Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	822
Gene name Gene Name - the full gene name approved by the HGNC.	Capping actin protein, gelsolin like
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	CAPG
Synonyms (NCBI Gene) Gene synonyms aliases	AFCP, HEL-S-66, MCP
Chromosome Chromosome number	2
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	2p11.2
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a member of the gelsolin/villin family of actin-regulatory proteins. The encoded protein reversibly blocks the barbed ends of F-actin filaments in a Ca2+ and phosphoinositide-regulated manner, but does not sever preformed actin filaments

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miRTarBase ID	miRNA	Experiments	Reference
MIRT001646	hsa-let-7b-5p	pSILAC	18668040
MIRT023906	hsa-miR-1-3p	Microarray	18668037
MIRT025493	hsa-miR-34a-5p	Proteomics	21566225
MIRT001646	hsa-let-7b-5p	Proteomics;Other	18668040
MIRT1955703	hsa-miR-1207-5p	CLIP-seq
MIRT1955704	hsa-miR-1909	CLIP-seq
MIRT1955705	hsa-miR-3665	CLIP-seq
MIRT1955706	hsa-miR-4447	CLIP-seq
MIRT1955707	hsa-miR-4472	CLIP-seq
MIRT1955708	hsa-miR-4736	CLIP-seq
MIRT1955709	hsa-miR-4763-3p	CLIP-seq
MIRT1955710	hsa-miR-486-3p	CLIP-seq
MIRT1955711	hsa-miR-541	CLIP-seq
MIRT1955712	hsa-miR-654-5p	CLIP-seq
MIRT1955713	hsa-miR-939	CLIP-seq
MIRT1955704	hsa-miR-1909	CLIP-seq
MIRT1955705	hsa-miR-3665	CLIP-seq
MIRT2496401	hsa-miR-3919	CLIP-seq
MIRT2496402	hsa-miR-4514	CLIP-seq
MIRT2496403	hsa-miR-4645-5p	CLIP-seq
MIRT2496404	hsa-miR-4673	CLIP-seq
MIRT2496405	hsa-miR-4690-5p	CLIP-seq
MIRT2496406	hsa-miR-4692	CLIP-seq
MIRT1955708	hsa-miR-4736	CLIP-seq
MIRT1955711	hsa-miR-541	CLIP-seq
MIRT1955712	hsa-miR-654-5p	CLIP-seq
MIRT2496407	hsa-miR-940	CLIP-seq
MIRT1955703	hsa-miR-1207-5p	CLIP-seq
MIRT1955704	hsa-miR-1909	CLIP-seq
MIRT1955705	hsa-miR-3665	CLIP-seq
MIRT2496401	hsa-miR-3919	CLIP-seq
MIRT1955706	hsa-miR-4447	CLIP-seq
MIRT1955707	hsa-miR-4472	CLIP-seq
MIRT2496402	hsa-miR-4514	CLIP-seq
MIRT2496403	hsa-miR-4645-5p	CLIP-seq
MIRT2496404	hsa-miR-4673	CLIP-seq
MIRT2496405	hsa-miR-4690-5p	CLIP-seq
MIRT2496406	hsa-miR-4692	CLIP-seq
MIRT1955708	hsa-miR-4736	CLIP-seq
MIRT1955709	hsa-miR-4763-3p	CLIP-seq
MIRT1955710	hsa-miR-486-3p	CLIP-seq
MIRT1955711	hsa-miR-541	CLIP-seq
MIRT1955712	hsa-miR-654-5p	CLIP-seq
MIRT1955713	hsa-miR-939	CLIP-seq
MIRT2496407	hsa-miR-940	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0001726	Component	Ruffle	IEA
GO:0003779	Function	Actin binding	IEA
GO:0005515	Function	Protein binding	IPI	18266911, 25416956, 32814053, 33961781
GO:0005546	Function	Phosphatidylinositol-4,5-bisphosphate binding	IBA
GO:0005634	Component	Nucleus	IDA	18266911
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA	18938132
GO:0005694	Component	Chromosome	IDA
GO:0005730	Component	Nucleolus	IDA	18938132
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IDA	18266911, 18938132, 19166812, 25468996
GO:0005737	Component	Cytoplasm	IEA
GO:0005814	Component	Centriole	IDA	19166812
GO:0007417	Process	Central nervous system development	IBA
GO:0008154	Process	Actin polymerization or depolymerization	IBA
GO:0008290	Component	F-actin capping protein complex	TAS	1322908
GO:0015629	Component	Actin cytoskeleton	IBA
GO:0019904	Function	Protein domain specific binding	IPI	18266911
GO:0022617	Process	Extracellular matrix disassembly	IMP
GO:0030027	Component	Lamellipodium	IEA
GO:0030031	Process	Cell projection assembly	IBA
GO:0042470	Component	Melanosome	IEA
GO:0042995	Component	Cell projection	IEA
GO:0044877	Function	Protein-containing complex binding	IDA	18266911
GO:0045296	Function	Cadherin binding	HDA	25468996
GO:0051014	Process	Actin filament severing	IBA
GO:0051015	Function	Actin filament binding	IBA
GO:0051015	Function	Actin filament binding	IEA
GO:0051016	Process	Barbed-end actin filament capping	IBA
GO:0051016	Process	Barbed-end actin filament capping	TAS	1322908
GO:0051693	Process	Actin filament capping	IEA
GO:0065003	Process	Protein-containing complex assembly	NAS	1322908
GO:0070062	Component	Extracellular exosome	HDA	19056867, 20458337, 23533145
GO:0071803	Process	Positive regulation of podosome assembly	IMP
GO:0072686	Component	Mitotic spindle	IDA	19166812
GO:0090543	Component	Flemming body	IDA	19166812

MIM	HGNC	e!Ensembl
153615	1474	ENSG00000042493

Protein

UniProt ID

P40121

Protein name

Macrophage-capping protein (Actin regulatory protein CAP-G)

Protein function

Calcium-sensitive protein which reversibly blocks the barbed ends of actin filaments but does not sever preformed actin filaments. May play an important role in macrophage function. May play a role in regulating cytoplasmic and/or nuclear struct

PDB

1J72 , 1JHW

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00626	Gelsolin	28 → 107	Gelsolin repeat	Domain
PF00626	Gelsolin	146 → 221	Gelsolin repeat	Domain
PF00626	Gelsolin	264 → 341	Gelsolin repeat	Domain

Tissue specificity

TISSUE SPECIFICITY: Macrophages and macrophage-like cells.

Sequence

MYTAIPQSGSPFPGSVQDPGLHVWRVEKLKPVPVAQENQGVFFSGDSYLVLHNGPEEVSH
LHLWIGQQSSRDEQGACAVLAVHLNTLLGERPVQHREVQGNESDLFMSYFPRGLKYQEGG
VESAFHKTSTGAPAAIKKLYQVKGKKNIRATERALNWDSFNTGDCFILDLGQNIFAWCGG
KSNILERNKARDLALAIRDSERQGKAQVEIVTDGEEPAEMIQVLGPKPALKEGNPEEDLT
ADKANAQAAALYKVSDATGQMNLTKVADSSPFALELLISDDCFVLDNGLCGKIYIWKGRK
ANEKERQAALQVAEGFISRMQYAPNTQVEILPQGHESPIFKQFFKDWK

Sequence length

348

Interactions

View interactions

CAPG (capping actin protein, gelsolin like)