SYT3 (synaptotagmin 3)

Gene

• Entrez ID: 84258
• Gene name: Synaptotagmin 3
• Gene symbol: SYT3
• Synonyms (NCBI Gene): SytIII
• Chromosome: 19
• Chromosome location: 19q13.33

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT2122133	hsa-miR-128	CLIP-seq
MIRT2122134	hsa-miR-15a	CLIP-seq
MIRT2122135	hsa-miR-15b	CLIP-seq
MIRT2122136	hsa-miR-16	CLIP-seq
MIRT2122137	hsa-miR-195	CLIP-seq
MIRT2122138	hsa-miR-3144-5p	CLIP-seq
MIRT2122139	hsa-miR-3612	CLIP-seq
MIRT2122140	hsa-miR-3929	CLIP-seq
MIRT2122141	hsa-miR-424	CLIP-seq
MIRT2122142	hsa-miR-4419b	CLIP-seq
MIRT2122143	hsa-miR-4443	CLIP-seq
MIRT2122144	hsa-miR-4447	CLIP-seq
MIRT2122145	hsa-miR-4472	CLIP-seq
MIRT2122146	hsa-miR-4478	CLIP-seq
MIRT2122147	hsa-miR-4519	CLIP-seq
MIRT2122148	hsa-miR-4524	CLIP-seq
MIRT2122149	hsa-miR-485-5p	CLIP-seq
MIRT2122150	hsa-miR-497	CLIP-seq
MIRT2122151	hsa-miR-503	CLIP-seq
MIRT2122152	hsa-miR-646	CLIP-seq
MIRT2122153	hsa-miR-650	CLIP-seq
MIRT2122134	hsa-miR-15a	CLIP-seq
MIRT2122135	hsa-miR-15b	CLIP-seq
MIRT2122136	hsa-miR-16	CLIP-seq
MIRT2122137	hsa-miR-195	CLIP-seq
MIRT2122141	hsa-miR-424	CLIP-seq
MIRT2122150	hsa-miR-497	CLIP-seq
MIRT2122134	hsa-miR-15a	CLIP-seq
MIRT2122135	hsa-miR-15b	CLIP-seq
MIRT2122136	hsa-miR-16	CLIP-seq
MIRT2122137	hsa-miR-195	CLIP-seq
MIRT2122141	hsa-miR-424	CLIP-seq
MIRT2122150	hsa-miR-497	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000149	Function	SNARE binding	IBA
GO:0005515	Function	Protein binding	IPI	32296183, 32814053
GO:0005544	Function	Calcium-dependent phospholipid binding	IBA
GO:0005544	Function	Calcium-dependent phospholipid binding	NAS	12526776
GO:0005768	Component	Endosome	IDA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0007268	Process	Chemical synaptic transmission	IBA
GO:0016020	Component	Membrane	IEA
GO:0016192	Process	Vesicle-mediated transport	IBA
GO:0017158	Process	Regulation of calcium ion-dependent exocytosis	IBA
GO:0030154	Process	Cell differentiation	IEA
GO:0030658	Component	Transport vesicle membrane	IEA
GO:0031340	Process	Positive regulation of vesicle fusion	IBA
GO:0031410	Component	Cytoplasmic vesicle	IEA
GO:0045202	Component	Synapse	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0061891	Function	Calcium ion sensor activity	IBA
GO:0070382	Component	Exocytic vesicle	IBA
GO:1903861	Process	Positive regulation of dendrite extension	IDA	23999003

Other IDs

• MIM: 600327
• HGNC: 11511
• e!Ensembl: ENSG00000213023

Protein

• UniProt ID: Q9BQG1
• Protein name: Synaptotagmin-3 (Synaptotagmin III) (SytIII)
• Protein function: Ca(2+) sensor involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain. Ca(2+) induces binding of the C2-domains to phospholipid membranes and to assembled SNARE-complexes; both actio
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00168	C2	314 → 421	C2 domain	Domain
  PF00168	C2	446 → 553	C2 domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Expressed in melanocytes (PubMed:23999003). {ECO:0000269|PubMed:23999003}.
• Sequence:

  MSGDYEDDLCRRALILVSDLCARVRDADTNDRCQEFNDRIRGYPRGPDADISVSLLSVIV
  TFCGIVLLGVSLFVSWKLCWVPWRDKGGSAVGGGPLRKDLGPGVGLAGLVGGGGHHLAAG
  LGGHPLLGGPHHHAHAAHHPPFAELLEPGSLGGSDTPEPSYLDMDSYPEAAAAAVAAGVK
  PSQTSPELPSEGGAGSGLLLLPPSGGGLPSAQSHQQVTSLAPTTRYPALPRPLTQQTLTS
  QPDPSSEERPPALPLPLPGGEEKAKLIGQIKPELYQGTGPGGRRSGGGPGSGEAGTGAPC
  GRISFALRYLYGSDQLVVRILQALDLPAKDSNGFSDPYVKIYLLPDRKKKFQTKVHRKTL
  NPVFNETFQFSVPLAELAQRKLHFSVYDFDRFSRHDLIGQVVLDNLLELAEQPPDRPLWR
  DIVEGGSEKADLGELNFSLCYLPTAGRLTVTIIKASNLKAMDLTGFSDPYVKASLISEGR
  RLKKRKTSIKKNTLNPTYNEALVFDVAPESVENVGLSIAVVDYDCIGHNEVIGVCRVGPD
  AADPHGREHWAEMLANPRKPVEHWHQLVEEKTVTSFTKGSKGLSEKENSE

• Sequence length: 590

Associated diseases

Unknown
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Ovarian serous cystadenocarcinoma	Benign	rs182688683	RCV005903388
Uterine corpus endometrial carcinoma	Benign	rs182688683	RCV005903389