Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
Entrez ID	840
Gene name	Caspase 7
Gene symbol	CASP7
Synonyms (NCBI Gene)	CASP-7CMH-1ICE-LAP3LICE2MCH3
Chromosome	10
Chromosome location	10q25.3
Summary	This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing

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miRTarBase ID	miRNA	Experiments	Reference
MIRT020444	hsa-miR-106b-5p	Microarray	17242205
MIRT021838	hsa-miR-132-3p	Microarray	17612493
MIRT023343	hsa-miR-122-5p	Microarray	17612493
MIRT024257	hsa-miR-215-5p	Microarray	19074876
MIRT024257	hsa-miR-215-5p	Microarray	19074876
MIRT026826	hsa-miR-192-5p	Microarray	19074876
MIRT030234	hsa-miR-26b-5p	Microarray	19088304
MIRT042101	hsa-miR-484	CLASH	23622248
MIRT053388	hsa-miR-106a-5p	Luciferase reporter assayWestern blot	23807165
MIRT053388	hsa-miR-106a-5p	Luciferase reporter assayWestern blot	23807165
MIRT020444	hsa-miR-106b-5p	Luciferase reporter assayqRT-PCRWestern blot	22986525
MIRT020444	hsa-miR-106b-5p	Luciferase reporter assayqRT-PCRWestern blot	22986525
MIRT020444	hsa-miR-106b-5p	Luciferase reporter assayqRT-PCRWestern blot	22986525
MIRT020444	hsa-miR-106b-5p	Luciferase reporter assayqRT-PCRWestern blot	22986525
MIRT731813	hsa-miR-146a-5p	Luciferase reporter assayqRT-PCRWestern blot	27449900
MIRT731813	hsa-miR-146a-5p	Luciferase reporter assayqRT-PCRWestern blot	27449900
MIRT732066	hsa-miR-224-5p	Luciferase reporter assayqRT-PCRWestern blot	26307684
MIRT732066	hsa-miR-224-5p	Luciferase reporter assayqRT-PCRWestern blot	26307684
MIRT732066	hsa-miR-224-5p	Luciferase reporter assayqRT-PCRWestern blot	26307684
MIRT735408	hsa-miR-371b-5p	Luciferase reporter assayWestern blottingMicroarray	32951155
MIRT864129	hsa-miR-1236	CLIP-seq
MIRT864130	hsa-miR-4659a-5p	CLIP-seq
MIRT864131	hsa-miR-4659b-5p	CLIP-seq
MIRT864132	hsa-miR-4698	CLIP-seq
MIRT864133	hsa-miR-4699-3p	CLIP-seq
MIRT864134	hsa-miR-4776-3p	CLIP-seq
MIRT864135	hsa-miR-495	CLIP-seq
MIRT864136	hsa-miR-548a-5p	CLIP-seq
MIRT864137	hsa-miR-548ab	CLIP-seq
MIRT864138	hsa-miR-548ak	CLIP-seq
MIRT864139	hsa-miR-548b-5p	CLIP-seq
MIRT864140	hsa-miR-548c-3p	CLIP-seq
MIRT864141	hsa-miR-548c-5p	CLIP-seq
MIRT864142	hsa-miR-548d-5p	CLIP-seq
MIRT864143	hsa-miR-548h	CLIP-seq
MIRT864144	hsa-miR-548i	CLIP-seq
MIRT864145	hsa-miR-548j	CLIP-seq
MIRT864146	hsa-miR-548n	CLIP-seq
MIRT864147	hsa-miR-548t	CLIP-seq
MIRT864148	hsa-miR-548w	CLIP-seq
MIRT864149	hsa-miR-548y	CLIP-seq
MIRT864150	hsa-miR-559	CLIP-seq
MIRT864151	hsa-miR-802	CLIP-seq
MIRT864152	hsa-miR-888	CLIP-seq
MIRT864153	hsa-miR-1245	CLIP-seq
MIRT864154	hsa-miR-190	CLIP-seq
MIRT864155	hsa-miR-190b	CLIP-seq
MIRT864156	hsa-miR-23a	CLIP-seq
MIRT864157	hsa-miR-23b	CLIP-seq
MIRT864158	hsa-miR-23c	CLIP-seq
MIRT864159	hsa-miR-3115	CLIP-seq
MIRT864160	hsa-miR-3180-5p	CLIP-seq
MIRT864161	hsa-miR-320a	CLIP-seq
MIRT864162	hsa-miR-320b	CLIP-seq
MIRT864163	hsa-miR-320c	CLIP-seq
MIRT864164	hsa-miR-320d	CLIP-seq
MIRT864165	hsa-miR-3606	CLIP-seq
MIRT864166	hsa-miR-3690	CLIP-seq
MIRT864167	hsa-miR-3977	CLIP-seq
MIRT864168	hsa-miR-4254	CLIP-seq
MIRT864169	hsa-miR-4427	CLIP-seq
MIRT864170	hsa-miR-4429	CLIP-seq
MIRT864171	hsa-miR-4434	CLIP-seq
MIRT864172	hsa-miR-4516	CLIP-seq
MIRT864173	hsa-miR-4531	CLIP-seq
MIRT864174	hsa-miR-4640-5p	CLIP-seq
MIRT864175	hsa-miR-4668-3p	CLIP-seq
MIRT864176	hsa-miR-4680-3p	CLIP-seq
MIRT864177	hsa-miR-4726-5p	CLIP-seq
MIRT864178	hsa-miR-4755-3p	CLIP-seq
MIRT864179	hsa-miR-4762-3p	CLIP-seq
MIRT864180	hsa-miR-4765	CLIP-seq
MIRT864181	hsa-miR-520a-5p	CLIP-seq
MIRT864182	hsa-miR-525-5p	CLIP-seq
MIRT864183	hsa-miR-660	CLIP-seq
MIRT864184	hsa-miR-921	CLIP-seq
MIRT1956163	hsa-miR-1208	CLIP-seq
MIRT864134	hsa-miR-4776-3p	CLIP-seq
MIRT864166	hsa-miR-3690	CLIP-seq
MIRT864168	hsa-miR-4254	CLIP-seq
MIRT864175	hsa-miR-4668-3p	CLIP-seq
MIRT1956163	hsa-miR-1208	CLIP-seq
MIRT864129	hsa-miR-1236	CLIP-seq
MIRT864153	hsa-miR-1245	CLIP-seq
MIRT2497004	hsa-miR-1261	CLIP-seq
MIRT2497005	hsa-miR-1294	CLIP-seq
MIRT2497006	hsa-miR-1976	CLIP-seq
MIRT2497007	hsa-miR-2116	CLIP-seq
MIRT864156	hsa-miR-23a	CLIP-seq
MIRT864157	hsa-miR-23b	CLIP-seq
MIRT864158	hsa-miR-23c	CLIP-seq
MIRT864159	hsa-miR-3115	CLIP-seq
MIRT2497008	hsa-miR-3119	CLIP-seq
MIRT2497009	hsa-miR-3120-5p	CLIP-seq
MIRT2497010	hsa-miR-3189-3p	CLIP-seq
MIRT864165	hsa-miR-3606	CLIP-seq
MIRT2497011	hsa-miR-3646	CLIP-seq
MIRT2497012	hsa-miR-3655	CLIP-seq
MIRT2497013	hsa-miR-375	CLIP-seq
MIRT2497014	hsa-miR-4264	CLIP-seq
MIRT2497015	hsa-miR-4273	CLIP-seq
MIRT2497016	hsa-miR-4279	CLIP-seq
MIRT864174	hsa-miR-4640-5p	CLIP-seq
MIRT2497017	hsa-miR-4659a-3p	CLIP-seq
MIRT2497018	hsa-miR-4659b-3p	CLIP-seq
MIRT2497019	hsa-miR-4677-5p	CLIP-seq
MIRT2497020	hsa-miR-4678	CLIP-seq
MIRT2497021	hsa-miR-4697-3p	CLIP-seq
MIRT2497022	hsa-miR-4704-3p	CLIP-seq
MIRT2497023	hsa-miR-4710	CLIP-seq
MIRT2497024	hsa-miR-4722-3p	CLIP-seq
MIRT864177	hsa-miR-4726-5p	CLIP-seq
MIRT2497025	hsa-miR-4753-3p	CLIP-seq
MIRT864178	hsa-miR-4755-3p	CLIP-seq
MIRT2497026	hsa-miR-4780	CLIP-seq
MIRT2497027	hsa-miR-4786-5p	CLIP-seq
MIRT2497028	hsa-miR-4790-3p	CLIP-seq
MIRT2497029	hsa-miR-4792	CLIP-seq
MIRT2497030	hsa-miR-4797-3p	CLIP-seq
MIRT2497031	hsa-miR-483-3p	CLIP-seq
MIRT864135	hsa-miR-495	CLIP-seq
MIRT2497032	hsa-miR-549	CLIP-seq
MIRT2497033	hsa-miR-578	CLIP-seq
MIRT2497034	hsa-miR-623	CLIP-seq
MIRT2497035	hsa-miR-630	CLIP-seq
MIRT2497036	hsa-miR-653	CLIP-seq
MIRT2497037	hsa-miR-769-5p	CLIP-seq
MIRT864184	hsa-miR-921	CLIP-seq
MIRT2497038	hsa-miR-942	CLIP-seq
MIRT1956163	hsa-miR-1208	CLIP-seq
MIRT864129	hsa-miR-1236	CLIP-seq
MIRT864153	hsa-miR-1245	CLIP-seq
MIRT2497004	hsa-miR-1261	CLIP-seq
MIRT2497005	hsa-miR-1294	CLIP-seq
MIRT2497006	hsa-miR-1976	CLIP-seq
MIRT2497007	hsa-miR-2116	CLIP-seq
MIRT864156	hsa-miR-23a	CLIP-seq
MIRT864157	hsa-miR-23b	CLIP-seq
MIRT864158	hsa-miR-23c	CLIP-seq
MIRT864159	hsa-miR-3115	CLIP-seq
MIRT2497009	hsa-miR-3120-5p	CLIP-seq
MIRT2497010	hsa-miR-3189-3p	CLIP-seq
MIRT864165	hsa-miR-3606	CLIP-seq
MIRT2497011	hsa-miR-3646	CLIP-seq
MIRT2497014	hsa-miR-4264	CLIP-seq
MIRT2497015	hsa-miR-4273	CLIP-seq
MIRT2497016	hsa-miR-4279	CLIP-seq
MIRT864174	hsa-miR-4640-5p	CLIP-seq
MIRT2497017	hsa-miR-4659a-3p	CLIP-seq
MIRT2497018	hsa-miR-4659b-3p	CLIP-seq
MIRT2497019	hsa-miR-4677-5p	CLIP-seq
MIRT2497020	hsa-miR-4678	CLIP-seq
MIRT2497021	hsa-miR-4697-3p	CLIP-seq
MIRT2497022	hsa-miR-4704-3p	CLIP-seq
MIRT2497023	hsa-miR-4710	CLIP-seq
MIRT2497024	hsa-miR-4722-3p	CLIP-seq
MIRT864177	hsa-miR-4726-5p	CLIP-seq
MIRT2497025	hsa-miR-4753-3p	CLIP-seq
MIRT864178	hsa-miR-4755-3p	CLIP-seq
MIRT2497026	hsa-miR-4780	CLIP-seq
MIRT2497027	hsa-miR-4786-5p	CLIP-seq
MIRT2497028	hsa-miR-4790-3p	CLIP-seq
MIRT2497029	hsa-miR-4792	CLIP-seq
MIRT2497030	hsa-miR-4797-3p	CLIP-seq
MIRT2497031	hsa-miR-483-3p	CLIP-seq
MIRT2497032	hsa-miR-549	CLIP-seq
MIRT2497033	hsa-miR-578	CLIP-seq
MIRT2497034	hsa-miR-623	CLIP-seq
MIRT2497035	hsa-miR-630	CLIP-seq
MIRT2497036	hsa-miR-653	CLIP-seq
MIRT2497037	hsa-miR-769-5p	CLIP-seq
MIRT864184	hsa-miR-921	CLIP-seq
MIRT2497038	hsa-miR-942	CLIP-seq

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Transcription factor	Regulation	Reference
E2F1	Activation	12766778
IRF1	Activation	10918594
RUNX3	Activation	15930301

Show/Hide all (71)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IDA	22464733
GO:0001650	Component	Fibrillar center	IDA
GO:0001778	Process	Plasma membrane repair	IDA	20530211
GO:0003723	Function	RNA binding	IDA	31586028
GO:0003723	Function	RNA binding	IEA
GO:0003824	Function	Catalytic activity	IEA
GO:0004190	Function	Aspartic-type endopeptidase activity	IEA
GO:0004197	Function	Cysteine-type endopeptidase activity	IBA
GO:0004197	Function	Cysteine-type endopeptidase activity	IDA	11257230, 16123041, 16352606, 16374543, 16916640, 17646170, 18723680, 19581639, 19617626, 20566630, 21157428, 22184066, 22451931, 22464733, 23650375, 23897474, 24904167, 27032039, 27889207, 28863261, 31586028, 37327784
GO:0004197	Function	Cysteine-type endopeptidase activity	IEA
GO:0004197	Function	Cysteine-type endopeptidase activity	IMP	22253444
GO:0004197	Function	Cysteine-type endopeptidase activity	ISS
GO:0005515	Function	Protein binding	IPI	11084335, 11257230, 11257231, 12888622, 21157428, 21555521, 25416956, 31467278, 31470122, 32296183, 32814053, 32911434, 33961781
GO:0005576	Component	Extracellular region	IEA
GO:0005615	Component	Extracellular space	IEA
GO:0005615	Component	Extracellular space	TAS	21157428
GO:0005634	Component	Nucleus	IDA	16374543, 19617626, 21555521, 22464733
GO:0005634	Component	Nucleus	IDA	17167422
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IDA	21555521
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	TAS	8576161
GO:0005829	Component	Cytosol	IDA	16352606
GO:0005829	Component	Cytosol	IDA	17167422
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IDA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IDA	15329343
GO:0006508	Process	Proteolysis	IDA	12888622
GO:0006508	Process	Proteolysis	IEA
GO:0006915	Process	Apoptotic process	IBA
GO:0006915	Process	Apoptotic process	IDA	17464193
GO:0006915	Process	Apoptotic process	IEA
GO:0006915	Process	Apoptotic process	TAS	8567622
GO:0007507	Process	Heart development	IEA
GO:0008233	Function	Peptidase activity	IDA	19740745
GO:0008233	Function	Peptidase activity	IEA
GO:0008234	Function	Cysteine-type peptidase activity	IEA
GO:0008234	Function	Cysteine-type peptidase activity	TAS	8567622
GO:0009411	Process	Response to UV	IEA
GO:0016485	Process	Protein processing	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0030163	Process	Protein catabolic process	IDA	16374543
GO:0030163	Process	Protein catabolic process	IDA	16374543, 22184066, 22464733
GO:0030163	Process	Protein catabolic process	IEA
GO:0042742	Process	Defense response to bacterium	IEA
GO:0043123	Process	Positive regulation of canonical NF-kappaB signal transduction	IDA	22464733
GO:0043525	Process	Positive regulation of neuron apoptotic process	IBA
GO:0044346	Process	Fibroblast apoptotic process	IEA
GO:0046513	Process	Ceramide biosynthetic process	IDA	17303575
GO:0051146	Process	Striated muscle cell differentiation	IEA
GO:0051402	Process	Neuron apoptotic process	IEA
GO:0051604	Process	Protein maturation	IDA	21157428
GO:0051604	Process	Protein maturation	IEA
GO:0070212	Process	Protein poly-ADP-ribosylation	IDA	33186521
GO:0070227	Process	Lymphocyte apoptotic process	IEA
GO:0070227	Process	Lymphocyte apoptotic process	ISS
GO:0070269	Process	Pyroptotic inflammatory response	IDA	33883744
GO:0071222	Process	Cellular response to lipopolysaccharide	IDA	22464733
GO:0071887	Process	Leukocyte apoptotic process	IEA
GO:0072734	Process	Cellular response to staurosporine	IEA
GO:0072734	Process	Cellular response to staurosporine	IMP	22253444
GO:0097194	Process	Execution phase of apoptosis	IBA
GO:0097194	Process	Execution phase of apoptosis	IDA	16374543
GO:0097194	Process	Execution phase of apoptosis	IDA	16374543, 16916640, 22184066, 31586028
GO:0097194	Process	Execution phase of apoptosis	IEA
GO:0097194	Process	Execution phase of apoptosis	IEA
GO:1905686	Process	Positive regulation of plasma membrane repair	IEA

MIM	HGNC	e!Ensembl
601761	1508	ENSG00000165806

P55210

Protein name

Caspase-7 (CASP-7) (EC 3.4.22.60) (Apoptotic protease Mch-3) (CMH-1) (ICE-like apoptotic protease 3) (ICE-LAP3) [Cleaved into: Caspase-7 subunit p20; Caspase-7 subunit p11]

Protein function

Thiol protease involved in different programmed cell death processes, such as apoptosis, pyroptosis or granzyme-mediated programmed cell death, by proteolytically cleaving target proteins (PubMed:11257230, PubMed:11257231, PubMed:11701129, PubMe

PDB

1F1J , 1GQF , 1I4O , 1I51 , 1K86 , 1K88 , 1KMC , 1SHJ , 1SHL , 2QL5 , 2QL7 , 2QL9 , 2QLB , 2QLF , 2QLJ , 3EDR , 3H1P , 3IBC , 3IBF , 3R5K , 4FDL , 4FEA , 4HQ0 , 4HQR , 4JB8 , 4JJ8 , 4JR1 , 4JR2 , 4LSZ , 4ZVO , 4ZVP , 4ZVQ , 4ZVR , 4ZVS , 4ZVT , 4ZVU , 5IC6 , 5K20 , 5V6U , 5V6Z , 7WZS , 8DGZ , 8DJ3

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00656	Peptidase_C14	68 → 301		Domain

Tissue specificity

TISSUE SPECIFICITY: Highly expressed in lung, skeletal muscle, liver, kidney, spleen and heart, and moderately in testis. No expression in the brain. {ECO:0000269|PubMed:8576161}.

Sequence

MADDQGCIEEQGVEDSANEDSVDAKPDRSSFVPSLFSKKKKNVTMRSIKTTRDRVPTYQY
NMNFEKLGKCIIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKMQ
DLLKKASEEDHTNAACFACILLSHGEENVIYGKDGVTPIKDLTAHFRGDRCKTLLEKPKL
FFIQACRGTELDDGIQADSGPINDTDANPRYKIPVEADFLFAYSTVPGYYSWRSPGRGSW
FVQALCSILEEHGKDLEIMQILTRVNDRVARHFESQSDDPHFHEKKQIPCVVSMLTKELY
FSQ

Sequence length

303

Interactions

View interactions

	KEGG		Reactome
	Efferocytosis Apoptosis Apoptosis - multiple species Cytosolic DNA-sensing pathway TNF signaling pathway Non-alcoholic fatty liver disease Alzheimer disease Pathways of neurodegeneration - multiple diseases Pathogenic Escherichia coli infection Salmonella infection Pertussis Legionellosis Pathways in cancer Lipid and atherosclerosis		Activation of caspases through apoptosome-mediated cleavage SMAC (DIABLO) binds to IAPs SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes Apoptotic cleavage of cellular proteins SMAC, XIAP-regulated apoptotic response Caspase-mediated cleavage of cytoskeletal proteins

CASP7 (caspase 7)