Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	81628
Gene name Gene Name - the full gene name approved by the HGNC.	TSC22 domain family member 4
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	TSC22D4
Synonyms (NCBI Gene) Gene synonyms aliases	SPACDR, THG-1, THG1, TILZ2
Chromosome Chromosome number	7
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	7q22.1
Summary Summary of gene provided in NCBI Entrez Gene.	TSC22D4 is a member of the TSC22 domain family of leucine zipper transcriptional regulators (see TSC22D3; MIM 300506) (Kester et al., 1999 [PubMed 10488076]; Fiorenza et al., 2001 [PubMed 11707329]).[supplied by OMIM, Mar 2008]

Show/Hide all(98)

miRTarBase ID	miRNA	Experiments	Reference
MIRT004100	hsa-miR-124-3p	Microarray	15685193
MIRT004100	hsa-miR-124-3p	Microarray	18668037
MIRT004100	hsa-miR-124-3p	Microarray	15685193
MIRT025708	hsa-miR-7-5p	Sequencing	20371350
MIRT030651	hsa-miR-22-3p	Sequencing	20371350
MIRT037825	hsa-miR-455-3p	CLASH	23622248
MIRT004100	hsa-miR-124-3p	PAR-CLIP	20371350
MIRT565203	hsa-miR-548an	PAR-CLIP	20371350
MIRT565202	hsa-miR-4323	PAR-CLIP	20371350
MIRT500673	hsa-miR-5582-5p	PAR-CLIP	20371350
MIRT565201	hsa-miR-186-3p	PAR-CLIP	20371350
MIRT565200	hsa-miR-5699-5p	PAR-CLIP	20371350
MIRT004100	hsa-miR-124-3p	PAR-CLIP	24398324
MIRT500673	hsa-miR-5582-5p	PAR-CLIP	24398324
MIRT004100	hsa-miR-124-3p	PAR-CLIP	20371350
MIRT565203	hsa-miR-548an	PAR-CLIP	20371350
MIRT565202	hsa-miR-4323	PAR-CLIP	20371350
MIRT500673	hsa-miR-5582-5p	PAR-CLIP	20371350
MIRT565201	hsa-miR-186-3p	PAR-CLIP	20371350
MIRT565200	hsa-miR-5699-5p	PAR-CLIP	20371350
MIRT004100	hsa-miR-124-3p	PAR-CLIP	24398324
MIRT500673	hsa-miR-5582-5p	PAR-CLIP	24398324
MIRT1458378	hsa-miR-124	CLIP-seq
MIRT1458379	hsa-miR-3922-5p	CLIP-seq
MIRT1458380	hsa-miR-3937	CLIP-seq
MIRT1458381	hsa-miR-4708-3p	CLIP-seq
MIRT1458382	hsa-miR-486-3p	CLIP-seq
MIRT1458383	hsa-miR-506	CLIP-seq
MIRT2137532	hsa-miR-1224-3p	CLIP-seq
MIRT2137533	hsa-miR-1260	CLIP-seq
MIRT2137534	hsa-miR-1260b	CLIP-seq
MIRT2137535	hsa-miR-1280	CLIP-seq
MIRT2137536	hsa-miR-1285	CLIP-seq
MIRT2137537	hsa-miR-1297	CLIP-seq
MIRT2137538	hsa-miR-1470	CLIP-seq
MIRT2137539	hsa-miR-2467-3p	CLIP-seq
MIRT2137540	hsa-miR-26a	CLIP-seq
MIRT2137541	hsa-miR-26b	CLIP-seq
MIRT2137542	hsa-miR-3140-5p	CLIP-seq
MIRT2137543	hsa-miR-3150b-3p	CLIP-seq
MIRT2137544	hsa-miR-3180-5p	CLIP-seq
MIRT2137545	hsa-miR-3187-5p	CLIP-seq
MIRT2137546	hsa-miR-331-3p	CLIP-seq
MIRT2137547	hsa-miR-3545-3p	CLIP-seq
MIRT2137548	hsa-miR-4292	CLIP-seq
MIRT2137549	hsa-miR-4462	CLIP-seq
MIRT2137550	hsa-miR-4465	CLIP-seq
MIRT2137551	hsa-miR-4469	CLIP-seq
MIRT2137552	hsa-miR-4532	CLIP-seq
MIRT2137553	hsa-miR-4659a-3p	CLIP-seq
MIRT2137554	hsa-miR-4659b-3p	CLIP-seq
MIRT2137555	hsa-miR-4667-3p	CLIP-seq
MIRT2137556	hsa-miR-4680-5p	CLIP-seq
MIRT2137557	hsa-miR-4784	CLIP-seq
MIRT2137558	hsa-miR-4795-3p	CLIP-seq
MIRT1458382	hsa-miR-486-3p	CLIP-seq
MIRT2137559	hsa-miR-520a-5p	CLIP-seq
MIRT2137560	hsa-miR-525-5p	CLIP-seq
MIRT2137561	hsa-miR-532-3p	CLIP-seq
MIRT2137562	hsa-miR-602	CLIP-seq
MIRT2137563	hsa-miR-612	CLIP-seq
MIRT2137564	hsa-miR-759	CLIP-seq
MIRT2137565	hsa-miR-944	CLIP-seq
MIRT2358384	hsa-miR-1272	CLIP-seq
MIRT2358385	hsa-miR-1273f	CLIP-seq
MIRT2137536	hsa-miR-1285	CLIP-seq
MIRT2137538	hsa-miR-1470	CLIP-seq
MIRT2358386	hsa-miR-1909	CLIP-seq
MIRT2358387	hsa-miR-1972	CLIP-seq
MIRT2137539	hsa-miR-2467-3p	CLIP-seq
MIRT2358388	hsa-miR-3144-5p	CLIP-seq
MIRT2137543	hsa-miR-3150b-3p	CLIP-seq
MIRT2137544	hsa-miR-3180-5p	CLIP-seq
MIRT2137545	hsa-miR-3187-5p	CLIP-seq
MIRT2137546	hsa-miR-331-3p	CLIP-seq
MIRT2358389	hsa-miR-342-5p	CLIP-seq
MIRT2358390	hsa-miR-346	CLIP-seq
MIRT2358391	hsa-miR-4288	CLIP-seq
MIRT2137548	hsa-miR-4292	CLIP-seq
MIRT2358392	hsa-miR-4426	CLIP-seq
MIRT2137549	hsa-miR-4462	CLIP-seq
MIRT2137551	hsa-miR-4469	CLIP-seq
MIRT2137552	hsa-miR-4532	CLIP-seq
MIRT2358393	hsa-miR-4647	CLIP-seq
MIRT2358394	hsa-miR-4651	CLIP-seq
MIRT2358395	hsa-miR-4662b	CLIP-seq
MIRT2358396	hsa-miR-4664-5p	CLIP-seq
MIRT2137555	hsa-miR-4667-3p	CLIP-seq
MIRT2358397	hsa-miR-4689	CLIP-seq
MIRT2137557	hsa-miR-4784	CLIP-seq
MIRT1458382	hsa-miR-486-3p	CLIP-seq
MIRT2137559	hsa-miR-520a-5p	CLIP-seq
MIRT2137560	hsa-miR-525-5p	CLIP-seq
MIRT2137562	hsa-miR-602	CLIP-seq
MIRT2358398	hsa-miR-608	CLIP-seq
MIRT2137563	hsa-miR-612	CLIP-seq
MIRT2358399	hsa-miR-632	CLIP-seq
MIRT2358400	hsa-miR-885-5p	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	16189514, 16713569, 19615732, 21516116, 21988832, 25416956, 28514442, 31515488, 32296183, 32814053
GO:0005634	Component	Nucleus	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IEA
GO:0006970	Process	Response to osmotic stress	IBA	21873635
GO:0045892	Process	Negative regulation of transcription, DNA-templated	NAS	10488076

MIM	HGNC	e!Ensembl
611914	21696	ENSG00000166925

Protein

UniProt ID

Q9Y3Q8

Protein name

TSC22 domain family protein 4 (TSC22-related-inducible leucine zipper protein 2)

Protein function

Binds DNA and acts as a transcriptional repressor (PubMed:10488076). Involved in the regulation of systematic glucose homeostasis and insulin sensitivity, via transcriptional repression of downstream insulin signaling targets such as OBP2A/LCN13

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01166	TSC22	326 → 381	TSC-22/dip/bun family	Coiled-coil

Tissue specificity

TISSUE SPECIFICITY: Expressed in the liver. {ECO:0000269|PubMed:27827363}.

Sequence

MSGGKKKSSFQITSVTTDYEGPGSPGASDPPTPQPPTGPPPRLPNGEPSPDPGGKGTPRN
GSPPPGAPSSRFRVVKLPHGLGEPYRRGRWTCVDVYERDLEPHSFGGLLEGIRGASGGAG
GRSLDSRLELASLGLGAPTPPSGLSQGPTSWLRPPPTSPGPQARSFTGGLGQLVVPSKAK
AEKPPLSASSPQQRPPEPETGESAGTSRAATPLPSLRVEAEAGGSGARTPPLSRRKAVDM
RLRMELGAPEEMGQVPPLDSRPSSPALYFTHDASLVHKSPDPFGAVAAQKFSLAHSMLAI
SGHLDSDDDSGSGSLVGIDNKIEQAMDLVKSHLMFAVREEVEVLKEQIRELAERNAALEQ
ENGLLRALASPEQLAQLPSSGVPRLGPPAPNGPSV

Sequence length

395

Interactions

View interactions

Show/Hide Causal Diseases (1)

Disease term	Disease name	dbSNP ID	References
Causal
Breast cancer	Malignant neoplasm of breast	rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158 View all (309 more)

Show/Hide Text Mining Associations (4)

Disease Name	Relationship Type	References
Associations from Text Mining
Carcinoma Squamous Cell	Associate	31864704
Cell Transformation Neoplastic	Associate	31864704
Esophageal Squamous Cell Carcinoma	Associate	31864704
Leukemia Myeloid Acute	Associate	37237254

TSC22D4 (TSC22 domain family member 4)