	Positive regulation of execution phase of apoptosis	IDA	16916640

MIM	HGNC	e!Ensembl
601762	1500	ENSG00000003400

Q92851

Protein name

Caspase-10 (CASP-10) (EC 3.4.22.63) (Apoptotic protease Mch-4) (FAS-associated death domain protein interleukin-1B-converting enzyme 2) (FLICE2) (ICE-like apoptotic protease 4) [Cleaved into: Caspase-10 subunit p23/17; Caspase-10 subunit p12]

Protein function

Involved in the activation cascade of caspases responsible for apoptosis execution. Recruited to both Fas- and TNFR-1 receptors in a FADD dependent manner. May participate in the granzyme B apoptotic pathways. Cleaves and activates effector casp

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01335	DED	20 → 101	Death effector domain	Domain
PF01335	DED	115 → 191	Death effector domain	Domain
PF00656	Peptidase_C14	284 → 498		Domain

Tissue specificity

TISSUE SPECIFICITY: Detectable in most tissues. Lowest expression is seen in brain, kidney, prostate, testis and colon.

Sequence

MKSQGQHWYSSSDKNCKVSFREKLLIIDSNLGVQDVENLKFLCIGLVPNKKLEKSSSASD
VFEHLLAEDLLSEEDPFFLAELLYIIRQKKLLQHLNCTKEEVERLLPTRQRVSLFRNLLY
ELSEGIDSENLKDMIFLLKDSLPKTEMTSLSFLAFLEKQGKIDEDNLTCLEDLCKTVVPK
LLRNIEKYKREKAIQIVTPPVDKEAESYQGEEELVSQTDVKTFLEALPQESWQNKHAGSN
GNRATNGAPSLVSRGMQGASANTLNSETSTKRAAVYRMNRNHRGLCVIVNNHSFTSLKDR
QGTHKDAEILSHVFQWLGFTVHIHNNVTKVEMEMVLQKQKCNPAHADGDCFVFCILTHGR
FGAVYSSDEALIPIREIMSHFTALQCPRLAEKPKLFFIQACQGEEIQPSVSIEADALNPE
QAPTSLQDSIPAEADFLLGLATVPGYVSFRHVEEGSWYIQSLCNHLKKLVPRMLKFLEKT
MEIRGRKRTVWGAKQISATSLPTAISAQTPRPPMRRWSSVS

Sequence length

521

Interactions

View interactions

	KEGG		Reactome
	Apoptosis RIG-I-like receptor signaling pathway TNF signaling pathway Tuberculosis Hepatitis B		TP53 Regulates Transcription of Caspase Activators and Caspases FasL/ CD95L signaling TRAIL signaling NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10

524

Show/Hide Causal Diseases (3)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Autoimmune lymphoproliferative syndrome type 2A	Pathogenic	rs2126062115	RCV002249327
Gastric cancer	Pathogenic	rs121909775	RCV002508110
Non-Hodgkin lymphoma	Pathogenic	rs28936699, rs121909775, rs398122800	RCV000008206 RCV000008207 RCV000008209

Show/Hide Unknown Diseases (16)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Acute myeloid leukemia	Uncertain significance; Benign	rs559244194, rs6753900	RCV005911167 RCV005896044
Autoimmune lymphoproliferative syndrome type 1	Uncertain significance; Likely benign; Conflicting classifications of pathogenicity; Benign	rs121909776, rs367989998, rs528903184, rs41351949, rs374515060, rs41506545, rs111572089, rs886055420, rs886055426, rs747900630, rs760580885, rs781551128, rs201601111	RCV000986973 RCV000377588 RCV000333597 RCV000384446 RCV000272486 RCV000374646 RCV000276360 RCV000289141 RCV000392735 RCV000986974 RCV000986975 RCV000986971 RCV000986972
CASP10-related disorder	Uncertain significance; Benign; Likely benign; Conflicting classifications of pathogenicity	rs759782468, rs374339540, rs762404236, rs770218906, rs2469385193, rs1189489209, rs952354110, rs200638628, rs114625983, rs772096617, rs769976012, rs748679960, rs41473647, rs747900630, rs774005416 View all (5 more)	RCV003405740 RCV003903728 RCV003403967 RCV003418901 RCV003391463 RCV003408396 RCV003402720 RCV003972407 RCV003940342 RCV004723494 RCV003896356 RCV003937339 RCV003942807 RCV003403483 RCV003980308 RCV003411810 RCV004745608 RCV003960380 RCV003942902 RCV003426007
Cervical cancer	Benign	rs6753900	RCV005896046
Clear cell carcinoma of kidney	Benign	rs6753900	RCV005896047
Colon adenocarcinoma	Benign	rs6753900	RCV005896043
Diffuse midline glioma, H3 K27-altered	Uncertain significance	rs2469359457	RCV003314777
Familial pancreatic carcinoma	Uncertain significance	rs6753900	RCV005930080
Hypomyelination and Congenital Cataract	Conflicting classifications of pathogenicity	rs80358239	RCV001258256
Lung cancer	Benign	rs6753900	RCV005896050
Lymphoma, non-Hodgkin, familial	Uncertain significance; Conflicting classifications of pathogenicity	rs559244194, rs574742344, rs747900630, rs551818122, rs1559309649	RCV002486412 RCV005016726 RCV005392211 RCV002060870 RCV003224392
Malignant tumor of esophagus	Uncertain significance; Benign	rs574742344, rs6753900	RCV005923966 RCV005896045
Neoplasm of stomach	Uncertain significance	rs780552445, rs1559320359, rs1559309649	RCV000662116 RCV000714834 RCV000767914
Sarcoma	Benign	rs6753900	RCV005896048
See cases	Uncertain significance	rs6753900	RCV002252571
Thymoma	Uncertain significance	rs372539994	RCV005924199

Show/Hide Text Mining Associations (52)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Adenocarcinoma	Associate	22843554, 34222478
Airway Obstruction	Associate	18823309
Arthralgia	Associate	27378136
Asthma	Associate	18823309
Autoimmune Lymphoproliferative Syndrome	Associate	12010812, 17999750, 27378136, 31309545, 32599613, 33995372, 34438083, 35628184
Autoimmune Lymphoproliferative Syndrome Type IIA	Associate	10412980
Breast Neoplasms	Associate	15767684, 19423537, 20978178, 31629678, 33735170
Carcinogenesis	Associate	16443735, 23303631
Carcinoma Non Small Cell Lung	Associate	22843554
Choriocarcinoma	Associate	16443735
Colorectal Neoplasms	Associate	23303631
Developmental Disabilities	Associate	29301000
Diabetes Mellitus	Associate	36585034
Drug Related Side Effects and Adverse Reactions	Associate	22843554
Dyskinesias	Associate	27378136
Esophageal Neoplasms	Associate	19558549
Evans Syndrome	Associate	35655776
Failure to Thrive	Associate	27378136
Genetic Diseases Inborn	Associate	33995372, 35655776
Head and Neck Neoplasms	Associate	25314064
Hematologic Diseases	Associate	22843554
Hereditary Breast and Ovarian Cancer Syndrome	Associate	20978178
Hypoxia Brain	Stimulate	15613236
Infections	Associate	27378136
Inflammation	Associate	36323068
Influenza Human	Stimulate	24641803
Leukemia	Associate	28715732, 32869129
Leukemia Promyelocytic Acute	Associate	12388546
Liver Cirrhosis Biliary	Associate	36323068
Lung Neoplasms	Associate	20661084
Lupus Erythematosus Systemic	Associate	19440200, 36075396
Lymphatic Diseases	Associate	27378136
Lymphoma Non Hodgkin	Associate	12010812
Lymphoma T Cell Cutaneous	Associate	17495957, 22011910
Melanoma Cutaneous Malignant	Associate	18563783
Michelin tire baby syndrome	Associate	29301000
Multiple Myeloma	Associate	23541952
Muscle Hypotonia	Associate	29301000
Muscle Weakness	Associate	27378136
Neoplasms	Associate	11583996, 12010812, 18381704, 18563783, 22843554, 24037645, 34741802
Neuroblastoma	Associate	14670183
Periodontitis	Associate	24631628
Philadelphia Chromosome	Associate	29542026
Precursor Cell Lymphoblastic Leukemia Lymphoma	Associate	25061812
Primary Immunodeficiency Diseases	Associate	38644452
Pulmonary Disease Chronic Obstructive	Associate	22829758
Purpura Thrombotic Thrombocytopenic	Associate	31714957
Sarcoma Ewing	Associate	25157404
Small Cell Lung Carcinoma	Associate	38181741
Stomach Neoplasms	Associate	12174360, 15288293, 23921907
Trophoblastic Neoplasms	Associate	16443735
Wounds and Injuries	Associate	22926077

CASP10 (caspase 10)