Gene Gene information from NCBI Gene database.
Entrez ID 83666
Gene name Poly(ADP-ribose) polymerase family member 9
Gene symbol PARP9
Synonyms (NCBI Gene)
ARTD9BALBAL1MGC:7868
Chromosome 3
Chromosome location 3q21.1
miRNA miRNA information provided by mirtarbase database.
439
miRTarBase ID miRNA Experiments Reference
MIRT022841 hsa-miR-124-3p Microarray 18668037
MIRT030872 hsa-miR-21-5p Microarray 18591254
MIRT1214658 hsa-miR-1299 CLIP-seq
MIRT1214659 hsa-miR-3148 CLIP-seq
MIRT1214660 hsa-miR-326 CLIP-seq
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
64
GO ID Ontology Definition Evidence Reference
GO:0000077 Process DNA damage checkpoint signaling IMP 28525742
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IMP 16061477
GO:0001961 Process Positive regulation of cytokine-mediated signaling pathway IEA
GO:0002230 Process Positive regulation of defense response to virus by host IGI 26479788
GO:0002376 Process Immune system process IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
612065 24118 ENSG00000138496
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q8IXQ6
Protein name Protein mono-ADP-ribosyltransferase PARP9 (EC 2.4.2.-) (ADP-ribosyltransferase diphtheria toxin-like 9) (ARTD9) (B aggressive lymphoma protein) (Poly [ADP-ribose] polymerase 9) (PARP-9)
Protein function ADP-ribosyltransferase which, in association with E3 ligase DTX3L, plays a role in DNA damage repair and in immune responses including interferon-mediated antiviral defenses (PubMed:16809771, PubMed:23230272, PubMed:26479788, PubMed:27796300). W
PDB 5AIL
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01661 Macro 136 255 Macro domain Domain
PF01661 Macro 335 446 Macro domain Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in lymphocyte-rich tissues, spleen, lymph nodes, peripheral blood lymphocytes and colonic mucosa (PubMed:11110709, PubMed:16809771). Expressed in macrophages (PubMed:27796300). Also expressed in nonhematopoietic tissues such
Sequence
MDFSMVAGAAAYNEKSGRITSLSLLFQKVFAQIFPQWRKGNTEECLPYKCSETGALGENY
SWQIPINHNDFKILKNNERQLCEVLQNKFGCISTLVSPVQEGNSKSLQVFRKMLTPRIEL
SVWKDDLTTHAVDAVVNAANEDLLHGGGLALALVKAGGFEIQEESKQFVARYGKVSAGEI
AVTGAGRLPCKQIIHAVGPRWMEWDKQGCTGKLQRAIVSILNYVIYKNTHIKTVAIPALS
SGIFQFPLNLCTKTI
VETIRVSLQGKPMMSNLKEIHLVSNEDPTVAAFKAASEFILGKSE
LGQETTPSFNAMVVNNLTLQIVQGHIEWQTADVIVNSVNPHDITVGPVAKSILQQAGVEM
KSEFLATKAKQFQRSQLVLVTKGFNLFCKYIYHVLWHSEFPKPQILKHAMKECLEKCIEQ
NITSISFPALGTGNMEIKKETAAEIL
FDEVLTFAKDHVKHQLTVKFVIFPTDLEIYKAFS
SEMAKRSKMLSLNNYSVPQSTREEKRENGLEARSPAINLMGFNVEEMYEAHAWIQRILSL
QNHHIIENNHILYLGRKEHDILSQLQKTSSVSITEIISPGRTELEIEGARADLIEVVMNI
EDMLCKVQEEMARKKERGLWRSLGQWTIQQQKTQDEMKENIIFLKCPVPPTQELLDQKKQ
FEKCGLQVLKVEKIDNEVLMAAFQRKKKMMEEKLHRQPVSHRLFQQVPYQFCNVVCRVGF
QRMYSTPCDPKYGAGIYFTKNLKNLAEKAKKISAADKLIYVFEAEVLTGFFCQGHPLNIV
PPPLSPGAIDGHDSVVDNVSSPETFVIFSGMQAIPQYLWTCTQEYVQSQDYSSGPMRPFA
QHPWRGFASGSPVD
Sequence length 854
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Nicotinamide salvaging
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
4
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Clear cell carcinoma of kidney Uncertain significance; Benign rs201391405, rs6780543 RCV005930687
RCV005910549
Familial cancer of breast Uncertain significance rs771406543 RCV005939382
Thyroid cancer, nonmedullary, 1 Benign rs6780543 RCV005910550
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Asthma Associate 34494468
Asthma Chronic Obstructive Pulmonary Disease Overlap Syndrome Associate 34494468
Breast Neoplasms Associate 36766731
Breast Neoplasms Stimulate 40707929
Colonic Neoplasms Associate 35593226
COVID 19 Associate 33913542
Glioma Associate 32678519
Inflammation Associate 16809771, 23487038, 32678519, 33913542, 39488703
Inflammatory Bowel Diseases Associate 34948292
Leukemia Myelogenous Chronic BCR ABL Positive Associate 35979386