Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID	83729
Gene name	Inhibin subunit beta E
Gene symbol	INHBE
Synonyms (NCBI Gene)	-
Chromosome	12
Chromosome location	12q13.3
Summary	This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate an inhibin beta subunit. Inhibins have been implicated in regulating numerous cellular

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miRTarBase ID	miRNA	Experiments	Reference
MIRT016770	hsa-miR-335-5p	Microarray	18185580
MIRT027405	hsa-miR-98-5p	Microarray	19088304
MIRT739666	hsa-miR-1470	CLIP-seq
MIRT1066651	hsa-miR-1827	CLIP-seq
MIRT1066652	hsa-miR-3148	CLIP-seq
MIRT1066653	hsa-miR-3153	CLIP-seq
MIRT1066654	hsa-miR-3178	CLIP-seq
MIRT1066655	hsa-miR-331-3p	CLIP-seq
MIRT1066656	hsa-miR-335	CLIP-seq
MIRT1066657	hsa-miR-3647-3p	CLIP-seq
MIRT1066658	hsa-miR-3672	CLIP-seq
MIRT1066659	hsa-miR-3926	CLIP-seq
MIRT1066660	hsa-miR-3929	CLIP-seq
MIRT1066661	hsa-miR-423-3p	CLIP-seq
MIRT1066662	hsa-miR-4292	CLIP-seq
MIRT739670	hsa-miR-4297	CLIP-seq
MIRT1066663	hsa-miR-4299	CLIP-seq
MIRT1066664	hsa-miR-4419b	CLIP-seq
MIRT1066665	hsa-miR-4421	CLIP-seq
MIRT1066666	hsa-miR-4461	CLIP-seq
MIRT739667	hsa-miR-4469	CLIP-seq
MIRT1066667	hsa-miR-4478	CLIP-seq
MIRT1066668	hsa-miR-4646-5p	CLIP-seq
MIRT1066669	hsa-miR-4649-3p	CLIP-seq
MIRT739665	hsa-miR-4667-3p	CLIP-seq
MIRT1066670	hsa-miR-4668-5p	CLIP-seq
MIRT739668	hsa-miR-4768-5p	CLIP-seq
MIRT1066671	hsa-miR-4775	CLIP-seq
MIRT1066672	hsa-miR-4786-5p	CLIP-seq
MIRT1066673	hsa-miR-4793-5p	CLIP-seq
MIRT1066674	hsa-miR-4795-3p	CLIP-seq
MIRT1066675	hsa-miR-485-5p	CLIP-seq
MIRT1066676	hsa-miR-508-5p	CLIP-seq
MIRT1066677	hsa-miR-542-3p	CLIP-seq
MIRT1066678	hsa-miR-548aa	CLIP-seq
MIRT1066679	hsa-miR-548ac	CLIP-seq
MIRT1066680	hsa-miR-548d-3p	CLIP-seq
MIRT1066681	hsa-miR-548s	CLIP-seq
MIRT1066682	hsa-miR-548z	CLIP-seq
MIRT1066683	hsa-miR-566	CLIP-seq
MIRT1066684	hsa-miR-590-3p	CLIP-seq
MIRT739669	hsa-miR-642a	CLIP-seq
MIRT1066685	hsa-miR-653	CLIP-seq
MIRT1066686	hsa-miR-766	CLIP-seq
MIRT1066687	hsa-miR-769-5p	CLIP-seq
MIRT2015990	hsa-miR-187	CLIP-seq
MIRT2015991	hsa-miR-298	CLIP-seq
MIRT1066653	hsa-miR-3153	CLIP-seq
MIRT2015992	hsa-miR-34b	CLIP-seq
MIRT2015993	hsa-miR-3614-5p	CLIP-seq
MIRT1066660	hsa-miR-3929	CLIP-seq
MIRT1066661	hsa-miR-423-3p	CLIP-seq
MIRT1066664	hsa-miR-4419b	CLIP-seq
MIRT1066667	hsa-miR-4478	CLIP-seq
MIRT1066668	hsa-miR-4646-5p	CLIP-seq
MIRT1066670	hsa-miR-4668-5p	CLIP-seq
MIRT2015994	hsa-miR-4768-3p	CLIP-seq
MIRT1066675	hsa-miR-485-5p	CLIP-seq
MIRT2015995	hsa-miR-597	CLIP-seq
MIRT2015996	hsa-miR-665	CLIP-seq
MIRT2248467	hsa-miR-106a	CLIP-seq
MIRT2248468	hsa-miR-106b	CLIP-seq
MIRT2248469	hsa-miR-1324	CLIP-seq
MIRT2248470	hsa-miR-17	CLIP-seq
MIRT1066651	hsa-miR-1827	CLIP-seq
MIRT2248471	hsa-miR-20a	CLIP-seq
MIRT2248472	hsa-miR-20b	CLIP-seq
MIRT2248473	hsa-miR-24	CLIP-seq
MIRT2015991	hsa-miR-298	CLIP-seq
MIRT1066654	hsa-miR-3178	CLIP-seq
MIRT2015992	hsa-miR-34b	CLIP-seq
MIRT2015993	hsa-miR-3614-5p	CLIP-seq
MIRT2248474	hsa-miR-371b-3p	CLIP-seq
MIRT1066660	hsa-miR-3929	CLIP-seq
MIRT2248475	hsa-miR-4284	CLIP-seq
MIRT2248476	hsa-miR-4330	CLIP-seq
MIRT1066664	hsa-miR-4419b	CLIP-seq
MIRT1066667	hsa-miR-4478	CLIP-seq
MIRT2248477	hsa-miR-4641	CLIP-seq
MIRT1066669	hsa-miR-4649-3p	CLIP-seq
MIRT2248478	hsa-miR-4755-3p	CLIP-seq
MIRT2015994	hsa-miR-4768-3p	CLIP-seq
MIRT1066675	hsa-miR-485-5p	CLIP-seq
MIRT2248479	hsa-miR-519d	CLIP-seq
MIRT2248480	hsa-miR-548l	CLIP-seq
MIRT1066683	hsa-miR-566	CLIP-seq
MIRT2015996	hsa-miR-665	CLIP-seq
MIRT2248481	hsa-miR-93	CLIP-seq
MIRT2451865	hsa-miR-2115	CLIP-seq
MIRT2451866	hsa-miR-4686	CLIP-seq
MIRT2451867	hsa-miR-4691-5p	CLIP-seq
MIRT2451868	hsa-miR-516a-3p	CLIP-seq
MIRT1066651	hsa-miR-1827	CLIP-seq
MIRT2015991	hsa-miR-298	CLIP-seq
MIRT2552003	hsa-miR-3150a-5p	CLIP-seq
MIRT2552004	hsa-miR-3150b-5p	CLIP-seq
MIRT1066654	hsa-miR-3178	CLIP-seq
MIRT1066659	hsa-miR-3926	CLIP-seq
MIRT1066660	hsa-miR-3929	CLIP-seq
MIRT1066661	hsa-miR-423-3p	CLIP-seq
MIRT1066664	hsa-miR-4419b	CLIP-seq
MIRT2552005	hsa-miR-4460	CLIP-seq
MIRT1066667	hsa-miR-4478	CLIP-seq
MIRT1066669	hsa-miR-4649-3p	CLIP-seq
MIRT2552006	hsa-miR-4727-3p	CLIP-seq
MIRT1066672	hsa-miR-4786-5p	CLIP-seq
MIRT1066673	hsa-miR-4793-5p	CLIP-seq
MIRT1066675	hsa-miR-485-5p	CLIP-seq
MIRT1066681	hsa-miR-548s	CLIP-seq
MIRT1066683	hsa-miR-566	CLIP-seq
MIRT1066685	hsa-miR-653	CLIP-seq
MIRT1066687	hsa-miR-769-5p	CLIP-seq
MIRT1066651	hsa-miR-1827	CLIP-seq
MIRT2552003	hsa-miR-3150a-5p	CLIP-seq
MIRT2552004	hsa-miR-3150b-5p	CLIP-seq
MIRT1066654	hsa-miR-3178	CLIP-seq
MIRT1066660	hsa-miR-3929	CLIP-seq
MIRT1066661	hsa-miR-423-3p	CLIP-seq
MIRT1066664	hsa-miR-4419b	CLIP-seq
MIRT1066667	hsa-miR-4478	CLIP-seq
MIRT1066669	hsa-miR-4649-3p	CLIP-seq
MIRT2552006	hsa-miR-4727-3p	CLIP-seq
MIRT1066675	hsa-miR-485-5p	CLIP-seq
MIRT1066683	hsa-miR-566	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0005125	Function	Cytokine activity	IBA
GO:0005125	Function	Cytokine activity	IEA
GO:0005125	Function	Cytokine activity	ISS
GO:0005179	Function	Hormone activity	IEA
GO:0005576	Component	Extracellular region	IEA
GO:0005615	Component	Extracellular space	IBA
GO:0005615	Component	Extracellular space	ISS
GO:0007178	Process	Cell surface receptor protein serine/threonine kinase signaling pathway	IBA
GO:0008083	Function	Growth factor activity	IEA
GO:0031012	Component	Extracellular matrix	HDA	25037231
GO:0032924	Process	Activin receptor signaling pathway	IMP	15150278
GO:1904178	Process	Negative regulation of adipose tissue development	IEA
GO:1904178	Process	Negative regulation of adipose tissue development	ISS

MIM	HGNC	e!Ensembl
612031	24029	ENSG00000139269

P58166

Protein name

Inhibin beta E chain (Activin beta-E chain)

Protein function

Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonad

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00019	TGF_beta	246 → 349	Transforming growth factor beta like domain	Domain

Sequence

MRLPDVQLWLVLLWALVRAQGTGSVCPSCGGSKLAPQAERALVLELAKQQILDGLHLTSR
PRITHPPPQAALTRALRRLQPGSVAPGNGEEVISFATVTDSTSAYSSLLTFHLSTPRSHH
LYHARLWLHVLPTLPGTLCLRIFRWGPRRRRQGSRTLLAEHHITNLGWHTLTLPSSGLRG
EKSGVLKLQLDCRPLEGNSTVTGQPRRLLDTAGHQQPFLELKIRANEPGAGRARRRTPTC
EPATPLCCRRDHYVDFQELGWRDWILQPEGYQLNYCSGQCPPHLAGSPGIAASFHSAVFS
LLKANNPWPASTSCCVPTARRPLSLLYLDHNGNVVKTDVPDMVVEACGCS

Sequence length

350

Interactions

View interactions

	KEGG		Reactome
	Cytokine-cytokine receptor interaction TGF-beta signaling pathway Signaling pathways regulating pluripotency of stem cells		Glycoprotein hormones

INHBE (inhibin subunit beta E)