Gene Gene information from NCBI Gene database.
Entrez ID 83892
Gene name Potassium channel tetramerization domain containing 10
Gene symbol KCTD10
Synonyms (NCBI Gene)
BTBD28MSTP028ULRO61hBACURD3
Chromosome 12
Chromosome location 12q24.11
Summary The protein encoded by this gene binds proliferating cell nuclear antigen (PCNA) and may be involved in DNA synthesis and cell proliferation. In addition, the encoded protein may be a tumor suppressor. Several protein-coding and non-protein coding transcr
miRNA miRNA information provided by mirtarbase database.
980
miRTarBase ID miRNA Experiments Reference
MIRT019854 hsa-miR-375 Microarray 20215506
MIRT020169 hsa-miR-130b-3p Sequencing 20371350
MIRT031145 hsa-miR-19b-3p Sequencing 20371350
MIRT041231 hsa-miR-193b-3p CLASH 23622248
MIRT536534 hsa-miR-548c-3p PAR-CLIP 22012620
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
20
GO ID Ontology Definition Evidence Reference
GO:0004842 Function Ubiquitin-protein transferase activity IBA
GO:0004842 Function Ubiquitin-protein transferase activity ISS
GO:0005112 Function Notch binding IPI 25401743
GO:0005515 Function Protein binding IPI 19615732, 21145461, 32296183, 33961781, 34591642
GO:0005634 Component Nucleus IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
613421 23236 ENSG00000110906
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9H3F6
Protein name BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3 (hBACURD3) (BTB/POZ domain-containing protein KCTD10) (Potassium channel tetramerization domain-containing protein 10)
Protein function Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex. The BCR(BACURD3) E3 ubiquitin ligase complex mediates the ubiquitination of target proteins, leading to their degradation by the proteasome (By similarity).
PDB 5FTA
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF02214 BTB_2 34 124 BTB/POZ domain Domain
Sequence
MEEMSGESVVSSAVPAAATRTTSFKGTSPSSKYVKLNVGGALYYTTMQTLTKQDTMLKAM
FSGRMEVLTDSEGWILIDRCGKHFGTILNYLRDGAVPLPESRREIEELLAEAKYYLVQGL
VEEC
QAALQNKDTYEPFCKVPVITSSKEEQKLIATSNKPAVKLLYNRSNNKYSYTSNSDD
NMLKNIELFDKLSLRFNGRVLFIKDVIGDEICCWSFYGQGRKIAEVCCTSIVYATEKKQT
KVEFPEARIYEETLNILLYEAQDGRGPDNALLEATGGAAGRSHHLDEDEERERIERVRRI
HIKRPDDRAHLHQ
Sequence length 313
Interactions View interactions