ING5 (inhibitor of growth family member 5)
Gene | |
Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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84289 |
Gene name
Gene Name - the full gene name approved by the HGNC.
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Inhibitor of growth family member 5 |
Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
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ING5 |
Synonyms (NCBI Gene)
Gene synonyms aliases
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p28ING5 |
Chromosome
Chromosome number
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2 |
Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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2q37.3 |
Summary
Summary of gene provided in NCBI Entrez Gene.
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This gene encodes a tumor suppressor protein that inhibits cell growth and induces apoptosis. This protein contains a PHD-type zinc finger. It interacts with tumor suppressor p53 and p300, a component of the histone acetyl transferase complex, suggesting |
miRNA
miRNA information provided by mirtarbase database.
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Transcription factors | |||||||
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Gene ontology (GO)
Gene ontology information of associated ontologies with gene provided by GO database.
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Other IDs
Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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Protein | |||||||||||
UniProt ID | Q8WYH8 | ||||||||||
Protein name | Inhibitor of growth protein 5 (p28ING5) | ||||||||||
Protein function | Component of the HBO1 complex, which specifically mediates acetylation of histone H3 at 'Lys-14' (H3K14ac) and, to a lower extent, acetylation of histone H4 (PubMed:24065767). Component of the MOZ/MORF complex which has a histone H3 acetyltransf | ||||||||||
PDB | 3C6W , 5ME8 , 5MTO | ||||||||||
Family and domains |
Pfam
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Tissue specificity | TISSUE SPECIFICITY: Down-regulated in bone marrow cells in acute myeloid leukemia patients as compared with normal bone marrow cells. {ECO:0000269|PubMed:21750715}. | ||||||||||
Sequence |
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Sequence length | 240 | ||||||||||
Interactions | View interactions |
Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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Associated diseases
Disease information provided by ClinVar, GenCC, and GWAS databases.
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