Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	84181
Gene name Gene Name - the full gene name approved by the HGNC.	Chromodomain helicase DNA binding protein 6
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	CHD6
Synonyms (NCBI Gene) Gene synonyms aliases	CHD-6, CHD5, RIGB
Chromosome Chromosome number	20
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	20q12
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a member of the SNF2/RAD54 helicase protein family. The encoded protein contains two chromodomains, a helicase domain, and an ATPase domain. Several multi-subunit protein complexes remodel chromatin to allow patterns of cell type-specifi

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miRTarBase ID	miRNA	Experiments	Reference
MIRT016929	hsa-miR-335-5p	Microarray	18185580
MIRT889230	hsa-miR-1265	CLIP-seq
MIRT889231	hsa-miR-1287	CLIP-seq
MIRT889232	hsa-miR-1296	CLIP-seq
MIRT889233	hsa-miR-1324	CLIP-seq
MIRT889234	hsa-miR-141	CLIP-seq
MIRT889235	hsa-miR-200a	CLIP-seq
MIRT889236	hsa-miR-200b	CLIP-seq
MIRT889237	hsa-miR-200c	CLIP-seq
MIRT889238	hsa-miR-221	CLIP-seq
MIRT889239	hsa-miR-222	CLIP-seq
MIRT889240	hsa-miR-2277-3p	CLIP-seq
MIRT889241	hsa-miR-2909	CLIP-seq
MIRT889242	hsa-miR-3065-5p	CLIP-seq
MIRT889243	hsa-miR-3135b	CLIP-seq
MIRT889244	hsa-miR-3143	CLIP-seq
MIRT889245	hsa-miR-3146	CLIP-seq
MIRT889246	hsa-miR-3154	CLIP-seq
MIRT889247	hsa-miR-3161	CLIP-seq
MIRT889248	hsa-miR-3609	CLIP-seq
MIRT889249	hsa-miR-3647-3p	CLIP-seq
MIRT889250	hsa-miR-369-3p	CLIP-seq
MIRT889251	hsa-miR-374a	CLIP-seq
MIRT889252	hsa-miR-374b	CLIP-seq
MIRT889253	hsa-miR-3920	CLIP-seq
MIRT889254	hsa-miR-3923	CLIP-seq
MIRT889255	hsa-miR-429	CLIP-seq
MIRT889256	hsa-miR-4310	CLIP-seq
MIRT889257	hsa-miR-4434	CLIP-seq
MIRT889258	hsa-miR-4436b-3p	CLIP-seq
MIRT889259	hsa-miR-4436b-5p	CLIP-seq
MIRT889260	hsa-miR-4475	CLIP-seq
MIRT889261	hsa-miR-4504	CLIP-seq
MIRT889262	hsa-miR-4516	CLIP-seq
MIRT889263	hsa-miR-451b	CLIP-seq
MIRT889264	hsa-miR-4522	CLIP-seq
MIRT889265	hsa-miR-4528	CLIP-seq
MIRT889266	hsa-miR-4531	CLIP-seq
MIRT889267	hsa-miR-4661-5p	CLIP-seq
MIRT889268	hsa-miR-4699-5p	CLIP-seq
MIRT889269	hsa-miR-4709-3p	CLIP-seq
MIRT889270	hsa-miR-4716-3p	CLIP-seq
MIRT889271	hsa-miR-4738-3p	CLIP-seq
MIRT889272	hsa-miR-4761-3p	CLIP-seq
MIRT889273	hsa-miR-4764-5p	CLIP-seq
MIRT889274	hsa-miR-4786-5p	CLIP-seq
MIRT889275	hsa-miR-4796-5p	CLIP-seq
MIRT889276	hsa-miR-493	CLIP-seq
MIRT889277	hsa-miR-498	CLIP-seq
MIRT889278	hsa-miR-514	CLIP-seq
MIRT889279	hsa-miR-514b-3p	CLIP-seq
MIRT889280	hsa-miR-539	CLIP-seq
MIRT889281	hsa-miR-542-3p	CLIP-seq
MIRT889282	hsa-miR-548aa	CLIP-seq
MIRT889283	hsa-miR-548ac	CLIP-seq
MIRT889284	hsa-miR-548ah	CLIP-seq
MIRT889285	hsa-miR-548d-3p	CLIP-seq
MIRT889286	hsa-miR-548t	CLIP-seq
MIRT889287	hsa-miR-548v	CLIP-seq
MIRT889288	hsa-miR-548z	CLIP-seq
MIRT889289	hsa-miR-549	CLIP-seq
MIRT889290	hsa-miR-579	CLIP-seq
MIRT889291	hsa-miR-582-3p	CLIP-seq
MIRT889292	hsa-miR-624	CLIP-seq
MIRT889293	hsa-miR-625	CLIP-seq
MIRT889294	hsa-miR-628-3p	CLIP-seq
MIRT889295	hsa-miR-769-5p	CLIP-seq
MIRT889296	hsa-miR-802	CLIP-seq
MIRT1963543	hsa-miR-103a	CLIP-seq
MIRT1963544	hsa-miR-103b	CLIP-seq
MIRT1963545	hsa-miR-107	CLIP-seq
MIRT1963546	hsa-miR-1278	CLIP-seq
MIRT889233	hsa-miR-1324	CLIP-seq
MIRT1963547	hsa-miR-1539	CLIP-seq
MIRT1963548	hsa-miR-15a	CLIP-seq
MIRT1963549	hsa-miR-15b	CLIP-seq
MIRT1963550	hsa-miR-16	CLIP-seq
MIRT1963551	hsa-miR-195	CLIP-seq
MIRT889240	hsa-miR-2277-3p	CLIP-seq
MIRT1963552	hsa-miR-2278	CLIP-seq
MIRT1963553	hsa-miR-3121-3p	CLIP-seq
MIRT1963554	hsa-miR-3133	CLIP-seq
MIRT889244	hsa-miR-3143	CLIP-seq
MIRT1963555	hsa-miR-3173-5p	CLIP-seq
MIRT1963556	hsa-miR-3193	CLIP-seq
MIRT1963557	hsa-miR-339-5p	CLIP-seq
MIRT1963558	hsa-miR-361-3p	CLIP-seq
MIRT1963559	hsa-miR-376a	CLIP-seq
MIRT1963560	hsa-miR-376b	CLIP-seq
MIRT889253	hsa-miR-3920	CLIP-seq
MIRT1963561	hsa-miR-3976	CLIP-seq
MIRT1963562	hsa-miR-424	CLIP-seq
MIRT889256	hsa-miR-4310	CLIP-seq
MIRT889257	hsa-miR-4434	CLIP-seq
MIRT889259	hsa-miR-4436b-5p	CLIP-seq
MIRT889261	hsa-miR-4504	CLIP-seq
MIRT889262	hsa-miR-4516	CLIP-seq
MIRT889263	hsa-miR-451b	CLIP-seq
MIRT889266	hsa-miR-4531	CLIP-seq
MIRT889267	hsa-miR-4661-5p	CLIP-seq
MIRT1963563	hsa-miR-4698	CLIP-seq
MIRT889268	hsa-miR-4699-5p	CLIP-seq
MIRT889269	hsa-miR-4709-3p	CLIP-seq
MIRT1963564	hsa-miR-4724-5p	CLIP-seq
MIRT1963565	hsa-miR-4742-3p	CLIP-seq
MIRT1963566	hsa-miR-4778-3p	CLIP-seq
MIRT1963567	hsa-miR-4802-3p	CLIP-seq
MIRT1963568	hsa-miR-497	CLIP-seq
MIRT889277	hsa-miR-498	CLIP-seq
MIRT1963569	hsa-miR-499a-5p	CLIP-seq
MIRT889278	hsa-miR-514	CLIP-seq
MIRT889279	hsa-miR-514b-3p	CLIP-seq
MIRT889281	hsa-miR-542-3p	CLIP-seq
MIRT1963570	hsa-miR-548a-3p	CLIP-seq
MIRT1963571	hsa-miR-548e	CLIP-seq
MIRT1963572	hsa-miR-548f	CLIP-seq
MIRT889290	hsa-miR-579	CLIP-seq
MIRT1963546	hsa-miR-1278	CLIP-seq
MIRT889233	hsa-miR-1324	CLIP-seq
MIRT2199956	hsa-miR-3682-5p	CLIP-seq
MIRT2199957	hsa-miR-3688-3p	CLIP-seq
MIRT889253	hsa-miR-3920	CLIP-seq
MIRT2199958	hsa-miR-4261	CLIP-seq
MIRT889256	hsa-miR-4310	CLIP-seq
MIRT2199959	hsa-miR-4330	CLIP-seq
MIRT889259	hsa-miR-4436b-5p	CLIP-seq
MIRT889261	hsa-miR-4504	CLIP-seq
MIRT889265	hsa-miR-4528	CLIP-seq
MIRT889268	hsa-miR-4699-5p	CLIP-seq
MIRT889269	hsa-miR-4709-3p	CLIP-seq
MIRT1963564	hsa-miR-4724-5p	CLIP-seq
MIRT1963569	hsa-miR-499a-5p	CLIP-seq
MIRT889281	hsa-miR-542-3p	CLIP-seq
MIRT1963570	hsa-miR-548a-3p	CLIP-seq
MIRT1963571	hsa-miR-548e	CLIP-seq
MIRT1963572	hsa-miR-548f	CLIP-seq
MIRT2199960	hsa-miR-550b	CLIP-seq
MIRT2199961	hsa-miR-7	CLIP-seq
MIRT2199962	hsa-miR-890	CLIP-seq
MIRT889259	hsa-miR-4436b-5p	CLIP-seq
MIRT2446996	hsa-miR-3185	CLIP-seq
MIRT2446997	hsa-miR-3915	CLIP-seq
MIRT2446998	hsa-miR-3928	CLIP-seq
MIRT2502669	hsa-miR-2110	CLIP-seq
MIRT2502670	hsa-miR-2682	CLIP-seq
MIRT2502671	hsa-miR-302a	CLIP-seq
MIRT2502672	hsa-miR-302b	CLIP-seq
MIRT2502673	hsa-miR-302c	CLIP-seq
MIRT2502674	hsa-miR-302d	CLIP-seq
MIRT2502675	hsa-miR-302e	CLIP-seq
MIRT889244	hsa-miR-3143	CLIP-seq
MIRT889246	hsa-miR-3154	CLIP-seq
MIRT2446996	hsa-miR-3185	CLIP-seq
MIRT2502676	hsa-miR-3673	CLIP-seq
MIRT2502677	hsa-miR-372	CLIP-seq
MIRT2502678	hsa-miR-373	CLIP-seq
MIRT2446997	hsa-miR-3915	CLIP-seq
MIRT2446998	hsa-miR-3928	CLIP-seq
MIRT2502679	hsa-miR-409-3p	CLIP-seq
MIRT2502680	hsa-miR-4264	CLIP-seq
MIRT2502681	hsa-miR-4271	CLIP-seq
MIRT2502682	hsa-miR-4277	CLIP-seq
MIRT2502683	hsa-miR-4423-3p	CLIP-seq
MIRT889257	hsa-miR-4434	CLIP-seq
MIRT889259	hsa-miR-4436b-5p	CLIP-seq
MIRT889260	hsa-miR-4475	CLIP-seq
MIRT2502684	hsa-miR-449c	CLIP-seq
MIRT889262	hsa-miR-4516	CLIP-seq
MIRT889266	hsa-miR-4531	CLIP-seq
MIRT2502685	hsa-miR-4662a-3p	CLIP-seq
MIRT889268	hsa-miR-4699-5p	CLIP-seq
MIRT889269	hsa-miR-4709-3p	CLIP-seq
MIRT2502686	hsa-miR-4725-3p	CLIP-seq
MIRT889274	hsa-miR-4786-5p	CLIP-seq
MIRT2502687	hsa-miR-4797-3p	CLIP-seq
MIRT1963567	hsa-miR-4802-3p	CLIP-seq
MIRT2502688	hsa-miR-488	CLIP-seq
MIRT889276	hsa-miR-493	CLIP-seq
MIRT2502689	hsa-miR-512-3p	CLIP-seq
MIRT2502690	hsa-miR-520a-3p	CLIP-seq
MIRT2502691	hsa-miR-520b	CLIP-seq
MIRT2502692	hsa-miR-520c-3p	CLIP-seq
MIRT2502693	hsa-miR-520d-3p	CLIP-seq
MIRT2502694	hsa-miR-520e	CLIP-seq
MIRT889295	hsa-miR-769-5p	CLIP-seq
MIRT2502695	hsa-miR-940	CLIP-seq
MIRT2502669	hsa-miR-2110	CLIP-seq
MIRT2502670	hsa-miR-2682	CLIP-seq
MIRT2502671	hsa-miR-302a	CLIP-seq
MIRT2502672	hsa-miR-302b	CLIP-seq
MIRT2502673	hsa-miR-302c	CLIP-seq
MIRT2502674	hsa-miR-302d	CLIP-seq
MIRT2502675	hsa-miR-302e	CLIP-seq
MIRT889244	hsa-miR-3143	CLIP-seq
MIRT889246	hsa-miR-3154	CLIP-seq
MIRT2446996	hsa-miR-3185	CLIP-seq
MIRT2502677	hsa-miR-372	CLIP-seq
MIRT2502678	hsa-miR-373	CLIP-seq
MIRT2446997	hsa-miR-3915	CLIP-seq
MIRT2446998	hsa-miR-3928	CLIP-seq
MIRT2502680	hsa-miR-4264	CLIP-seq
MIRT2502681	hsa-miR-4271	CLIP-seq
MIRT2502682	hsa-miR-4277	CLIP-seq
MIRT2502683	hsa-miR-4423-3p	CLIP-seq
MIRT889257	hsa-miR-4434	CLIP-seq
MIRT889260	hsa-miR-4475	CLIP-seq
MIRT2502684	hsa-miR-449c	CLIP-seq
MIRT889262	hsa-miR-4516	CLIP-seq
MIRT889266	hsa-miR-4531	CLIP-seq
MIRT2502686	hsa-miR-4725-3p	CLIP-seq
MIRT889274	hsa-miR-4786-5p	CLIP-seq
MIRT2502687	hsa-miR-4797-3p	CLIP-seq
MIRT1963567	hsa-miR-4802-3p	CLIP-seq
MIRT2502688	hsa-miR-488	CLIP-seq
MIRT889276	hsa-miR-493	CLIP-seq
MIRT2502689	hsa-miR-512-3p	CLIP-seq
MIRT2502690	hsa-miR-520a-3p	CLIP-seq
MIRT2502691	hsa-miR-520b	CLIP-seq
MIRT2502692	hsa-miR-520c-3p	CLIP-seq
MIRT2502693	hsa-miR-520d-3p	CLIP-seq
MIRT2502694	hsa-miR-520e	CLIP-seq
MIRT889295	hsa-miR-769-5p	CLIP-seq
MIRT2502695	hsa-miR-940	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0000785	Component	Chromatin	IBA
GO:0001221	Function	Transcription coregulator binding	IPI	16314513
GO:0003677	Function	DNA binding	IBA
GO:0003677	Function	DNA binding	IEA
GO:0003682	Function	Chromatin binding	IBA
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA	17027977
GO:0005654	Component	Nucleoplasm	IEA
GO:0006325	Process	Chromatin organization	IEA
GO:0006338	Process	Chromatin remodeling	IBA
GO:0008094	Function	ATP-dependent activity, acting on DNA	IDA	17027977
GO:0010468	Process	Regulation of gene expression	IBA
GO:0016787	Function	Hydrolase activity	IEA
GO:0016887	Function	ATP hydrolysis activity	IBA
GO:0016887	Function	ATP hydrolysis activity	IEA
GO:0042393	Function	Histone binding	IBA
GO:0045454	Process	Cell redox homeostasis	IMP	16314513
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IMP	16314513
GO:0140658	Function	ATP-dependent chromatin remodeler activity	IBA

MIM	HGNC	e!Ensembl
616114	19057	ENSG00000124177

Protein

UniProt ID

Q8TD26

Protein name

Chromodomain-helicase-DNA-binding protein 6 (CHD-6) (EC 3.6.4.-) (ATP-dependent helicase CHD6) (Radiation-induced gene B protein)

Protein function

ATP-dependent chromatin-remodeling factor (PubMed:17027977, PubMed:28533432). Regulates transcription by disrupting nucleosomes in a largely non-sliding manner which strongly increases the accessibility of chromatin; nucleosome disruption requir

PDB

2EPB

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00385	Chromo	292 → 354	Chromo (CHRromatin Organisation MOdifier) domain	Domain
PF00385	Chromo	375 → 429	Chromo (CHRromatin Organisation MOdifier) domain	Domain
PF00176	SNF2_N	436 → 751	SNF2 family N-terminal domain	Family
PF00271	Helicase_C	783 → 897	Helicase conserved C-terminal domain	Family

Tissue specificity

TISSUE SPECIFICITY: Widely expressed.

Sequence

MKMKIQKKEKQLSNLKVLNHSPMSDASVNFDYKSPSPFDCSTDQEEKIEDVASHCLPQKD
LYTAEEEAATLFPRKMTSHNGMEDSGGGGTGVKKKRKKKEPGDQEGAAKGSKDREPKPKR
KREPKEPKEPRKAKEPKKAKEHKEPKQKDGAKKARKPREASGTKEAKEKRSCTDSAARTK
SRKASKEQGPTPVEKKKKGKRKSETTVESLELDQGLTNPSLRSPEESTESTDSQKRRSGR
QVKRRKYNEDLDFKVVDDDGETIAVLGAGRTSALSASTLAWQAEEPPEDDANIIEKILAS
KTVQEVHPGEPPFDLELFYVKYRNFSYLHCKWATMEELEKDPRIAQKIKRFRNKQAQMKH
IFTEPDEDLFNPDYVEVDRILEVAHTKDAETGEEVTHYLVKWCSLPYEESTWELEEDVDP
AKVKEFESLQVLPEIKHVERPASDSWQKLEKSREYKNSNQLREYQLEGMNWLLFNWYNRK
NCILADEMGLGKTIQSITFLSEIFLRGIHGPFLIIAPLSTITNWEREFRTWTEMNAIVYH
GSQISRQMIQQYEMVYRDAQGNPLSGVFKFHVVITTFEMILADCPELKKIHWSCVIIDEA
HRLKNRNCKLLEGLKLMALEHKVLLTGTPLQNSVEELFSLLNFLEPSQFPSETAFLEEFG
DLKTEEQVKKLQSILKPMMLRRLKDDVEKNLAPKQETIIEVELTNIQKKYYRAILEKNFS
FLTKGANQHNMPNLINTMMELRKCCNHPYLINGAEEKILEDFRKTHSPDAPDFQLQAMIQ
AAGKLVLIDKLLPKLIAGGHKVLIFSQMVRCLDILEDYLIQRRYTYERIDGRVRGNLRQA
AIDRFCKPDSDRFVFLLCTRAGGLGINLTAADTCIIFDSDWNPQNDLQAQARCHRIGQSK
AVKVYRLITRNSYEREMFDKASLKLGLDKAVLQDINRKGGTNGVQQLSKMEVEDLLRKGA
YGALMDEEDEGSKFCEEDIDQILQRRTHTITIQSEGKGSTFAKASFVASGNRTDISLDDP
NFWQKWAKIAELDTEAKNEKESLVIDRPRVRKQTKHYNSFEEDELMEFSELDSDSDERPT
RSRRLNDKARRYLRAECFRVEKNLLIFGWGRWKDILTHGRFKWHLNEKDMEMICRALLVY
CVKHYKGDEKIKSFIWELITPTKDGQAQTLQNHSGLSAPVPRGRKGKKTKNQLLIPELKD
ADWLATCNPEVVLHDDGYKKHLKQHCNKVLLRVRMLYYLKAEILGEAAEKAFEGSPAREL
DVPLPDIDYMEIPVDWWDAEADKSLLIGVFKHGYERYNAMRADPALCFLEKVGMPDEKSL
SAEQGVTDGTSDIPERGNTDKEDNAEDKVDGLQKQTESSSDGGDGVFSEKKDDSRAAQDG
SDPDKSPWPVSSALTARLRRLVTVYQRCNRKELCRPEILGPGNQGYWVQEEMFRRTSEMD
LINKEAQKRWTRREQADFYRTVSSFGVVYDQEKKTFDWTQFRIISRLDKKSDESLEQYFY
SFVAMCRNVCRLPTWKDGGPPDTTIYVEPITEERAARTLYRIELLRKVREQVLKCPQLHE
RLQLCRPSLYLPVWWECGKHDRDLLIGTAKHGLNRTDCYIMNDPQLSFLDAYRNYAQHKR
SGTQAPGNLCCLYQTNSKLYESLTYSQMSRTSESLENEPENLVRVESRDDHLSLPDVTCE
NFISKVQDVISINHDESLLPESLESMMYGKKVLSQEPSSFQESPSTNTESRKDVITISIS
KDGNCQSGGPEAEIASGPTFMGSLEAGGVAQANIKNGKHLLMSISKEGELCCSEAGQRPE
NIGQLEAKCLASPSLNPGNESGFVDMCSLSVCDSKRNLSSDQQLIDLLENKSLESKLILS
QNHSDEEEEEEENEEENLAMAVGMGERPEVLHLTEPTTNISREKNQGFQDETKKGSLEVA
NQTPGLQRAFPAPAACQCHCKHMERWMHGLENDEFEIEKPKAYIPDLFKSKTNTIAMEGE
PTAIPSQPFKVKHELLKEPWKESAEGQNVFPTYPLEGSELKSEDMDFENKDDYDRDGNCH
SQDYPGKYSEEESKSSTSGITGDIGDELQEARAPTIAQLLQEKTLYSFSEWPKDRVIINR
LDNICHVVLKGKWPSSQQYEPSGTLPTPVLTSSAGSRTSLSEPEAAEHSFSNGAALAAQI
HKESFLAPVFTKDEQKHRRPYEFEVERDAKARGLEQFSATHGHTPIILNGWHGESAMDLS
CSSEGSPGATSPFPVSASTPKIGAISSLQGALGMDLSGILQAGLIHPVTGQIVNGSLRRD
DAATRRRRGRRKHVEGGMDLIFLKEQTLQAGILEVHEDPGQATLSTTHPEGPGPATSAPE
PATAASSQAEKSIPSKSLLDWLRQQADYSLEVPGFGANFSDKPKQRRPRCKEPGKLDVSS
LSGEERVPAIPKEPGLRGFLPENKFNHTLAEPILRDTGPRRRGRRPRSELLKAPSIVADS
PSGMGPLFMNGLIAGMDLVGLQNMRNMPGIPLTGLVGFPAGFATMPTGEEVKSTLSMLPM
MLPGMAAVPQMFGVGGLLSPPMATTCTSTAPASLSSTTKSGTAVTEKTAEDKPSSHDVKT
DTLAEDKPGPGPFSDQSEPAITTSSPVAFNPFLIPGVSPGLIYPSMFLSPGMGMALPAMQ
QARHSEIVGLESQKRKKKKTKGDNPNSHPEPAPSCEREPSGDENCAEPSAPLPAEREHGA
QAGEGALKDSNNDTN

Sequence length

2715

Interactions

View interactions

CHD6 (chromodomain helicase DNA binding protein 6)