FBXO30 (F-box protein 30)

Gene

• Entrez ID: 84085
• Gene name: F-box protein 30
• Gene symbol: FBXO30
• Synonyms (NCBI Gene): Fbx30
• Chromosome: 6
• Chromosome location: 6q24.3
• Summary: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT028220	hsa-miR-33a-5p	Sequencing	20371350
MIRT046470	hsa-miR-15b-5p	CLASH	23622248
MIRT991807	hsa-miR-124	CLIP-seq
MIRT991808	hsa-miR-1267	CLIP-seq
MIRT991809	hsa-miR-198	CLIP-seq
MIRT991810	hsa-miR-2113	CLIP-seq
MIRT991811	hsa-miR-216a	CLIP-seq
MIRT991812	hsa-miR-3121-3p	CLIP-seq
MIRT991813	hsa-miR-338-3p	CLIP-seq
MIRT991814	hsa-miR-34a	CLIP-seq
MIRT991815	hsa-miR-34c-5p	CLIP-seq
MIRT991816	hsa-miR-3607-3p	CLIP-seq
MIRT991817	hsa-miR-3691-5p	CLIP-seq
MIRT991818	hsa-miR-3692	CLIP-seq
MIRT991819	hsa-miR-3714	CLIP-seq
MIRT991820	hsa-miR-377	CLIP-seq
MIRT991821	hsa-miR-3910	CLIP-seq
MIRT991822	hsa-miR-4282	CLIP-seq
MIRT991823	hsa-miR-4475	CLIP-seq
MIRT991824	hsa-miR-449a	CLIP-seq
MIRT991825	hsa-miR-449b	CLIP-seq
MIRT991826	hsa-miR-4530	CLIP-seq
MIRT991827	hsa-miR-4668-5p	CLIP-seq
MIRT991828	hsa-miR-4718	CLIP-seq
MIRT991829	hsa-miR-4720-3p	CLIP-seq
MIRT991830	hsa-miR-4728-3p	CLIP-seq
MIRT991831	hsa-miR-4752	CLIP-seq
MIRT991832	hsa-miR-4775	CLIP-seq
MIRT991833	hsa-miR-4804-3p	CLIP-seq
MIRT991834	hsa-miR-495	CLIP-seq
MIRT991835	hsa-miR-506	CLIP-seq
MIRT991836	hsa-miR-513a-3p	CLIP-seq
MIRT991837	hsa-miR-520f	CLIP-seq
MIRT991838	hsa-miR-548ac	CLIP-seq
MIRT991839	hsa-miR-548c-3p	CLIP-seq
MIRT991840	hsa-miR-548d-3p	CLIP-seq
MIRT991841	hsa-miR-548z	CLIP-seq
MIRT991842	hsa-miR-568	CLIP-seq
MIRT991843	hsa-miR-570	CLIP-seq
MIRT991844	hsa-miR-579	CLIP-seq
MIRT991845	hsa-miR-590-3p	CLIP-seq
MIRT991846	hsa-miR-607	CLIP-seq
MIRT991847	hsa-miR-891b	CLIP-seq
MIRT1548642	hsa-miR-128	CLIP-seq
MIRT1548643	hsa-miR-1323	CLIP-seq
MIRT1548644	hsa-miR-4504	CLIP-seq
MIRT1548645	hsa-miR-4528	CLIP-seq
MIRT1548646	hsa-miR-4672	CLIP-seq
MIRT1548647	hsa-miR-4789-5p	CLIP-seq
MIRT1548648	hsa-miR-548o	CLIP-seq
MIRT1548649	hsa-miR-576-3p	CLIP-seq
MIRT1548650	hsa-miR-668	CLIP-seq
MIRT1994164	hsa-miR-5096	CLIP-seq
MIRT1994165	hsa-miR-513b	CLIP-seq
MIRT991845	hsa-miR-590-3p	CLIP-seq
MIRT1548650	hsa-miR-668	CLIP-seq
MIRT2228127	hsa-miR-10a	CLIP-seq
MIRT2228128	hsa-miR-10b	CLIP-seq
MIRT1548643	hsa-miR-1323	CLIP-seq
MIRT2228129	hsa-miR-18a	CLIP-seq
MIRT2228130	hsa-miR-18b	CLIP-seq
MIRT991809	hsa-miR-198	CLIP-seq
MIRT991812	hsa-miR-3121-3p	CLIP-seq
MIRT2228131	hsa-miR-3148	CLIP-seq
MIRT991813	hsa-miR-338-3p	CLIP-seq
MIRT2228132	hsa-miR-339-5p	CLIP-seq
MIRT2228133	hsa-miR-3620	CLIP-seq
MIRT1548645	hsa-miR-4528	CLIP-seq
MIRT991826	hsa-miR-4530	CLIP-seq
MIRT1548646	hsa-miR-4672	CLIP-seq
MIRT2228134	hsa-miR-4735-3p	CLIP-seq
MIRT1548647	hsa-miR-4789-5p	CLIP-seq
MIRT1548648	hsa-miR-548o	CLIP-seq
MIRT1548649	hsa-miR-576-3p	CLIP-seq
MIRT1548650	hsa-miR-668	CLIP-seq
MIRT2531643	hsa-miR-105	CLIP-seq
MIRT2531644	hsa-miR-1224-3p	CLIP-seq
MIRT2531645	hsa-miR-1260	CLIP-seq
MIRT2531646	hsa-miR-1260b	CLIP-seq
MIRT991808	hsa-miR-1267	CLIP-seq
MIRT2531647	hsa-miR-1280	CLIP-seq
MIRT2531648	hsa-miR-1305	CLIP-seq
MIRT1548643	hsa-miR-1323	CLIP-seq
MIRT2531649	hsa-miR-155	CLIP-seq
MIRT2531650	hsa-miR-1827	CLIP-seq
MIRT2531651	hsa-miR-188-3p	CLIP-seq
MIRT2531652	hsa-miR-208a	CLIP-seq
MIRT2531653	hsa-miR-208b	CLIP-seq
MIRT991811	hsa-miR-216a	CLIP-seq
MIRT991812	hsa-miR-3121-3p	CLIP-seq
MIRT2531654	hsa-miR-3121-5p	CLIP-seq
MIRT2531655	hsa-miR-3156-3p	CLIP-seq
MIRT2531656	hsa-miR-3194-3p	CLIP-seq
MIRT2531657	hsa-miR-342-3p	CLIP-seq
MIRT2531658	hsa-miR-3617	CLIP-seq
MIRT2531659	hsa-miR-3662	CLIP-seq
MIRT2531660	hsa-miR-3675-3p	CLIP-seq
MIRT991818	hsa-miR-3692	CLIP-seq
MIRT991819	hsa-miR-3714	CLIP-seq
MIRT2531661	hsa-miR-3938	CLIP-seq
MIRT2531662	hsa-miR-3942-3p	CLIP-seq
MIRT2531663	hsa-miR-3976	CLIP-seq
MIRT2531664	hsa-miR-4272	CLIP-seq
MIRT2531665	hsa-miR-4291	CLIP-seq
MIRT2531666	hsa-miR-4299	CLIP-seq
MIRT2531667	hsa-miR-4316	CLIP-seq
MIRT2531668	hsa-miR-4474-5p	CLIP-seq
MIRT2531669	hsa-miR-4494	CLIP-seq
MIRT2531670	hsa-miR-4503	CLIP-seq
MIRT2531671	hsa-miR-450b-5p	CLIP-seq
MIRT2531672	hsa-miR-452	CLIP-seq
MIRT2531673	hsa-miR-4521	CLIP-seq
MIRT2531674	hsa-miR-4652-3p	CLIP-seq
MIRT2531675	hsa-miR-4676-3p	CLIP-seq
MIRT2531676	hsa-miR-4699-3p	CLIP-seq
MIRT2531677	hsa-miR-4710	CLIP-seq
MIRT2531678	hsa-miR-4735-5p	CLIP-seq
MIRT2531679	hsa-miR-4753-3p	CLIP-seq
MIRT2531680	hsa-miR-4792	CLIP-seq
MIRT2531681	hsa-miR-499-5p	CLIP-seq
MIRT2531682	hsa-miR-499a-5p	CLIP-seq
MIRT2531683	hsa-miR-539	CLIP-seq
MIRT2531684	hsa-miR-545	CLIP-seq
MIRT2531685	hsa-miR-548an	CLIP-seq
MIRT1548648	hsa-miR-548o	CLIP-seq
MIRT2531686	hsa-miR-548p	CLIP-seq
MIRT2531687	hsa-miR-584	CLIP-seq
MIRT2531688	hsa-miR-630	CLIP-seq
MIRT2531689	hsa-miR-641	CLIP-seq
MIRT2531690	hsa-miR-642b	CLIP-seq
MIRT2531691	hsa-miR-889	CLIP-seq
MIRT2531692	hsa-miR-944	CLIP-seq
MIRT2531643	hsa-miR-105	CLIP-seq
MIRT991808	hsa-miR-1267	CLIP-seq
MIRT1548642	hsa-miR-128	CLIP-seq
MIRT2531648	hsa-miR-1305	CLIP-seq
MIRT1548643	hsa-miR-1323	CLIP-seq
MIRT2531649	hsa-miR-155	CLIP-seq
MIRT2531650	hsa-miR-1827	CLIP-seq
MIRT991811	hsa-miR-216a	CLIP-seq
MIRT2680884	hsa-miR-27a	CLIP-seq
MIRT2680885	hsa-miR-27b	CLIP-seq
MIRT991812	hsa-miR-3121-3p	CLIP-seq
MIRT2531656	hsa-miR-3194-3p	CLIP-seq
MIRT2531657	hsa-miR-342-3p	CLIP-seq
MIRT2531659	hsa-miR-3662	CLIP-seq
MIRT2531660	hsa-miR-3675-3p	CLIP-seq
MIRT991818	hsa-miR-3692	CLIP-seq
MIRT991819	hsa-miR-3714	CLIP-seq
MIRT2531662	hsa-miR-3942-3p	CLIP-seq
MIRT2531663	hsa-miR-3976	CLIP-seq
MIRT2531664	hsa-miR-4272	CLIP-seq
MIRT2531665	hsa-miR-4291	CLIP-seq
MIRT2531666	hsa-miR-4299	CLIP-seq
MIRT2531667	hsa-miR-4316	CLIP-seq
MIRT2531668	hsa-miR-4474-5p	CLIP-seq
MIRT2531669	hsa-miR-4494	CLIP-seq
MIRT2531672	hsa-miR-452	CLIP-seq
MIRT2531673	hsa-miR-4521	CLIP-seq
MIRT2531674	hsa-miR-4652-3p	CLIP-seq
MIRT2531675	hsa-miR-4676-3p	CLIP-seq
MIRT2531676	hsa-miR-4699-3p	CLIP-seq
MIRT2531677	hsa-miR-4710	CLIP-seq
MIRT2531678	hsa-miR-4735-5p	CLIP-seq
MIRT2531679	hsa-miR-4753-3p	CLIP-seq
MIRT2531680	hsa-miR-4792	CLIP-seq
MIRT2531682	hsa-miR-499a-5p	CLIP-seq
MIRT2531683	hsa-miR-539	CLIP-seq
MIRT2531684	hsa-miR-545	CLIP-seq
MIRT2531685	hsa-miR-548an	CLIP-seq
MIRT1548648	hsa-miR-548o	CLIP-seq
MIRT2531686	hsa-miR-548p	CLIP-seq
MIRT2531687	hsa-miR-584	CLIP-seq
MIRT2531688	hsa-miR-630	CLIP-seq
MIRT2531690	hsa-miR-642b	CLIP-seq
MIRT2531691	hsa-miR-889	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	28514442, 33961781
GO:0005829	Component	Cytosol	TAS
GO:0006325	Process	Chromatin organization	IEA
GO:0007059	Process	Chromosome segregation	IEA
GO:0008270	Function	Zinc ion binding	IEA
GO:0010467	Process	Gene expression	IEA
GO:0016567	Process	Protein ubiquitination	IEA
GO:0030261	Process	Chromosome condensation	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0061630	Function	Ubiquitin protein ligase activity	IEA

Other IDs

• MIM: 609101
• HGNC: 15600
• e!Ensembl: ENSG00000118496

Protein

• UniProt ID: Q8TB52
• Protein name: F-box only protein 30
• Protein function: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Required for muscle atrophy following denervation.
• PDB: 2YRE
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF15965	zf-TRAF_2	7 → 99	TRAF-like zinc-finger	Domain
  PF15966	F-box_4	609 → 724	F-box	Domain

• Sequence:

  MEEELQHSHCVNCVSRRCMTRPEPGISCDLIGCPLVCGAVFHSCKADEHRLLCPFERVPC
  LNSDFGCPFTMARNKVAEHLEMCPASVVCCTMEWNRWPVSYADRKSYENLSRDVDEVAQL
  DMALALQDQRMLLESLKVATMMSKATDKVSKPREQISVKSSVPEIPHANGLVSVDEESYG
  ALYQATVETTRSLAAALDILNTATRDIGMLNTSVPNDMDEQQNARESLEDQNLKDQDHLY
  EEEIGAVGGIDYNDTNQNAQSEQNGSSDLLCDLNTSSYDTSALCNGFPLENICTQVIDQN
  QNLHGDSKQSNLTNGDCVASSDGTSKPSSSLAVAAQLREIIPSSALPNGTVQHILMPDDE
  GEGELCWKKVDLGDVKNVDVLSFSHAPSFNFLSNSCWSKPKEDKAVDTSDLEVAEDPMGL
  QGIDLITAALLFCLGDSPGGRGISDSRMADIYHIDVGTQTFSLPSAILATSTMVGEIASA
  SACDHANPQLSNPSPFQTLGLDLVLECVARYQPKQRSMFTFVCGQLFRRKEFSSHFKNVH
  GDIHAGLNGWMEQRCPLAYYGCTYSQRRFCPSIQGAKIIHDRHLRSFGVQPCVSTVLVEP
  ARNCVLGLHNDHLSSLPFEVLQHIAGFLDGFSLCQLSCVSKLMRDVCGSLLQSRGMVILQ
  WGKRKYPEGNSSWQIKEKVWRFSTAFCSVNEWKFADILSMADHLKKCSYNVVEKREEAIP
  LPCMCVTRELTKEGRSLRSVLKPVL

• Sequence length: 745

Pathways

Reactome:

Neddylation
Antigen processing: Ubiquitination & Proteasome degradation