Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	84258
Gene name Gene Name - the full gene name approved by the HGNC.	Synaptotagmin 3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	SYT3
Synonyms (NCBI Gene) Gene synonyms aliases	SytIII
Chromosome Chromosome number	19
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	19q13.33

Show/Hide all(33)

miRTarBase ID	miRNA	Experiments
MIRT2122133	hsa-miR-128	CLIP-seq
MIRT2122134	hsa-miR-15a	CLIP-seq
MIRT2122135	hsa-miR-15b	CLIP-seq
MIRT2122136	hsa-miR-16	CLIP-seq
MIRT2122137	hsa-miR-195	CLIP-seq
MIRT2122138	hsa-miR-3144-5p	CLIP-seq
MIRT2122139	hsa-miR-3612	CLIP-seq
MIRT2122140	hsa-miR-3929	CLIP-seq
MIRT2122141	hsa-miR-424	CLIP-seq
MIRT2122142	hsa-miR-4419b	CLIP-seq
MIRT2122143	hsa-miR-4443	CLIP-seq
MIRT2122144	hsa-miR-4447	CLIP-seq
MIRT2122145	hsa-miR-4472	CLIP-seq
MIRT2122146	hsa-miR-4478	CLIP-seq
MIRT2122147	hsa-miR-4519	CLIP-seq
MIRT2122148	hsa-miR-4524	CLIP-seq
MIRT2122149	hsa-miR-485-5p	CLIP-seq
MIRT2122150	hsa-miR-497	CLIP-seq
MIRT2122151	hsa-miR-503	CLIP-seq
MIRT2122152	hsa-miR-646	CLIP-seq
MIRT2122153	hsa-miR-650	CLIP-seq
MIRT2122134	hsa-miR-15a	CLIP-seq
MIRT2122135	hsa-miR-15b	CLIP-seq
MIRT2122136	hsa-miR-16	CLIP-seq
MIRT2122137	hsa-miR-195	CLIP-seq
MIRT2122141	hsa-miR-424	CLIP-seq
MIRT2122150	hsa-miR-497	CLIP-seq
MIRT2122134	hsa-miR-15a	CLIP-seq
MIRT2122135	hsa-miR-15b	CLIP-seq
MIRT2122136	hsa-miR-16	CLIP-seq
MIRT2122137	hsa-miR-195	CLIP-seq
MIRT2122141	hsa-miR-424	CLIP-seq
MIRT2122150	hsa-miR-497	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000149	Function	SNARE binding	IBA	21873635
GO:0001786	Function	Phosphatidylserine binding	IBA	21873635
GO:0005509	Function	Calcium ion binding	IBA	21873635
GO:0005515	Function	Protein binding	IPI	32296183, 32814053
GO:0005544	Function	Calcium-dependent phospholipid binding	IBA	21873635
GO:0005544	Function	Calcium-dependent phospholipid binding	NAS	12526776
GO:0005768	Component	Endosome	IDA
GO:0005886	Component	Plasma membrane	IBA	21873635
GO:0014059	Process	Regulation of dopamine secretion	IBA	21873635
GO:0016021	Component	Integral component of membrane	IEA
GO:0016192	Process	Vesicle-mediated transport	IBA	21873635
GO:0017156	Process	Calcium-ion regulated exocytosis	IBA	21873635
GO:0017158	Process	Regulation of calcium ion-dependent exocytosis	IBA	21873635
GO:0019905	Function	Syntaxin binding	IBA	21873635
GO:0030154	Process	Cell differentiation	IEA
GO:0030276	Function	Clathrin binding	IBA	21873635
GO:0030658	Component	Transport vesicle membrane	IEA
GO:0070382	Component	Exocytic vesicle	IBA	21873635
GO:0071277	Process	Cellular response to calcium ion	IBA	21873635
GO:1903861	Process	Positive regulation of dendrite extension	IDA	23999003

MIM	HGNC	e!Ensembl
600327	11511	ENSG00000213023

Protein

UniProt ID

Q9BQG1

Protein name

Synaptotagmin-3 (Synaptotagmin III) (SytIII)

Protein function

Ca(2+) sensor involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain. Ca(2+) induces binding of the C2-domains to phospholipid membranes and to assembled SNARE-complexes; both actio

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00168	C2	314 → 421	C2 domain	Domain
PF00168	C2	446 → 553	C2 domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in melanocytes (PubMed:23999003). {ECO:0000269|PubMed:23999003}.

Sequence

MSGDYEDDLCRRALILVSDLCARVRDADTNDRCQEFNDRIRGYPRGPDADISVSLLSVIV
TFCGIVLLGVSLFVSWKLCWVPWRDKGGSAVGGGPLRKDLGPGVGLAGLVGGGGHHLAAG
LGGHPLLGGPHHHAHAAHHPPFAELLEPGSLGGSDTPEPSYLDMDSYPEAAAAAVAAGVK
PSQTSPELPSEGGAGSGLLLLPPSGGGLPSAQSHQQVTSLAPTTRYPALPRPLTQQTLTS
QPDPSSEERPPALPLPLPGGEEKAKLIGQIKPELYQGTGPGGRRSGGGPGSGEAGTGAPC
GRISFALRYLYGSDQLVVRILQALDLPAKDSNGFSDPYVKIYLLPDRKKKFQTKVHRKTL
NPVFNETFQFSVPLAELAQRKLHFSVYDFDRFSRHDLIGQVVLDNLLELAEQPPDRPLWR
DIVEGGSEKADLGELNFSLCYLPTAGRLTVTIIKASNLKAMDLTGFSDPYVKASLISEGR
RLKKRKTSIKKNTLNPTYNEALVFDVAPESVENVGLSIAVVDYDCIGHNEVIGVCRVGPD
AADPHGREHWAEMLANPRKPVEHWHQLVEEKTVTSFTKGSKGLSEKENSE

Sequence length

590

Interactions

View interactions

Show/Hide Causal Diseases (1)

Disease term	Disease name	dbSNP ID	References
Causal
Breast cancer	Malignant neoplasm of breast	rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158 View all (309 more)

SYT3 (synaptotagmin 3)