Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	84164
Gene name Gene Name - the full gene name approved by the HGNC.	Activating signal cointegrator 1 complex subunit 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	ASCC2
Synonyms (NCBI Gene) Gene synonyms aliases	ASC1p100, p100
Chromosome Chromosome number	22
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	22q12.2

Show/Hide all(37)

miRTarBase ID	miRNA	Experiments	Reference
MIRT022446	hsa-miR-124-3p	Microarray	18668037
MIRT050191	hsa-miR-26a-5p	CLASH	23622248
MIRT044724	hsa-miR-320a	CLASH	23622248
MIRT042189	hsa-miR-484	CLASH	23622248
MIRT1936987	hsa-miR-1207-3p	CLIP-seq
MIRT1936988	hsa-miR-1275	CLIP-seq
MIRT1936989	hsa-miR-18a	CLIP-seq
MIRT1936990	hsa-miR-18b	CLIP-seq
MIRT1936991	hsa-miR-3124-3p	CLIP-seq
MIRT1936992	hsa-miR-3688-5p	CLIP-seq
MIRT1936993	hsa-miR-4271	CLIP-seq
MIRT1936994	hsa-miR-4320	CLIP-seq
MIRT1936995	hsa-miR-4327	CLIP-seq
MIRT1936996	hsa-miR-4525	CLIP-seq
MIRT1936997	hsa-miR-4665-5p	CLIP-seq
MIRT1936998	hsa-miR-4723-5p	CLIP-seq
MIRT1936999	hsa-miR-4725-3p	CLIP-seq
MIRT1937000	hsa-miR-4731-5p	CLIP-seq
MIRT1937001	hsa-miR-4735-3p	CLIP-seq
MIRT1937002	hsa-miR-4747-5p	CLIP-seq
MIRT1937003	hsa-miR-4753-3p	CLIP-seq
MIRT1937004	hsa-miR-4758-3p	CLIP-seq
MIRT1937005	hsa-miR-4763-5p	CLIP-seq
MIRT1937006	hsa-miR-550a	CLIP-seq
MIRT1937007	hsa-miR-625	CLIP-seq
MIRT1937008	hsa-miR-637	CLIP-seq
MIRT2176772	hsa-miR-198	CLIP-seq
MIRT2176773	hsa-miR-3074-5p	CLIP-seq
MIRT2176774	hsa-miR-370	CLIP-seq
MIRT1936993	hsa-miR-4271	CLIP-seq
MIRT2176775	hsa-miR-431	CLIP-seq
MIRT2176776	hsa-miR-4685-5p	CLIP-seq
MIRT2176777	hsa-miR-4711-3p	CLIP-seq
MIRT1936999	hsa-miR-4725-3p	CLIP-seq
MIRT2176778	hsa-miR-4795-5p	CLIP-seq
MIRT2176779	hsa-miR-581	CLIP-seq
MIRT2176780	hsa-miR-626	CLIP-seq

Show/Hide all(9)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005634	Component	Nucleus	IDA	12077347, 26924529
GO:0005654	Component	Nucleoplasm	TAS
GO:0006307	Process	DNA dealkylation involved in DNA repair	TAS
GO:0006355	Process	Regulation of transcription, DNA-templated	IBA	21873635
GO:0006355	Process	Regulation of transcription, DNA-templated	IDA	12077347
GO:0016607	Component	Nuclear speck	IEA
GO:0043130	Function	Ubiquitin binding	IBA	21873635
GO:0099053	Component	Activating signal cointegrator 1 complex	IDA	12077347

MIM	HGNC	e!Ensembl
614216	24103	ENSG00000100325

Protein

UniProt ID

Q9H1I8

Protein name

Activating signal cointegrator 1 complex subunit 2 (ASC-1 complex subunit p100) (Trip4 complex subunit p100)

Protein function

Ubiquitin-binding protein involved in DNA repair and rescue of stalled ribosomes (PubMed:29144457, PubMed:32099016, PubMed:32579943, PubMed:36302773). Plays a role in DNA damage repair as component of the ASCC complex (PubMed:29144457). Recruits

PDB

2DI0 , 6YXQ

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02845	CUE	468 → 509	CUE domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Ubiquitous. {ECO:0000269|PubMed:12077347}.

Sequence

MPALPLDQLQITHKDPKTGKLRTSPALHPEQKADRYFVLYKPPPKDNIPALVEEYLERAT
FVANDLDWLLALPHDKFWCQVIFDETLQKCLDSYLRYVPRKFDEGVASAPEVVDMQKRLH
RSVFLTFLRMSTHKESKDHFISPSAFGEILYNNFLFDIPKILDLCVLFGKGNSPLLQKMI
GNIFTQQPSYYSDLDETLPTILQVFSNILQHCGLQGDGANTTPQKLEERGRLTPSDMPLL
ELKDIVLYLCDTCTTLWAFLDIFPLACQTFQKHDFCYRLASFYEAAIPEMESAIKKRRLE
DSKLLGDLWQRLSHSRKKLMEIFHIILNQICLLPILESSCDNIQGFIEEFLQIFSSLLQE
KRFLRDYDALFPVAEDISLLQQASSVLDETRTAYILQAVESAWEGVDRRKATDAKDPSVI
EEPNGEPNGVTVTAEAVSQASSHPENSEEEECMGAAAAVGPAMCGVELDSLISQVKDLLP
DLGEGFILACLEYYHYDPEQVINNILEERLAPTLSQLDRNLDREMKPDPTPLLTSRHNVF
QNDEFDVFSRDSVDLSRVHKGKSTRKEENTRSLLNDKRAVAAQRQRYEQYSVVVEEVPLQ
PGESLPYHSVYYEDEYDDTYDGNQVGANDADSDDELISRRPFTIPQVLRTKVPREGQEED
DDDEEDDADEEAPKPDHFVQDPAVLREKAEARRMAFLAKKGYRHDSSTAVAGSPRGHGQS
RETTQERRKKEANKATRANHNRRTMADRKRSKGMIPS

Sequence length

757

Interactions

View interactions

	Reactome
			ALKBH3 mediated reversal of alkylation damage

Show/Hide Causal Diseases (2)

Disease term	Disease name	dbSNP ID	References
Causal
Attention deficit hyperactivity disorder	Attention deficit hyperactivity disorder	rs786205019	27890468
Diabetes mellitus	Diabetes Mellitus, Non-Insulin-Dependent	rs587776515, rs61730328, rs606231121, rs606231122, rs79020217, rs77625743, rs78378398, rs606231123, rs1362648752, rs104893649, rs80356624, rs80356616, rs80356625, rs80356611, rs104894237 View all (293 more)	29632382

Show/Hide Unknown Diseases (3)

Disease term	Disease name	Source
Unknown
Diabetes	Diabetes	GWAS
Inflammatory Bowel Disease	Inflammatory Bowel Disease	GWAS
Dental caries	Dental caries	GWAS

Show/Hide Text Mining Associations (3)

Disease Name	Relationship Type	References
Associations from Text Mining
Coronary Artery Disease	Associate	33686958
Myoepithelioma	Associate	36577525
Neoplasms	Associate	33139697, 36577525

ASCC2 (activating signal cointegrator 1 complex subunit 2)