Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
81831
Gene name Gene Name - the full gene name approved by the HGNC.
Neuropilin and tolloid like 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
NETO2
Synonyms (NCBI Gene) Gene synonyms aliases
BTCL2, NEOT2
Chromosome Chromosome number
16
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
16q12.1
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a predicted transmembrane protein containing two extracellular CUB domains followed by a low-density lipoprotein class A (LDLa) domain. A similar gene in rats encodes a protein that modulates glutamate signaling in the brain by regulatin
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT002815 hsa-miR-1-3p Luciferase reporter assay, Microarray 15685193
MIRT020025 hsa-miR-375 Microarray 20215506
MIRT002815 hsa-miR-1-3p Microarray 18668037
MIRT002815 hsa-miR-1-3p Microarray 15685193
MIRT030591 hsa-miR-24-3p Microarray 19748357
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0014069 Component Postsynaptic density IEA
GO:0016021 Component Integral component of membrane IEA
GO:0035255 Function Ionotropic glutamate receptor binding IEA
GO:2000312 Process Regulation of kainate selective glutamate receptor activity IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
607974 14644 ENSG00000171208
Protein
UniProt ID Q8NC67
Protein name Neuropilin and tolloid-like protein 2 (Brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 2)
Protein function Accessory subunit of neuronal kainate-sensitive glutamate receptors, GRIK2 and GRIK3. Increases kainate-receptor channel activity, slowing the decay kinetics of the receptors, without affecting their expression at the cell surface, and increasin
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00431 CUB 45 156 CUB domain Domain
PF00431 CUB 177 289 CUB domain Domain
PF00057 Ldl_recept_a 295 331 Low-density lipoprotein receptor domain class A Repeat
Sequence
MALERLCSVLKVLLITVLVVEGIAVAQKTQDGQNIGIKHIPATQCGIWVRTSNGGHFASP
NYPDSYPPNKECIYILEAAPRQRIELTFDEHYYIEPSFECRFDHLEVRDGPFGFSPLIDR
YCGVKSPPLIRSTGRFMWIKFSSDEELEGLGFRAKY
SFIPDPDFTYLGGILNPIPDCQFE
LSGADGIVRSSQVEQEEKTKPGQAVDCIWTIKATPKAKIYLRFLDYQMEHSNECKRNFVA
VYDGSSSIENLKAKFCSTVANDVMLKTGIGVIRMWADEGSRLSRFRMLF
TSFVEPPCTSS
TFFCHSNMCINNSLVCNGVQNCAYPWDENHC
KEKKKAGVFEQITKTHGTIIGITSGIVLV
LLIISILVQVKQPRKKVMACKTAFNKTGFQEVFDPPHYELFSLRDKEISADLADLSEELD
NYQKMRRSSTASRCIHDHHCGSQASSVKQSRTNLSSMELPFRNDFAQPQPMKTFNSTFKK
SSYTFKQGHECPEQALEDRVMEEIPCEIYVRGREDSAQASISIDF
Sequence length 525
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Adenocarcinoma Adenoid Cystic Carcinoma rs121913530, rs886039394, rs121913474 16762588
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma of Lung Associate 31514295
Carcinogenesis Associate 33390848
Carcinoma Hepatocellular Associate 40158169
Colorectal Neoplasms Stimulate 26699544, 29297384
Death Stimulate 26699544
Esophageal Neoplasms Associate 33390848
Esophageal Squamous Cell Carcinoma Associate 33006432, 33390848
Glioma Associate 36639372
Hemangioma Associate 19349369
Lymphatic Metastasis Stimulate 26699544, 30770791