LOXL4 (lysyl oxidase like 4)

Gene

• Entrez ID: 84171
• Gene name: Lysyl oxidase like 4
• Gene symbol: LOXL4
• Synonyms (NCBI Gene): LOXC
• Chromosome: 10
• Chromosome location: 10q24.2
• Summary: This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation o

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT017606	hsa-miR-335-5p	Microarray	18185580
MIRT022543	hsa-miR-124-3p	Microarray	18668037
MIRT438917	hsa-miR-29b-3p	Luciferase reporter assay, qRT-PCR	23354167
MIRT438917	hsa-miR-29b-3p	Luciferase reporter assay, qRT-PCR	23354167
MIRT1115401	hsa-miR-1275	CLIP-seq
MIRT1115402	hsa-miR-3168	CLIP-seq
MIRT1115403	hsa-miR-3199	CLIP-seq
MIRT1115404	hsa-miR-4515	CLIP-seq
MIRT1115405	hsa-miR-4525	CLIP-seq
MIRT1115406	hsa-miR-4640-5p	CLIP-seq
MIRT1115407	hsa-miR-4652-5p	CLIP-seq
MIRT1115408	hsa-miR-4665-5p	CLIP-seq
MIRT1115409	hsa-miR-4723-5p	CLIP-seq
MIRT1115410	hsa-miR-4726-5p	CLIP-seq
MIRT1115411	hsa-miR-4773	CLIP-seq
MIRT1115412	hsa-miR-4797-5p	CLIP-seq
MIRT1115413	hsa-miR-574-5p	CLIP-seq
MIRT1115414	hsa-miR-625	CLIP-seq
MIRT1115415	hsa-miR-759	CLIP-seq
MIRT1550872	hsa-miR-122	CLIP-seq
MIRT1550873	hsa-miR-202	CLIP-seq
MIRT1550874	hsa-miR-2277-3p	CLIP-seq
MIRT1550875	hsa-miR-3126-3p	CLIP-seq
MIRT1550876	hsa-miR-3944-5p	CLIP-seq
MIRT1550877	hsa-miR-4299	CLIP-seq
MIRT1550878	hsa-miR-4456	CLIP-seq
MIRT1550879	hsa-miR-542-3p	CLIP-seq
MIRT1550880	hsa-miR-548q	CLIP-seq
MIRT1115413	hsa-miR-574-5p	CLIP-seq
MIRT1550881	hsa-miR-646	CLIP-seq
MIRT1550882	hsa-miR-648	CLIP-seq
MIRT2032465	hsa-miR-1200	CLIP-seq
MIRT2032466	hsa-miR-3140-5p	CLIP-seq
MIRT2032467	hsa-miR-4324	CLIP-seq
MIRT2032468	hsa-miR-4468	CLIP-seq
MIRT2032469	hsa-miR-516a-3p	CLIP-seq
MIRT2032470	hsa-miR-544b	CLIP-seq
MIRT2032471	hsa-miR-657	CLIP-seq
MIRT2032465	hsa-miR-1200	CLIP-seq
MIRT2262972	hsa-miR-1910	CLIP-seq
MIRT2262973	hsa-miR-2115	CLIP-seq
MIRT2262974	hsa-miR-218	CLIP-seq
MIRT2262975	hsa-miR-223	CLIP-seq
MIRT1550875	hsa-miR-3126-3p	CLIP-seq
MIRT2032466	hsa-miR-3140-5p	CLIP-seq
MIRT2262976	hsa-miR-3179	CLIP-seq
MIRT1115403	hsa-miR-3199	CLIP-seq
MIRT2262977	hsa-miR-320e	CLIP-seq
MIRT2262978	hsa-miR-323b-3p	CLIP-seq
MIRT2262979	hsa-miR-328	CLIP-seq
MIRT2262980	hsa-miR-3622b-5p	CLIP-seq
MIRT2262981	hsa-miR-4253	CLIP-seq
MIRT2262982	hsa-miR-4278	CLIP-seq
MIRT2032467	hsa-miR-4324	CLIP-seq
MIRT2032468	hsa-miR-4468	CLIP-seq
MIRT2262983	hsa-miR-455-3p	CLIP-seq
MIRT2262984	hsa-miR-4677-3p	CLIP-seq
MIRT2262985	hsa-miR-4679	CLIP-seq
MIRT2262986	hsa-miR-4688	CLIP-seq
MIRT2262987	hsa-miR-4697-3p	CLIP-seq
MIRT2262988	hsa-miR-4738-3p	CLIP-seq
MIRT2262989	hsa-miR-4761-3p	CLIP-seq
MIRT2262990	hsa-miR-4793-5p	CLIP-seq
MIRT2262991	hsa-miR-486-3p	CLIP-seq
MIRT2262992	hsa-miR-486-5p	CLIP-seq
MIRT2262993	hsa-miR-513c	CLIP-seq
MIRT2262994	hsa-miR-514b-5p	CLIP-seq
MIRT2032469	hsa-miR-516a-3p	CLIP-seq
MIRT2032470	hsa-miR-544b	CLIP-seq
MIRT2262995	hsa-miR-595	CLIP-seq
MIRT2262996	hsa-miR-636	CLIP-seq
MIRT2032465	hsa-miR-1200	CLIP-seq
MIRT2430811	hsa-miR-1273f	CLIP-seq
MIRT2430812	hsa-miR-143	CLIP-seq
MIRT2430813	hsa-miR-2116	CLIP-seq
MIRT2430814	hsa-miR-3124-3p	CLIP-seq
MIRT2430815	hsa-miR-3616-5p	CLIP-seq
MIRT2430816	hsa-miR-3647-5p	CLIP-seq
MIRT2430817	hsa-miR-3672	CLIP-seq
MIRT2430818	hsa-miR-3684	CLIP-seq
MIRT2430819	hsa-miR-4272	CLIP-seq
MIRT2430820	hsa-miR-4282	CLIP-seq
MIRT2032467	hsa-miR-4324	CLIP-seq
MIRT2430821	hsa-miR-4470	CLIP-seq
MIRT2430822	hsa-miR-4635	CLIP-seq
MIRT2430823	hsa-miR-4670-3p	CLIP-seq
MIRT2430824	hsa-miR-4677-5p	CLIP-seq
MIRT2430825	hsa-miR-4708-5p	CLIP-seq
MIRT2430826	hsa-miR-4770	CLIP-seq
MIRT2032470	hsa-miR-544b	CLIP-seq
MIRT2430827	hsa-miR-573	CLIP-seq
MIRT2430828	hsa-miR-587	CLIP-seq
MIRT1115401	hsa-miR-1275	CLIP-seq
MIRT2562351	hsa-miR-133a	CLIP-seq
MIRT2562352	hsa-miR-133b	CLIP-seq
MIRT2562353	hsa-miR-141	CLIP-seq
MIRT2562354	hsa-miR-200a	CLIP-seq
MIRT2262973	hsa-miR-2115	CLIP-seq
MIRT2562355	hsa-miR-214	CLIP-seq
MIRT2262974	hsa-miR-218	CLIP-seq
MIRT2562356	hsa-miR-29a	CLIP-seq
MIRT2562357	hsa-miR-29b	CLIP-seq
MIRT2562358	hsa-miR-29c	CLIP-seq
MIRT1550875	hsa-miR-3126-3p	CLIP-seq
MIRT2562359	hsa-miR-3127-3p	CLIP-seq
MIRT2562360	hsa-miR-3136-3p	CLIP-seq
MIRT2562361	hsa-miR-3137	CLIP-seq
MIRT2562362	hsa-miR-3176	CLIP-seq
MIRT2562363	hsa-miR-3187-3p	CLIP-seq
MIRT2562364	hsa-miR-3194-3p	CLIP-seq
MIRT1115403	hsa-miR-3199	CLIP-seq
MIRT2262979	hsa-miR-328	CLIP-seq
MIRT2562365	hsa-miR-330-3p	CLIP-seq
MIRT2562366	hsa-miR-337-3p	CLIP-seq
MIRT2562367	hsa-miR-3617	CLIP-seq
MIRT2562368	hsa-miR-3619-5p	CLIP-seq
MIRT2562369	hsa-miR-370	CLIP-seq
MIRT2562370	hsa-miR-3909	CLIP-seq
MIRT2562371	hsa-miR-3922-3p	CLIP-seq
MIRT2562372	hsa-miR-3936	CLIP-seq
MIRT2562373	hsa-miR-4269	CLIP-seq
MIRT2562374	hsa-miR-4274	CLIP-seq
MIRT2562375	hsa-miR-4291	CLIP-seq
MIRT2562376	hsa-miR-4476	CLIP-seq
MIRT2562377	hsa-miR-4492	CLIP-seq
MIRT2562378	hsa-miR-4493	CLIP-seq
MIRT2562379	hsa-miR-4498	CLIP-seq
MIRT2562380	hsa-miR-4505	CLIP-seq
MIRT2562381	hsa-miR-450b-5p	CLIP-seq
MIRT2562382	hsa-miR-4514	CLIP-seq
MIRT1115404	hsa-miR-4515	CLIP-seq
MIRT1115405	hsa-miR-4525	CLIP-seq
MIRT2562383	hsa-miR-4529-5p	CLIP-seq
MIRT1115406	hsa-miR-4640-5p	CLIP-seq
MIRT2562384	hsa-miR-4652-3p	CLIP-seq
MIRT1115407	hsa-miR-4652-5p	CLIP-seq
MIRT1115408	hsa-miR-4665-5p	CLIP-seq
MIRT2262984	hsa-miR-4677-3p	CLIP-seq
MIRT2262985	hsa-miR-4679	CLIP-seq
MIRT2562385	hsa-miR-4691-5p	CLIP-seq
MIRT2562386	hsa-miR-4692	CLIP-seq
MIRT2562387	hsa-miR-4694-5p	CLIP-seq
MIRT1115409	hsa-miR-4723-5p	CLIP-seq
MIRT1115410	hsa-miR-4726-5p	CLIP-seq
MIRT2562388	hsa-miR-4731-5p	CLIP-seq
MIRT2262988	hsa-miR-4738-3p	CLIP-seq
MIRT2562389	hsa-miR-4742-5p	CLIP-seq
MIRT2562390	hsa-miR-4749-3p	CLIP-seq
MIRT2562391	hsa-miR-4777-3p	CLIP-seq
MIRT2262993	hsa-miR-513c	CLIP-seq
MIRT2262994	hsa-miR-514b-5p	CLIP-seq
MIRT2032469	hsa-miR-516a-3p	CLIP-seq
MIRT2562392	hsa-miR-518a-5p	CLIP-seq
MIRT2562393	hsa-miR-527	CLIP-seq
MIRT2562394	hsa-miR-544	CLIP-seq
MIRT2562395	hsa-miR-615-5p	CLIP-seq
MIRT1115414	hsa-miR-625	CLIP-seq
MIRT2262996	hsa-miR-636	CLIP-seq
MIRT2562396	hsa-miR-641	CLIP-seq
MIRT2562397	hsa-miR-676	CLIP-seq
MIRT2562398	hsa-miR-761	CLIP-seq
MIRT2562399	hsa-miR-762	CLIP-seq
MIRT2562400	hsa-miR-922	CLIP-seq
MIRT2562355	hsa-miR-214	CLIP-seq
MIRT2562359	hsa-miR-3127-3p	CLIP-seq
MIRT2562360	hsa-miR-3136-3p	CLIP-seq
MIRT2262979	hsa-miR-328	CLIP-seq
MIRT2562368	hsa-miR-3619-5p	CLIP-seq
MIRT2562372	hsa-miR-3936	CLIP-seq
MIRT2562373	hsa-miR-4269	CLIP-seq
MIRT2562374	hsa-miR-4274	CLIP-seq
MIRT2562375	hsa-miR-4291	CLIP-seq
MIRT2562377	hsa-miR-4492	CLIP-seq
MIRT2562379	hsa-miR-4498	CLIP-seq
MIRT2562380	hsa-miR-4505	CLIP-seq
MIRT2562382	hsa-miR-4514	CLIP-seq
MIRT2562386	hsa-miR-4692	CLIP-seq
MIRT2562387	hsa-miR-4694-5p	CLIP-seq
MIRT2562388	hsa-miR-4731-5p	CLIP-seq
MIRT2262988	hsa-miR-4738-3p	CLIP-seq
MIRT2562389	hsa-miR-4742-5p	CLIP-seq
MIRT2562390	hsa-miR-4749-3p	CLIP-seq
MIRT2562391	hsa-miR-4777-3p	CLIP-seq
MIRT2262993	hsa-miR-513c	CLIP-seq
MIRT2262994	hsa-miR-514b-5p	CLIP-seq
MIRT2562394	hsa-miR-544	CLIP-seq
MIRT2562395	hsa-miR-615-5p	CLIP-seq
MIRT2562398	hsa-miR-761	CLIP-seq
MIRT2562399	hsa-miR-762	CLIP-seq
MIRT2562400	hsa-miR-922	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
SP1	Activation	18949373

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004720	Function	Protein-lysine 6-oxidase activity	IBA
GO:0004720	Function	Protein-lysine 6-oxidase activity	IDA	14551188
GO:0004720	Function	Protein-lysine 6-oxidase activity	IEA
GO:0005507	Function	Copper ion binding	IEA
GO:0005515	Function	Protein binding	IPI	16189514, 19060904, 23455924, 25416956, 28514442, 32814053, 33961781
GO:0005576	Component	Extracellular region	IEA
GO:0005615	Component	Extracellular space	IBA
GO:0016020	Component	Membrane	IEA
GO:0016491	Function	Oxidoreductase activity	IEA
GO:0016641	Function	Oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor	IEA
GO:0030199	Process	Collagen fibril organization	IBA
GO:0043235	Component	Receptor complex	IDA	23382219
GO:0046872	Function	Metal ion binding	IEA
GO:0070062	Component	Extracellular exosome	HDA	19199708

Other IDs

• MIM: 607318
• HGNC: 17171
• e!Ensembl: ENSG00000138131

Protein

• UniProt ID: Q96JB6
• Protein name: Lysyl oxidase homolog 4 (EC 1.4.3.13) (Lysyl oxidase-like protein 4) (Lysyl oxidase-related protein C)
• Protein function: Catalyzes the oxidative deamination of lysine and hydroxylysine residues in collagen and elastin, resulting in the formation of covalent cross-linkages, and the stabilization of collagen and elastin fibers.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00530	SRCR	37 → 133	Scavenger receptor cysteine-rich domain	Domain
  PF00530	SRCR	169 → 287	Scavenger receptor cysteine-rich domain	Domain
  PF00530	SRCR	314 → 411	Scavenger receptor cysteine-rich domain	Domain
  PF00530	SRCR	424 → 529	Scavenger receptor cysteine-rich domain	Domain
  PF01186	Lysyl_oxidase	533 → 733	Lysyl oxidase	Family

• Tissue specificity: TISSUE SPECIFICITY: Expressed in many tissues, the highest levels among the tissues studied being in the skeletal muscle, testis and pancreas. Expressed in cartilage.
• Sequence:

  MAWSPPATLFLFLLLLGQPPPSRPQSLGTTKLRLVGPESKPEEGRLEVLHQGQWGTVCDD
  NFAIQEATVACRQLGFEAALTWAHSAKYGQGEGPIWLDNVRCVGTESSLDQCGSNGWGVS
  DCSHSEDVGVICHPRRHRGYLSETVSNALGPQGRRLEEVRLKPILASAKQHSPVTEGAVE
  VKYEGHWRQVCDQGWTMNNSRVVCGMLGFPSEVPVDSHYYRKVWDLKMRDPKSRLKSLTN
  KNSFWIHQVTCLGTEPHMANCQVQVAPARGKLRPACPGGMHAVVSCVAGPHFRPPKTKPQ
  RKGSWAEEPRVRLRSGAQVGEGRVEVLMNRQWGTVCDHRWNLISASVVCRQLGFGSAREA
  LFGARLGQGLGPIHLSEVRCRGYERTLSDCPALEGSQNGCQHENDAAVRCNVPNMGFQNQ
  VRLAGGRIPEEGLLEVQVEVNGVPRWGSVCSENWGLTEAMVACRQLGLGFAIHAYKETWF
  WSGTPRAQEVVMSGVRCSGTELALQQCQRHGPVHCSHGGGRFLAGVSCMDSAPDLVMNAQ
  LVQETAYLEDRPLSQLYCAHEENCLSKSADHMDWPYGYRRLLRFSTQIYNLGRTDFRPKT
  GRDSWVWHQCHRHYHSIEVFTHYDLLTLNGSKVAEGHKASFCLEDTNCPTGLQRRYACAN
  FGEQGVTVGCWDTYRHDIDCQWVDITDVGPGNYIFQVIVNPHYEVAESDFSNNMLQCRCK
  YDGHRVWLHNCHTGNSYPANAELSLEQEQRLRNNLI

• Sequence length: 756

Pathways

Reactome:

Elastic fibre formation
Crosslinking of collagen fibrils