Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
83667
Gene name Gene Name - the full gene name approved by the HGNC.
Sestrin 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
SESN2
Synonyms (NCBI Gene) Gene synonyms aliases
HI95, SES2, SEST2
Chromosome Chromosome number
1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
1p35.3
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the sestrin family of PA26-related proteins. The encoded protein may function in the regulation of cell growth and survival. This protein may be involved in cellular response to different stress conditions. [provided by RefSe
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT016428 hsa-miR-193b-3p Microarray 20304954
MIRT017581 hsa-miR-335-5p Microarray 18185580
MIRT052416 hsa-let-7a-5p CLASH 23622248
MIRT041989 hsa-miR-484 CLASH 23622248
MIRT067319 hsa-miR-23a-3p PAR-CLIP 20371350
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001932 Process Regulation of protein phosphorylation IDA 25040165
GO:0004601 Function Peroxidase activity IDA 26612684
GO:0005092 Function GDP-dissociation inhibitor activity IEA
GO:0005515 Function Protein binding IPI 15105503, 18692468, 23274085, 25040165, 25263562, 26449471, 26586190, 26972053, 28199315, 29294217
GO:0005634 Component Nucleus IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
607767 20746 ENSG00000130766
Protein
UniProt ID P58004
Protein name Sestrin-2 (EC 1.11.1.-) (Hypoxia-induced gene)
Protein function Functions as an intracellular leucine sensor that negatively regulates the mTORC1 signaling pathway through the GATOR complex (PubMed:18692468, PubMed:25263562, PubMed:25457612, PubMed:26449471, PubMed:26586190, PubMed:26612684, PubMed:31586034,
PDB 5CUF , 5DJ4 , 5T0N , 6N0M
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF04636 PA26 43 479 PA26 p53-induced protein (sestrin) Family
Tissue specificity TISSUE SPECIFICITY: Widely expressed. {ECO:0000269|PubMed:12607115}.
Sequence
Sequence length 480
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  p53 signaling pathway
mTOR signaling pathway
Longevity regulating pathway
  TP53 Regulates Metabolic Genes
Amino acids regulate mTORC1
<