FRMD8 (FERM domain containing 8)
Gene | |
Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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83786 |
Gene name
Gene Name - the full gene name approved by the HGNC.
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FERM domain containing 8 |
Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
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FRMD8 |
Synonyms (NCBI Gene)
Gene synonyms aliases
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FKSG44, iTAP |
Chromosome
Chromosome number
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11 |
Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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11q13.1 |
miRNA
miRNA information provided by mirtarbase database.
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Gene ontology (GO)
Gene ontology information of associated ontologies with gene provided by GO database.
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Other IDs
Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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Protein | |||||||||||
UniProt ID | Q9BZ67 | ||||||||||
Protein name | FERM domain-containing protein 8 (Band4.1 inhibitor LRP interactor) (Bili) (iRhom tail-associated protein) (iTAP) | ||||||||||
Protein function | Promotes the cell surface stability of iRhom1/RHBDF1 and iRhom2/RHBDF2 and prevents their degradation via the endolysosomal pathway. By acting on iRhoms, involved in ADAM17-mediated shedding of TNF, amphiregulin/AREG, HBEGF and TGFA from the cel | ||||||||||
Family and domains |
Pfam
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Tissue specificity | TISSUE SPECIFICITY: Widely expressed, with high expression in heart and spleen. {ECO:0000269|PubMed:19572019}. | ||||||||||
Sequence |
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Sequence length | 464 | ||||||||||
Interactions | View interactions |
Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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Associated diseases
Disease information provided by ClinVar, GenCC, and GWAS databases.
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