Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	84085
Gene name Gene Name - the full gene name approved by the HGNC.	F-box protein 30
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	FBXO30
Synonyms (NCBI Gene) Gene synonyms aliases	Fbx30
Chromosome Chromosome number	6
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	6q24.3
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box

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miRTarBase ID	miRNA	Experiments	Reference
MIRT028220	hsa-miR-33a-5p	Sequencing	20371350
MIRT046470	hsa-miR-15b-5p	CLASH	23622248
MIRT991807	hsa-miR-124	CLIP-seq
MIRT991808	hsa-miR-1267	CLIP-seq
MIRT991809	hsa-miR-198	CLIP-seq
MIRT991810	hsa-miR-2113	CLIP-seq
MIRT991811	hsa-miR-216a	CLIP-seq
MIRT991812	hsa-miR-3121-3p	CLIP-seq
MIRT991813	hsa-miR-338-3p	CLIP-seq
MIRT991814	hsa-miR-34a	CLIP-seq
MIRT991815	hsa-miR-34c-5p	CLIP-seq
MIRT991816	hsa-miR-3607-3p	CLIP-seq
MIRT991817	hsa-miR-3691-5p	CLIP-seq
MIRT991818	hsa-miR-3692	CLIP-seq
MIRT991819	hsa-miR-3714	CLIP-seq
MIRT991820	hsa-miR-377	CLIP-seq
MIRT991821	hsa-miR-3910	CLIP-seq
MIRT991822	hsa-miR-4282	CLIP-seq
MIRT991823	hsa-miR-4475	CLIP-seq
MIRT991824	hsa-miR-449a	CLIP-seq
MIRT991825	hsa-miR-449b	CLIP-seq
MIRT991826	hsa-miR-4530	CLIP-seq
MIRT991827	hsa-miR-4668-5p	CLIP-seq
MIRT991828	hsa-miR-4718	CLIP-seq
MIRT991829	hsa-miR-4720-3p	CLIP-seq
MIRT991830	hsa-miR-4728-3p	CLIP-seq
MIRT991831	hsa-miR-4752	CLIP-seq
MIRT991832	hsa-miR-4775	CLIP-seq
MIRT991833	hsa-miR-4804-3p	CLIP-seq
MIRT991834	hsa-miR-495	CLIP-seq
MIRT991835	hsa-miR-506	CLIP-seq
MIRT991836	hsa-miR-513a-3p	CLIP-seq
MIRT991837	hsa-miR-520f	CLIP-seq
MIRT991838	hsa-miR-548ac	CLIP-seq
MIRT991839	hsa-miR-548c-3p	CLIP-seq
MIRT991840	hsa-miR-548d-3p	CLIP-seq
MIRT991841	hsa-miR-548z	CLIP-seq
MIRT991842	hsa-miR-568	CLIP-seq
MIRT991843	hsa-miR-570	CLIP-seq
MIRT991844	hsa-miR-579	CLIP-seq
MIRT991845	hsa-miR-590-3p	CLIP-seq
MIRT991846	hsa-miR-607	CLIP-seq
MIRT991847	hsa-miR-891b	CLIP-seq
MIRT1548642	hsa-miR-128	CLIP-seq
MIRT1548643	hsa-miR-1323	CLIP-seq
MIRT1548644	hsa-miR-4504	CLIP-seq
MIRT1548645	hsa-miR-4528	CLIP-seq
MIRT1548646	hsa-miR-4672	CLIP-seq
MIRT1548647	hsa-miR-4789-5p	CLIP-seq
MIRT1548648	hsa-miR-548o	CLIP-seq
MIRT1548649	hsa-miR-576-3p	CLIP-seq
MIRT1548650	hsa-miR-668	CLIP-seq
MIRT1994164	hsa-miR-5096	CLIP-seq
MIRT1994165	hsa-miR-513b	CLIP-seq
MIRT991845	hsa-miR-590-3p	CLIP-seq
MIRT1548650	hsa-miR-668	CLIP-seq
MIRT2228127	hsa-miR-10a	CLIP-seq
MIRT2228128	hsa-miR-10b	CLIP-seq
MIRT1548643	hsa-miR-1323	CLIP-seq
MIRT2228129	hsa-miR-18a	CLIP-seq
MIRT2228130	hsa-miR-18b	CLIP-seq
MIRT991809	hsa-miR-198	CLIP-seq
MIRT991812	hsa-miR-3121-3p	CLIP-seq
MIRT2228131	hsa-miR-3148	CLIP-seq
MIRT991813	hsa-miR-338-3p	CLIP-seq
MIRT2228132	hsa-miR-339-5p	CLIP-seq
MIRT2228133	hsa-miR-3620	CLIP-seq
MIRT1548645	hsa-miR-4528	CLIP-seq
MIRT991826	hsa-miR-4530	CLIP-seq
MIRT1548646	hsa-miR-4672	CLIP-seq
MIRT2228134	hsa-miR-4735-3p	CLIP-seq
MIRT1548647	hsa-miR-4789-5p	CLIP-seq
MIRT1548648	hsa-miR-548o	CLIP-seq
MIRT1548649	hsa-miR-576-3p	CLIP-seq
MIRT1548650	hsa-miR-668	CLIP-seq
MIRT2531643	hsa-miR-105	CLIP-seq
MIRT2531644	hsa-miR-1224-3p	CLIP-seq
MIRT2531645	hsa-miR-1260	CLIP-seq
MIRT2531646	hsa-miR-1260b	CLIP-seq
MIRT991808	hsa-miR-1267	CLIP-seq
MIRT2531647	hsa-miR-1280	CLIP-seq
MIRT2531648	hsa-miR-1305	CLIP-seq
MIRT1548643	hsa-miR-1323	CLIP-seq
MIRT2531649	hsa-miR-155	CLIP-seq
MIRT2531650	hsa-miR-1827	CLIP-seq
MIRT2531651	hsa-miR-188-3p	CLIP-seq
MIRT2531652	hsa-miR-208a	CLIP-seq
MIRT2531653	hsa-miR-208b	CLIP-seq
MIRT991811	hsa-miR-216a	CLIP-seq
MIRT991812	hsa-miR-3121-3p	CLIP-seq
MIRT2531654	hsa-miR-3121-5p	CLIP-seq
MIRT2531655	hsa-miR-3156-3p	CLIP-seq
MIRT2531656	hsa-miR-3194-3p	CLIP-seq
MIRT2531657	hsa-miR-342-3p	CLIP-seq
MIRT2531658	hsa-miR-3617	CLIP-seq
MIRT2531659	hsa-miR-3662	CLIP-seq
MIRT2531660	hsa-miR-3675-3p	CLIP-seq
MIRT991818	hsa-miR-3692	CLIP-seq
MIRT991819	hsa-miR-3714	CLIP-seq
MIRT2531661	hsa-miR-3938	CLIP-seq
MIRT2531662	hsa-miR-3942-3p	CLIP-seq
MIRT2531663	hsa-miR-3976	CLIP-seq
MIRT2531664	hsa-miR-4272	CLIP-seq
MIRT2531665	hsa-miR-4291	CLIP-seq
MIRT2531666	hsa-miR-4299	CLIP-seq
MIRT2531667	hsa-miR-4316	CLIP-seq
MIRT2531668	hsa-miR-4474-5p	CLIP-seq
MIRT2531669	hsa-miR-4494	CLIP-seq
MIRT2531670	hsa-miR-4503	CLIP-seq
MIRT2531671	hsa-miR-450b-5p	CLIP-seq
MIRT2531672	hsa-miR-452	CLIP-seq
MIRT2531673	hsa-miR-4521	CLIP-seq
MIRT2531674	hsa-miR-4652-3p	CLIP-seq
MIRT2531675	hsa-miR-4676-3p	CLIP-seq
MIRT2531676	hsa-miR-4699-3p	CLIP-seq
MIRT2531677	hsa-miR-4710	CLIP-seq
MIRT2531678	hsa-miR-4735-5p	CLIP-seq
MIRT2531679	hsa-miR-4753-3p	CLIP-seq
MIRT2531680	hsa-miR-4792	CLIP-seq
MIRT2531681	hsa-miR-499-5p	CLIP-seq
MIRT2531682	hsa-miR-499a-5p	CLIP-seq
MIRT2531683	hsa-miR-539	CLIP-seq
MIRT2531684	hsa-miR-545	CLIP-seq
MIRT2531685	hsa-miR-548an	CLIP-seq
MIRT1548648	hsa-miR-548o	CLIP-seq
MIRT2531686	hsa-miR-548p	CLIP-seq
MIRT2531687	hsa-miR-584	CLIP-seq
MIRT2531688	hsa-miR-630	CLIP-seq
MIRT2531689	hsa-miR-641	CLIP-seq
MIRT2531690	hsa-miR-642b	CLIP-seq
MIRT2531691	hsa-miR-889	CLIP-seq
MIRT2531692	hsa-miR-944	CLIP-seq
MIRT2531643	hsa-miR-105	CLIP-seq
MIRT991808	hsa-miR-1267	CLIP-seq
MIRT1548642	hsa-miR-128	CLIP-seq
MIRT2531648	hsa-miR-1305	CLIP-seq
MIRT1548643	hsa-miR-1323	CLIP-seq
MIRT2531649	hsa-miR-155	CLIP-seq
MIRT2531650	hsa-miR-1827	CLIP-seq
MIRT991811	hsa-miR-216a	CLIP-seq
MIRT2680884	hsa-miR-27a	CLIP-seq
MIRT2680885	hsa-miR-27b	CLIP-seq
MIRT991812	hsa-miR-3121-3p	CLIP-seq
MIRT2531656	hsa-miR-3194-3p	CLIP-seq
MIRT2531657	hsa-miR-342-3p	CLIP-seq
MIRT2531659	hsa-miR-3662	CLIP-seq
MIRT2531660	hsa-miR-3675-3p	CLIP-seq
MIRT991818	hsa-miR-3692	CLIP-seq
MIRT991819	hsa-miR-3714	CLIP-seq
MIRT2531662	hsa-miR-3942-3p	CLIP-seq
MIRT2531663	hsa-miR-3976	CLIP-seq
MIRT2531664	hsa-miR-4272	CLIP-seq
MIRT2531665	hsa-miR-4291	CLIP-seq
MIRT2531666	hsa-miR-4299	CLIP-seq
MIRT2531667	hsa-miR-4316	CLIP-seq
MIRT2531668	hsa-miR-4474-5p	CLIP-seq
MIRT2531669	hsa-miR-4494	CLIP-seq
MIRT2531672	hsa-miR-452	CLIP-seq
MIRT2531673	hsa-miR-4521	CLIP-seq
MIRT2531674	hsa-miR-4652-3p	CLIP-seq
MIRT2531675	hsa-miR-4676-3p	CLIP-seq
MIRT2531676	hsa-miR-4699-3p	CLIP-seq
MIRT2531677	hsa-miR-4710	CLIP-seq
MIRT2531678	hsa-miR-4735-5p	CLIP-seq
MIRT2531679	hsa-miR-4753-3p	CLIP-seq
MIRT2531680	hsa-miR-4792	CLIP-seq
MIRT2531682	hsa-miR-499a-5p	CLIP-seq
MIRT2531683	hsa-miR-539	CLIP-seq
MIRT2531684	hsa-miR-545	CLIP-seq
MIRT2531685	hsa-miR-548an	CLIP-seq
MIRT1548648	hsa-miR-548o	CLIP-seq
MIRT2531686	hsa-miR-548p	CLIP-seq
MIRT2531687	hsa-miR-584	CLIP-seq
MIRT2531688	hsa-miR-630	CLIP-seq
MIRT2531690	hsa-miR-642b	CLIP-seq
MIRT2531691	hsa-miR-889	CLIP-seq

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GO ID	Ontology	Definition	Evidence
GO:0000209	Process	Protein polyubiquitination	TAS
GO:0005829	Component	Cytosol	TAS
GO:0008270	Function	Zinc ion binding	IEA
GO:0043687	Process	Post-translational protein modification	TAS
GO:0061630	Function	Ubiquitin protein ligase activity	IEA

MIM	HGNC	e!Ensembl
609101	15600	ENSG00000118496

Protein

UniProt ID

Q8TB52

Protein name

F-box only protein 30

Protein function

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Required for muscle atrophy following denervation.

PDB

2YRE

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF15965	zf-TRAF_2	7 → 99	TRAF-like zinc-finger	Domain
PF15966	F-box_4	609 → 724	F-box	Domain

Sequence

MEEELQHSHCVNCVSRRCMTRPEPGISCDLIGCPLVCGAVFHSCKADEHRLLCPFERVPC
LNSDFGCPFTMARNKVAEHLEMCPASVVCCTMEWNRWPVSYADRKSYENLSRDVDEVAQL
DMALALQDQRMLLESLKVATMMSKATDKVSKPREQISVKSSVPEIPHANGLVSVDEESYG
ALYQATVETTRSLAAALDILNTATRDIGMLNTSVPNDMDEQQNARESLEDQNLKDQDHLY
EEEIGAVGGIDYNDTNQNAQSEQNGSSDLLCDLNTSSYDTSALCNGFPLENICTQVIDQN
QNLHGDSKQSNLTNGDCVASSDGTSKPSSSLAVAAQLREIIPSSALPNGTVQHILMPDDE
GEGELCWKKVDLGDVKNVDVLSFSHAPSFNFLSNSCWSKPKEDKAVDTSDLEVAEDPMGL
QGIDLITAALLFCLGDSPGGRGISDSRMADIYHIDVGTQTFSLPSAILATSTMVGEIASA
SACDHANPQLSNPSPFQTLGLDLVLECVARYQPKQRSMFTFVCGQLFRRKEFSSHFKNVH
GDIHAGLNGWMEQRCPLAYYGCTYSQRRFCPSIQGAKIIHDRHLRSFGVQPCVSTVLVEP
ARNCVLGLHNDHLSSLPFEVLQHIAGFLDGFSLCQLSCVSKLMRDVCGSLLQSRGMVILQ
WGKRKYPEGNSSWQIKEKVWRFSTAFCSVNEWKFADILSMADHLKKCSYNVVEKREEAIP
LPCMCVTRELTKEGRSLRSVLKPVL

Sequence length

745

Interactions

View interactions

	Reactome
			Neddylation Antigen processing: Ubiquitination & Proteasome degradation

Show/Hide Causal Diseases (1)

Disease term	Disease name	dbSNP ID	References
Causal
Colorectal cancer	Colorectal Carcinoma	rs137854568, rs137854573, rs137854575, rs387906234, rs121908380, rs121908702, rs267606674, rs794729661, rs121909055, rs281865417, rs267606884, rs28934575, rs587776769, rs104893815, rs587776800 View all (467 more)

Show/Hide Text Mining Associations (4)

Disease Name	Relationship Type	References
Associations from Text Mining
Alzheimer Disease	Associate	36895559
Lung Neoplasms	Associate	30697967
Polycystic Ovary Syndrome	Associate	39773546
Prostatic Neoplasms	Associate	30866497, 32486483

FBXO30 (F-box protein 30)