Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	83729
Gene name Gene Name - the full gene name approved by the HGNC.	Inhibin subunit beta E
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	INHBE
Synonyms (NCBI Gene) Gene synonyms aliases	-
Chromosome Chromosome number	12
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	12q13.3
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate an inhibin beta subunit. Inhibins have been implicated in regulating numerous cellular

Show/Hide all(124)

miRTarBase ID	miRNA	Experiments	Reference
MIRT016770	hsa-miR-335-5p	Microarray	18185580
MIRT027405	hsa-miR-98-5p	Microarray	19088304
MIRT739666	hsa-miR-1470	CLIP-seq
MIRT1066651	hsa-miR-1827	CLIP-seq
MIRT1066652	hsa-miR-3148	CLIP-seq
MIRT1066653	hsa-miR-3153	CLIP-seq
MIRT1066654	hsa-miR-3178	CLIP-seq
MIRT1066655	hsa-miR-331-3p	CLIP-seq
MIRT1066656	hsa-miR-335	CLIP-seq
MIRT1066657	hsa-miR-3647-3p	CLIP-seq
MIRT1066658	hsa-miR-3672	CLIP-seq
MIRT1066659	hsa-miR-3926	CLIP-seq
MIRT1066660	hsa-miR-3929	CLIP-seq
MIRT1066661	hsa-miR-423-3p	CLIP-seq
MIRT1066662	hsa-miR-4292	CLIP-seq
MIRT739670	hsa-miR-4297	CLIP-seq
MIRT1066663	hsa-miR-4299	CLIP-seq
MIRT1066664	hsa-miR-4419b	CLIP-seq
MIRT1066665	hsa-miR-4421	CLIP-seq
MIRT1066666	hsa-miR-4461	CLIP-seq
MIRT739667	hsa-miR-4469	CLIP-seq
MIRT1066667	hsa-miR-4478	CLIP-seq
MIRT1066668	hsa-miR-4646-5p	CLIP-seq
MIRT1066669	hsa-miR-4649-3p	CLIP-seq
MIRT739665	hsa-miR-4667-3p	CLIP-seq
MIRT1066670	hsa-miR-4668-5p	CLIP-seq
MIRT739668	hsa-miR-4768-5p	CLIP-seq
MIRT1066671	hsa-miR-4775	CLIP-seq
MIRT1066672	hsa-miR-4786-5p	CLIP-seq
MIRT1066673	hsa-miR-4793-5p	CLIP-seq
MIRT1066674	hsa-miR-4795-3p	CLIP-seq
MIRT1066675	hsa-miR-485-5p	CLIP-seq
MIRT1066676	hsa-miR-508-5p	CLIP-seq
MIRT1066677	hsa-miR-542-3p	CLIP-seq
MIRT1066678	hsa-miR-548aa	CLIP-seq
MIRT1066679	hsa-miR-548ac	CLIP-seq
MIRT1066680	hsa-miR-548d-3p	CLIP-seq
MIRT1066681	hsa-miR-548s	CLIP-seq
MIRT1066682	hsa-miR-548z	CLIP-seq
MIRT1066683	hsa-miR-566	CLIP-seq
MIRT1066684	hsa-miR-590-3p	CLIP-seq
MIRT739669	hsa-miR-642a	CLIP-seq
MIRT1066685	hsa-miR-653	CLIP-seq
MIRT1066686	hsa-miR-766	CLIP-seq
MIRT1066687	hsa-miR-769-5p	CLIP-seq
MIRT2015990	hsa-miR-187	CLIP-seq
MIRT2015991	hsa-miR-298	CLIP-seq
MIRT1066653	hsa-miR-3153	CLIP-seq
MIRT2015992	hsa-miR-34b	CLIP-seq
MIRT2015993	hsa-miR-3614-5p	CLIP-seq
MIRT1066660	hsa-miR-3929	CLIP-seq
MIRT1066661	hsa-miR-423-3p	CLIP-seq
MIRT1066664	hsa-miR-4419b	CLIP-seq
MIRT1066667	hsa-miR-4478	CLIP-seq
MIRT1066668	hsa-miR-4646-5p	CLIP-seq
MIRT1066670	hsa-miR-4668-5p	CLIP-seq
MIRT2015994	hsa-miR-4768-3p	CLIP-seq
MIRT1066675	hsa-miR-485-5p	CLIP-seq
MIRT2015995	hsa-miR-597	CLIP-seq
MIRT2015996	hsa-miR-665	CLIP-seq
MIRT2248467	hsa-miR-106a	CLIP-seq
MIRT2248468	hsa-miR-106b	CLIP-seq
MIRT2248469	hsa-miR-1324	CLIP-seq
MIRT2248470	hsa-miR-17	CLIP-seq
MIRT1066651	hsa-miR-1827	CLIP-seq
MIRT2248471	hsa-miR-20a	CLIP-seq
MIRT2248472	hsa-miR-20b	CLIP-seq
MIRT2248473	hsa-miR-24	CLIP-seq
MIRT2015991	hsa-miR-298	CLIP-seq
MIRT1066654	hsa-miR-3178	CLIP-seq
MIRT2015992	hsa-miR-34b	CLIP-seq
MIRT2015993	hsa-miR-3614-5p	CLIP-seq
MIRT2248474	hsa-miR-371b-3p	CLIP-seq
MIRT1066660	hsa-miR-3929	CLIP-seq
MIRT2248475	hsa-miR-4284	CLIP-seq
MIRT2248476	hsa-miR-4330	CLIP-seq
MIRT1066664	hsa-miR-4419b	CLIP-seq
MIRT1066667	hsa-miR-4478	CLIP-seq
MIRT2248477	hsa-miR-4641	CLIP-seq
MIRT1066669	hsa-miR-4649-3p	CLIP-seq
MIRT2248478	hsa-miR-4755-3p	CLIP-seq
MIRT2015994	hsa-miR-4768-3p	CLIP-seq
MIRT1066675	hsa-miR-485-5p	CLIP-seq
MIRT2248479	hsa-miR-519d	CLIP-seq
MIRT2248480	hsa-miR-548l	CLIP-seq
MIRT1066683	hsa-miR-566	CLIP-seq
MIRT2015996	hsa-miR-665	CLIP-seq
MIRT2248481	hsa-miR-93	CLIP-seq
MIRT2451865	hsa-miR-2115	CLIP-seq
MIRT2451866	hsa-miR-4686	CLIP-seq
MIRT2451867	hsa-miR-4691-5p	CLIP-seq
MIRT2451868	hsa-miR-516a-3p	CLIP-seq
MIRT1066651	hsa-miR-1827	CLIP-seq
MIRT2015991	hsa-miR-298	CLIP-seq
MIRT2552003	hsa-miR-3150a-5p	CLIP-seq
MIRT2552004	hsa-miR-3150b-5p	CLIP-seq
MIRT1066654	hsa-miR-3178	CLIP-seq
MIRT1066659	hsa-miR-3926	CLIP-seq
MIRT1066660	hsa-miR-3929	CLIP-seq
MIRT1066661	hsa-miR-423-3p	CLIP-seq
MIRT1066664	hsa-miR-4419b	CLIP-seq
MIRT2552005	hsa-miR-4460	CLIP-seq
MIRT1066667	hsa-miR-4478	CLIP-seq
MIRT1066669	hsa-miR-4649-3p	CLIP-seq
MIRT2552006	hsa-miR-4727-3p	CLIP-seq
MIRT1066672	hsa-miR-4786-5p	CLIP-seq
MIRT1066673	hsa-miR-4793-5p	CLIP-seq
MIRT1066675	hsa-miR-485-5p	CLIP-seq
MIRT1066681	hsa-miR-548s	CLIP-seq
MIRT1066683	hsa-miR-566	CLIP-seq
MIRT1066685	hsa-miR-653	CLIP-seq
MIRT1066687	hsa-miR-769-5p	CLIP-seq
MIRT1066651	hsa-miR-1827	CLIP-seq
MIRT2552003	hsa-miR-3150a-5p	CLIP-seq
MIRT2552004	hsa-miR-3150b-5p	CLIP-seq
MIRT1066654	hsa-miR-3178	CLIP-seq
MIRT1066660	hsa-miR-3929	CLIP-seq
MIRT1066661	hsa-miR-423-3p	CLIP-seq
MIRT1066664	hsa-miR-4419b	CLIP-seq
MIRT1066667	hsa-miR-4478	CLIP-seq
MIRT1066669	hsa-miR-4649-3p	CLIP-seq
MIRT2552006	hsa-miR-4727-3p	CLIP-seq
MIRT1066675	hsa-miR-485-5p	CLIP-seq
MIRT1066683	hsa-miR-566	CLIP-seq

Show/Hide all(13)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005125	Function	Cytokine activity	IBA
GO:0005125	Function	Cytokine activity	IEA
GO:0005125	Function	Cytokine activity	ISS
GO:0005179	Function	Hormone activity	IEA
GO:0005576	Component	Extracellular region	IEA
GO:0005615	Component	Extracellular space	IBA
GO:0005615	Component	Extracellular space	ISS
GO:0007178	Process	Cell surface receptor protein serine/threonine kinase signaling pathway	IBA
GO:0008083	Function	Growth factor activity	IEA
GO:0031012	Component	Extracellular matrix	HDA	25037231
GO:0032924	Process	Activin receptor signaling pathway	IMP	15150278
GO:1904178	Process	Negative regulation of adipose tissue development	IEA
GO:1904178	Process	Negative regulation of adipose tissue development	ISS

MIM	HGNC	e!Ensembl
612031	24029	ENSG00000139269

Protein

UniProt ID

P58166

Protein name

Inhibin beta E chain (Activin beta-E chain)

Protein function

Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonad

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00019	TGF_beta	246 → 349	Transforming growth factor beta like domain	Domain

Sequence

MRLPDVQLWLVLLWALVRAQGTGSVCPSCGGSKLAPQAERALVLELAKQQILDGLHLTSR
PRITHPPPQAALTRALRRLQPGSVAPGNGEEVISFATVTDSTSAYSSLLTFHLSTPRSHH
LYHARLWLHVLPTLPGTLCLRIFRWGPRRRRQGSRTLLAEHHITNLGWHTLTLPSSGLRG
EKSGVLKLQLDCRPLEGNSTVTGQPRRLLDTAGHQQPFLELKIRANEPGAGRARRRTPTC
EPATPLCCRRDHYVDFQELGWRDWILQPEGYQLNYCSGQCPPHLAGSPGIAASFHSAVFS
LLKANNPWPASTSCCVPTARRPLSLLYLDHNGNVVKTDVPDMVVEACGCS

Sequence length

350

Interactions

View interactions

	KEGG		Reactome
	Cytokine-cytokine receptor interaction TGF-beta signaling pathway Signaling pathways regulating pluripotency of stem cells		Glycoprotein hormones

Show/Hide Unknown Diseases (3)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Diabetes	Type 2 diabetes	N/A	N/A	GWAS
Insomnia	Insomnia	N/A	N/A	GWAS
Metabolic Syndrome	Metabolic syndrome	N/A	N/A	GWAS

Show/Hide Text Mining Associations (59)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Abortion Spontaneous	Associate	17074342
Adenocarcinoma Of Esophagus	Associate	36064338
Angina Unstable	Associate	15261933
Anodontia	Associate	17258738
Asthma	Associate	19733294
Atherosclerosis	Associate	10559140, 20954112
Barrett Esophagus	Associate	26447543
Brain Neoplasms	Associate	7670558
Breast Neoplasms	Associate	11278744, 30343527, 37870468
Cachexia	Associate	32970737
Calcinosis Cutis	Associate	28418896
Carcinogenesis	Associate	26449823, 28418896, 38030164
Carcinoma Embryonal	Associate	9365168
Carcinoma Hepatocellular	Associate	31375600
Carcinoma Non Small Cell Lung	Associate	25432175
Carcinoma Ovarian Epithelial	Associate	10780520, 12366660, 24302632, 39248018
Carcinoma Renal Cell	Associate	33761648
Cell Transformation Neoplastic	Inhibit	36064338
Cell Transformation Viral	Associate	26449823
Colonic Neoplasms	Associate	37845228
Colorectal Neoplasms	Associate	17258738, 20011542, 22761777, 28418896, 28717230, 36591565, 9482899
Colorectal Neoplasms	Inhibit	25374171
Cystadenoma Papillary	Associate	24302632
Diabetes Mellitus	Associate	25833251, 35999217
Diabetes Mellitus Type 2	Associate	34391409, 35999217
Embolism Fat	Associate	37963137
Endometrial Neoplasms	Associate	26384307
Endometriosis	Associate	21496809
Hydatidiform Mole	Associate	16033091, 17649811
Hyperlipoproteinemia Type II	Associate	26384307
Hyperplasia	Associate	20954112
IgA Vasculitis	Associate	13130463
Lipodystrophy	Associate	35999217
Lung Diseases	Associate	26238393
Melanoma	Associate	15064726
Mesothelioma	Associate	25557874
Neoplasm Metastasis	Stimulate	36591565
Neoplasms	Stimulate	12366660
Neoplasms	Associate	12750556, 18450971, 25432175, 27939373, 28647698, 28717230, 30315637, 32970737, 36064338, 37870468
Neoplasms Cystic Mucinous and Serous	Associate	26384307
Neoplasms Germ Cell and Embryonal	Associate	30315637, 9365168
Non alcoholic Fatty Liver Disease	Associate	39748602
Obesity	Associate	34391409
Obesity Abdominal	Associate	35896531
Ovarian Neoplasms	Associate	22685544
Pancreatic Neoplasms	Associate	26238393
Peripheral Arterial Disease	Associate	36300658
Pituitary Neoplasms	Associate	7599706
Precancerous Conditions	Associate	28418896
Prostatic Neoplasms	Associate	10638976, 23967299
Prostatitis	Associate	10638976
Sarcopenia	Associate	37963137
Seminoma	Inhibit	24781282
Small Cell Lung Carcinoma	Associate	34741430
Squamous Cell Carcinoma of Head and Neck	Associate	38030164
Stomach Neoplasms	Associate	16718778
Triple Negative Breast Neoplasms	Associate	34481843
Trophoblastic Neoplasms	Associate	16033091, 17649811
Uterine Diseases	Associate	27833918

INHBE (inhibin subunit beta E)