SGIP1 (SH3GL interacting endocytic adaptor 1)
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Gene
Gene information from NCBI Gene database.
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| Entrez ID | 84251 |
| Gene name | SH3GL interacting endocytic adaptor 1 |
| Gene symbol | SGIP1 |
| Synonyms (NCBI Gene) |
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| Chromosome | 1 |
| Chromosome location | 1p31.3 |
| Summary | SGIP1 functions as an endocytic protein that affects signaling by receptors in neuronal systems involved in energy homeostasis via its interaction with endophilins (see SH3GL3; MIM 603362) (Trevaskis et al., 2005 [PubMed 15919751] and Uezu et al., 2007 [P |
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miRNA
miRNA information provided by mirtarbase database.
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Gene ontology (GO)
Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
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Other IDs
Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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Protein
Protein information from UniProt database.
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UniProt ID
Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
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Q9BQI5 | ||||||||||
| Protein name | SH3-containing GRB2-like protein 3-interacting protein 1 (Endophilin-3-interacting protein) | ||||||||||
| Protein function | May function in clathrin-mediated endocytosis. Has both a membrane binding/tubulating activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a preference for membranes enriched in phosphat | ||||||||||
| PDB | 5AWR , 5AWS , 5AWT , 5AWU , 6A9Y | ||||||||||
| Family and domains |
Pfam
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| Tissue specificity | TISSUE SPECIFICITY: Specifically expressed in brain. {ECO:0000269|PubMed:15919751}. | ||||||||||
| Sequence |
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| Sequence length | 828 | ||||||||||
| Interactions | View interactions | ||||||||||
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Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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Associated diseases
Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
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Evidence Score:
★☆☆☆☆ Gene-disease association found in Text Mining only
★★☆☆☆ Found in Text Mining and Unknown/Other Associations
★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources
★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
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