TMEM175 (transmembrane protein 175)

Gene

• Entrez ID: 84286
• Gene name: Transmembrane protein 175
• Gene symbol: TMEM175
• Synonyms (NCBI Gene): hTMEM175
• Chromosome: 4
• Chromosome location: 4p16.3

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT037472	hsa-miR-744-5p	CLASH	23622248
MIRT719514	hsa-miR-181c-3p	HITS-CLIP	19536157
MIRT719513	hsa-miR-6515-3p	HITS-CLIP	19536157
MIRT719512	hsa-miR-1236-3p	HITS-CLIP	19536157
MIRT719511	hsa-miR-585-3p	HITS-CLIP	19536157
MIRT719510	hsa-miR-1268a	HITS-CLIP	19536157
MIRT719509	hsa-miR-1268b	HITS-CLIP	19536157
MIRT719514	hsa-miR-181c-3p	HITS-CLIP	19536157
MIRT719513	hsa-miR-6515-3p	HITS-CLIP	19536157
MIRT719512	hsa-miR-1236-3p	HITS-CLIP	19536157
MIRT719511	hsa-miR-585-3p	HITS-CLIP	19536157
MIRT719510	hsa-miR-1268a	HITS-CLIP	19536157
MIRT719509	hsa-miR-1268b	HITS-CLIP	19536157
MIRT1432817	hsa-miR-3145-3p	CLIP-seq
MIRT1432818	hsa-miR-3169	CLIP-seq
MIRT1432819	hsa-miR-4740-5p	CLIP-seq
MIRT2351223	hsa-miR-1972	CLIP-seq
MIRT2351224	hsa-miR-3647-3p	CLIP-seq
MIRT2351225	hsa-miR-4717-5p	CLIP-seq
MIRT2351226	hsa-miR-548aa	CLIP-seq
MIRT2351223	hsa-miR-1972	CLIP-seq
MIRT1432817	hsa-miR-3145-3p	CLIP-seq
MIRT2351224	hsa-miR-3647-3p	CLIP-seq
MIRT2351225	hsa-miR-4717-5p	CLIP-seq
MIRT2644910	hsa-miR-513b	CLIP-seq
MIRT2351226	hsa-miR-548aa	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005267	Function	Potassium channel activity	IDA	28723891
GO:0005764	Component	Lysosome	IBA	21873635
GO:0005764	Component	Lysosome	IDA	26317472
GO:0005765	Component	Lysosomal membrane	HDA	17897319
GO:0005768	Component	Endosome	IBA	21873635
GO:0005768	Component	Endosome	IDA	26317472
GO:0010008	Component	Endosome membrane	IEA
GO:0016021	Component	Integral component of membrane	IEA
GO:0022841	Function	Potassium ion leak channel activity	IBA	21873635
GO:0022841	Function	Potassium ion leak channel activity	IDA	26317472
GO:0035751	Process	Regulation of lysosomal lumen pH	IEA
GO:0071805	Process	Potassium ion transmembrane transport	IDA	26317472, 28723891
GO:0090385	Process	Phagosome-lysosome fusion	IEA

Other IDs

• MIM: 616660
• HGNC: 28709
• e!Ensembl: ENSG00000127419

Protein

• UniProt ID: Q9BSA9
• Protein name: Endosomal/lysosomal proton channel TMEM175 (Potassium channel TMEM175) (Transmembrane protein 175) (hTMEM175)
• Protein function: Proton-activated proton channel that catalyzes proton efflux from endosomes and lysosomes to maintain a steady-state pH (PubMed:35333573, PubMed:35750034, PubMed:37390818). Activated at low pH (under pH 4.6) by luminal side protons: selectively
• PDB: 6W8N, 6W8O, 6W8P, 6WC9, 6WCA, 6WCB, 6WCC, 7LF6, 7UNL, 7UNM, 8DHM, 8FY5, 8FYF, 8VIC, 8VIE
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF06736	DUF1211	35 → 124	Protein of unknown function (DUF1211)	Family
  PF06736	DUF1211	260 → 356	Protein of unknown function (DUF1211)	Family

• Tissue specificity: TISSUE SPECIFICITY: Widely expressed. {ECO:0000269|PubMed:26317472}.
• Sequence:

  MSQPRTPEQALDTPGDCPPGRRDEDAGEGIQCSQRMLSFSDALLSIIATVMILPVTHTEI
  SPEQQFDRSVQRLLATRIAVYLMTFLIVTVAWAAHTRLFQVVGKTDDTLALLNLACMMTI
  TFLPYTFSLMVTFPDVPLGIFLFCVCVIAIGVVQALIVGYAFHFPHLLSPQIQRSAHRAL
  YRRHVLGIVLQGPALCFAAAIFSLFFVPLSYLLMVTVILLPYVSKVTGWCRDRLLGHREP
  SAHPVEVFSFDLHEPLSKERVEAFSDGVYAIVATLLILDICEDNVPDPKDVKERFSGSLV
  AALSATGPRFLAYFGSFATVGLLWFAHHSLFLHVRKATRAMGLLNTLSLAFVGGLPLAYQ
  QTSAFARQPRDELERVRVSCTIIFLASIFQLAMWTTALLHQAETLQPSVWFGGREHVLMF
  AKLALYPCASLLAFASTCLLSRFSVGIFHLMQIAVPCAFLLLRLLVGLALATLRVLRGLA
  RPEHPPPAPTGQDDPQSQLLPAPC

• Sequence length: 504

Associated diseases

Causal
Disease term	Disease name	dbSNP ID	References
Parkinson disease	Parkinson Disease	rs33939927, rs35801418, rs34805604, rs35870237, rs34995376, rs74315355, rs28940284, rs74315356, rs74315357, rs28940285, rs730880302, rs750664040, rs74315359, rs74315360, rs45539432, rs119451946, rs80356771, rs74500255, rs75822236, rs1141814, rs78973108, rs121908681, rs121908686, rs121908687, rs137853054, rs137853055, rs137853056, rs137853057, rs137853058, rs137853059, rs34424986, rs137853060, rs397518439, rs28938172, rs74315351, rs74315353, rs137853051, rs118192098, rs121918104, rs1589451049, rs104893877, rs104893878, rs188286943, rs387906863, rs387906864, rs774631197, rs199935023, rs397514694, rs398122403, rs398122404, rs398122405, rs104886460, rs409652, rs431905511, rs63751392, rs756677845, rs864309527, rs864309650, rs750014782, rs1554391082, rs864622011, rs869312810, rs869312809, rs869312811, rs369100678, rs879253853, rs869320761, rs747506979, rs879255630, rs886039854, rs191486604, rs781442277, rs1060499619, rs751037529, rs55777503, rs768091663, rs34208370, rs1553122929, rs772786691, rs754809877, rs1555907463, rs1557561340, rs781600849, rs141263564, rs1557901552, rs777160388, rs756783990, rs867929413, rs1237637353, rs1005937012, rs755000580, rs747427602, rs1578089802, rs771586218, rs748142049, rs1582953433, rs746646126, rs771529549, rs121918106	25064009, 21738487, 21292315, 22438815, 30957308, 28892059

Unknown
Disease term	Disease name	Evidence	References	Source
Parkinson Disease	Parkinson Disease			GWAS
Diabetes	Diabetes			GWAS
Metabolic Syndrome	Metabolic Syndrome			GWAS

Associations from Text Mining
Disease Name	Relationship Type	References
Amyotrophic Lateral Sclerosis	Associate	37328865, 37639066
Autonomic Nervous System Diseases	Associate	34994165
Diffuse Neurofibrillary Tangles with Calcification	Associate	35729600
Lewy Body Disease	Associate	35729600
Multiple Sclerosis	Associate	36279431
Parkinson Disease	Associate	26601739, 30957308, 31261387, 33436766, 34148545, 34994165, 35750034, 36279431, 36609826, 37328865
REM Sleep Behavior Disorder	Associate	32986685
Synucleinopathies	Associate	32986685