Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene Gene ontology Other IDs Protein Pathways
Entrez ID	8290
Gene name	H3.4 histone, cluster member
Gene symbol	H3-4
Synonyms (NCBI Gene)	H3.4H3/gH3C16H3FTH3tHIST3H3
Chromosome	1
Chromosome location	1q42.13
Summary	Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core hi

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000781	Component	Chromosome, telomeric region	HDA	19135898
GO:0000786	Component	Nucleosome	IDA	20498094, 25615412
GO:0000786	Component	Nucleosome	IEA
GO:0000786	Component	Nucleosome	IPI	20498094
GO:0000792	Component	Heterochromatin	IEA
GO:0000794	Component	Condensed nuclear chromosome	IEA
GO:0003677	Function	DNA binding	IEA
GO:0005515	Function	Protein binding	IPI	17537733, 17567753, 17599839, 20224553, 20498094, 21888893, 29340707, 30021884, 32296183
GO:0005634	Component	Nucleus	HDA	21630459
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	IEA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005694	Component	Chromosome	IEA
GO:0006325	Process	Chromatin organization	NAS	31790919
GO:0006334	Process	Nucleosome assembly	IDA	25615412
GO:0006334	Process	Nucleosome assembly	IMP	20498094
GO:0006335	Process	DNA replication-dependent chromatin assembly	IEA
GO:0007284	Process	Spermatogonial cell division	IEA
GO:0030527	Function	Structural constituent of chromatin	IEA
GO:0045595	Process	Regulation of cell differentiation	IEA
GO:0046982	Function	Protein heterodimerization activity	IEA
GO:0070062	Component	Extracellular exosome	HDA	20458337

MIM	HGNC	e!Ensembl
602820	4778	ENSG00000168148

Q16695

Protein name

Histone H3.1t (H3/t) (H3t) (H3/g) (Histone H3.4)

Protein function

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair,

PDB

2V1D , 2YBP , 2YBS , 3A6N , 3T6R , 4V2V , 4V2W , 6OIE , 6WAT , 6WAU , 8VMI , 8Z50

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00125	Histone	1 → 132	Core histone H2A/H2B/H3/H4	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in testicular cells.

Sequence

MARTKQTARKSTGGKAPRKQLATKVARKSAPATGGVKKPHRYRPGTVALREIRRYQKSTE
LLIRKLPFQRLMREIAQDFKTDLRFQSSAVMALQEACESYLVGLFEDTNLCVIHAKRVTI
MPKDIQLARRIRGERA

Sequence length

136

Interactions

View interactions

	KEGG		Reactome
	Neutrophil extracellular trap formation Alcoholism Shigellosis Transcriptional misregulation in cancer Systemic lupus erythematosus		Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Packaging Of Telomere Ends Formation of the beta-catenin:TCF transactivating complex Condensation of Prophase Chromosomes DNA Damage/Telomere Stress Induced Senescence Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint

H3-4 (H3.4 histone, cluster member)