Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
81788
Gene name Gene Name - the full gene name approved by the HGNC.
NUAK family kinase 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
NUAK2
Synonyms (NCBI Gene) Gene synonyms aliases
ANPH2, SNARK
Disease Acronyms (UniProt) Disease acronyms from UniProt database
ANPH2
Chromosome Chromosome number
1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
1q32.1
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT027532 hsa-miR-98-5p Microarray 19088304
MIRT471908 hsa-miR-3925-5p PAR-CLIP 23592263
MIRT471907 hsa-miR-2392 PAR-CLIP 23592263
MIRT471906 hsa-miR-4464 PAR-CLIP 23592263
MIRT471905 hsa-miR-4748 PAR-CLIP 23592263
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000287 Function Magnesium ion binding IDA 14976552
GO:0004674 Function Protein serine/threonine kinase activity IBA 21873635
GO:0004674 Function Protein serine/threonine kinase activity IDA 14976552, 19927127
GO:0005515 Function Protein binding IPI 19927127, 32296183
GO:0005524 Function ATP binding IDA 14976552
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
608131 29558 ENSG00000163545
Protein
UniProt ID Q9H093
Protein name NUAK family SNF1-like kinase 2 (EC 2.7.11.1) (Omphalocele kinase 2) (SNF1/AMP kinase-related kinase) (SNARK)
Protein function Stress-activated kinase involved in tolerance to glucose starvation. Induces cell-cell detachment by increasing F-actin conversion to G-actin. Expression is induced by CD95 or TNF-alpha, via NF-kappa-B. Protects cells from CD95-mediated apoptosi
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00069 Pkinase 53 303 Protein kinase domain Domain
Sequence
MESLVFARRSGPTPSAAELARPLAEGLIKSPKPLMKKQAVKRHHHKHNLRHRYEFLETLG
KGTYGKVKKARESSGRLVAIKSIRKDKIKDEQDLMHIRREIEIMSSLNHPHIIAIHEVFE
NSSKIVIVMEYASRGDLYDYISERQQLSEREARHFFRQIVSAVHYCHQNRVVHRDLKLEN
ILLDANGNIKIADFGLSNLYHQGKFLQTFCGSPLYASPEIVNGKPYTGPEVDSWSLGVLL
YILVHGTMPFDGHDHKILVKQISNGAYREPPKPSDACGLIRWLLMVNPTRRATLEDVASH
WWV
NWGYATRVGEQEAPHEGGHPGSDSARASMADWLRRSSRPLLENGAKVCSFFKQHAPG
GGSTTPGLERQHSLKKSRKENDMAQSLHSDTADDTAHRPGKSNLKLPKGILKKKVSASAE
GVQEDPPELSPIPASPGQAAPLLPKKGILKKPRQRESGYYSSPEPSESGELLDAGDVFVS
GDPKEQKPPQASGLLLHRKGILKLNGKFSQTALELAAPTTFGSLDELAPPRPLARASRPS
GAVSEDSILSSESFDQLDLPERLPEPPLRGCVSVDNLTGLEEPPSEGPGSCLRRWRQDPL
GDSCFSLTDCQEVTATYRQALRVCSKLT
Sequence length 628
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Unknown
Disease term Disease name Evidence References Source
Anencephaly anencephaly 2 GenCC
Associations from Text Mining
Disease Name Relationship Type References
Anencephaly Associate 32845958
Breast Neoplasms Associate 33880593
Carcinoma Hepatocellular Associate 32755597
Chemical and Drug Induced Liver Injury Associate 23831117
Diabetes Mellitus Associate 19652946
Diabetes Mellitus Type 2 Stimulate 19652946
Mammary Neoplasms Animal Associate 30158528
Neoplasms Associate 15345718, 30158528, 33880593, 34558636
Obesity Stimulate 19652946
Urinary Bladder Neoplasms Stimulate 30158528