H3-4 (H3.4 histone, cluster member)

Gene
Gene Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
8290
Gene name Gene Name - the full gene name approved by the HGNC.
H3.4 histone, cluster member
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
H3-4
Synonyms (NCBI Gene) Gene synonyms aliases
H3.4, H3/g, H3C16, H3FT, H3t, HIST3H3
Chromosome Chromosome number
1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
1q42.13
Summary Summary of gene provided in NCBI Entrez Gene.
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core hi
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(23)
GO ID Ontology Definition Evidence Reference
GO:0000781 Component Chromosome, telomeric region HDA 19135898
GO:0000786 Component Nucleosome IDA 20498094, 25615412
GO:0000786 Component Nucleosome IEA
GO:0000786 Component Nucleosome IPI 20498094
GO:0000792 Component Heterochromatin IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
602820 4778 ENSG00000168148
Protein
Gene Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Q16695
Protein name Histone H3.1t (H3/t) (H3t) (H3/g) (Histone H3.4)
Protein function Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair,
PDB 2V1D , 2YBP , 2YBS , 3A6N , 3T6R , 4V2V , 4V2W , 6OIE , 6WAT , 6WAU , 8VMI , 8Z50
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00125 Histone 1 → 132 Core histone H2A/H2B/H3/H4 Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in testicular cells.
Sequence
Sequence length 136
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  Neutrophil extracellular trap formation
Alcoholism
Shigellosis
Transcriptional misregulation in cancer
Systemic lupus erythematosus 		  Recognition and association of DNA glycosylase with site containing an affected purine
Cleavage of the damaged purine
Packaging Of Telomere Ends
Formation of the beta-catenin:TCF transactivating complex
Condensation of Prophase Chromosomes
DNA Damage/Telomere Stress Induced Senescence
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Nonhomologous End-Joining (NHEJ)
Processing of DNA double-strand break ends
G2/M DNA damage checkpoint
<
Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Gene Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (1)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Neurodevelopmental Disorders neurodevelopmental disorder N/A N/A GenCC