Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
83786
Gene name Gene Name - the full gene name approved by the HGNC.
FERM domain containing 8
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
FRMD8
Synonyms (NCBI Gene) Gene synonyms aliases
FKSG44, iTAP
Chromosome Chromosome number
11
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
11q13.1
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT023130 hsa-miR-124-3p Microarray 18668037
MIRT037767 hsa-miR-874-3p CLASH 23622248
MIRT647814 hsa-miR-4787-3p HITS-CLIP 23824327
MIRT647813 hsa-miR-483-3p HITS-CLIP 23824327
MIRT647812 hsa-miR-1273g-3p HITS-CLIP 23824327
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 25416956, 29897333, 29897336, 32296183
GO:0005654 Component Nucleoplasm IDA
GO:0005829 Component Cytosol IDA 29897333
GO:0005886 Component Plasma membrane IDA 29897333
GO:0032760 Process Positive regulation of tumor necrosis factor production IDA 29897333
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
618337 25462 ENSG00000126391
Protein
UniProt ID Q9BZ67
Protein name FERM domain-containing protein 8 (Band4.1 inhibitor LRP interactor) (Bili) (iRhom tail-associated protein) (iTAP)
Protein function Promotes the cell surface stability of iRhom1/RHBDF1 and iRhom2/RHBDF2 and prevents their degradation via the endolysosomal pathway. By acting on iRhoms, involved in ADAM17-mediated shedding of TNF, amphiregulin/AREG, HBEGF and TGFA from the cel
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00373 FERM_M 135 272 FERM central domain Domain
Tissue specificity TISSUE SPECIFICITY: Widely expressed, with high expression in heart and spleen. {ECO:0000269|PubMed:19572019}.
Sequence
MDGTEGSAGQPGPAERSHRSSVSSVGARAADVLVYLADDTVVPLAVENLPSLSAHELHRA
VREVLQLPDIALDVFALWLVSPLLEVQLKPKHQPYKLGRQWPELLLRFTSAPDDDVAMDE
PFLQFRRNVFFPKRRELQIHDEEVLRLLYEEAKGNVLAARYPCDVEDCEALGALVCRVQL
GPYQPGRPAACDLREKLDSFLPAHLCKRGQSLFAALRGRGARAGPGEQGLLNAYRQVQEV
SSDGGCEAALGTHYRAYLLKCHELPFYGCAFF
HGEVDKPAQGFLHRGGRKPVSVAISLEG
VHVIDSREKHVLLGLRFQELSWDHTSPEEEEPILWLEFDGDSEGTPVNKLLKIYSKQAEL
MSSLIEYCIELSQAAEPAGPQDSATGSPSDPSSSLAPVQRPKLRRQGSVVSSRIQHLSTI
DYVEDGKGIRRVKPKRTTSFFSRQLSLGQGSYTVVQPGDSLEQG
Sequence length 464
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  
  TNF signaling pathway  
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Leukemia Leukemia, Myelocytic, Acute rs121909646, rs121913488, rs587776834, rs752746786, rs869312821, rs767454740, rs1554564297 27903959
Associations from Text Mining
Disease Name Relationship Type References
Amyotrophic Lateral Sclerosis Associate 37872557
Carcinoma Basal Cell Associate 29967001
Carcinoma Endometrioid Associate 29967001
Leukemia Myeloid Acute Associate 30760869
Lymphoma Non Hodgkin Associate 29967001
Sick Sinus Syndrome Stimulate 36171622
Stomach Neoplasms Associate 36171622