Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	8165
Gene name Gene Name - the full gene name approved by the HGNC.	A-kinase anchoring protein 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	AKAP1
Synonyms (NCBI Gene) Gene synonyms aliases	AKAP, AKAP121, AKAP149, AKAP84, D-AKAP1, PPP1R43, PRKA1, SAKAP84, TDRD17
Chromosome Chromosome number	17
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	17q22
Summary Summary of gene provided in NCBI Entrez Gene.	The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene

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miRTarBase ID	miRNA	Experiments	Reference
MIRT005814	hsa-miR-204-5p	Microarray	21282569
MIRT037317	hsa-miR-877-5p	CLASH	23622248
MIRT549404	hsa-miR-409-5p	PAR-CLIP	21572407
MIRT078141	hsa-miR-3121-3p	PAR-CLIP	21572407
MIRT078134	hsa-miR-224-3p	PAR-CLIP	21572407
MIRT078137	hsa-miR-522-3p	PAR-CLIP	21572407
MIRT288386	hsa-miR-4797-5p	PAR-CLIP	21572407
MIRT549403	hsa-miR-4699-3p	PAR-CLIP	21572407
MIRT078143	hsa-miR-4719	PAR-CLIP	21572407
MIRT078136	hsa-miR-520d-5p	PAR-CLIP	21572407
MIRT078135	hsa-miR-524-5p	PAR-CLIP	21572407
MIRT078138	hsa-miR-507	PAR-CLIP	21572407
MIRT078139	hsa-miR-557	PAR-CLIP	21572407
MIRT446603	hsa-miR-7-5p	PAR-CLIP	22100165
MIRT446601	hsa-miR-6077	PAR-CLIP	22100165
MIRT446600	hsa-miR-3652	PAR-CLIP	22100165
MIRT446599	hsa-miR-4430	PAR-CLIP	22100165
MIRT446598	hsa-miR-4505	PAR-CLIP	22100165
MIRT446597	hsa-miR-5787	PAR-CLIP	22100165
MIRT446596	hsa-miR-526b-5p	PAR-CLIP	22100165
MIRT446595	hsa-miR-6842-3p	PAR-CLIP	22100165
MIRT446594	hsa-miR-4474-3p	PAR-CLIP	22100165
MIRT549404	hsa-miR-409-5p	PAR-CLIP	21572407
MIRT078141	hsa-miR-3121-3p	PAR-CLIP	21572407
MIRT078134	hsa-miR-224-3p	PAR-CLIP	21572407
MIRT078137	hsa-miR-522-3p	PAR-CLIP	21572407
MIRT288386	hsa-miR-4797-5p	PAR-CLIP	21572407
MIRT549403	hsa-miR-4699-3p	PAR-CLIP	21572407
MIRT078143	hsa-miR-4719	PAR-CLIP	21572407
MIRT078136	hsa-miR-520d-5p	PAR-CLIP	21572407
MIRT078135	hsa-miR-524-5p	PAR-CLIP	21572407
MIRT078138	hsa-miR-507	PAR-CLIP	21572407
MIRT078139	hsa-miR-557	PAR-CLIP	21572407
MIRT446603	hsa-miR-7-5p	PAR-CLIP	22100165
MIRT446601	hsa-miR-6077	PAR-CLIP	22100165
MIRT446600	hsa-miR-3652	PAR-CLIP	22100165
MIRT446599	hsa-miR-4430	PAR-CLIP	22100165
MIRT446598	hsa-miR-4505	PAR-CLIP	22100165
MIRT446597	hsa-miR-5787	PAR-CLIP	22100165
MIRT446596	hsa-miR-526b-5p	PAR-CLIP	22100165
MIRT446595	hsa-miR-6842-3p	PAR-CLIP	22100165
MIRT446594	hsa-miR-4474-3p	PAR-CLIP	22100165
MIRT775480	hsa-miR-103a	CLIP-seq
MIRT775481	hsa-miR-107	CLIP-seq
MIRT775482	hsa-miR-1207-3p	CLIP-seq
MIRT775483	hsa-miR-1207-5p	CLIP-seq
MIRT775484	hsa-miR-1266	CLIP-seq
MIRT775485	hsa-miR-1273d	CLIP-seq
MIRT775486	hsa-miR-130a	CLIP-seq
MIRT775487	hsa-miR-130b	CLIP-seq
MIRT775488	hsa-miR-148a	CLIP-seq
MIRT775489	hsa-miR-148b	CLIP-seq
MIRT775490	hsa-miR-152	CLIP-seq
MIRT775491	hsa-miR-15a	CLIP-seq
MIRT775492	hsa-miR-15b	CLIP-seq
MIRT775493	hsa-miR-16	CLIP-seq
MIRT775494	hsa-miR-195	CLIP-seq
MIRT775495	hsa-miR-19a	CLIP-seq
MIRT775496	hsa-miR-19b	CLIP-seq
MIRT775497	hsa-miR-2053	CLIP-seq
MIRT775498	hsa-miR-301a	CLIP-seq
MIRT775499	hsa-miR-301b	CLIP-seq
MIRT775500	hsa-miR-3119	CLIP-seq
MIRT775501	hsa-miR-3121-5p	CLIP-seq
MIRT775502	hsa-miR-3613-3p	CLIP-seq
MIRT775503	hsa-miR-362-5p	CLIP-seq
MIRT775504	hsa-miR-3664-3p	CLIP-seq
MIRT775505	hsa-miR-3666	CLIP-seq
MIRT775506	hsa-miR-3925-5p	CLIP-seq
MIRT775507	hsa-miR-421	CLIP-seq
MIRT775508	hsa-miR-424	CLIP-seq
MIRT775509	hsa-miR-4295	CLIP-seq
MIRT775510	hsa-miR-4432	CLIP-seq
MIRT775511	hsa-miR-450a	CLIP-seq
MIRT775512	hsa-miR-4518	CLIP-seq
MIRT775513	hsa-miR-454	CLIP-seq
MIRT775514	hsa-miR-4709-5p	CLIP-seq
MIRT775515	hsa-miR-4736	CLIP-seq
MIRT775516	hsa-miR-4763-3p	CLIP-seq
MIRT775517	hsa-miR-497	CLIP-seq
MIRT775518	hsa-miR-500b	CLIP-seq
MIRT775519	hsa-miR-501-5p	CLIP-seq
MIRT775520	hsa-miR-548u	CLIP-seq
MIRT775521	hsa-miR-589	CLIP-seq
MIRT775522	hsa-miR-873	CLIP-seq
MIRT775523	hsa-miR-1245b-3p	CLIP-seq
MIRT775524	hsa-miR-1279	CLIP-seq
MIRT775525	hsa-miR-1825	CLIP-seq
MIRT775526	hsa-miR-199a-5p	CLIP-seq
MIRT775527	hsa-miR-199b-5p	CLIP-seq
MIRT775528	hsa-miR-2117	CLIP-seq
MIRT775529	hsa-miR-3925-3p	CLIP-seq
MIRT775530	hsa-miR-3974	CLIP-seq
MIRT775531	hsa-miR-4273	CLIP-seq
MIRT775532	hsa-miR-4677-5p	CLIP-seq
MIRT775533	hsa-miR-4684-3p	CLIP-seq
MIRT775534	hsa-miR-4789-3p	CLIP-seq
MIRT775535	hsa-miR-515-5p	CLIP-seq
MIRT775536	hsa-miR-576-3p	CLIP-seq
MIRT775537	hsa-miR-582-5p	CLIP-seq
MIRT775538	hsa-miR-591	CLIP-seq
MIRT775539	hsa-miR-643	CLIP-seq
MIRT775540	hsa-miR-766	CLIP-seq
MIRT1928833	hsa-miR-1206	CLIP-seq
MIRT775525	hsa-miR-1825	CLIP-seq
MIRT775526	hsa-miR-199a-5p	CLIP-seq
MIRT775527	hsa-miR-199b-5p	CLIP-seq
MIRT1928834	hsa-miR-2467-3p	CLIP-seq
MIRT1928835	hsa-miR-3158-5p	CLIP-seq
MIRT1928836	hsa-miR-320e	CLIP-seq
MIRT1928837	hsa-miR-329	CLIP-seq
MIRT1928838	hsa-miR-362-3p	CLIP-seq
MIRT1928839	hsa-miR-3678-3p	CLIP-seq
MIRT1928840	hsa-miR-3681	CLIP-seq
MIRT1928841	hsa-miR-380	CLIP-seq
MIRT1928842	hsa-miR-3924	CLIP-seq
MIRT1928843	hsa-miR-4418	CLIP-seq
MIRT1928844	hsa-miR-4495	CLIP-seq
MIRT1928845	hsa-miR-4658	CLIP-seq
MIRT1928846	hsa-miR-4718	CLIP-seq
MIRT1928847	hsa-miR-4758-5p	CLIP-seq
MIRT775534	hsa-miR-4789-3p	CLIP-seq
MIRT1928848	hsa-miR-4793-3p	CLIP-seq
MIRT1928849	hsa-miR-509-3-5p	CLIP-seq
MIRT1928850	hsa-miR-509-5p	CLIP-seq
MIRT775480	hsa-miR-103a	CLIP-seq
MIRT775481	hsa-miR-107	CLIP-seq
MIRT1928833	hsa-miR-1206	CLIP-seq
MIRT775483	hsa-miR-1207-5p	CLIP-seq
MIRT775484	hsa-miR-1266	CLIP-seq
MIRT775485	hsa-miR-1273d	CLIP-seq
MIRT2169596	hsa-miR-128	CLIP-seq
MIRT2169597	hsa-miR-1286	CLIP-seq
MIRT2169598	hsa-miR-1291	CLIP-seq
MIRT2169599	hsa-miR-1305	CLIP-seq
MIRT775486	hsa-miR-130a	CLIP-seq
MIRT775487	hsa-miR-130b	CLIP-seq
MIRT775488	hsa-miR-148a	CLIP-seq
MIRT775489	hsa-miR-148b	CLIP-seq
MIRT775490	hsa-miR-152	CLIP-seq
MIRT775491	hsa-miR-15a	CLIP-seq
MIRT775492	hsa-miR-15b	CLIP-seq
MIRT775493	hsa-miR-16	CLIP-seq
MIRT775525	hsa-miR-1825	CLIP-seq
MIRT775494	hsa-miR-195	CLIP-seq
MIRT2169600	hsa-miR-198	CLIP-seq
MIRT775526	hsa-miR-199a-5p	CLIP-seq
MIRT775527	hsa-miR-199b-5p	CLIP-seq
MIRT775495	hsa-miR-19a	CLIP-seq
MIRT775496	hsa-miR-19b	CLIP-seq
MIRT775497	hsa-miR-2053	CLIP-seq
MIRT2169601	hsa-miR-27a	CLIP-seq
MIRT2169602	hsa-miR-27b	CLIP-seq
MIRT775498	hsa-miR-301a	CLIP-seq
MIRT775499	hsa-miR-301b	CLIP-seq
MIRT775500	hsa-miR-3119	CLIP-seq
MIRT2169603	hsa-miR-3120-3p	CLIP-seq
MIRT775501	hsa-miR-3121-5p	CLIP-seq
MIRT1928836	hsa-miR-320e	CLIP-seq
MIRT775502	hsa-miR-3613-3p	CLIP-seq
MIRT2169604	hsa-miR-3622a-3p	CLIP-seq
MIRT2169605	hsa-miR-3622b-3p	CLIP-seq
MIRT775503	hsa-miR-362-5p	CLIP-seq
MIRT775504	hsa-miR-3664-3p	CLIP-seq
MIRT775505	hsa-miR-3666	CLIP-seq
MIRT1928840	hsa-miR-3681	CLIP-seq
MIRT1928841	hsa-miR-380	CLIP-seq
MIRT1928842	hsa-miR-3924	CLIP-seq
MIRT775506	hsa-miR-3925-5p	CLIP-seq
MIRT2169606	hsa-miR-3944-5p	CLIP-seq
MIRT775507	hsa-miR-421	CLIP-seq
MIRT775508	hsa-miR-424	CLIP-seq
MIRT775509	hsa-miR-4295	CLIP-seq
MIRT2169607	hsa-miR-4302	CLIP-seq
MIRT775510	hsa-miR-4432	CLIP-seq
MIRT1928844	hsa-miR-4495	CLIP-seq
MIRT775511	hsa-miR-450a	CLIP-seq
MIRT775512	hsa-miR-4518	CLIP-seq
MIRT775513	hsa-miR-454	CLIP-seq
MIRT1928845	hsa-miR-4658	CLIP-seq
MIRT2169608	hsa-miR-4684-5p	CLIP-seq
MIRT2169609	hsa-miR-4704-3p	CLIP-seq
MIRT775514	hsa-miR-4709-5p	CLIP-seq
MIRT1928846	hsa-miR-4718	CLIP-seq
MIRT2169610	hsa-miR-4722-5p	CLIP-seq
MIRT2169611	hsa-miR-4729	CLIP-seq
MIRT775515	hsa-miR-4736	CLIP-seq
MIRT1928847	hsa-miR-4758-5p	CLIP-seq
MIRT775516	hsa-miR-4763-3p	CLIP-seq
MIRT2169612	hsa-miR-4786-3p	CLIP-seq
MIRT775517	hsa-miR-497	CLIP-seq
MIRT775518	hsa-miR-500b	CLIP-seq
MIRT775519	hsa-miR-501-5p	CLIP-seq
MIRT2169613	hsa-miR-513c	CLIP-seq
MIRT2169614	hsa-miR-514b-5p	CLIP-seq
MIRT2169615	hsa-miR-545	CLIP-seq
MIRT2169616	hsa-miR-548p	CLIP-seq
MIRT775520	hsa-miR-548u	CLIP-seq
MIRT775521	hsa-miR-589	CLIP-seq
MIRT2169617	hsa-miR-648	CLIP-seq
MIRT2169618	hsa-miR-671-5p	CLIP-seq
MIRT775522	hsa-miR-873	CLIP-seq
MIRT2443447	hsa-miR-548g	CLIP-seq
MIRT775523	hsa-miR-1245b-3p	CLIP-seq
MIRT775524	hsa-miR-1279	CLIP-seq
MIRT2472239	hsa-miR-1303	CLIP-seq
MIRT2472240	hsa-miR-204	CLIP-seq
MIRT2472241	hsa-miR-211	CLIP-seq
MIRT775528	hsa-miR-2117	CLIP-seq
MIRT2472242	hsa-miR-375	CLIP-seq
MIRT775530	hsa-miR-3974	CLIP-seq
MIRT775531	hsa-miR-4273	CLIP-seq
MIRT775532	hsa-miR-4677-5p	CLIP-seq
MIRT775533	hsa-miR-4684-3p	CLIP-seq
MIRT2472243	hsa-miR-4755-5p	CLIP-seq
MIRT775535	hsa-miR-515-5p	CLIP-seq
MIRT2472244	hsa-miR-526b	CLIP-seq
MIRT775536	hsa-miR-576-3p	CLIP-seq
MIRT775537	hsa-miR-582-5p	CLIP-seq
MIRT775538	hsa-miR-591	CLIP-seq
MIRT2472245	hsa-miR-623	CLIP-seq
MIRT2472246	hsa-miR-7	CLIP-seq
MIRT775523	hsa-miR-1245b-3p	CLIP-seq
MIRT775524	hsa-miR-1279	CLIP-seq
MIRT775530	hsa-miR-3974	CLIP-seq
MIRT775533	hsa-miR-4684-3p	CLIP-seq
MIRT775536	hsa-miR-576-3p	CLIP-seq
MIRT775537	hsa-miR-582-5p	CLIP-seq
MIRT775538	hsa-miR-591	CLIP-seq

Show/Hide all(19)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003676	Function	Nucleic acid binding	IEA
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0003723	Function	RNA binding	IEA
GO:0003723	Function	RNA binding	TAS	8769136
GO:0005515	Function	Protein binding	IPI	12223483, 16642035, 24083380, 24981860, 26496610, 31522117, 33961781
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IBA
GO:0005739	Component	Mitochondrion	IDA
GO:0005739	Component	Mitochondrion	IEA
GO:0005741	Component	Mitochondrial outer membrane	IEA
GO:0005829	Component	Cytosol	TAS
GO:0006915	Process	Apoptotic process	IEA
GO:0006915	Process	Apoptotic process	ISS
GO:0016020	Component	Membrane	HDA	19946888
GO:0016020	Component	Membrane	IBA
GO:0016020	Component	Membrane	IEA
GO:0034237	Function	Protein kinase A regulatory subunit binding	IBA
GO:0034237	Function	Protein kinase A regulatory subunit binding	IPI	17911601
GO:0140374	Process	Antiviral innate immune response	IMP	31522117

MIM	HGNC	e!Ensembl
602449	367	ENSG00000121057

Protein

UniProt ID

Q92667

Protein name

A-kinase anchor protein 1, mitochondrial (A-kinase anchor protein 149 kDa) (AKAP 149) (Dual specificity A-kinase-anchoring protein 1) (D-AKAP-1) (Protein kinase A-anchoring protein 1) (PRKA1) (Spermatid A-kinase anchor protein 84) (S-AKAP84)

Protein function

Binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane (By similarity). Involved in mitochondrial-mediated antiviral innate immunity (PubMed:31522117). Promotes

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00013	KH_1	609 → 673	KH domain	Domain
PF00567	TUDOR	704 → 828	Tudor domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Isoform 1 is detected in thymus, prostate, testis, ovary, colon and small intestine (PubMed:8769136). Isoform 2 is highly expressed in testis and detected at much lower levels in kidney, pancreas, liver, lung and brain (PubMed:7499250)

Sequence

MAIQFRSLFPLALPGMLALLGWWWFFSRKKGHVSSHDEQQVEAGAVQLRADPAIKEPLPV
EDVCPKVVSTPPSVTEPPEKELSTVSKLPAEPPALLQTHPPCRRSESSGILPNTTDMRLR
PGTRRDDSTKLELALTGGEAKSIPLECPLSSPKGVLFSSKSAEVCKQDSPFSRVPRKVQP
GYPVVPAEKRSSGERARETGGAEGTGDAVLGEKVLEEALLSREHVLELENSKGPSLASLE
GEEDKGKSSSSQVVGPVQEEEYVAEKLPSRFIESAHTELAKDDAAPAPPVADAKAQDRGV
EGELGNEESLDRNEEGLDRNEEGLDRNEESLDRNEEGLDRNEEIKRAAFQIISQVISEAT
EQVLATTVGKVAGRVCQASQLQGQKEESCVPVHQKTVLGPDTAEPATAEAAVAPPDAGLP
LPGLPAEGSPPPKTYVSCLKSLLSSPTKDSKPNISAHHISLASCLALTTPSEELPDRAGI
LVEDATCVTCMSDSSQSVPLVASPGHCSDSFSTSGLEDSCTETSSSPRDKAITPPLPEST
VPFSNGVLKGELSDLGAEDGWTMDAEADHSGGSDRNSMDSVDSCCSLKKTESFQNAQAGS
NPKKVDLIIWEIEVPKHLVGRLIGKQGRYVSFLKQTSGAKIYISTLPYTQSVQICHIEGS
QHHVDKALNLIGKKFKELNLTNIYAPPLPSLALPSLPMTSWLMLPDGITVEVIVVNQVNA
GHLFVQQHTHPTFHALRSLDQQMYLCYSQPGIPTLPTPVEITVICAAPGADGAWWRAQVV
ASYEETNEVEIRYVDYGGYKRVKVDVLRQIRSDFVTLPFQGAEVLLDSVMPLSDDDQFSP
EADAAMSEMTGNTALLAQVTSYSPTGLPLIQLWSVVGDEVVLINRSLVERGLAQWVDSYY
TSL

Sequence length

903

Interactions

View interactions

	Reactome
			Factors involved in megakaryocyte development and platelet production

AKAP1 (A-kinase anchoring protein 1)