CAPN2 (calpain 2)
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Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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824 |
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Gene name
Gene Name - the full gene name approved by the HGNC.
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Calpain 2 |
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Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
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CAPN2 |
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Synonyms (NCBI Gene)
Gene synonyms aliases
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CANP2, CANPL2, CANPml, mCANP |
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Chromosome
Chromosome number
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1 |
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Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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1q41 |
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Summary
Summary of gene provided in NCBI Entrez Gene.
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The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct |
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miRNA
miRNA information provided by mirtarbase database.
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Gene ontology (GO)
Gene ontology information of associated ontologies with gene provided by GO database.
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Other IDs
Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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| Protein | |||||||||||||||||||||
| UniProt ID | P17655 | ||||||||||||||||||||
| Protein name | Calpain-2 catalytic subunit (EC 3.4.22.53) (Calcium-activated neutral proteinase 2) (CANP 2) (Calpain M-type) (Calpain large polypeptide L2) (Calpain-2 large subunit) (Millimolar-calpain) (M-calpain) | ||||||||||||||||||||
| Protein function | Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves MYOC at 'Arg-226' (PubMed:17650508). Proteolytically cleaves CP | ||||||||||||||||||||
| PDB | 1KFU , 1KFX , 2NQA | ||||||||||||||||||||
| Family and domains |
Pfam
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| Tissue specificity | TISSUE SPECIFICITY: Ubiquitous. | ||||||||||||||||||||
| Sequence |
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| Sequence length | 700 | ||||||||||||||||||||
| Interactions | View interactions | ||||||||||||||||||||
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Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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Associated diseases
Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
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