Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein
Entrez ID	81628
Gene name	TSC22 domain family member 4
Gene symbol	TSC22D4
Synonyms (NCBI Gene)	SPACDRTHG-1THG1TILZ2
Chromosome	7
Chromosome location	7q22.1
Summary	TSC22D4 is a member of the TSC22 domain family of leucine zipper transcriptional regulators (see TSC22D3; MIM 300506) (Kester et al., 1999 [PubMed 10488076]; Fiorenza et al., 2001 [PubMed 11707329]).[supplied by OMIM, Mar 2008]

Show/Hide all (98)

miRTarBase ID	miRNA	Experiments	Reference
MIRT004100	hsa-miR-124-3p	Microarray	15685193
MIRT004100	hsa-miR-124-3p	Microarray	18668037
MIRT004100	hsa-miR-124-3p	Microarray	15685193
MIRT025708	hsa-miR-7-5p	Sequencing	20371350
MIRT030651	hsa-miR-22-3p	Sequencing	20371350
MIRT037825	hsa-miR-455-3p	CLASH	23622248
MIRT004100	hsa-miR-124-3p	PAR-CLIP	20371350
MIRT565203	hsa-miR-548an	PAR-CLIP	20371350
MIRT565202	hsa-miR-4323	PAR-CLIP	20371350
MIRT500673	hsa-miR-5582-5p	PAR-CLIP	20371350
MIRT565201	hsa-miR-186-3p	PAR-CLIP	20371350
MIRT565200	hsa-miR-5699-5p	PAR-CLIP	20371350
MIRT004100	hsa-miR-124-3p	PAR-CLIP	24398324
MIRT500673	hsa-miR-5582-5p	PAR-CLIP	24398324
MIRT004100	hsa-miR-124-3p	PAR-CLIP	20371350
MIRT565203	hsa-miR-548an	PAR-CLIP	20371350
MIRT565202	hsa-miR-4323	PAR-CLIP	20371350
MIRT500673	hsa-miR-5582-5p	PAR-CLIP	20371350
MIRT565201	hsa-miR-186-3p	PAR-CLIP	20371350
MIRT565200	hsa-miR-5699-5p	PAR-CLIP	20371350
MIRT004100	hsa-miR-124-3p	PAR-CLIP	24398324
MIRT500673	hsa-miR-5582-5p	PAR-CLIP	24398324
MIRT1458378	hsa-miR-124	CLIP-seq
MIRT1458379	hsa-miR-3922-5p	CLIP-seq
MIRT1458380	hsa-miR-3937	CLIP-seq
MIRT1458381	hsa-miR-4708-3p	CLIP-seq
MIRT1458382	hsa-miR-486-3p	CLIP-seq
MIRT1458383	hsa-miR-506	CLIP-seq
MIRT2137532	hsa-miR-1224-3p	CLIP-seq
MIRT2137533	hsa-miR-1260	CLIP-seq
MIRT2137534	hsa-miR-1260b	CLIP-seq
MIRT2137535	hsa-miR-1280	CLIP-seq
MIRT2137536	hsa-miR-1285	CLIP-seq
MIRT2137537	hsa-miR-1297	CLIP-seq
MIRT2137538	hsa-miR-1470	CLIP-seq
MIRT2137539	hsa-miR-2467-3p	CLIP-seq
MIRT2137540	hsa-miR-26a	CLIP-seq
MIRT2137541	hsa-miR-26b	CLIP-seq
MIRT2137542	hsa-miR-3140-5p	CLIP-seq
MIRT2137543	hsa-miR-3150b-3p	CLIP-seq
MIRT2137544	hsa-miR-3180-5p	CLIP-seq
MIRT2137545	hsa-miR-3187-5p	CLIP-seq
MIRT2137546	hsa-miR-331-3p	CLIP-seq
MIRT2137547	hsa-miR-3545-3p	CLIP-seq
MIRT2137548	hsa-miR-4292	CLIP-seq
MIRT2137549	hsa-miR-4462	CLIP-seq
MIRT2137550	hsa-miR-4465	CLIP-seq
MIRT2137551	hsa-miR-4469	CLIP-seq
MIRT2137552	hsa-miR-4532	CLIP-seq
MIRT2137553	hsa-miR-4659a-3p	CLIP-seq
MIRT2137554	hsa-miR-4659b-3p	CLIP-seq
MIRT2137555	hsa-miR-4667-3p	CLIP-seq
MIRT2137556	hsa-miR-4680-5p	CLIP-seq
MIRT2137557	hsa-miR-4784	CLIP-seq
MIRT2137558	hsa-miR-4795-3p	CLIP-seq
MIRT1458382	hsa-miR-486-3p	CLIP-seq
MIRT2137559	hsa-miR-520a-5p	CLIP-seq
MIRT2137560	hsa-miR-525-5p	CLIP-seq
MIRT2137561	hsa-miR-532-3p	CLIP-seq
MIRT2137562	hsa-miR-602	CLIP-seq
MIRT2137563	hsa-miR-612	CLIP-seq
MIRT2137564	hsa-miR-759	CLIP-seq
MIRT2137565	hsa-miR-944	CLIP-seq
MIRT2358384	hsa-miR-1272	CLIP-seq
MIRT2358385	hsa-miR-1273f	CLIP-seq
MIRT2137536	hsa-miR-1285	CLIP-seq
MIRT2137538	hsa-miR-1470	CLIP-seq
MIRT2358386	hsa-miR-1909	CLIP-seq
MIRT2358387	hsa-miR-1972	CLIP-seq
MIRT2137539	hsa-miR-2467-3p	CLIP-seq
MIRT2358388	hsa-miR-3144-5p	CLIP-seq
MIRT2137543	hsa-miR-3150b-3p	CLIP-seq
MIRT2137544	hsa-miR-3180-5p	CLIP-seq
MIRT2137545	hsa-miR-3187-5p	CLIP-seq
MIRT2137546	hsa-miR-331-3p	CLIP-seq
MIRT2358389	hsa-miR-342-5p	CLIP-seq
MIRT2358390	hsa-miR-346	CLIP-seq
MIRT2358391	hsa-miR-4288	CLIP-seq
MIRT2137548	hsa-miR-4292	CLIP-seq
MIRT2358392	hsa-miR-4426	CLIP-seq
MIRT2137549	hsa-miR-4462	CLIP-seq
MIRT2137551	hsa-miR-4469	CLIP-seq
MIRT2137552	hsa-miR-4532	CLIP-seq
MIRT2358393	hsa-miR-4647	CLIP-seq
MIRT2358394	hsa-miR-4651	CLIP-seq
MIRT2358395	hsa-miR-4662b	CLIP-seq
MIRT2358396	hsa-miR-4664-5p	CLIP-seq
MIRT2137555	hsa-miR-4667-3p	CLIP-seq
MIRT2358397	hsa-miR-4689	CLIP-seq
MIRT2137557	hsa-miR-4784	CLIP-seq
MIRT1458382	hsa-miR-486-3p	CLIP-seq
MIRT2137559	hsa-miR-520a-5p	CLIP-seq
MIRT2137560	hsa-miR-525-5p	CLIP-seq
MIRT2137562	hsa-miR-602	CLIP-seq
MIRT2358398	hsa-miR-608	CLIP-seq
MIRT2137563	hsa-miR-612	CLIP-seq
MIRT2358399	hsa-miR-632	CLIP-seq
MIRT2358400	hsa-miR-885-5p	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	ISS
GO:0005515	Function	Protein binding	IPI	16189514, 16713569, 19615732, 21448135, 21516116, 21988832, 22510880, 25416956, 28514442, 31515488, 32296183, 32707033, 32814053, 33961781, 35271311
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	ISS
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	ISS
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IEA
GO:0006970	Process	Response to osmotic stress	IBA
GO:0030425	Component	Dendrite	IEA
GO:0030425	Component	Dendrite	ISS
GO:0042593	Process	Glucose homeostasis	ISS
GO:0042995	Component	Cell projection	IEA
GO:0045202	Component	Synapse	IEA
GO:0045202	Component	Synapse	ISS
GO:0045892	Process	Negative regulation of DNA-templated transcription	NAS	10488076
GO:0070050	Process	Neuron cellular homeostasis	ISS
GO:1990138	Process	Neuron projection extension	ISS

MIM	HGNC	e!Ensembl
611914	21696	ENSG00000166925

Q9Y3Q8

Protein name

TSC22 domain family protein 4 (TSC22-related-inducible leucine zipper protein 2)

Protein function

Binds DNA and acts as a transcriptional repressor (PubMed:10488076). Involved in the regulation of systematic glucose homeostasis and insulin sensitivity, via transcriptional repression of downstream insulin signaling targets such as OBP2A/LCN13

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01166	TSC22	326 → 381	TSC-22/dip/bun family	Coiled-coil

Tissue specificity

TISSUE SPECIFICITY: Expressed in the liver. {ECO:0000269|PubMed:27827363}.

Sequence

MSGGKKKSSFQITSVTTDYEGPGSPGASDPPTPQPPTGPPPRLPNGEPSPDPGGKGTPRN
GSPPPGAPSSRFRVVKLPHGLGEPYRRGRWTCVDVYERDLEPHSFGGLLEGIRGASGGAG
GRSLDSRLELASLGLGAPTPPSGLSQGPTSWLRPPPTSPGPQARSFTGGLGQLVVPSKAK
AEKPPLSASSPQQRPPEPETGESAGTSRAATPLPSLRVEAEAGGSGARTPPLSRRKAVDM
RLRMELGAPEEMGQVPPLDSRPSSPALYFTHDASLVHKSPDPFGAVAAQKFSLAHSMLAI
SGHLDSDDDSGSGSLVGIDNKIEQAMDLVKSHLMFAVREEVEVLKEQIRELAERNAALEQ
ENGLLRALASPEQLAQLPSSGVPRLGPPAPNGPSV

Sequence length

395

Interactions

View interactions

TSC22D4 (TSC22 domain family member 4)