CASP1 (caspase 1)

Gene
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
834
Gene name Gene Name - the full gene name approved by the HGNC.
Caspase 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
CASP1
Synonyms (NCBI Gene) Gene synonyms aliases
ICE, IL1BC, P45
Chromosome Chromosome number
11
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
11q22.3
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo pro
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(18)
miRTarBase ID miRNA Experiments Reference
MIRT642898 hsa-miR-4712-3p HITS-CLIP 23824327
MIRT642897 hsa-miR-6515-3p HITS-CLIP 23824327
MIRT642896 hsa-miR-1236-3p HITS-CLIP 23824327
MIRT642895 hsa-miR-412-3p HITS-CLIP 23824327
MIRT642894 hsa-miR-6754-3p HITS-CLIP 23824327
Transcription factors
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(2)
Transcription factor Regulation Reference
ETS1 Activation 16103071
TP53 Unknown 11278253
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(60)
GO ID Ontology Definition Evidence Reference
GO:0001666 Process Response to hypoxia IEA
GO:0004175 Function Endopeptidase activity IDA 24548080
GO:0004197 Function Cysteine-type endopeptidase activity IDA 11821383, 16920334, 32109412, 32553275
GO:0004197 Function Cysteine-type endopeptidase activity IGI 15882992
GO:0005515 Function Protein binding IPI 11374873, 11390368, 11432859, 11536016, 12888622, 15030775, 15107016, 15383541, 15817483, 15882992, 16575408, 16785446, 17360653, 17418785, 18329368, 18511561, 24630722, 25416956, 25605870, 27043298, 29892012, 30692621
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
147678 1499 ENSG00000137752
Protein
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P29466
Protein name Caspase-1 (CASP-1) (EC 3.4.22.36) (Interleukin-1 beta convertase) (IL-1BC) (Interleukin-1 beta-converting enzyme) (ICE) (IL-1 beta-converting enzyme) (p45) [Cleaved into: Caspase-1 subunit p20; Caspase-1 subunit p10]
Protein function Thiol protease involved in a variety of inflammatory processes by proteolytically cleaving other proteins, such as the precursors of the inflammatory cytokines interleukin-1 beta (IL1B) and interleukin 18 (IL18) as well as the pyroptosis inducer
PDB 1BMQ , 1IBC , 1ICE , 1RWK , 1RWM , 1RWN , 1RWO , 1RWP , 1RWV , 1RWW , 1RWX , 1SC1 , 1SC3 , 1SC4 , 2FQQ , 2H48 , 2H4W , 2H4Y , 2H51 , 2H54 , 2HBQ , 2HBR , 2HBY , 2HBZ , 3D6F , 3D6H , 3D6M , 3E4C , 3NS7 , 5FNA , 5MMV , 5MTK , 6BZ9 , 6F6R , 6KN0 , 6PZP , 6VIE , 7KEU , 8SV1 , 8WRA
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00619 CARD 3 → 90 Caspase recruitment domain Domain
PF00656 Peptidase_C14 163 → 400 Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in larger amounts in spleen and lung. Detected in liver, heart, small intestine, colon, thymus, prostate, skeletal muscle, peripheral blood leukocytes, kidney and testis. No expression in the brain. {ECO:0000269|PubMed:154984
Sequence
Sequence length 404
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  Efferocytosis
Necroptosis
Neutrophil extracellular trap formation
NOD-like receptor signaling pathway
Cytosolic DNA-sensing pathway
C-type lectin receptor signaling pathway
Amyotrophic lateral sclerosis
Pathogenic Escherichia coli infection
Shigellosis
Salmonella infection
Pertussis
Legionellosis
Yersinia infection
Influenza A
Coronavirus disease - COVID-19
Lipid and atherosclerosis 		  NOD1/2 Signaling Pathway
Interleukin-1 processing
TP53 Regulates Transcription of Caspase Activators and Caspases
The NLRP3 inflammasome
The IPAF inflammasome
Interleukin-37 signaling
Purinergic signaling in leishmaniasis infection
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Causal Diseases (6)
Causal
Disease term Disease name dbSNP ID References
Amyotrophic lateral sclerosis Amyotrophic Lateral Sclerosis, Familial rs267607084, rs312262720, rs312262752, rs121908287, rs121908288, rs29001584, rs28941475, rs121434378, rs386134173, rs386134174, rs80356730, rs80356727, rs4884357, rs80356717, rs80356733
View all (171 more)		 11796754
Hyperhomocysteinemia Hyperhomocysteinemia rs121964962, rs121964963, rs121964964, rs5742905, rs121964966, rs121964967, rs121964968, rs121964969, rs28934891, rs375846341, rs121964972, rs121964973, rs398123151, rs786204466, rs786204679
View all (66 more)		 22647887
Kidney disease Kidney Diseases rs74315342, rs749740335, rs757649673, rs112417755, rs35138315 22647887
Lateral sclerosis AMYOTROPHIC LATERAL SCLEROSIS 1, Amyotrophic Lateral Sclerosis, Sporadic rs386134181, rs386134176, rs386134174, rs386134184, rs386134178, rs1693780539, rs1574698048 11796754
Show/Hide Text Mining Associations (257)
Associations from Text Mining
Disease Name Relationship Type References
AA amyloidosis Associate 36579934
Abortion Habitual Associate 26474737
Abortion Habitual Stimulate 29665864
Abortion Spontaneous Stimulate 39408839
Acne Vulgaris Associate 23884315
Acquired Immunodeficiency Syndrome Associate 11122242
Acute Coronary Syndrome Associate 14729783
Acute Disease Associate 14729783
Acute On Chronic Liver Failure Associate 31429707
Adenocarcinoma Associate 14669344