Gene Gene information from NCBI Gene database.
Entrez ID 824
Gene name Calpain 2
Gene symbol CAPN2
Synonyms (NCBI Gene)
CANP2CANPL2CANPmlmCANP
Chromosome 1
Chromosome location 1q41
Summary The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct
miRNA miRNA information provided by mirtarbase database.
211
miRTarBase ID miRNA Experiments Reference
MIRT025966 hsa-miR-7-5p Sequencing 20371350
MIRT027353 hsa-miR-101-3p Sequencing 20371350
MIRT028659 hsa-miR-30a-5p Proteomics 18668040
MIRT736216 hsa-miR-147a Luciferase reporter assayWestern blottingImmunoprecipitaion (IP)qRT-PCR 33731671
MIRT861925 hsa-miR-1253 CLIP-seq
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
75
GO ID Ontology Definition Evidence Reference
GO:0000785 Component Chromatin IEA
GO:0001666 Process Response to hypoxia IEA
GO:0001824 Process Blastocyst development IEA
GO:0004198 Function Calcium-dependent cysteine-type endopeptidase activity IBA
GO:0004198 Function Calcium-dependent cysteine-type endopeptidase activity IDA 12150984
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
114230 1479 ENSG00000162909
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P17655
Protein name Calpain-2 catalytic subunit (EC 3.4.22.53) (Calcium-activated neutral proteinase 2) (CANP 2) (Calpain M-type) (Calpain large polypeptide L2) (Calpain-2 large subunit) (Millimolar-calpain) (M-calpain)
Protein function Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves MYOC at 'Arg-226' (PubMed:17650508). Proteolytically cleaves CP
PDB 1KFU , 1KFX , 2NQA
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00648 Peptidase_C2 46 342 Calpain family cysteine protease Family
PF01067 Calpain_III 363 502 Calpain large subunit, domain III Domain
PF13833 EF-hand_8 544 603 EF-hand domain pair Domain
Tissue specificity TISSUE SPECIFICITY: Ubiquitous.
Sequence
Sequence length 700
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Protein processing in endoplasmic reticulum
Apoptosis
Necroptosis
Cellular senescence
Focal adhesion
Alzheimer disease
Pathways of neurodegeneration - multiple diseases
Shigellosis
  Degradation of the extracellular matrix
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
1
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Gastric cancer Uncertain significance rs541384226 RCV005932259
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Amyotrophic Lateral Sclerosis Associate 35355568
Aortic Aneurysm Associate 19720936
Arthritis Associate 15501405
Arthritis Psoriatic Associate 15501405
Brain Ischemia Stimulate 16524385
Breast Neoplasms Associate 18332219, 22745213, 25539577, 27323818
Burns Associate 22079905
Carcinoma Basal Cell Associate 21829505, 22745213
Carcinoma Non Small Cell Lung Stimulate 33321157
Carcinoma Renal Cell Associate 36328501