RNF170 (ring finger protein 170)

Gene

• Entrez ID: 81790
• Gene name: Ring finger protein 170
• Gene symbol: RNF170
• Synonyms (NCBI Gene): ADSA, SNAX1, SPG85
• Chromosome: 8
• Chromosome location: 8p11.21
• Summary: This gene encodes a RING domain-containing protein that resides in the endoplasmic reticulum (ER) membrane. This protein functions as an E3 ubiquitin ligase and mediates ubiquitination and processing of inositol 1,4,5-trisphosphate (IP3) receptors via the

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs397514478	G>A	Pathogenic	Coding sequence variant, missense variant, intron variant, non coding transcript variant
rs587780441	T>C	Likely-pathogenic	Missense variant, non coding transcript variant, coding sequence variant, intron variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT021592	hsa-miR-142-3p	Microarray	17612493
MIRT023233	hsa-miR-122-5p	Microarray	17612493
MIRT040795	hsa-miR-18a-3p	CLASH	23622248
MIRT666530	hsa-miR-3664-5p	HITS-CLIP	23824327
MIRT666529	hsa-miR-1306-5p	HITS-CLIP	23824327
MIRT666528	hsa-miR-5693	HITS-CLIP	23824327
MIRT666527	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT666526	hsa-miR-939-3p	HITS-CLIP	23824327
MIRT666525	hsa-miR-6852-5p	HITS-CLIP	23824327
MIRT666524	hsa-miR-6742-3p	HITS-CLIP	23824327
MIRT666523	hsa-miR-1267	HITS-CLIP	23824327
MIRT666522	hsa-miR-367-5p	HITS-CLIP	23824327
MIRT666521	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT666520	hsa-miR-3135b	HITS-CLIP	23824327
MIRT666519	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT023233	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT666518	hsa-miR-6722-5p	HITS-CLIP	23824327
MIRT666517	hsa-miR-3652	HITS-CLIP	23824327
MIRT666516	hsa-miR-4430	HITS-CLIP	23824327
MIRT666515	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT666514	hsa-miR-6501-5p	HITS-CLIP	23824327
MIRT666513	hsa-miR-4423-5p	HITS-CLIP	23824327
MIRT666512	hsa-miR-1343-3p	HITS-CLIP	23824327
MIRT666511	hsa-miR-6783-3p	HITS-CLIP	23824327
MIRT666510	hsa-miR-744-3p	HITS-CLIP	23824327
MIRT666509	hsa-miR-5698	HITS-CLIP	23824327
MIRT439761	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT439761	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT666530	hsa-miR-3664-5p	HITS-CLIP	23824327
MIRT666529	hsa-miR-1306-5p	HITS-CLIP	23824327
MIRT666528	hsa-miR-5693	HITS-CLIP	23824327
MIRT666527	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT666526	hsa-miR-939-3p	HITS-CLIP	23824327
MIRT666525	hsa-miR-6852-5p	HITS-CLIP	23824327
MIRT666524	hsa-miR-6742-3p	HITS-CLIP	23824327
MIRT666523	hsa-miR-1267	HITS-CLIP	23824327
MIRT666522	hsa-miR-367-5p	HITS-CLIP	23824327
MIRT666521	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT666520	hsa-miR-3135b	HITS-CLIP	23824327
MIRT666519	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT023233	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT666518	hsa-miR-6722-5p	HITS-CLIP	23824327
MIRT666517	hsa-miR-3652	HITS-CLIP	23824327
MIRT666516	hsa-miR-4430	HITS-CLIP	23824327
MIRT666515	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT666514	hsa-miR-6501-5p	HITS-CLIP	23824327
MIRT666513	hsa-miR-4423-5p	HITS-CLIP	23824327
MIRT666512	hsa-miR-1343-3p	HITS-CLIP	23824327
MIRT666511	hsa-miR-6783-3p	HITS-CLIP	23824327
MIRT666510	hsa-miR-744-3p	HITS-CLIP	23824327
MIRT666509	hsa-miR-5698	HITS-CLIP	23824327
MIRT1311420	hsa-miR-1273f	CLIP-seq
MIRT1311421	hsa-miR-143	CLIP-seq
MIRT1311422	hsa-miR-146b-3p	CLIP-seq
MIRT1311423	hsa-miR-3173-5p	CLIP-seq
MIRT1311424	hsa-miR-371b-3p	CLIP-seq
MIRT1311425	hsa-miR-3936	CLIP-seq
MIRT1311426	hsa-miR-3944-3p	CLIP-seq
MIRT1311427	hsa-miR-4292	CLIP-seq
MIRT1311428	hsa-miR-4708-5p	CLIP-seq
MIRT1311429	hsa-miR-4728-5p	CLIP-seq
MIRT1311430	hsa-miR-4770	CLIP-seq
MIRT1311431	hsa-miR-555	CLIP-seq
MIRT1311432	hsa-miR-874	CLIP-seq
MIRT1311433	hsa-miR-106a	CLIP-seq
MIRT1311434	hsa-miR-106b	CLIP-seq
MIRT1311435	hsa-miR-129-5p	CLIP-seq
MIRT1311436	hsa-miR-150	CLIP-seq
MIRT1311437	hsa-miR-17	CLIP-seq
MIRT1311438	hsa-miR-20a	CLIP-seq
MIRT1311439	hsa-miR-20b	CLIP-seq
MIRT1311440	hsa-miR-302a	CLIP-seq
MIRT1311441	hsa-miR-302b	CLIP-seq
MIRT1311442	hsa-miR-302c	CLIP-seq
MIRT1311443	hsa-miR-302d	CLIP-seq
MIRT1311444	hsa-miR-302e	CLIP-seq
MIRT1311445	hsa-miR-3159	CLIP-seq
MIRT1311446	hsa-miR-34a	CLIP-seq
MIRT1311447	hsa-miR-34c-5p	CLIP-seq
MIRT1311448	hsa-miR-3667-3p	CLIP-seq
MIRT1311449	hsa-miR-372	CLIP-seq
MIRT1311450	hsa-miR-373	CLIP-seq
MIRT1311451	hsa-miR-4294	CLIP-seq
MIRT1311452	hsa-miR-4302	CLIP-seq
MIRT1311453	hsa-miR-4419a	CLIP-seq
MIRT1311454	hsa-miR-4438	CLIP-seq
MIRT1311455	hsa-miR-4490	CLIP-seq
MIRT1311456	hsa-miR-449a	CLIP-seq
MIRT1311457	hsa-miR-449b	CLIP-seq
MIRT1311458	hsa-miR-4504	CLIP-seq
MIRT1311459	hsa-miR-4510	CLIP-seq
MIRT1311460	hsa-miR-4699-5p	CLIP-seq
MIRT1311461	hsa-miR-4774-5p	CLIP-seq
MIRT1311462	hsa-miR-4802-3p	CLIP-seq
MIRT1311463	hsa-miR-5095	CLIP-seq
MIRT1311464	hsa-miR-519d	CLIP-seq
MIRT1311465	hsa-miR-520a-3p	CLIP-seq
MIRT1311466	hsa-miR-520b	CLIP-seq
MIRT1311467	hsa-miR-520c-3p	CLIP-seq
MIRT1311468	hsa-miR-520d-3p	CLIP-seq
MIRT1311469	hsa-miR-520e	CLIP-seq
MIRT1311470	hsa-miR-520g	CLIP-seq
MIRT1311471	hsa-miR-520h	CLIP-seq
MIRT1311472	hsa-miR-542-3p	CLIP-seq
MIRT1311473	hsa-miR-93	CLIP-seq
MIRT1311474	hsa-miR-1343	CLIP-seq
MIRT1311475	hsa-miR-141	CLIP-seq
MIRT1311476	hsa-miR-200a	CLIP-seq
MIRT1311477	hsa-miR-345	CLIP-seq
MIRT1311446	hsa-miR-34a	CLIP-seq
MIRT1311447	hsa-miR-34c-5p	CLIP-seq
MIRT1311452	hsa-miR-4302	CLIP-seq
MIRT1311455	hsa-miR-4490	CLIP-seq
MIRT1311456	hsa-miR-449a	CLIP-seq
MIRT1311457	hsa-miR-449b	CLIP-seq
MIRT1311458	hsa-miR-4504	CLIP-seq
MIRT1311461	hsa-miR-4774-5p	CLIP-seq
MIRT1311462	hsa-miR-4802-3p	CLIP-seq
MIRT1311472	hsa-miR-542-3p	CLIP-seq
MIRT1311478	hsa-miR-622	CLIP-seq
MIRT2092517	hsa-miR-4677-3p	CLIP-seq
MIRT2092518	hsa-miR-4679	CLIP-seq
MIRT2092519	hsa-miR-4639-3p	CLIP-seq
MIRT2317034	hsa-miR-4659a-3p	CLIP-seq
MIRT2317035	hsa-miR-4659b-3p	CLIP-seq
MIRT2317036	hsa-let-7a	CLIP-seq
MIRT2317037	hsa-let-7b	CLIP-seq
MIRT2317038	hsa-let-7c	CLIP-seq
MIRT2317039	hsa-let-7d	CLIP-seq
MIRT2317040	hsa-let-7e	CLIP-seq
MIRT2317041	hsa-let-7f	CLIP-seq
MIRT2317042	hsa-let-7g	CLIP-seq
MIRT2317043	hsa-let-7i	CLIP-seq
MIRT2317044	hsa-miR-103b	CLIP-seq
MIRT1311433	hsa-miR-106a	CLIP-seq
MIRT1311434	hsa-miR-106b	CLIP-seq
MIRT2317045	hsa-miR-122	CLIP-seq
MIRT2317046	hsa-miR-1294	CLIP-seq
MIRT1311436	hsa-miR-150	CLIP-seq
MIRT2317047	hsa-miR-153	CLIP-seq
MIRT1311437	hsa-miR-17	CLIP-seq
MIRT2317048	hsa-miR-181a	CLIP-seq
MIRT2317049	hsa-miR-181b	CLIP-seq
MIRT2317050	hsa-miR-181c	CLIP-seq
MIRT2317051	hsa-miR-181d	CLIP-seq
MIRT2317052	hsa-miR-202	CLIP-seq
MIRT1311438	hsa-miR-20a	CLIP-seq
MIRT1311439	hsa-miR-20b	CLIP-seq
MIRT1311440	hsa-miR-302a	CLIP-seq
MIRT1311441	hsa-miR-302b	CLIP-seq
MIRT1311442	hsa-miR-302c	CLIP-seq
MIRT1311443	hsa-miR-302d	CLIP-seq
MIRT1311444	hsa-miR-302e	CLIP-seq
MIRT1311445	hsa-miR-3159	CLIP-seq
MIRT2317053	hsa-miR-3163	CLIP-seq
MIRT2317054	hsa-miR-331-5p	CLIP-seq
MIRT1311449	hsa-miR-372	CLIP-seq
MIRT1311450	hsa-miR-373	CLIP-seq
MIRT2317055	hsa-miR-4262	CLIP-seq
MIRT1311451	hsa-miR-4294	CLIP-seq
MIRT2317056	hsa-miR-4316	CLIP-seq
MIRT1311453	hsa-miR-4419a	CLIP-seq
MIRT1311454	hsa-miR-4438	CLIP-seq
MIRT2317057	hsa-miR-4457	CLIP-seq
MIRT2317058	hsa-miR-4458	CLIP-seq
MIRT2317059	hsa-miR-4500	CLIP-seq
MIRT1311459	hsa-miR-4510	CLIP-seq
MIRT2317060	hsa-miR-4540	CLIP-seq
MIRT2092519	hsa-miR-4639-3p	CLIP-seq
MIRT2317034	hsa-miR-4659a-3p	CLIP-seq
MIRT2317035	hsa-miR-4659b-3p	CLIP-seq
MIRT2092517	hsa-miR-4677-3p	CLIP-seq
MIRT2317061	hsa-miR-4678	CLIP-seq
MIRT2092518	hsa-miR-4679	CLIP-seq
MIRT2317062	hsa-miR-4680-3p	CLIP-seq
MIRT2317063	hsa-miR-4686	CLIP-seq
MIRT2317064	hsa-miR-4713-3p	CLIP-seq
MIRT2317065	hsa-miR-4713-5p	CLIP-seq
MIRT2317066	hsa-miR-4715-3p	CLIP-seq
MIRT2317067	hsa-miR-4722-3p	CLIP-seq
MIRT2317068	hsa-miR-4735-5p	CLIP-seq
MIRT2317069	hsa-miR-4763-5p	CLIP-seq
MIRT2317070	hsa-miR-4775	CLIP-seq
MIRT2317071	hsa-miR-4794	CLIP-seq
MIRT2317072	hsa-miR-485-3p	CLIP-seq
MIRT1311463	hsa-miR-5095	CLIP-seq
MIRT1311464	hsa-miR-519d	CLIP-seq
MIRT1311465	hsa-miR-520a-3p	CLIP-seq
MIRT1311466	hsa-miR-520b	CLIP-seq
MIRT1311467	hsa-miR-520c-3p	CLIP-seq
MIRT1311468	hsa-miR-520d-3p	CLIP-seq
MIRT1311469	hsa-miR-520e	CLIP-seq
MIRT1311470	hsa-miR-520g	CLIP-seq
MIRT1311471	hsa-miR-520h	CLIP-seq
MIRT2317073	hsa-miR-532-3p	CLIP-seq
MIRT2317074	hsa-miR-566	CLIP-seq
MIRT2317075	hsa-miR-590-3p	CLIP-seq
MIRT1311473	hsa-miR-93	CLIP-seq
MIRT2317076	hsa-miR-98	CLIP-seq
MIRT2317036	hsa-let-7a	CLIP-seq
MIRT2317037	hsa-let-7b	CLIP-seq
MIRT2317038	hsa-let-7c	CLIP-seq
MIRT2317039	hsa-let-7d	CLIP-seq
MIRT2317040	hsa-let-7e	CLIP-seq
MIRT2317041	hsa-let-7f	CLIP-seq
MIRT2317042	hsa-let-7g	CLIP-seq
MIRT2317043	hsa-let-7i	CLIP-seq
MIRT2317046	hsa-miR-1294	CLIP-seq
MIRT2317052	hsa-miR-202	CLIP-seq
MIRT2317054	hsa-miR-331-5p	CLIP-seq
MIRT2317056	hsa-miR-4316	CLIP-seq
MIRT2317058	hsa-miR-4458	CLIP-seq
MIRT2317059	hsa-miR-4500	CLIP-seq
MIRT2092517	hsa-miR-4677-3p	CLIP-seq
MIRT2317061	hsa-miR-4678	CLIP-seq
MIRT2092518	hsa-miR-4679	CLIP-seq
MIRT2317063	hsa-miR-4686	CLIP-seq
MIRT2317076	hsa-miR-98	CLIP-seq
MIRT2317045	hsa-miR-122	CLIP-seq
MIRT1311435	hsa-miR-129-5p	CLIP-seq
MIRT2458418	hsa-miR-3149	CLIP-seq
MIRT2458419	hsa-miR-3199	CLIP-seq
MIRT2458420	hsa-miR-411	CLIP-seq
MIRT1311451	hsa-miR-4294	CLIP-seq
MIRT1311453	hsa-miR-4419a	CLIP-seq
MIRT1311454	hsa-miR-4438	CLIP-seq
MIRT1311459	hsa-miR-4510	CLIP-seq
MIRT2092519	hsa-miR-4639-3p	CLIP-seq
MIRT2317066	hsa-miR-4715-3p	CLIP-seq
MIRT2317067	hsa-miR-4722-3p	CLIP-seq
MIRT2317068	hsa-miR-4735-5p	CLIP-seq
MIRT2317069	hsa-miR-4763-5p	CLIP-seq
MIRT2317070	hsa-miR-4775	CLIP-seq
MIRT2317071	hsa-miR-4794	CLIP-seq
MIRT2458421	hsa-miR-483-5p	CLIP-seq
MIRT1311463	hsa-miR-5095	CLIP-seq
MIRT2317074	hsa-miR-566	CLIP-seq
MIRT2317075	hsa-miR-590-3p	CLIP-seq
MIRT2458422	hsa-miR-595	CLIP-seq
MIRT2458423	hsa-miR-628-5p	CLIP-seq
MIRT2458424	hsa-miR-648	CLIP-seq
MIRT1311433	hsa-miR-106a	CLIP-seq
MIRT1311434	hsa-miR-106b	CLIP-seq
MIRT2612876	hsa-miR-1193	CLIP-seq
MIRT2612877	hsa-miR-1208	CLIP-seq
MIRT2317045	hsa-miR-122	CLIP-seq
MIRT2612878	hsa-miR-1237	CLIP-seq
MIRT2612879	hsa-miR-1248	CLIP-seq
MIRT1311420	hsa-miR-1273f	CLIP-seq
MIRT2612880	hsa-miR-1284	CLIP-seq
MIRT2612881	hsa-miR-1285	CLIP-seq
MIRT1311435	hsa-miR-129-5p	CLIP-seq
MIRT1311474	hsa-miR-1343	CLIP-seq
MIRT1311421	hsa-miR-143	CLIP-seq
MIRT1311436	hsa-miR-150	CLIP-seq
MIRT1311437	hsa-miR-17	CLIP-seq
MIRT2612882	hsa-miR-188-5p	CLIP-seq
MIRT2612883	hsa-miR-197	CLIP-seq
MIRT2612884	hsa-miR-1976	CLIP-seq
MIRT2612885	hsa-miR-204	CLIP-seq
MIRT1311438	hsa-miR-20a	CLIP-seq
MIRT1311439	hsa-miR-20b	CLIP-seq
MIRT2612886	hsa-miR-211	CLIP-seq
MIRT2612887	hsa-miR-2110	CLIP-seq
MIRT2612888	hsa-miR-22	CLIP-seq
MIRT2612889	hsa-miR-2355-3p	CLIP-seq
MIRT2612890	hsa-miR-2355-5p	CLIP-seq
MIRT2612891	hsa-miR-2392	CLIP-seq
MIRT1311440	hsa-miR-302a	CLIP-seq
MIRT1311441	hsa-miR-302b	CLIP-seq
MIRT1311442	hsa-miR-302c	CLIP-seq
MIRT1311443	hsa-miR-302d	CLIP-seq
MIRT1311444	hsa-miR-302e	CLIP-seq
MIRT2612892	hsa-miR-3117-5p	CLIP-seq
MIRT2612893	hsa-miR-3145-3p	CLIP-seq
MIRT2458418	hsa-miR-3149	CLIP-seq
MIRT1311445	hsa-miR-3159	CLIP-seq
MIRT2317053	hsa-miR-3163	CLIP-seq
MIRT2612894	hsa-miR-3182	CLIP-seq
MIRT2612895	hsa-miR-3187-5p	CLIP-seq
MIRT2458419	hsa-miR-3199	CLIP-seq
MIRT2612896	hsa-miR-323-3p	CLIP-seq
MIRT2612897	hsa-miR-324-5p	CLIP-seq
MIRT2612898	hsa-miR-338-5p	CLIP-seq
MIRT2612899	hsa-miR-3614-5p	CLIP-seq
MIRT2612900	hsa-miR-3679-3p	CLIP-seq
MIRT2612901	hsa-miR-370	CLIP-seq
MIRT1311449	hsa-miR-372	CLIP-seq
MIRT1311450	hsa-miR-373	CLIP-seq
MIRT2612902	hsa-miR-3945	CLIP-seq
MIRT2612903	hsa-miR-410	CLIP-seq
MIRT2458420	hsa-miR-411	CLIP-seq
MIRT2612904	hsa-miR-4251	CLIP-seq
MIRT2612905	hsa-miR-4253	CLIP-seq
MIRT2612906	hsa-miR-4268	CLIP-seq
MIRT2612907	hsa-miR-4271	CLIP-seq
MIRT2612908	hsa-miR-4282	CLIP-seq
MIRT2612909	hsa-miR-4286	CLIP-seq
MIRT1311451	hsa-miR-4294	CLIP-seq
MIRT2612910	hsa-miR-4303	CLIP-seq
MIRT2612911	hsa-miR-4314	CLIP-seq
MIRT2612912	hsa-miR-432	CLIP-seq
MIRT2612913	hsa-miR-4329	CLIP-seq
MIRT2612914	hsa-miR-4330	CLIP-seq
MIRT1311453	hsa-miR-4419a	CLIP-seq
MIRT2612915	hsa-miR-4422	CLIP-seq
MIRT1311454	hsa-miR-4438	CLIP-seq
MIRT2612916	hsa-miR-4446-5p	CLIP-seq
MIRT2612917	hsa-miR-4448	CLIP-seq
MIRT2612918	hsa-miR-4468	CLIP-seq
MIRT2612919	hsa-miR-4509	CLIP-seq
MIRT1311459	hsa-miR-4510	CLIP-seq
MIRT2612920	hsa-miR-4522	CLIP-seq
MIRT2092519	hsa-miR-4639-3p	CLIP-seq
MIRT2612921	hsa-miR-4645-3p	CLIP-seq
MIRT2612922	hsa-miR-4646-3p	CLIP-seq
MIRT2612923	hsa-miR-4652-3p	CLIP-seq
MIRT2612924	hsa-miR-4659a-5p	CLIP-seq
MIRT2612925	hsa-miR-4659b-5p	CLIP-seq
MIRT2612926	hsa-miR-4662a-5p	CLIP-seq
MIRT2612927	hsa-miR-4667-5p	CLIP-seq
MIRT2612928	hsa-miR-4668-3p	CLIP-seq
MIRT2612929	hsa-miR-4668-5p	CLIP-seq
MIRT2612930	hsa-miR-4676-5p	CLIP-seq
MIRT2317063	hsa-miR-4686	CLIP-seq
MIRT2612931	hsa-miR-4695-3p	CLIP-seq
MIRT2612932	hsa-miR-4700-5p	CLIP-seq
MIRT1311428	hsa-miR-4708-5p	CLIP-seq
MIRT2317066	hsa-miR-4715-3p	CLIP-seq
MIRT2612933	hsa-miR-4716-5p	CLIP-seq
MIRT2317067	hsa-miR-4722-3p	CLIP-seq
MIRT2612934	hsa-miR-4725-3p	CLIP-seq
MIRT2612935	hsa-miR-4727-3p	CLIP-seq
MIRT2612936	hsa-miR-4729	CLIP-seq
MIRT2317068	hsa-miR-4735-5p	CLIP-seq
MIRT2612937	hsa-miR-4744	CLIP-seq
MIRT2317069	hsa-miR-4763-5p	CLIP-seq
MIRT1311430	hsa-miR-4770	CLIP-seq
MIRT2612938	hsa-miR-4773	CLIP-seq
MIRT2317070	hsa-miR-4775	CLIP-seq
MIRT2612939	hsa-miR-4793-5p	CLIP-seq
MIRT2317071	hsa-miR-4794	CLIP-seq
MIRT2612940	hsa-miR-4795-3p	CLIP-seq
MIRT2458421	hsa-miR-483-5p	CLIP-seq
MIRT2612941	hsa-miR-495	CLIP-seq
MIRT1311463	hsa-miR-5095	CLIP-seq
MIRT2612942	hsa-miR-5096	CLIP-seq
MIRT2612943	hsa-miR-513b	CLIP-seq
MIRT1311464	hsa-miR-519d	CLIP-seq
MIRT1311465	hsa-miR-520a-3p	CLIP-seq
MIRT1311466	hsa-miR-520b	CLIP-seq
MIRT1311467	hsa-miR-520c-3p	CLIP-seq
MIRT1311468	hsa-miR-520d-3p	CLIP-seq
MIRT1311469	hsa-miR-520e	CLIP-seq
MIRT1311470	hsa-miR-520g	CLIP-seq
MIRT1311471	hsa-miR-520h	CLIP-seq
MIRT2612944	hsa-miR-548ac	CLIP-seq
MIRT2612945	hsa-miR-548ae	CLIP-seq
MIRT2612946	hsa-miR-548aj	CLIP-seq
MIRT2612947	hsa-miR-548am	CLIP-seq
MIRT2612948	hsa-miR-548c-3p	CLIP-seq
MIRT2612949	hsa-miR-548d-3p	CLIP-seq
MIRT2612950	hsa-miR-548x	CLIP-seq
MIRT2612951	hsa-miR-548z	CLIP-seq
MIRT2612952	hsa-miR-549	CLIP-seq
MIRT2612953	hsa-miR-558	CLIP-seq
MIRT2612954	hsa-miR-561	CLIP-seq
MIRT2317074	hsa-miR-566	CLIP-seq
MIRT2612955	hsa-miR-575	CLIP-seq
MIRT2317075	hsa-miR-590-3p	CLIP-seq
MIRT2612956	hsa-miR-612	CLIP-seq
MIRT2612957	hsa-miR-628-3p	CLIP-seq
MIRT2612958	hsa-miR-637	CLIP-seq
MIRT2612959	hsa-miR-767-3p	CLIP-seq
MIRT2612960	hsa-miR-890	CLIP-seq
MIRT1311473	hsa-miR-93	CLIP-seq
MIRT1311433	hsa-miR-106a	CLIP-seq
MIRT1311434	hsa-miR-106b	CLIP-seq
MIRT2612876	hsa-miR-1193	CLIP-seq
MIRT2612877	hsa-miR-1208	CLIP-seq
MIRT2317045	hsa-miR-122	CLIP-seq
MIRT2612878	hsa-miR-1237	CLIP-seq
MIRT2612879	hsa-miR-1248	CLIP-seq
MIRT1311420	hsa-miR-1273f	CLIP-seq
MIRT2612880	hsa-miR-1284	CLIP-seq
MIRT2612881	hsa-miR-1285	CLIP-seq
MIRT1311435	hsa-miR-129-5p	CLIP-seq
MIRT1311474	hsa-miR-1343	CLIP-seq
MIRT1311421	hsa-miR-143	CLIP-seq
MIRT1311436	hsa-miR-150	CLIP-seq
MIRT1311437	hsa-miR-17	CLIP-seq
MIRT2612882	hsa-miR-188-5p	CLIP-seq
MIRT2612883	hsa-miR-197	CLIP-seq
MIRT2612884	hsa-miR-1976	CLIP-seq
MIRT1311438	hsa-miR-20a	CLIP-seq
MIRT1311439	hsa-miR-20b	CLIP-seq
MIRT2612890	hsa-miR-2355-5p	CLIP-seq
MIRT2612891	hsa-miR-2392	CLIP-seq
MIRT1311440	hsa-miR-302a	CLIP-seq
MIRT1311441	hsa-miR-302b	CLIP-seq
MIRT1311442	hsa-miR-302c	CLIP-seq
MIRT1311443	hsa-miR-302d	CLIP-seq
MIRT1311444	hsa-miR-302e	CLIP-seq
MIRT2612892	hsa-miR-3117-5p	CLIP-seq
MIRT2612893	hsa-miR-3145-3p	CLIP-seq
MIRT2458418	hsa-miR-3149	CLIP-seq
MIRT1311445	hsa-miR-3159	CLIP-seq
MIRT2317053	hsa-miR-3163	CLIP-seq
MIRT2612894	hsa-miR-3182	CLIP-seq
MIRT2612895	hsa-miR-3187-5p	CLIP-seq
MIRT2458419	hsa-miR-3199	CLIP-seq
MIRT2612896	hsa-miR-323-3p	CLIP-seq
MIRT2612897	hsa-miR-324-5p	CLIP-seq
MIRT2612898	hsa-miR-338-5p	CLIP-seq
MIRT2689835	hsa-miR-3613-3p	CLIP-seq
MIRT2689836	hsa-miR-361-3p	CLIP-seq
MIRT2612899	hsa-miR-3614-5p	CLIP-seq
MIRT2689837	hsa-miR-3662	CLIP-seq
MIRT2612900	hsa-miR-3679-3p	CLIP-seq
MIRT1311449	hsa-miR-372	CLIP-seq
MIRT1311450	hsa-miR-373	CLIP-seq
MIRT2689838	hsa-miR-3913-3p	CLIP-seq
MIRT2689839	hsa-miR-3919	CLIP-seq
MIRT2612902	hsa-miR-3945	CLIP-seq
MIRT2458420	hsa-miR-411	CLIP-seq
MIRT2612904	hsa-miR-4251	CLIP-seq
MIRT2612905	hsa-miR-4253	CLIP-seq
MIRT2612909	hsa-miR-4286	CLIP-seq
MIRT1311451	hsa-miR-4294	CLIP-seq
MIRT2612910	hsa-miR-4303	CLIP-seq
MIRT2612912	hsa-miR-432	CLIP-seq
MIRT2612913	hsa-miR-4329	CLIP-seq
MIRT2612914	hsa-miR-4330	CLIP-seq
MIRT1311453	hsa-miR-4419a	CLIP-seq
MIRT2689840	hsa-miR-4421	CLIP-seq
MIRT1311454	hsa-miR-4438	CLIP-seq
MIRT2612916	hsa-miR-4446-5p	CLIP-seq
MIRT2612918	hsa-miR-4468	CLIP-seq
MIRT2612919	hsa-miR-4509	CLIP-seq
MIRT1311459	hsa-miR-4510	CLIP-seq
MIRT2612920	hsa-miR-4522	CLIP-seq
MIRT2092519	hsa-miR-4639-3p	CLIP-seq
MIRT2612921	hsa-miR-4645-3p	CLIP-seq
MIRT2612923	hsa-miR-4652-3p	CLIP-seq
MIRT2612924	hsa-miR-4659a-5p	CLIP-seq
MIRT2612925	hsa-miR-4659b-5p	CLIP-seq
MIRT2612926	hsa-miR-4662a-5p	CLIP-seq
MIRT2612928	hsa-miR-4668-3p	CLIP-seq
MIRT2612930	hsa-miR-4676-5p	CLIP-seq
MIRT2612931	hsa-miR-4695-3p	CLIP-seq
MIRT1311428	hsa-miR-4708-5p	CLIP-seq
MIRT2317066	hsa-miR-4715-3p	CLIP-seq
MIRT2612933	hsa-miR-4716-5p	CLIP-seq
MIRT2317067	hsa-miR-4722-3p	CLIP-seq
MIRT2612935	hsa-miR-4727-3p	CLIP-seq
MIRT2612936	hsa-miR-4729	CLIP-seq
MIRT2317068	hsa-miR-4735-5p	CLIP-seq
MIRT2612937	hsa-miR-4744	CLIP-seq
MIRT2689841	hsa-miR-4756-3p	CLIP-seq
MIRT2317069	hsa-miR-4763-5p	CLIP-seq
MIRT1311430	hsa-miR-4770	CLIP-seq
MIRT2612938	hsa-miR-4773	CLIP-seq
MIRT2317070	hsa-miR-4775	CLIP-seq
MIRT2612939	hsa-miR-4793-5p	CLIP-seq
MIRT2317071	hsa-miR-4794	CLIP-seq
MIRT2458421	hsa-miR-483-5p	CLIP-seq
MIRT2689842	hsa-miR-489	CLIP-seq
MIRT2689843	hsa-miR-499-3p	CLIP-seq
MIRT2689844	hsa-miR-499a-3p	CLIP-seq
MIRT1311463	hsa-miR-5095	CLIP-seq
MIRT2612942	hsa-miR-5096	CLIP-seq
MIRT2612943	hsa-miR-513b	CLIP-seq
MIRT1311464	hsa-miR-519d	CLIP-seq
MIRT1311465	hsa-miR-520a-3p	CLIP-seq
MIRT1311466	hsa-miR-520b	CLIP-seq
MIRT1311467	hsa-miR-520c-3p	CLIP-seq
MIRT1311468	hsa-miR-520d-3p	CLIP-seq
MIRT1311469	hsa-miR-520e	CLIP-seq
MIRT1311470	hsa-miR-520g	CLIP-seq
MIRT1311471	hsa-miR-520h	CLIP-seq
MIRT2689845	hsa-miR-544	CLIP-seq
MIRT2612944	hsa-miR-548ac	CLIP-seq
MIRT2612945	hsa-miR-548ae	CLIP-seq
MIRT2612946	hsa-miR-548aj	CLIP-seq
MIRT2612947	hsa-miR-548am	CLIP-seq
MIRT2612949	hsa-miR-548d-3p	CLIP-seq
MIRT2612950	hsa-miR-548x	CLIP-seq
MIRT2612951	hsa-miR-548z	CLIP-seq
MIRT2612952	hsa-miR-549	CLIP-seq
MIRT2612954	hsa-miR-561	CLIP-seq
MIRT2317074	hsa-miR-566	CLIP-seq
MIRT2612955	hsa-miR-575	CLIP-seq
MIRT2317075	hsa-miR-590-3p	CLIP-seq
MIRT2612956	hsa-miR-612	CLIP-seq
MIRT2612957	hsa-miR-628-3p	CLIP-seq
MIRT2612960	hsa-miR-890	CLIP-seq
MIRT1311473	hsa-miR-93	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000209	Process	Protein polyubiquitination	IEA
GO:0005515	Function	Protein binding	IPI	25416956, 32296183
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0007628	Process	Adult walking behavior	IEA
GO:0008270	Function	Zinc ion binding	IEA
GO:0009266	Process	Response to temperature stimulus	IEA
GO:0010467	Process	Gene expression	IEA
GO:0010498	Process	Proteasomal protein catabolic process	IEA
GO:0014823	Process	Response to activity	IEA
GO:0016020	Component	Membrane	IEA
GO:0016567	Process	Protein ubiquitination	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0030163	Process	Protein catabolic process	IEA
GO:0034138	Process	Toll-like receptor 3 signaling pathway	IEA
GO:0043161	Process	Proteasome-mediated ubiquitin-dependent protein catabolic process	IEA
GO:0045087	Process	Innate immune response	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0061630	Function	Ubiquitin protein ligase activity	IEA
GO:0070936	Process	Protein K48-linked ubiquitination	IEA
GO:0090659	Process	Walking behavior	IEA

Other IDs

• MIM: 614649
• HGNC: 25358
• e!Ensembl: ENSG00000120925

Protein

• UniProt ID: Q96K19
• Protein name: E3 ubiquitin-protein ligase RNF170 (EC 2.3.2.27) (Putative LAG1-interacting protein) (RING finger protein 170) (RING-type E3 ubiquitin transferase RNF170)
• Protein function: E3 ubiquitin-protein ligase that plays an essential role in stimulus-induced inositol 1,4,5-trisphosphate receptor type 1 (ITPR1) ubiquitination and degradation via the endoplasmic reticulum-associated degradation (ERAD) pathway. Also involved i
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00097	zf-C3HC4	87 → 129	Zinc finger, C3HC4 type (RING finger)	Domain
  PF06803	DUF1232	202 → 239	Protein of unknown function (DUF1232)	Family

• Tissue specificity: TISSUE SPECIFICITY: Expressed in the spinal cord. {ECO:0000269|PubMed:21115467}.
• Sequence:

  MAKYQGEVQSLKLDDDSVIEGVSDQVLVAVVVSFALIATLVYALFRNVHQNIHPENQELV
  RVLREQLQTEQDAPAATRQQFYTDMYCPICLHQASFPVETNCGHLFCGACIIAYWRYGSW
  LGAISCPICRQTVTLLLTVFGEDDQSQDVLRLHQDINDYNRRFSGQPRSIMERIMDLPTL
  LRHAFREMFSVGGLFWMFRIRIILCLMGAFFYLISPLDFVPEALFGILGFLDDFFVIFLL
  LIYISIMYREVITQRLTR

• Sequence length: 258

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Causal
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Autosomal dominant sensory ataxia 1	Pathogenic	rs397514478	RCV000024296	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Neurodevelopmental disorder	Pathogenic	rs2128929811	RCV001780019	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Spastic paraplegia	Likely pathogenic	rs1159600703	RCV001849523	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Spastic paraplegia 85, autosomal recessive	Likely pathogenic; Pathogenic	rs1159600703, rs2128922898, rs2128934252, rs397514478	RCV001806233 RCV001804215 RCV002255107 RCV003226168	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ATAXIA, SENSORY, 1, AUTOSOMAL DOMINANT	—	CTD, HPO CTD, HPO	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ATAXIA, SENSORY, AUTOSOMAL DOMINANT	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
AUTOSOMAL RECESSIVE SPASTIC PARAPLEGIA TYPE 85	—	Disgenet, Orphanet Disgenet, Orphanet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NEURODEVELOPMENTAL DISORDERS	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
RNF170-related disorder	Uncertain significance; Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Relationship Type	References	Evidence Score
Ataxia	Associate	34469621	★☆☆☆☆ Found in Text Mining only
Ataxia Sensory Autosomal Dominant	Associate	34469621	★☆☆☆☆ Found in Text Mining only
Metabolic Syndrome	Associate	37138862	★☆☆☆☆ Found in Text Mining only
Neurodegenerative Diseases	Associate	31874412	★☆☆☆☆ Found in Text Mining only
Osteoarthritis	Associate	37138862	★☆☆☆☆ Found in Text Mining only
Pallidopyramidal syndrome	Associate	34469621	★☆☆☆☆ Found in Text Mining only
Spastic Paraplegia Hereditary	Associate	31874412, 34469621	★☆☆☆☆ Found in Text Mining only