Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	824
Gene name Gene Name - the full gene name approved by the HGNC.	Calpain 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	CAPN2
Synonyms (NCBI Gene) Gene synonyms aliases	CANP2, CANPL2, CANPml, mCANP
Chromosome Chromosome number	1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	1q41
Summary Summary of gene provided in NCBI Entrez Gene.	The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct

Show/Hide all(211)

miRTarBase ID	miRNA	Experiments	Reference
MIRT025966	hsa-miR-7-5p	Sequencing	20371350
MIRT027353	hsa-miR-101-3p	Sequencing	20371350
MIRT028659	hsa-miR-30a-5p	Proteomics	18668040
MIRT736216	hsa-miR-147a	Luciferase reporter assay, Western blotting, Immunoprecipitaion (IP), qRT-PCR	33731671
MIRT861925	hsa-miR-1253	CLIP-seq
MIRT861926	hsa-miR-1264	CLIP-seq
MIRT861927	hsa-miR-1283	CLIP-seq
MIRT861928	hsa-miR-1304	CLIP-seq
MIRT861929	hsa-miR-140-5p	CLIP-seq
MIRT861930	hsa-miR-142-5p	CLIP-seq
MIRT861931	hsa-miR-1468	CLIP-seq
MIRT861932	hsa-miR-198	CLIP-seq
MIRT861933	hsa-miR-2052	CLIP-seq
MIRT861934	hsa-miR-21	CLIP-seq
MIRT861935	hsa-miR-2355-3p	CLIP-seq
MIRT861936	hsa-miR-3117-5p	CLIP-seq
MIRT861937	hsa-miR-3121-5p	CLIP-seq
MIRT861938	hsa-miR-3189-3p	CLIP-seq
MIRT861939	hsa-miR-323-5p	CLIP-seq
MIRT861940	hsa-miR-3545-5p	CLIP-seq
MIRT861941	hsa-miR-3688-5p	CLIP-seq
MIRT861942	hsa-miR-4269	CLIP-seq
MIRT861943	hsa-miR-4421	CLIP-seq
MIRT861944	hsa-miR-4460	CLIP-seq
MIRT861945	hsa-miR-4470	CLIP-seq
MIRT861946	hsa-miR-4514	CLIP-seq
MIRT861947	hsa-miR-4528	CLIP-seq
MIRT861948	hsa-miR-4540	CLIP-seq
MIRT861949	hsa-miR-4646-3p	CLIP-seq
MIRT861950	hsa-miR-4670-3p	CLIP-seq
MIRT861951	hsa-miR-4692	CLIP-seq
MIRT861952	hsa-miR-4704-5p	CLIP-seq
MIRT861953	hsa-miR-4711-3p	CLIP-seq
MIRT861954	hsa-miR-4742-5p	CLIP-seq
MIRT861955	hsa-miR-4761-5p	CLIP-seq
MIRT861956	hsa-miR-4775	CLIP-seq
MIRT861957	hsa-miR-487a	CLIP-seq
MIRT861958	hsa-miR-511	CLIP-seq
MIRT861959	hsa-miR-561	CLIP-seq
MIRT861960	hsa-miR-587	CLIP-seq
MIRT861961	hsa-miR-590-3p	CLIP-seq
MIRT861962	hsa-miR-590-5p	CLIP-seq
MIRT861963	hsa-miR-593	CLIP-seq
MIRT861964	hsa-miR-647	CLIP-seq
MIRT861965	hsa-miR-649	CLIP-seq
MIRT861966	hsa-miR-676	CLIP-seq
MIRT861967	hsa-miR-876-3p	CLIP-seq
MIRT861925	hsa-miR-1253	CLIP-seq
MIRT861926	hsa-miR-1264	CLIP-seq
MIRT861932	hsa-miR-198	CLIP-seq
MIRT861938	hsa-miR-3189-3p	CLIP-seq
MIRT2193370	hsa-miR-3688-3p	CLIP-seq
MIRT861942	hsa-miR-4269	CLIP-seq
MIRT861946	hsa-miR-4514	CLIP-seq
MIRT861948	hsa-miR-4540	CLIP-seq
MIRT861951	hsa-miR-4692	CLIP-seq
MIRT861954	hsa-miR-4742-5p	CLIP-seq
MIRT2193371	hsa-miR-520d-5p	CLIP-seq
MIRT2193372	hsa-miR-520g	CLIP-seq
MIRT2193373	hsa-miR-520h	CLIP-seq
MIRT2193374	hsa-miR-524-5p	CLIP-seq
MIRT861960	hsa-miR-587	CLIP-seq
MIRT861964	hsa-miR-647	CLIP-seq
MIRT2193375	hsa-miR-671-5p	CLIP-seq
MIRT2427014	hsa-miR-1200	CLIP-seq
MIRT2427015	hsa-miR-1207-3p	CLIP-seq
MIRT2427016	hsa-miR-137	CLIP-seq
MIRT2427017	hsa-miR-192	CLIP-seq
MIRT2427018	hsa-miR-215	CLIP-seq
MIRT2427019	hsa-miR-3074-5p	CLIP-seq
MIRT2427020	hsa-miR-3160-5p	CLIP-seq
MIRT2427021	hsa-miR-320a	CLIP-seq
MIRT2427022	hsa-miR-320b	CLIP-seq
MIRT2427023	hsa-miR-320c	CLIP-seq
MIRT2427024	hsa-miR-320d	CLIP-seq
MIRT2427025	hsa-miR-33a	CLIP-seq
MIRT2427026	hsa-miR-33b	CLIP-seq
MIRT2427027	hsa-miR-4429	CLIP-seq
MIRT2427028	hsa-miR-579	CLIP-seq
MIRT2427029	hsa-miR-875-5p	CLIP-seq
MIRT2427030	hsa-miR-889	CLIP-seq
MIRT2496430	hsa-miR-1254	CLIP-seq
MIRT2496431	hsa-miR-1269	CLIP-seq
MIRT2496432	hsa-miR-1269b	CLIP-seq
MIRT2496433	hsa-miR-1271	CLIP-seq
MIRT2496434	hsa-miR-1288	CLIP-seq
MIRT861928	hsa-miR-1304	CLIP-seq
MIRT861929	hsa-miR-140-5p	CLIP-seq
MIRT861930	hsa-miR-142-5p	CLIP-seq
MIRT2496435	hsa-miR-144	CLIP-seq
MIRT861931	hsa-miR-1468	CLIP-seq
MIRT2496436	hsa-miR-182	CLIP-seq
MIRT861932	hsa-miR-198	CLIP-seq
MIRT861933	hsa-miR-2052	CLIP-seq
MIRT861934	hsa-miR-21	CLIP-seq
MIRT861935	hsa-miR-2355-3p	CLIP-seq
MIRT2496437	hsa-miR-24	CLIP-seq
MIRT2496438	hsa-miR-299-5p	CLIP-seq
MIRT2496439	hsa-miR-3116	CLIP-seq
MIRT861936	hsa-miR-3117-5p	CLIP-seq
MIRT2496440	hsa-miR-3153	CLIP-seq
MIRT861939	hsa-miR-323-5p	CLIP-seq
MIRT2496441	hsa-miR-3529	CLIP-seq
MIRT861940	hsa-miR-3545-5p	CLIP-seq
MIRT2496442	hsa-miR-3682-5p	CLIP-seq
MIRT2193370	hsa-miR-3688-3p	CLIP-seq
MIRT861941	hsa-miR-3688-5p	CLIP-seq
MIRT2496443	hsa-miR-379	CLIP-seq
MIRT2496444	hsa-miR-421	CLIP-seq
MIRT2496445	hsa-miR-4284	CLIP-seq
MIRT2496446	hsa-miR-432	CLIP-seq
MIRT2496447	hsa-miR-433	CLIP-seq
MIRT2496448	hsa-miR-4451	CLIP-seq
MIRT861944	hsa-miR-4460	CLIP-seq
MIRT861945	hsa-miR-4470	CLIP-seq
MIRT2496449	hsa-miR-4515	CLIP-seq
MIRT861947	hsa-miR-4528	CLIP-seq
MIRT2496450	hsa-miR-4529-3p	CLIP-seq
MIRT861948	hsa-miR-4540	CLIP-seq
MIRT2496451	hsa-miR-4642	CLIP-seq
MIRT2496452	hsa-miR-4645-3p	CLIP-seq
MIRT861949	hsa-miR-4646-3p	CLIP-seq
MIRT2496453	hsa-miR-4650-3p	CLIP-seq
MIRT2496454	hsa-miR-4668-5p	CLIP-seq
MIRT861950	hsa-miR-4670-3p	CLIP-seq
MIRT861952	hsa-miR-4704-5p	CLIP-seq
MIRT2496455	hsa-miR-4709-5p	CLIP-seq
MIRT2496456	hsa-miR-4715-5p	CLIP-seq
MIRT2496457	hsa-miR-4716-5p	CLIP-seq
MIRT2496458	hsa-miR-4740-5p	CLIP-seq
MIRT861956	hsa-miR-4775	CLIP-seq
MIRT861957	hsa-miR-487a	CLIP-seq
MIRT2193371	hsa-miR-520d-5p	CLIP-seq
MIRT2193372	hsa-miR-520g	CLIP-seq
MIRT2193373	hsa-miR-520h	CLIP-seq
MIRT2496459	hsa-miR-522	CLIP-seq
MIRT2193374	hsa-miR-524-5p	CLIP-seq
MIRT861959	hsa-miR-561	CLIP-seq
MIRT861961	hsa-miR-590-3p	CLIP-seq
MIRT861962	hsa-miR-590-5p	CLIP-seq
MIRT2496460	hsa-miR-661	CLIP-seq
MIRT2193375	hsa-miR-671-5p	CLIP-seq
MIRT861966	hsa-miR-676	CLIP-seq
MIRT861967	hsa-miR-876-3p	CLIP-seq
MIRT2496461	hsa-miR-96	CLIP-seq
MIRT2496430	hsa-miR-1254	CLIP-seq
MIRT2496431	hsa-miR-1269	CLIP-seq
MIRT2496432	hsa-miR-1269b	CLIP-seq
MIRT2496433	hsa-miR-1271	CLIP-seq
MIRT2496434	hsa-miR-1288	CLIP-seq
MIRT861928	hsa-miR-1304	CLIP-seq
MIRT861929	hsa-miR-140-5p	CLIP-seq
MIRT861930	hsa-miR-142-5p	CLIP-seq
MIRT2496435	hsa-miR-144	CLIP-seq
MIRT861931	hsa-miR-1468	CLIP-seq
MIRT2496436	hsa-miR-182	CLIP-seq
MIRT861932	hsa-miR-198	CLIP-seq
MIRT861933	hsa-miR-2052	CLIP-seq
MIRT861934	hsa-miR-21	CLIP-seq
MIRT861935	hsa-miR-2355-3p	CLIP-seq
MIRT2496437	hsa-miR-24	CLIP-seq
MIRT2496438	hsa-miR-299-5p	CLIP-seq
MIRT2496439	hsa-miR-3116	CLIP-seq
MIRT861936	hsa-miR-3117-5p	CLIP-seq
MIRT2496440	hsa-miR-3153	CLIP-seq
MIRT861938	hsa-miR-3189-3p	CLIP-seq
MIRT861939	hsa-miR-323-5p	CLIP-seq
MIRT2496441	hsa-miR-3529	CLIP-seq
MIRT861940	hsa-miR-3545-5p	CLIP-seq
MIRT2496442	hsa-miR-3682-5p	CLIP-seq
MIRT2193370	hsa-miR-3688-3p	CLIP-seq
MIRT861941	hsa-miR-3688-5p	CLIP-seq
MIRT2496443	hsa-miR-379	CLIP-seq
MIRT2496444	hsa-miR-421	CLIP-seq
MIRT2496445	hsa-miR-4284	CLIP-seq
MIRT2496446	hsa-miR-432	CLIP-seq
MIRT2496447	hsa-miR-433	CLIP-seq
MIRT2496448	hsa-miR-4451	CLIP-seq
MIRT861944	hsa-miR-4460	CLIP-seq
MIRT861945	hsa-miR-4470	CLIP-seq
MIRT2496449	hsa-miR-4515	CLIP-seq
MIRT861947	hsa-miR-4528	CLIP-seq
MIRT2496450	hsa-miR-4529-3p	CLIP-seq
MIRT861948	hsa-miR-4540	CLIP-seq
MIRT2496451	hsa-miR-4642	CLIP-seq
MIRT2496452	hsa-miR-4645-3p	CLIP-seq
MIRT861949	hsa-miR-4646-3p	CLIP-seq
MIRT2496453	hsa-miR-4650-3p	CLIP-seq
MIRT2496454	hsa-miR-4668-5p	CLIP-seq
MIRT861950	hsa-miR-4670-3p	CLIP-seq
MIRT861952	hsa-miR-4704-5p	CLIP-seq
MIRT2496455	hsa-miR-4709-5p	CLIP-seq
MIRT2496456	hsa-miR-4715-5p	CLIP-seq
MIRT2496457	hsa-miR-4716-5p	CLIP-seq
MIRT2496458	hsa-miR-4740-5p	CLIP-seq
MIRT861956	hsa-miR-4775	CLIP-seq
MIRT861957	hsa-miR-487a	CLIP-seq
MIRT2193371	hsa-miR-520d-5p	CLIP-seq
MIRT2193372	hsa-miR-520g	CLIP-seq
MIRT2193373	hsa-miR-520h	CLIP-seq
MIRT2496459	hsa-miR-522	CLIP-seq
MIRT2193374	hsa-miR-524-5p	CLIP-seq
MIRT861959	hsa-miR-561	CLIP-seq
MIRT861961	hsa-miR-590-3p	CLIP-seq
MIRT861962	hsa-miR-590-5p	CLIP-seq
MIRT861964	hsa-miR-647	CLIP-seq
MIRT2496460	hsa-miR-661	CLIP-seq
MIRT2193375	hsa-miR-671-5p	CLIP-seq
MIRT861966	hsa-miR-676	CLIP-seq
MIRT861967	hsa-miR-876-3p	CLIP-seq
MIRT2496461	hsa-miR-96	CLIP-seq

Show/Hide all(50)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000785	Component	Chromatin	IEA
GO:0001666	Process	Response to hypoxia	IEA
GO:0001824	Process	Blastocyst development	IEA
GO:0004198	Function	Calcium-dependent cysteine-type endopeptidase activity	IBA	21873635
GO:0004198	Function	Calcium-dependent cysteine-type endopeptidase activity	IDA	12150984
GO:0004198	Function	Calcium-dependent cysteine-type endopeptidase activity	ISS
GO:0005509	Function	Calcium ion binding	IEA
GO:0005515	Function	Protein binding	IPI	10639123, 18519038, 24705354, 28319173, 32814053
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0005737	Component	Cytoplasm	ISS
GO:0005758	Component	Mitochondrial intermembrane space	IEA
GO:0005764	Component	Lysosome	IEA
GO:0005783	Component	Endoplasmic reticulum	IDA	14559243
GO:0005794	Component	Golgi apparatus	IDA	14559243
GO:0005829	Component	Cytosol	IDA	12150984, 14559243
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IDA	12150984
GO:0005886	Component	Plasma membrane	TAS
GO:0005925	Component	Focal adhesion	HDA	21423176
GO:0006508	Process	Proteolysis	IBA	21873635
GO:0006508	Process	Proteolysis	ISS
GO:0007520	Process	Myoblast fusion	IEA
GO:0007565	Process	Female pregnancy	IEA
GO:0008092	Function	Cytoskeletal protein binding	NAS	12150984
GO:0008234	Function	Cysteine-type peptidase activity	TAS	2209092
GO:0009897	Component	External side of plasma membrane	IEA
GO:0010666	Process	Positive regulation of cardiac muscle cell apoptotic process	IEA
GO:0019899	Function	Enzyme binding	IEA
GO:0022617	Process	Extracellular matrix disassembly	TAS
GO:0030425	Component	Dendrite	ISS
GO:0030864	Component	Cortical actin cytoskeleton	TAS	12150984
GO:0031143	Component	Pseudopodium	IDA	14559243
GO:0032675	Process	Regulation of interleukin-6 production	IEA
GO:0035458	Process	Cellular response to interferon-beta	IEA
GO:0042542	Process	Response to hydrogen peroxide	IEA
GO:0043025	Component	Neuronal cell body	IEA
GO:0044877	Function	Protein-containing complex binding	IEA
GO:0045121	Component	Membrane raft	IDA	14559243
GO:0045121	Component	Membrane raft	IDA	12150984
GO:0048266	Process	Behavioral response to pain	IEA
GO:0051493	Process	Regulation of cytoskeleton organization	TAS	12150984
GO:0051603	Process	Proteolysis involved in cellular protein catabolic process	IDA	12150984
GO:0070062	Component	Extracellular exosome	HDA	19056867, 19199708
GO:0071222	Process	Cellular response to lipopolysaccharide	IEA
GO:0071230	Process	Cellular response to amino acid stimulus	ISS
GO:0097038	Component	Perinuclear endoplasmic reticulum	IDA	14559243
GO:1901216	Process	Positive regulation of neuron death	IEA
GO:1901741	Process	Positive regulation of myoblast fusion	IEA
GO:2001247	Process	Positive regulation of phosphatidylcholine biosynthetic process	IEA

MIM	HGNC	e!Ensembl
114230	1479	ENSG00000162909

Protein

UniProt ID

P17655

Protein name

Calpain-2 catalytic subunit (EC 3.4.22.53) (Calcium-activated neutral proteinase 2) (CANP 2) (Calpain M-type) (Calpain large polypeptide L2) (Calpain-2 large subunit) (Millimolar-calpain) (M-calpain)

Protein function

Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves MYOC at 'Arg-226' (PubMed:17650508). Proteolytically cleaves CP

PDB

1KFU , 1KFX , 2NQA

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00648	Peptidase_C2	46 → 342	Calpain family cysteine protease	Family
PF01067	Calpain_III	363 → 502	Calpain large subunit, domain III	Domain
PF13833	EF-hand_8	544 → 603	EF-hand domain pair	Domain

Tissue specificity

TISSUE SPECIFICITY: Ubiquitous.

Sequence

MAGIAAKLAKDREAAEGLGSHDRAIKYLNQDYEALRNECLEAGTLFQDPSFPAIPSALGF
KELGPYSSKTRGIEWKRPTEICADPQFIIGGATRTDICQGALGDCWLLAAIASLTLNEEI
LARVVPLNQSFQENYAGIFHFQFWQYGEWVEVVVDDRLPTKDGELLFVHSAEGSEFWSAL
LEKAYAKINGCYEALSGGATTEGFEDFTGGIAEWYELKKPPPNLFKIIQKALQKGSLLGC
SIDITSAADSEAITFQKLVKGHAYSVTGAEEVESNGSLQKLIRIRNPWGEVEWTGRWNDN
CPSWNTIDPEERERLTRRHEDGEFWMSFSDFLRHYSRLEICNLTPDTLTSDTYKKWKLTK
MDGNWRRGSTAGGCRNYPNTFWMNPQYLIKLEEEDEDEEDGESGCTFLVGLIQKHRRRQR
KMGEDMHTIGFGIYEVPEELSGQTNIHLSKNFFLTNRARERSDTFINLREVLNRFKLPPG
EYILVPSTFEPNKDGDFCIRVFSEKKADYQAVDDEIEANLEEFDISEDDIDDGFRRLFAQ
LAGEDAEISAFELQTILRRVLAKRQDIKSDGFSIETCKIMVDMLDSDGSGKLGLKEFYIL
WTKIQKYQKIYREIDVDRSGTMNSYEMRKALEEAGFKMPCQLHQVIVARFADDQLIIDFD
NFVRCLVRLETLFKIFKQLDPENTGTIELDLISWLCFSVL

Sequence length

700

Interactions

View interactions

	KEGG		Reactome
	Protein processing in endoplasmic reticulum Apoptosis Necroptosis Cellular senescence Focal adhesion Alzheimer disease Pathways of neurodegeneration - multiple diseases Shigellosis		Degradation of the extracellular matrix Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models

Show/Hide Causal Diseases (1)

Disease term	Disease name	dbSNP ID	References
Causal
Leukemia	Leukemia, Myelocytic, Acute, Acute Myeloid Leukemia (AML-M2)	rs121909646, rs121913488, rs587776834, rs752746786, rs869312821, rs767454740, rs1554564297	17330099

Show/Hide Unknown Diseases (2)

Disease term	Disease name	Evidence	Source
Unknown
Schizophrenia	Schizophrenia		GWAS
Glioblastoma	Glioblastoma	CRISPR screening of E3 ubiquitin ligases reveals Ring Finger Protein 185 as a novel tumor suppressor in glioblastoma repressed by promoter hypermethylation and miR-587	GWAS, CBGDA

Show/Hide Text Mining Associations (39)

Disease Name	Relationship Type	References
Associations from Text Mining
Amyotrophic Lateral Sclerosis	Associate	35355568
Aortic Aneurysm	Associate	19720936
Arthritis	Associate	15501405
Arthritis Psoriatic	Associate	15501405
Brain Ischemia	Stimulate	16524385
Breast Neoplasms	Associate	18332219, 22745213, 25539577, 27323818
Burns	Associate	22079905
Carcinoma Basal Cell	Associate	21829505, 22745213
Carcinoma Non Small Cell Lung	Stimulate	33321157
Carcinoma Renal Cell	Associate	36328501
Carcinoma Small Cell	Associate	27456359
Chronic Traumatic Encephalopathy	Associate	29338612
Cluster Headache	Stimulate	36404298
Cluster Headache	Associate	36404298
Diabetes Mellitus Type 2	Associate	30598071
Gaucher like disease	Associate	22745213
Glioblastoma	Associate	20730561
Hematologic Neoplasms	Associate	26358320
Hypoxia	Associate	39351249
Intervertebral Disc Degeneration	Associate	21839844
Laryngeal Neoplasms	Associate	27456359
Leukemia	Associate	26358320
Leukemia Lymphocytic Chronic B Cell	Associate	12176903
Leukemia Lymphoma Adult T Cell	Inhibit	23538341
Leukemia Myelogenous Chronic BCR ABL Positive	Associate	26358320
Lung Neoplasms	Associate	15471877, 16982626, 19568240
Marfan Syndrome	Associate	19720936
Muscular Atrophy	Associate	12181300
Neoplasms	Associate	16982626, 22435971, 29909039, 32618099
Neoplasms	Stimulate	33321157
Osteitis Deformans	Associate	35355568
Ovarian Neoplasms	Associate	22435971, 30448882, 30737623, 35370009
Pancreatic Neoplasms	Associate	23140395, 39351249
Parkinson Disease	Associate	23875735
Precursor T Cell Lymphoblastic Leukemia Lymphoma	Associate	30646895
Prostatic Neoplasms	Associate	12393869, 24297527, 28280729, 31243108
Stomach Neoplasms	Associate	32951272
Tachycardia Atrioventricular Nodal Reentry	Associate	27456359
Urethral Neoplasms	Associate	28940965

CAPN2 (calpain 2)