Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	84171
Gene name Gene Name - the full gene name approved by the HGNC.	Lysyl oxidase like 4
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	LOXL4
Synonyms (NCBI Gene) Gene synonyms aliases	LOXC
Chromosome Chromosome number	10
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	10q24.2
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation o

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miRTarBase ID	miRNA	Experiments	Reference
MIRT017606	hsa-miR-335-5p	Microarray	18185580
MIRT022543	hsa-miR-124-3p	Microarray	18668037
MIRT438917	hsa-miR-29b-3p	Luciferase reporter assay, qRT-PCR	23354167
MIRT438917	hsa-miR-29b-3p	Luciferase reporter assay, qRT-PCR	23354167
MIRT1115401	hsa-miR-1275	CLIP-seq
MIRT1115402	hsa-miR-3168	CLIP-seq
MIRT1115403	hsa-miR-3199	CLIP-seq
MIRT1115404	hsa-miR-4515	CLIP-seq
MIRT1115405	hsa-miR-4525	CLIP-seq
MIRT1115406	hsa-miR-4640-5p	CLIP-seq
MIRT1115407	hsa-miR-4652-5p	CLIP-seq
MIRT1115408	hsa-miR-4665-5p	CLIP-seq
MIRT1115409	hsa-miR-4723-5p	CLIP-seq
MIRT1115410	hsa-miR-4726-5p	CLIP-seq
MIRT1115411	hsa-miR-4773	CLIP-seq
MIRT1115412	hsa-miR-4797-5p	CLIP-seq
MIRT1115413	hsa-miR-574-5p	CLIP-seq
MIRT1115414	hsa-miR-625	CLIP-seq
MIRT1115415	hsa-miR-759	CLIP-seq
MIRT1550872	hsa-miR-122	CLIP-seq
MIRT1550873	hsa-miR-202	CLIP-seq
MIRT1550874	hsa-miR-2277-3p	CLIP-seq
MIRT1550875	hsa-miR-3126-3p	CLIP-seq
MIRT1550876	hsa-miR-3944-5p	CLIP-seq
MIRT1550877	hsa-miR-4299	CLIP-seq
MIRT1550878	hsa-miR-4456	CLIP-seq
MIRT1550879	hsa-miR-542-3p	CLIP-seq
MIRT1550880	hsa-miR-548q	CLIP-seq
MIRT1115413	hsa-miR-574-5p	CLIP-seq
MIRT1550881	hsa-miR-646	CLIP-seq
MIRT1550882	hsa-miR-648	CLIP-seq
MIRT2032465	hsa-miR-1200	CLIP-seq
MIRT2032466	hsa-miR-3140-5p	CLIP-seq
MIRT2032467	hsa-miR-4324	CLIP-seq
MIRT2032468	hsa-miR-4468	CLIP-seq
MIRT2032469	hsa-miR-516a-3p	CLIP-seq
MIRT2032470	hsa-miR-544b	CLIP-seq
MIRT2032471	hsa-miR-657	CLIP-seq
MIRT2032465	hsa-miR-1200	CLIP-seq
MIRT2262972	hsa-miR-1910	CLIP-seq
MIRT2262973	hsa-miR-2115	CLIP-seq
MIRT2262974	hsa-miR-218	CLIP-seq
MIRT2262975	hsa-miR-223	CLIP-seq
MIRT1550875	hsa-miR-3126-3p	CLIP-seq
MIRT2032466	hsa-miR-3140-5p	CLIP-seq
MIRT2262976	hsa-miR-3179	CLIP-seq
MIRT1115403	hsa-miR-3199	CLIP-seq
MIRT2262977	hsa-miR-320e	CLIP-seq
MIRT2262978	hsa-miR-323b-3p	CLIP-seq
MIRT2262979	hsa-miR-328	CLIP-seq
MIRT2262980	hsa-miR-3622b-5p	CLIP-seq
MIRT2262981	hsa-miR-4253	CLIP-seq
MIRT2262982	hsa-miR-4278	CLIP-seq
MIRT2032467	hsa-miR-4324	CLIP-seq
MIRT2032468	hsa-miR-4468	CLIP-seq
MIRT2262983	hsa-miR-455-3p	CLIP-seq
MIRT2262984	hsa-miR-4677-3p	CLIP-seq
MIRT2262985	hsa-miR-4679	CLIP-seq
MIRT2262986	hsa-miR-4688	CLIP-seq
MIRT2262987	hsa-miR-4697-3p	CLIP-seq
MIRT2262988	hsa-miR-4738-3p	CLIP-seq
MIRT2262989	hsa-miR-4761-3p	CLIP-seq
MIRT2262990	hsa-miR-4793-5p	CLIP-seq
MIRT2262991	hsa-miR-486-3p	CLIP-seq
MIRT2262992	hsa-miR-486-5p	CLIP-seq
MIRT2262993	hsa-miR-513c	CLIP-seq
MIRT2262994	hsa-miR-514b-5p	CLIP-seq
MIRT2032469	hsa-miR-516a-3p	CLIP-seq
MIRT2032470	hsa-miR-544b	CLIP-seq
MIRT2262995	hsa-miR-595	CLIP-seq
MIRT2262996	hsa-miR-636	CLIP-seq
MIRT2032465	hsa-miR-1200	CLIP-seq
MIRT2430811	hsa-miR-1273f	CLIP-seq
MIRT2430812	hsa-miR-143	CLIP-seq
MIRT2430813	hsa-miR-2116	CLIP-seq
MIRT2430814	hsa-miR-3124-3p	CLIP-seq
MIRT2430815	hsa-miR-3616-5p	CLIP-seq
MIRT2430816	hsa-miR-3647-5p	CLIP-seq
MIRT2430817	hsa-miR-3672	CLIP-seq
MIRT2430818	hsa-miR-3684	CLIP-seq
MIRT2430819	hsa-miR-4272	CLIP-seq
MIRT2430820	hsa-miR-4282	CLIP-seq
MIRT2032467	hsa-miR-4324	CLIP-seq
MIRT2430821	hsa-miR-4470	CLIP-seq
MIRT2430822	hsa-miR-4635	CLIP-seq
MIRT2430823	hsa-miR-4670-3p	CLIP-seq
MIRT2430824	hsa-miR-4677-5p	CLIP-seq
MIRT2430825	hsa-miR-4708-5p	CLIP-seq
MIRT2430826	hsa-miR-4770	CLIP-seq
MIRT2032470	hsa-miR-544b	CLIP-seq
MIRT2430827	hsa-miR-573	CLIP-seq
MIRT2430828	hsa-miR-587	CLIP-seq
MIRT1115401	hsa-miR-1275	CLIP-seq
MIRT2562351	hsa-miR-133a	CLIP-seq
MIRT2562352	hsa-miR-133b	CLIP-seq
MIRT2562353	hsa-miR-141	CLIP-seq
MIRT2562354	hsa-miR-200a	CLIP-seq
MIRT2262973	hsa-miR-2115	CLIP-seq
MIRT2562355	hsa-miR-214	CLIP-seq
MIRT2262974	hsa-miR-218	CLIP-seq
MIRT2562356	hsa-miR-29a	CLIP-seq
MIRT2562357	hsa-miR-29b	CLIP-seq
MIRT2562358	hsa-miR-29c	CLIP-seq
MIRT1550875	hsa-miR-3126-3p	CLIP-seq
MIRT2562359	hsa-miR-3127-3p	CLIP-seq
MIRT2562360	hsa-miR-3136-3p	CLIP-seq
MIRT2562361	hsa-miR-3137	CLIP-seq
MIRT2562362	hsa-miR-3176	CLIP-seq
MIRT2562363	hsa-miR-3187-3p	CLIP-seq
MIRT2562364	hsa-miR-3194-3p	CLIP-seq
MIRT1115403	hsa-miR-3199	CLIP-seq
MIRT2262979	hsa-miR-328	CLIP-seq
MIRT2562365	hsa-miR-330-3p	CLIP-seq
MIRT2562366	hsa-miR-337-3p	CLIP-seq
MIRT2562367	hsa-miR-3617	CLIP-seq
MIRT2562368	hsa-miR-3619-5p	CLIP-seq
MIRT2562369	hsa-miR-370	CLIP-seq
MIRT2562370	hsa-miR-3909	CLIP-seq
MIRT2562371	hsa-miR-3922-3p	CLIP-seq
MIRT2562372	hsa-miR-3936	CLIP-seq
MIRT2562373	hsa-miR-4269	CLIP-seq
MIRT2562374	hsa-miR-4274	CLIP-seq
MIRT2562375	hsa-miR-4291	CLIP-seq
MIRT2562376	hsa-miR-4476	CLIP-seq
MIRT2562377	hsa-miR-4492	CLIP-seq
MIRT2562378	hsa-miR-4493	CLIP-seq
MIRT2562379	hsa-miR-4498	CLIP-seq
MIRT2562380	hsa-miR-4505	CLIP-seq
MIRT2562381	hsa-miR-450b-5p	CLIP-seq
MIRT2562382	hsa-miR-4514	CLIP-seq
MIRT1115404	hsa-miR-4515	CLIP-seq
MIRT1115405	hsa-miR-4525	CLIP-seq
MIRT2562383	hsa-miR-4529-5p	CLIP-seq
MIRT1115406	hsa-miR-4640-5p	CLIP-seq
MIRT2562384	hsa-miR-4652-3p	CLIP-seq
MIRT1115407	hsa-miR-4652-5p	CLIP-seq
MIRT1115408	hsa-miR-4665-5p	CLIP-seq
MIRT2262984	hsa-miR-4677-3p	CLIP-seq
MIRT2262985	hsa-miR-4679	CLIP-seq
MIRT2562385	hsa-miR-4691-5p	CLIP-seq
MIRT2562386	hsa-miR-4692	CLIP-seq
MIRT2562387	hsa-miR-4694-5p	CLIP-seq
MIRT1115409	hsa-miR-4723-5p	CLIP-seq
MIRT1115410	hsa-miR-4726-5p	CLIP-seq
MIRT2562388	hsa-miR-4731-5p	CLIP-seq
MIRT2262988	hsa-miR-4738-3p	CLIP-seq
MIRT2562389	hsa-miR-4742-5p	CLIP-seq
MIRT2562390	hsa-miR-4749-3p	CLIP-seq
MIRT2562391	hsa-miR-4777-3p	CLIP-seq
MIRT2262993	hsa-miR-513c	CLIP-seq
MIRT2262994	hsa-miR-514b-5p	CLIP-seq
MIRT2032469	hsa-miR-516a-3p	CLIP-seq
MIRT2562392	hsa-miR-518a-5p	CLIP-seq
MIRT2562393	hsa-miR-527	CLIP-seq
MIRT2562394	hsa-miR-544	CLIP-seq
MIRT2562395	hsa-miR-615-5p	CLIP-seq
MIRT1115414	hsa-miR-625	CLIP-seq
MIRT2262996	hsa-miR-636	CLIP-seq
MIRT2562396	hsa-miR-641	CLIP-seq
MIRT2562397	hsa-miR-676	CLIP-seq
MIRT2562398	hsa-miR-761	CLIP-seq
MIRT2562399	hsa-miR-762	CLIP-seq
MIRT2562400	hsa-miR-922	CLIP-seq
MIRT2562355	hsa-miR-214	CLIP-seq
MIRT2562359	hsa-miR-3127-3p	CLIP-seq
MIRT2562360	hsa-miR-3136-3p	CLIP-seq
MIRT2262979	hsa-miR-328	CLIP-seq
MIRT2562368	hsa-miR-3619-5p	CLIP-seq
MIRT2562372	hsa-miR-3936	CLIP-seq
MIRT2562373	hsa-miR-4269	CLIP-seq
MIRT2562374	hsa-miR-4274	CLIP-seq
MIRT2562375	hsa-miR-4291	CLIP-seq
MIRT2562377	hsa-miR-4492	CLIP-seq
MIRT2562379	hsa-miR-4498	CLIP-seq
MIRT2562380	hsa-miR-4505	CLIP-seq
MIRT2562382	hsa-miR-4514	CLIP-seq
MIRT2562386	hsa-miR-4692	CLIP-seq
MIRT2562387	hsa-miR-4694-5p	CLIP-seq
MIRT2562388	hsa-miR-4731-5p	CLIP-seq
MIRT2262988	hsa-miR-4738-3p	CLIP-seq
MIRT2562389	hsa-miR-4742-5p	CLIP-seq
MIRT2562390	hsa-miR-4749-3p	CLIP-seq
MIRT2562391	hsa-miR-4777-3p	CLIP-seq
MIRT2262993	hsa-miR-513c	CLIP-seq
MIRT2262994	hsa-miR-514b-5p	CLIP-seq
MIRT2562394	hsa-miR-544	CLIP-seq
MIRT2562395	hsa-miR-615-5p	CLIP-seq
MIRT2562398	hsa-miR-761	CLIP-seq
MIRT2562399	hsa-miR-762	CLIP-seq
MIRT2562400	hsa-miR-922	CLIP-seq

Transcription factors

Show/Hide all(1)

Transcription factor	Regulation	Reference
SP1	Activation	18949373

Show/Hide all(14)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004720	Function	Protein-lysine 6-oxidase activity	IBA
GO:0004720	Function	Protein-lysine 6-oxidase activity	IDA	14551188
GO:0004720	Function	Protein-lysine 6-oxidase activity	IEA
GO:0005507	Function	Copper ion binding	IEA
GO:0005515	Function	Protein binding	IPI	16189514, 19060904, 23455924, 25416956, 28514442, 32814053, 33961781
GO:0005576	Component	Extracellular region	IEA
GO:0005615	Component	Extracellular space	IBA
GO:0016020	Component	Membrane	IEA
GO:0016491	Function	Oxidoreductase activity	IEA
GO:0016641	Function	Oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor	IEA
GO:0030199	Process	Collagen fibril organization	IBA
GO:0043235	Component	Receptor complex	IDA	23382219
GO:0046872	Function	Metal ion binding	IEA
GO:0070062	Component	Extracellular exosome	HDA	19199708

MIM	HGNC	e!Ensembl
607318	17171	ENSG00000138131

Protein

UniProt ID

Q96JB6

Protein name

Lysyl oxidase homolog 4 (EC 1.4.3.13) (Lysyl oxidase-like protein 4) (Lysyl oxidase-related protein C)

Protein function

Catalyzes the oxidative deamination of lysine and hydroxylysine residues in collagen and elastin, resulting in the formation of covalent cross-linkages, and the stabilization of collagen and elastin fibers.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00530	SRCR	37 → 133	Scavenger receptor cysteine-rich domain	Domain
PF00530	SRCR	169 → 287	Scavenger receptor cysteine-rich domain	Domain
PF00530	SRCR	314 → 411	Scavenger receptor cysteine-rich domain	Domain
PF00530	SRCR	424 → 529	Scavenger receptor cysteine-rich domain	Domain
PF01186	Lysyl_oxidase	533 → 733	Lysyl oxidase	Family

Tissue specificity

TISSUE SPECIFICITY: Expressed in many tissues, the highest levels among the tissues studied being in the skeletal muscle, testis and pancreas. Expressed in cartilage.

Sequence

MAWSPPATLFLFLLLLGQPPPSRPQSLGTTKLRLVGPESKPEEGRLEVLHQGQWGTVCDD
NFAIQEATVACRQLGFEAALTWAHSAKYGQGEGPIWLDNVRCVGTESSLDQCGSNGWGVS
DCSHSEDVGVICHPRRHRGYLSETVSNALGPQGRRLEEVRLKPILASAKQHSPVTEGAVE
VKYEGHWRQVCDQGWTMNNSRVVCGMLGFPSEVPVDSHYYRKVWDLKMRDPKSRLKSLTN
KNSFWIHQVTCLGTEPHMANCQVQVAPARGKLRPACPGGMHAVVSCVAGPHFRPPKTKPQ
RKGSWAEEPRVRLRSGAQVGEGRVEVLMNRQWGTVCDHRWNLISASVVCRQLGFGSAREA
LFGARLGQGLGPIHLSEVRCRGYERTLSDCPALEGSQNGCQHENDAAVRCNVPNMGFQNQ
VRLAGGRIPEEGLLEVQVEVNGVPRWGSVCSENWGLTEAMVACRQLGLGFAIHAYKETWF
WSGTPRAQEVVMSGVRCSGTELALQQCQRHGPVHCSHGGGRFLAGVSCMDSAPDLVMNAQ
LVQETAYLEDRPLSQLYCAHEENCLSKSADHMDWPYGYRRLLRFSTQIYNLGRTDFRPKT
GRDSWVWHQCHRHYHSIEVFTHYDLLTLNGSKVAEGHKASFCLEDTNCPTGLQRRYACAN
FGEQGVTVGCWDTYRHDIDCQWVDITDVGPGNYIFQVIVNPHYEVAESDFSNNMLQCRCK
YDGHRVWLHNCHTGNSYPANAELSLEQEQRLRNNLI

Sequence length

756

Interactions

View interactions

	Reactome
			Elastic fibre formation Crosslinking of collagen fibrils

Show/Hide Unknown Diseases (4)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Heart Failure	Heart failure	N/A	N/A	GWAS
Metabolic Syndrome	Metabolic syndrome	N/A	N/A	GWAS
Myocardial Infarction	Myocardial infarction	N/A	N/A	GWAS
Skeletal Dysplasia	skeletal dysplasia	N/A	N/A	GenCC

Show/Hide Text Mining Associations (22)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Breast Neoplasms	Associate	38518152
Carcinoma Hepatocellular	Inhibit	26097573
Carcinoma Hepatocellular	Associate	30704479
Diabetic Nephropathies	Associate	36949528
Endometriosis	Associate	21733505
Esophageal Neoplasms	Associate	40234833
Fibrosis	Associate	37235663
Glioma	Associate	32725165
Glomerulosclerosis Focal Segmental	Associate	34565340
Head and Neck Neoplasms	Associate	33757755
Hypoxia	Stimulate	33757755
Infertility	Associate	21733505
Laryngeal Neoplasms	Associate	33757755
Lymphatic Metastasis	Associate	30704479
Neoplasm Metastasis	Associate	30704479, 32844403, 38518152
Neoplasms	Associate	26097573, 30704479
Neoplasms	Inhibit	33757755
Odontogenic Tumors	Associate	24357854
Pelvic Organ Prolapse	Associate	33413618
Personality Disorders	Associate	26097573
Squamous Cell Carcinoma of Head and Neck	Associate	35113007
Stomach Neoplasms	Associate	36044785

LOXL4 (lysyl oxidase like 4)